Clinical trials: Block, Heart
Chronic Stable Angina, Dyspnea
A Randomized Multicentre Trial to Evaluate the Utilization of Revascularization or Optimal Medical Therapy for the Treatment of Chronic Total Coronary Occlusions
CTOs are common among patients with angina, and are detected in around 20% of patients undergoing coronary angiography. Treatment of CTO has been found to constitute only 7% of PCI practice on average.
- Conditions
- Chronic Stable Angina, Dyspnea, Coronary Occlusion
- Trial name
- EuroCTO (NCT01760083)
- Testing
- Biolimus-eluting stent implantation
- Where
- 19 sites in France, Germany and 4 more
- Volunteers
- 450 people
- Sponsor
- Euro CTO Club
Amyloidosis, Aortic Valve Stenosis
Early Detection of Cardiac Amyloidosis
Due to a lack of therapeutic options, the diagnosis of cardiac (wt)-ATTR amyloidosis was for a long time overshadowed by other diseases and therefore was or still is often diagnosed with considerable delay.
- Trial name
- NCT05010980
- Testing
- CMR, scintigraphy
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Aortic Stenosis
U.S. Multicenter Feasibility Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR
The goal of this clinical trial is to learn about the safety and performance of the F2 device for cerebral embolic protection in participants with symptomatic aortic stenosis undergoing a Transcatheter Aortic Valve replacement…
- Trial name
- NCT06069661
- Testing
- Aortic Stenosis
- Where
- United States
- Sponsor
- EnCompass Technologies, Inc.
Coronary Disease, Acute Coronary Syndrome
Clinical Study Protocol - Debris Interventional Removal in ACS (DESIRE-ACS)
DebriS Interventional REmoval in ACS (DESIRE-ACS) Study to assess the safety and performance of the ECA Bell balloon in subjects undergoing coronary percutaneous interventions.
- Conditions
- Coronary Disease, Acute Coronary Syndrome, Coronary Occlusion
- Trial name
- DESIRE-ACS (NCT02325869)
- Testing
- Bell Balloon Catheter
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Angioslide Ltd.
Sick Sinus Syndrome, Paroxysmal Atrial Fibrillation
Optimal Sensing in Atrial Tachyarrhythmia's Study
The aim of the study is the comparison of two different leads in their capabilities to detect episodes and duration of paroxysmal atrial fibrillation (AF) and atrial tachyarrhythmia (AT), and the rejection of far field sensing of…
- Trial name
- OSAT (NCT01074749)
- Testing
- Accent Pacemaker
- Where
- Netherlands
- Volunteers
- 111 people
- Sponsor
- Abbott Medical Devices
Complete Heart Block
PECs Block for Pacemaker Insertion in Children
Evaluation of Ultrasound Guided Modified Pectoral Nerves Blocks in Transvenous Subpectoral pacemaker insertion in Children: Randomized Controlled Trial
- Trial name
- NCT04931693
- Testing
- paracetamol, modifiedPECs block
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kasr El Aini Hospital
Lung Neoplasms, Respiratory Failure
Clearance Of Mucus In Stents (COMIS)
The goal of this clinical research study is to compare the effects of sodium bicarbonate to normal saline when used for clearing mucus blockage in patients with airway stents.
- Conditions
- Lung Neoplasms, Respiratory Failure, Pneumonia, Acute Coronary Syndromes
- Trial name
- NCT01370278
- Testing
- Normal Saline, Sodium Bicarbonate
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Vasoplegia
Postoperative Hemodynamics Comparison After High Spinal Block With or Without Intrathecal Morphine.
There is paucity of literature on the effects of intrathecal morphine on the postoperative hemodynamics in the cardiac-surgical patients.We planned this study to compare the post-operative hemodynamic effects (particularly the…
- Trial name
- NCT02825056
- Testing
- Bupivacaine, Bupivacaine + Morphine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Aortic Valve Stenosis
DEFLECT II: A Study to Evaluate the Safety and Performance of the TriGuard™HDH in Patients Undergoing TAVR
Pilot study enrolling up to 12 patients at a single investigational site in the Netherlands. Patients for TAVR will be enrolled to receive the Embolic Deflection Device throughout the duration of the TAVR procedure.
- Trial name
- NCT02073851
- Testing
- TriGuard™HDH
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Keystone Heart
Bypass Complication, Cardioplegia Solution Adverse Reaction
Investigation of Myocardial Protection Level With Specific Cardioplegia Methods in Cardiac Surgery
Investigating the myocardial effects of cold blood cardioplegia and del nido cardioplegia solution, which are routinely used in clinical practice, will contribute to the studies in the literature on the safety and efficacy of…
- Conditions
- Bypass Complication, Cardioplegia Solution Adverse Reaction, Endothelial Degeneration, Oxidative Stress
- Trial name
- NCT05603429
- Testing
- Endocan, E-Selectin, TNF-alpha, Total Oxidant and Antioxidant Status
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital
Aortic Valve Stenosis
5 Year Observation of Patients With PORTICO Valves
The purpose of this clinical investigation is to further assess the performance and safety profile of the commercially-available Portico™ TAVI System in patients with severe symptomatic aortic stenosis.
- Trial name
- PORTICO-1 (NCT01802788)
- Testing
- St Jude Medical Portico replacement aortic valve, Transcatheter Aortic Valve Implant
- Where
- 60 sites in Australia, Belgium and 11 more
- Volunteers
- 1,032 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Systolic, Left Bundle-Branch Block
Optimizing CRT With ECGI
CRT is delivered from two electrodes on opposite sides of the heart [right (RV) and left ventricle (LV)] delivering stimulation for more efficient heart beats.
- Trial name
- optCRT (NCT03492788)
- Testing
- ECGI-optimized VV-offset, Zero VV-offset
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Washington University School of Medicine
Valvular Heart Disease, Mitral Valve Disease
Prevalence Study of Cardiovascular Diseases in a Population ≥ 65 Years in Italy
This registry is a large-scale epidemiological study (PREVASC) aimed at estimating the prevalence of symptomatic and asymptomatic valvular hear disease in men and women aged over 65 years randomly selected in Italy.
- Conditions
- Valvular Heart Disease, Mitral Valve Disease, Aortic Valve Stenosis, Aortic Valve Insufficiency
- Trial name
- PREVASC (NCT05892588)
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Pelvic Organ Prolapse
Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse
The aim of our study is to investigate the alterations in connective tissue of vaginal wall in patients with and without pelvic organ prolapse (POP).
- Trial name
- NCT01749696
- Where
- Finland
- Volunteers
- 78 people
- Sponsor
- Turku University Hospital
Aortic Valve Stenosis, Aneurysm of Ascending Aorta
Progel Vascular Sealant
This study is being conducted to evaluate the safety and effectiveness of the Progel Vascular Sealant for use in vascular reconstructions to achieve adjunctive hemostasis by mechanically sealing areas of leakage.
- Conditions
- Aortic Valve Stenosis, Aneurysm of Ascending Aorta, Aortic Valve Disorder, Bicuspid Valve Disorder
- Trial name
- NCT01959503
- Testing
- Progel Vascular Sealant, Gelfoam Plus
- Where
- 19 sites in United States
- Volunteers
- 158 people
- Sponsor
- C. R. Bard
Mild Cognitive Impairment, Aortic Stenosis
Prospective Evaluation of Neurocognition in Patients Undergoing Transcatheter Aortic Valve Replacement
This trail is for patients with mild cognitive impairment (MCI) who are receiving a transcatheter aortic valve replacement (TAVR).
- Trial name
- Neurcog TAVR (NCT05614986)
- Testing
- 5 minute Montreal Cognitive Assessment (mini MoCA)
- Where
- 4 sites in United States
- Volunteers
- 81 people
- Sponsor
- Baylor Research Institute
Hypertension Arterial, Desaturation
Dexmedetomidine During Carotid Endarterectomy: a Registry on Safety and Satisfaction of Patients and Operators (DexTEA)
From an anesthesiological perspective, carotid endarterectomy (CEA) is an operation that is increasingly being performed with locoregional techniques and sedation.
- Conditions
- Hypertension Arterial, Desaturation, Bradycardia, Surgery (Major Vascular)
- Trial name
- NCT07105527
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Saint Camillus International University of Health Sciences
Risk of Coronary Obstruction Following Transcatheter Aortic Valve Replacement (TAVR) Procedure
The ShortCut™ Study Protocol
A Prospective, Multicenter, Non-Randomized, Single-Arm, Open-Label Clinical Study to Demonstrate the Safety and Effectiveness of the ShortCut™ device for splitting bioprosthetic aortic valve leaflets in patients who are presented…
- Trial name
- NCT04952909
- Testing
- ShortCut™
- Where
- 23 sites in United States, France and 3 more
- Volunteers
- 60 people
- Sponsor
- Pi-cardia
Coronary Artery Disease
Effect of Introducer Length on the Rate of Radial Artery Occlusion During Endovascular Coronary Procedures
This study evaluates estimate impact of introducers length during endovascular coronary procedures on rate of a radial artery occlusion.
- Trial name
- IntroLength (NCT03854253)
- Testing
- Long introducer sheath, Short introducer sheath
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Left Bundle Branch Block, Transcatheter Aortic Valve Replacement
HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients
TAVI induced LBBB is a complication that occurs between 7 and 65 % of the cases, numbers that differ considerably between devices.
- Conditions
- Left Bundle Branch Block, Transcatheter Aortic Valve Replacement, Transcatheter Aortic Valve Implantation
- Trial name
- HESITATE (NCT02659137)
- Testing
- HV measurement
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center