Clinical trials: Blood Component Transfusion
Arthritis of the Hip, Transfusion Related Complications
Preoperative Versus Postoperative Start With Thromboprophylaxis in THA (Total Hip Arthroplasty)
The purpose of this study is to determine if there are differences in clinical events, i.e bleeding with associated morbidity, if thromboprophylaxis with LMWH (Low Molecular Weight Heparin) is initiated before or after surgery.
- Conditions
- Arthritis of the Hip, Transfusion Related Complications, Infection, Wound Discharge
- Trial name
- NCT01714297
- Testing
- dalteparin 5000 IU s.c.
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vestre Viken Hospital Trust
Blood Transfusion Complication, Wrong Blood in Tube
Proficiency Based Training to Investigate Blood Sampling Errors Including WBIT
The objective of this study is to determine the effectiveness of a Proficiency Based Progression training programme, together with evidence based individual feedback for any residual errors, which has been specifically developed…
- Conditions
- Blood Transfusion Complication, Wrong Blood in Tube, Pre Analytical Blood Sample Errors
- Trial name
- NCT03577561
- Testing
- Proficiency Based Progression Training in Phlebotomy
- Where
- Ireland
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Patrick Henn
Thalassemia Major, Covid19
Frequency of COVID-19 Antibodies in Patients With Hereditary Hematological Diseases
In Italy there are about 5000 patients with dependent transfusion thalassemia (source Italian Thalassemia and Hemoglobinopathies - SITE) and a smaller number, currently not definable, of patients with sickle cell anemia in…
- Trial name
- ThalaCoV (NCT04526405)
- Testing
- SARS-CoV-2 S1/S2 IgG
- Where
- Italy
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Newborn Morbidity, Simulation Training
Educational Strategy in Exchange Transfusion
Abstract Background: Exchange transfusion is a highly complex procedure that requires high levels of expertise. Paediatricians trainees do not have adequate training because opportunities to perform this procedure in practice are…
- Conditions
- Newborn Morbidity, Simulation Training, Telemedicine, Assessment, Self
- Trial name
- INTEXUS (NCT04070066)
- Testing
- Digital didactic environment, • Simulated scenario
- Where
- Colombia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidad de la Sabana
Surgical Blood Loss, Surgical Hemorrhage
TEG Use in Children Undergoing Procedures With High Anticipated Blood Loss
The research team proposes a prospective, observational study to better understand how TEG can be useful in guiding clinical practice in the Main OR for subject's undergoing high transfusion risk surgeries.
- Conditions
- Surgical Blood Loss, Surgical Hemorrhage, Post Operative Hemorrhage
- Trial name
- NCT05379530
- Testing
- Thromboelastography (TEG), Anesthesia Provider Survey
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Healthy
The Effect of Game-Based Activity on Blood Transfusion in Nursing Students
The aim of this randomized controlled study, which included pre-test, posttest and perseverance test, was to determine the effect of game-based learning on nursing students' knowledge levels about blood transfusion, to determine…
- Trial name
- NCT05661526
- Testing
- Bloodpoly board game, Text-to-speech group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Blood Transfusion
Blood Transfusion Reduction - QI Project
Blood Banks of large medical centers have large annual budgets, typically millions of dollars. Blood product wastage results in not only in a loss of the product's cost, but also of the fees involved in transporting, handling…
- Trial name
- NCT04823273
- Testing
- General improvement, In-line help text, Interruptive alert
- Where
- United States
- Volunteers
- 1,640 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy
Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide (NO) Homeostasis
The purpose of this study is to explore the impact of aged blood on endothelial function by measuring forearm blood flow during intra-arterial acetylcholine infusion in normal healthy human volunteers after infusion of autologous…
- Trial name
- NCT01137656
- Testing
- Acetylcholine and Blood
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Mark Gladwin
Healthy Volunteer Red Blood Cell Labeling Study; Not Disease Focused
Comparative Analysis of Biotinylated, Irradiated and 51-Chromium Radiolabeled Red Blood Cells for Analysis of Recovery and Survival After Autologous Transfusion
This research is being done to compare the red blood circulation survival in healthy adult volunteers between the 51 chromium (51Cr) red blood cell (RBC) labeling method and the Biotin (BioRBC) red blood cell (RBC) labeling…
- Trial name
- NCT07446647
- Testing
- Biotinylated Red Blood Cells (BioRBC), Irradiated Biotinylated Red Blood Cells (Irradiated BioRBC), 51 Chromium Labeled Red Blood Cells (51Cr RBC)
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jose Cancelas
Aplastic Anemia
A Study of Romiplostim for the Treatment of Refractory Transfusion-dependent NSAA
Efficacy and safety of Romiplostim in the treatment of refractory transfusion-dependent NSAA.
- Trial name
- NCT06535685
- Testing
- Romiplostim
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Ticagrelor, Aspirin
Reversal of the Antiplatelet Effects of Ticagrelor in Combination With Aspirin, Using Normal Platelets
The specific objective of this study is to investigate the potential for normal platelets to reverse the inhibition of platelet aggregation in patients treated with ticagrelor in combination with aspirin.
- Conditions
- Ticagrelor, Aspirin, Platelet Dysfunction Due to Drugs, Transfusion
- Trial name
- REVSTARTS (NCT03005704)
- Testing
- Antiplatelet treatment
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Trauma Injury, Haemorrhagic Shock
Prediction of Massive Transfusion in Trauma Patients
Since the 2000s, many prognostic scores were developed to predict traumatic haemorrhage. Most of these studies were retrospectives based on registers.
- Conditions
- Trauma Injury, Haemorrhagic Shock, Bleeding, Emergencies
- Trial name
- MTP (NCT04561050)
- Testing
- Comparison of score performances (Overall performance, discrimination and calibration)
- Where
- Switzerland
- Volunteers
- 13,222 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Sickle Cell Anemia, Blood Transfusion
Full Assessment of Clinical Transfusion Support
This study looks at why some children develop very severe anemia that leads to a blood transfusion. It also checks for diseases in the blood they receive.
- Conditions
- Sickle Cell Anemia, Blood Transfusion, Malaria Parasitaemia
- Trial name
- FACTS (NCT07094646)
- Where
- Uganda
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Red Blood Cell Transfusion
The Effect of Retrograde Autologous Priming on Transfusion Requirements After Cardiac Surgery
The TheRAPy vanguard trial is a multicentre, multiple period randomized, cluster crossover vanguard trial testing the feasibility of a full-scale trial to evaluate whether a centre-based policy of routine use of RAP versus a…
- Trial name
- TheRAPy (NCT06230198)
- Testing
- retrograde autologous priming (RAP), Crystalloid priming
- Where
- 4 sites in Canada
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Cardiovascular Disease
Study of the Tolerability, Pharmacokinetics, and Pharmacodynamics of INS50589 Intravenous Infusion in Healthy Volunteers
The objectives of this study are to look at the safety and tolerability of the experimental drug, how people process the drug, how the drug affects people, and to identify a dose or doses to study in subsequent future studies.
- Trial name
- NCT00099450
- Testing
- INS50589 Intravenous Infusion
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Coagulopathy, Blood Transfusion Complication
Thromboelastography Normal Reference Values in China Hunan Province
The purpose of this study was to establish the normal reference range of Thrombelastogram parameters in Hunan by a multicenter study, and to analyze the specificity of Thrombelastogram detection and the influence of gender, age…
- Trial name
- NCT03146455
- Testing
- no intervention
- Where
- China
- Volunteers
- 498 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Coronary Artery Disease
Conservation of Red Cell Mass , Oxygen Supply and Demand in Cardiac Surgery
Fifty patients will be enrolled into the study. The purpose of the study is to investigate the relevance of Hct levels in determining need for transfusion during operations employing bypass as well as to test the hypothesis that…
- Trial name
- NCT00660608
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Transfusion Reaction
Detection of Autologous DEHP (DiEthylHexyl Phthalate)-Free Blood Transfusion in Anti-doping
The aim of the proposed project is to perform a clinical study in which volunteers will receive autologous blood transfusions in DEHP-free blood bags.
- Trial name
- NCT02423135
- Testing
- Autologous blood transfusion
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Transfusion-dependent Beta-Thalassemia, Gene Therapy
Growth and Development-related Outcomes in Children With Transfusion-dependent Beta-thalassemia After Gene Therapy
The investigate will conduct a cohort study to compare the growth and development, metabolism, lifestyle behavior, and health-related quality of life among three groups: children with transfusion-dependent β-thalassemia (TDT) who…
- Trial name
- NCT05991336
- Testing
- Gene therapy
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
SARS-Associated Coronavirus, Covid19
Treatment of Critically Ill Patients With Covid-19 With Convalescent Plasma
This study aims to collect convalescent plasma and use it as experimental treatment in critically ill Covid-19 patients in order to reduce mortality and length of stay in intensive care unit.
- Conditions
- SARS-Associated Coronavirus, Covid19, SARS-CoV Infection
- Trial name
- NCT04468009
- Testing
- Convalescent plasma
- Where
- Argentina
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Hospital de Infecciosas Francisco Javier Muniz