Clinical trials: Blood Components Transfusion
Trauma/Injury Problem
Early Whole Blood in Patients Requiring Transfusion After Major Trauma
The proposal will assess if patients who require massive transfusion can be accurately predicted early after emergency department arrival and assess if the use of stored whole blood during initial resuscitation will reduce…
- Trial name
- NCT01227005
- Testing
- Transfusion of blood products
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- The University of Texas Health Science Center, Houston
Blood Safety, Blood Transfusion
Decreased Consumption of Blood Components During Cardiac Surgery Procedures: Causes and Effects.
There is a decrease in the amount of blood components used during cardiac surgery in the last four years. As the hemovigilance team of the investigators' Hospital the investigators want to find out the causes and effects of this…
- Trial name
- NCT02513966
- Volunteers
- 7,835 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hemorrhagic Shock, Acute Blood Loss Anemia
Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Adult male patients brought to the emergency department as Level A trauma activations who are receiving emergency blood transfusion. Objectives 1.
- Conditions
- Hemorrhagic Shock, Acute Blood Loss Anemia, Traumatic Brain Injury
- Trial name
- NCT05081063
- Testing
- Routine labs
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Loma Linda University
Blood Component Transfusion
Immunomodulation Following Transfusion
This study is designed to provide information on patients' immune response after exposure to transfused blood. Blood transfusions may have opposite immune effects on patients. One is sensitization. The other is immunosuppression.
- Trial name
- NCT00810810
- Testing
- Standard blood components, Leukoreduced blood components, Leukoreduced and irradiated
- Where
- 2 sites in United States
- Volunteers
- 287 people
- Sponsor
- University of Washington
Liver Transplantation, Postoperative Renal Complication
Postoperative Complications After Liver Transplantation
Incidence and risk factors for renal, cardiovascular and pulmonary complications after liver transplantation are not well defined.
- Conditions
- Liver Transplantation, Postoperative Renal Complication, Postoperative Pulmonary Complication, Postoperative Cardiovascular Complication
- Trial name
- NCT02761109
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
Trauma, Trauma Injury
Whole Blood in Trauma Patients With Hemorrhagic Shock
This study aims to evaluate among trauma patients with hemorrhagic shock the clinical impact of hemostatic resuscitation between whole blood vs.
- Conditions
- Trauma, Trauma Injury, Trauma, Multiple
- Trial name
- WEBSTER (NCT05634109)
- Testing
- Transfusion of blood products
- Where
- Colombia
- Volunteers
- 220 people
- Sponsor
- Fundacion Clinica Valle del Lili
Liver Cirrhosis With Acute Decompensation
Thrombelastometry-guided Blood Component Administration Versus Standard of Care in Patients With Decompensated Liver Cirrhosis Undergoing Invasive Procedures
Patients with liver cirrhosis have historically received prophylactic transfusions before invasive procedures with high risk of bleeding.
- Trial name
- PROTECT-CIRR (NCT07437755)
- Testing
- Blood Products transfusion
- Where
- Romania
- Volunteers
- 116 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Cardiac Arrest
Goal-orientated Coagulation Management in Hypothermic Cardiac Arrest Surgery
Cardiac surgery including hypothermic cardiac arrest (HCA) commonly involves perioperative transfusion of allogeneic blood products which is associated with increased morbidity and mortality.
- Trial name
- NCT01446354
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Blood Component Transfusion
Appropriateness of Frozen Plasma Use in Canada
There is little evidence to guide the current use of Frozen Plasma. Despite this, over 260,000 units of frozen plasma are transfused in Canada annually.
- Trial name
- NCT01187030
- Volunteers
- 2,580 people
- Sponsor
- Ottawa Hospital Research Institute
Hemorrhage, Cardiopulmonary Bypass
Management of Bleeding Following Cardiopulmonary Bypass
We believe ongoing bleeding during complex cardiac surgery can be accurately measured and that administration of a specific blood product replacement strategy designed to optimally slow or stop the bleeding can be followed by the…
- Trial name
- NCT00672516
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Minnesota
Transfusion-related Acute Lung Injury, Chronic Liver Disease
Predicting Lung Injury From Transfusion in Patients With Liver Disease
A certain molecule floating in the blood may represent a risk of lung injury after a transfusion. We are determining whether detection of this molecule on a simple blood clotting test will predict the development of lung injury…
- Conditions
- Transfusion-related Acute Lung Injury, Chronic Liver Disease, Gastrointestinal Bleeding
- Trial name
- NCT01756690
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Hemorrhage, Blood Component Transfusion
Prehospital Transfusion Strategy in Bleeding Patients
The aim of study is to compare clinical and biochemical effect of three different transfusion strategies among patients with major hemorrhage requiring prehospital transfusion.
- Trial name
- NCT04879485
- Testing
- Blood products
- Where
- 2 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- University of Aarhus
Obstetric Labor Complications, Hemorrhage
Thromboelastometry-guided Treatment Protocol Versus Standard Care of Major Haemorrhage in Obstetric Patients
This is a prospective, randomized and controlled study to find out if a rotational thromboelastometry(ROTEM) guided treatment protocol reduces the need for blood transfusions in major obstetric haemorrhage compared to standard…
- Trial name
- ROTEM-PPH (NCT02461251)
- Testing
- Rotational Thromboelastometry (ROTEM)
- Where
- Finland
- Volunteers
- 59 people
- Sponsor
- Tampere University Hospital
Hemorrhage
Tranexamic Acid, Hemorrhage and Transfusions After Combined Aortic Valve Replacement and Coronary Artery Bypass Surgery.
In this study we will investigate whether tranexamic acid given as an intravenous bolus injection before start of surgery, followed by a continuous infusion during surgery reduces, perioperative hemostatic activation, and…
- Trial name
- NCT00375466
- Testing
- Tranexamic acid
- Where
- Norway
- Volunteers
- 63 people
- Sponsor
- St. Olavs Hospital
Wounds and Injuries, Shock, Hemorrhagic
Trauma Resuscitation With Low-Titer Group O Whole Blood or Products
The goal of this clinical trial is to compare the effectiveness of unseparated whole blood (referred to as Low-Titer Group O Whole Blood) and the separate components of whole blood (including red cells, plasma, platelets, and…
- Trial name
- TROOP (NCT05638581)
- Testing
- LTOWB, Components
- Where
- 13 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- University of Alabama at Birmingham
Cirrhosis, Liver
Rotational Thromboelastometry Guided Blood Component Use in Children With Cirrhosis Undergoing Invasive Procedures: A Randomized Controlled Trial
Blood products are commonly used before invasive procedures in patients with end-stage liver diseases despite cirrhosis being a thrombophilic state.
- Trial name
- NCT04460222
- Testing
- Rotational Thromboelastometry to guide blood product transfusion pre invasive procedure, Conventional transfusion methods to guide blood product transfusion pre invasive procedure
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hemorrhagic Shock, Trauma Injury
Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children
The MATIC-2 is a multicenter clinical trial enrolling children who are less than 18 years of age with hemorrhagic shock potentially needing significant blood transfusion.
- Trial name
- MATIC-2 (NCT06070350)
- Testing
- Low Titer Group O Whole Blood (LTOWB), Tranexamic Acid (TXA), Component Therapy (CT)
- Where
- 23 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Philip Spinella
Blood Component Transfusion, Cardiac Surgical Procedures
Plasma Utilization Following Cardiac Surgery
In Canada, 218,000 units of fresh frozen plasma and frozen plasma were transfused in 2005.Cardiac surgery patients are the largest recipient group for FP transfusions.
- Trial name
- PUCS (NCT01187394)
- Where
- Canada
- Volunteers
- 970 people
- Sponsor
- Ottawa Hospital Research Institute
Blood Donation, Blood Transfusion
Donor Lifestyle and Nutritional Status, Blood Component Quality, and Patient Safety (ESENCIA)
The goal of this observational study is to evaluate how blood donors' lifestyle and nutritional status influence the quality of packed red blood cells (pRBCs) during storage and their impact on patient safety in transfused…
- Trial name
- ESENCIA (NCT07558369)
- Where
- Mexico
- Volunteers
- 1,014 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Perinatologia
Placenta Accreta Spectrum
Blood Components Changes by Using of Ringer's Lactated as Detergent In Autologous Blood Cell Transfusion
Placenta accreta spectrum (PAS) disorders are associated with increased maternal morbidity and mortality related to life-threatening hemorrhage, and greater potential need for blood transfusion.
- Trial name
- NCT04927988
- Testing
- Ringer's Lactated
- Where
- China
- Sponsor
- Maternal and Child Health Hospital of Foshan