Clinical trials: Blood Eosinophil Count
COPD
Biannual Review of Exhaled Air and Trends in Health Evaluation in COPD
This study aims to evaluate how airway inflammation, lung function, and symptoms change over time in people with chronic obstructive pulmonary disease (COPD).
- Trial name
- BREATHE-COPD (NCT07045948)
- Testing
- Blood eosinophil Count
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Anesthesia, Exhaled Nitric Oxide
Effect of Type of General Anesthesia Maintenance on Exhaled Nitric Oxide and Eosinophil Blood Count
Nitric oxide (NO) is a free radical in gas state which plays an important role in a variety of processes relevant to respiratory physiology.
- Conditions
- Anesthesia, Exhaled Nitric Oxide, Eosinophil Blood Count
- Trial name
- NCT02065635
- Testing
- maintenance with sevoflurane, maintenance with propofol
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Chronic Obstructive Pulmonary Disease (COPD)
This After Market Study is Seeing if Dupilumab Plus Usual Standard of Care (SOC) is Better Than Usual Care Alone for Adult Participants After a Severe Chronic Obstructive Pulmonary Disease (COPD) Flare-Up Requiring Hospitalization
This study is researching a drug called dupilumab, referred to as "study drug". The study is focused on people diagnosed with COPD to determine if the study drug, in addition to standard of care treatment for COPD, might reduce…
- Trial name
- MISSION (NCT07587658)
- Testing
- dupilumab
- Where
- United States
- Volunteers
- 754 people
- Sponsor
- Regeneron Pharmaceuticals
Lung Diseases, Obstructive, Blood Eosinophil Count
Corticosteroid Reduction in COPD
This study explores whether patients hospitalized with chronic obstructive pulmonary disease (COPD) exacerbation may have fewer days with prednisolone and with the same treatment effect by controlling the treatment by daily…
- Conditions
- Lung Diseases, Obstructive, Blood Eosinophil Count, Glucocorticoids, COPD
- Trial name
- Cortico-cop (NCT02857842)
- Testing
- Prednisolone
- Where
- 4 sites in Denmark
- Volunteers
- 318 people
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Diagnosis, Inflammation
Diagnosing Asthma With Clinically Accessible, Non-invasive, and Efficient Tests: a Child-inclusive Translational Investigation
Asthma is a common inflammatory respiratory disease affecting 11% of Canadians, but its diagnosis remains challenging, leading to delays in treatment or overtreatment.
- Conditions
- Diagnosis, Inflammation, Asthma in Children, Asthma
- Trial name
- DIVE 2 (NCT07011394)
- Testing
- FeNO, Blood eosinophil count
- Where
- 3 sites in Canada
- Volunteers
- 123 people
- Sponsor
- Université de Sherbrooke
Asthma
Dose Ranging Pharmacokinetics and Pharmacodynamics Study With Mepolizumab in Asthma Patients With Elevated Eosinophils
A multi-center, randomized, open-label, parallel-group, repeat dose study in asthma patients with elevated eosinophils. Eligible subjects will receive 3 doses (28 days apart) of mepolizumab given intravenous (IV) or…
- Trial name
- NCT01366521
- Testing
- Mepolizumab
- Where
- 11 sites in United States, Estonia and 2 more
- Volunteers
- 70 people
- Sponsor
- GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive
Use of Diagnostic Measures in Chronic Obstructive Pulmonary Disease (COPD) in Routine Practice and Their Impact on Treatment Decisions
This study will evaluate the diagnostic measures (including blood eosinophil counts) commonly used by lung specialist's in routine clinical care of subjects with COPD in Germany and how these diagnostic tests influence the…
- Trial name
- NCT03465332
- Testing
- Doctor's questionnaire, Subject file
- Where
- 26 sites in Germany
- Volunteers
- 251 people
- Sponsor
- GlaxoSmithKline
Asthma, Mild-to-moderate Asthma
Remission in Adults With Mild-to-moderate Asthma in Thailand
The goal of this observational study is to determine the prevalence of remission among adults with mild-to-moderate asthma, as well as the factors associated with remission in Thailand.
- Conditions
- Asthma, Mild-to-moderate Asthma, Asthma Control Level
- Trial name
- NCT07351916
- Testing
- Global Initiative for Asthma (GINA) and Asthma Control Test (ACT) questionnaires, Spirometry, Fractional exhaled nitric oxide (FeNO) test
- Where
- 2 sites in Thailand
- Volunteers
- 289 people
- Sponsor
- Thammasat University
Acute Exacerbation of COPD, Corticosteroid
Treatment Efficacy of Systemic Corticosteroids in AECOPD Patients With Higher Blood Eosinophil Levels
Chronic Obstructive Pulmonary Disease (COPD) is one of the top three causes of death worldwide now. Acute exacerbations (AEs) of COPD are a risk factor for lung function deterioration, poor quality of life, longer…
- Conditions
- Acute Exacerbation of COPD, Corticosteroid, Morality, Lung Diseases, Obstructive
- Trial name
- NCT05059873
- Testing
- Prednisone
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Capital Medical University
Immune System Diseases, Eosinophilia
Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia
This study will investigate how, why and under what conditions eosinophils (a type of white blood cell) become activated and will examine their function in immune reactions.
- Conditions
- Immune System Diseases, Eosinophilia, Helminthiasis, Hypersensitivity
- Trial name
- NCT00001406
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma Exacerbations, Biomarkers / Blood
Blood Eosinophil Guided Versus Usual Care In The Management Of Mild To Moderate Asthma at Primary Care (BEAM)
The aim of this study is to evaluate usual care versus biomarker-directed care (using blood eosinophil counts) for the management of asthma patients in primary care setting.
- Conditions
- Asthma Exacerbations, Biomarkers / Blood, Eosinophil Blood Count
- Trial name
- BEAM (NCT07486401)
- Testing
- Biomarker-directed treatment for asthma management, Usual Care
- Where
- Singapore
- Volunteers
- 240 people
- Sponsor
- National Healthcare Group Polyclinics
Chronic Obstructive Pulmonary Disease
Influence of Reliance on Historical Blood Eosinophil Counts on ICS Prescribing by GOLD 2019 Thresholds in COPD
Blood eosinophils are a type of white blood cell that helps fight infection. They have a number of different functions but are primarily involved in numerous inflammatory processes.
- Trial name
- BECCOPD (NCT04571983)
- Testing
- Blood Eosinophil counts - comparing historical with stable state
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Northumbria Healthcare NHS Foundation Trust
Systemic Sclerosis, Systemic Scleroderma
Role of Eosinophil in Fibrogenesis of Systemic Sclerosis
Eosinophils are involved in tissue remodeling and fibrosis in many inflammatory diseases. Systemic sclerosis (SSc) is an autoimmune disease with fibrotic skin and lung complications.
- Trial name
- EOFIB-SSC (NCT03816189)
- Testing
- Blood test, Skin biopsies
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
COPD Asthma, Eosinophilic Asthma
Phenotype Assessment of Blood and Airway Eosinophils in Patients With COPD and Asthma
Around 1/3 of patients with COPD have elevated eosinophil levels. However, the role of eosinophils in COPD has not been yet understood and is probably different in COPD and in asthma.
- Trial name
- NCT05398133
- Where
- Poland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Asthma, Inflammation
PROPULSION SANTE: Inflammometry to Improve the Diagnostic Trajectory in Situations of Suspected Asthma in Children and Adults
The objective of this observational study is to assess the relevance of inflammometry (based on the measurement of fractional exhaled nitric oxide (FeNO) and blood eosinophil count (BEC)) as a tool for prioritizing respiratory…
- Conditions
- Asthma, Inflammation, Asthma in Children
- Trial name
- PROPULSION (NCT06981169)
- Testing
- FeNO, blood sample
- Where
- 3 sites in Canada
- Volunteers
- 1,500 people
- Sponsor
- Université de Sherbrooke
Chronic Obstructive Pulmonary Disease
Blood Eosinophil Measurements in Patients With Chronic Obstructive Pulmonary Disease
This study will assess the within-day variation of blood eosinophils in patients with Chronic Obstructive Pulmonary disease (COPD) in stable state and determine if there is a correlation between the blood eosinophils and certain…
- Trial name
- NCT03853642
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitair Ziekenhuis Brussel
Chronic Obstructive Pulmonary Disease, Adherence, Treatment
Role of Inhaler Adherence and Blood Eosinophil Count in Exacerbations of COPD
This is an observational study examining inhaler adherence and subsequent changes in blood eosinophil count in exacerbations of Chronic obstructive pulmonary disease (COPD) population.
- Trial name
- INCLINE (NCT05814484)
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- University of Leicester
Asthma Attack, Asthma
Using the Blood Eosinophil Count to Guide Systemic Corticosteroid Treatment in Asthma Exacerbations
Asthma attacks which are moderate-to-severe are typically treated with corticosteroids, but the optimal treatment duration is unknown and treatment responses can be variable.
- Trial name
- NCT05417906
- Testing
- Standard care, Eosinophil-directed care
- Where
- 2 sites in Singapore
- Volunteers
- 110 people
- Sponsor
- Changi General Hospital
Preoperative Anxiety, Preoperative Evaluation
Association Between Preoperative Anxiety and Blood Eosinophil Levels
In the studies, the presence of preoperative anxiety has been evaluated and reported with anxiety scales. The presence of anxiety and allergic diseases has also been examined in a limited study with the analysis of neuroendocrine…
- Conditions
- Preoperative Anxiety, Preoperative Evaluation, STAI, Eosinophil Blood Count
- Trial name
- NCT06837415
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Naime Yalçın
Asthma
Effectiveness and Safety Study of Tezepelumab in Adults & Adolescent Participants With Severe Asthma in the United States
To asses effectiveness and safety of tezepelumab in adult and adolescent participants with severe asthma including several under-studied populations in the United States.
- Trial name
- PASSAGE (NCT05329194)
- Testing
- Tezepelumab
- Where
- 37 sites in United States
- Volunteers
- 286 people
- Sponsor
- AstraZeneca