Clinical trials: Blood Loss Massive, open to volunteers
Massive Hemorrhage, Trauma
Calcium Administration in Life-saving Management During Massive Hemorrhage
This study evaluates the feasibility of conducting a larger study on the impact of treating massive hemorrhage with calcium in trauma patients.
- Conditions
- Massive Hemorrhage, Trauma, Hypocalcemia
- Trial name
- CALM (NCT06820645)
- Testing
- calcium gluconate
- Volunteers
- 81 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Bleeding, Aortic Rupture
Life-saving Treatment With Dry-plasma for Massive Bleeding in an Pre-hospital Setting
The overall goal of this clinical trial is to study how prehospital transfused dry plasma affect outcomes in terms of mortality as well as complications and coagulation status of patients in or about to develop bleeding shock.
- Conditions
- Bleeding, Aortic Rupture, Gastrointestinal Hemorrhage, Obstetric Bleeding
- Trial name
- NCT07012863
- Testing
- Dry plasma
- Volunteers
- 650 people
- Sponsor
- Vastra Gotaland Region
Massive Transfusion, Trauma
Australian and New Zealand Massive Transfusion Registry
Severe and un-stopped blood loss can occur for a number of different reasons including after a serious injury, delivery of a baby and following other medical and surgical emergencies.
- Conditions
- Massive Transfusion, Trauma, Cardiothoracic Surgery, Gastrointestinal Bleeding
- Trial name
- ANZ-MTR (NCT02863250)
- Where
- Australia
- Volunteers
- 50,000 people
- Sponsor
- Monash University
Surgical Blood Loss, Surgical Hemorrhage
TEG Use in Children Undergoing Procedures With High Anticipated Blood Loss
The research team proposes a prospective, observational study to better understand how TEG can be useful in guiding clinical practice in the Main OR for subject's undergoing high transfusion risk surgeries.
- Conditions
- Surgical Blood Loss, Surgical Hemorrhage, Post Operative Hemorrhage
- Trial name
- NCT05379530
- Testing
- Thromboelastography (TEG), Anesthesia Provider Survey
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Abdominal Injuries, Wounds and Injuries
Predictors of In-Hospital Mortality in Severe Abdominal Trauma
Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and…
- Conditions
- Abdominal Injuries, Wounds and Injuries, Wounds, Nonpenetrating, Wounds, Penetrating
- Trial name
- NCT07843628
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Trauma Induced Coagulopathy, Trauma Coagulopathy
Point of Care Fibrinogen Measurement in Trauma Patients in the Emergency Department
Background: Why This Study Matters When someone suffers a severe injury (like from a car crash), they can bleed heavily. One complication doctors often face is something called Trauma-Induced Coagulopathy (TIC).
- Conditions
- Trauma Induced Coagulopathy, Trauma Coagulopathy, Fibrinogen Deficiency, Fibrinogen; Deficiency, Acquired
- Trial name
- POCFIB (NCT07097337)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Erasmus Medical Center
Hemorrhagic Shock, Trauma Injury
Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children
The MATIC-2 is a multicenter clinical trial enrolling children who are less than 18 years of age with hemorrhagic shock potentially needing significant blood transfusion.
- Trial name
- MATIC-2 (NCT06070350)
- Testing
- Low Titer Group O Whole Blood (LTOWB), Tranexamic Acid (TXA), Component Therapy (CT)
- Where
- 23 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Philip Spinella
Liver Cirrhosis, Clinically Significant Portal Hypertension
Portal Inflow Modulation Prior to Liver Transplantation in Patients With Increased Risk of Intraoperative Blood Loss
Liver transplantation is a procedure associated with an exceptionally high risk of blood loss. Liver failure, which is the most common indication for transplantation, not only leads to coagulation disorders but also to the…
- Trial name
- PIMLivT (NCT07111221)
- Testing
- Transjugular Intrahepatic Portosystemic Shunt, Non-selective beta-blockers
- Where
- Poland
- Volunteers
- 104 people
- Sponsor
- Medical University of Warsaw
Trauma Associated Hemorrhage
Prehospital Transfusion Outcomes in Traumatic Hemorrhage: a Prospective Cohort Study
Traumatic injuries can cause severe bleeding, which causes a lot of deaths worldwide that could be prevented. Starting treatment as early as possible has been shown to improve survival, which makes fast care very important.
- Trial name
- PRONTO (NCT07883252)
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- Erasmus Medical Center