Clinical trials: Blood Platelet Disease
Ischemic Stroke
Multi-center, Prospective, Cohort Study to Evaluate the Relationship of Stroke Recurrence and Anti-platelet Resistance in Ischemic Stroke Patients
This cohort study will evaluate the relatiobship of stroke recurrence and anti-platelet resistance in ischemic stroke patients
- Trial name
- NCT03823274
- Testing
- Aspirin, Clopidogrel
- Where
- South Korea
- Volunteers
- 1,011 people
- Sponsor
- Yuhan Corporation
Coronary Arteriosclerosis, Acute Coronary Syndrome
GRAVITAS: Gauging Responsiveness With A VerifyNow Assay-Impact On Thrombosis And Safety
The objective of the GRAVITAS trial is to determine whether tailored anti-platelet therapy using the Accumetrics VerifyNow P2Y12 assay reduces major adverse cardiovascular events after drug-eluting stent implantation.
- Trial name
- GRAVITAS (NCT00645918)
- Testing
- clopidogrel
- Where
- 82 sites in United States, Canada
- Volunteers
- 2,800 people
- Sponsor
- Accumetrics, Inc.
Myocardial Infarction, STEMI
Cost-effectiveness of Genotype Guided Treatment With Antiplatelet Drugs in STEMI Patients: Optimization of Treatment (POPular Genetics)
Rationale: the use of antiplatelet drugs (i.e. clopidogrel, ticagrelor or prasugrel) is crucial in the treatment of patients undergoing percutaneous coronary intervention (PCI) with stent implantation to prevent atherothrombotic…
- Trial name
- NCT01761786
- Testing
- CYP2C19 genotyping
- Where
- 10 sites in Belgium, Italy and 1 more
- Volunteers
- 2,700 people
- Sponsor
- Vera HM Deneer
Ischaemic Heart Diseases
The Effect of Ischaemic-Reperfusion in Man - A Bradykinin Dependent Pathway
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed to relieve this blockage as quickly as possible to minimize damage to the heart muscle.
- Trial name
- NCT00965120
- Testing
- Forearm vascular study, bradykinin receptor antagonist (HOE-140)
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Purpura, Thrombocytopenic, Idiopathic
Drug-drug Interaction Study of Eltrombopag and Cyclosporine in Healthy Subjects
A drug-drug interaction study between eltrombopag and cyclosporine is being conducted to support the use of these drugs together in subjects, such as those with severe aplastic anemia or immune thrombocytopenia purpura.
- Trial name
- NCT02281370
- Testing
- Eltrombopag, Cyclosporine
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Myeloproliferative Disorder, Essential Thrombocythemia
Pilot Study for the Development of a Diagnostic Score to Differentiate Myeloproliferative Neoplasms.
Prospective study for the development of a non-invasive score for differentiating prefibrotic myelofibrosis from essential thrombocytosis and overt myelofibrosis.
- Conditions
- Myeloproliferative Disorder, Essential Thrombocythemia, Primary Myelofibrosis, Prefibrotic Stage, Primary Myelofibrosis, Fibrotic Stage
- Trial name
- BioScoreSMP (NCT03869476)
- Testing
- Non-invasive diagnosis score
- Where
- 2 sites in France
- Volunteers
- 133 people
- Sponsor
- University Hospital, Angers
Hypospadias
Comparison Of Outcome Of Different Layers in Hypospadias Surgery
To compare the outcome of applying autologous platelet-rich plasma membrane layer and dartos fascial flap versus only dartos fascial flap in mid and distal penile hypospadias surgery.
- Trial name
- NCT06275646
- Testing
- PRP layer, dartos flap
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Children Hospital and Institute of Child Health, Lahore
Neuropathic Pain, Chronic Postsurgical Pain
Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation
The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the treatments recommended for neuropathic pain, namely antidepressants and/or gabapentinoids, requires the development of…
- Trial name
- NeuroPRF (NCT05196503)
- Testing
- Treatment
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Angle Class I
Root Resorption and Alveolar Bone in the Maxillary Canine Retraction Using Injectable Platelet-rich Fibrin: A Split-Mouth Trial
Prolonged orthodontic treatment is a risk factor for root resorption, so accelerating the speed of tooth movement using different methods can limit tooth root resorption.
- Trial name
- NCT06634888
- Testing
- Injectable platelet rich fbirin
- Where
- Vietnam
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Thrombocytopaenia
Meta-analysis - Eltrombopag
The purpose of the meta-analysis was to explore the efficacy of eltrombopag versus placebo (standard of care)
- Trial name
- NCT01235988
- Testing
- Eltrombopag
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Tennis Elbow
Platelet Rich Plasma vs Open Surgery in the Treatment of Tennis Elbow
Chronic Lateral Epicondylar Tendinopathy is a debilitating condition that is associated with repetitive use of the forearm extensor muscles.
- Trial name
- NCT02755727
- Testing
- Platelet Rich Plasma Injection, Open Surgical Release
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Aplastic Anemia
Prophylactic NAC to Improve Platelet Engraftment After Haploidentical Transplantation in Severe Aplastic Anemia Patients
This study aims to evaluate the efficacy and safety of prophylactic oral N-acetylcysteine (NAC) for facilitating platelet engraftment in patients with severe aplastic anemia (SAA) receiving haploidentical hematopoietic stem cell…
- Trial name
- NCT07737262
- Testing
- N-acetylcysteine
- Volunteers
- 142 people
- Sponsor
- Peking University People's Hospital
Hemolytic-Uremic Syndrome
Efficacy of INM004 in Children With STEC-HUS
The objectives of this study are to evaluate the efficacy, safety, and pharmacokinetics of INM004 in pediatric patients with Hemolytic Uremic Syndrome associated to infection by Shiga toxin-producing Escherichia coli (STEC-HUS).
- Trial name
- NCT06389474
- Testing
- INM004
- Where
- 52 sites in Argentina, Belgium and 7 more
- Volunteers
- 220 people
- Sponsor
- Inmunova S.A.
Atrial Fibrillation
Multidisciplinary Team Approach to Prescribe Antithrombotic Therapy in Older People With Atrial Fibrillation
Antithrombotic drugs, which include antiplatelet and anticoagulant therapies, are used to prevent and treat many cardiovascular disorders.
- Trial name
- ANTITHROMBOTEA (NCT04932603)
- Testing
- Standard of care, with intervention of the multidisciplinary team
- Where
- France
- Volunteers
- 833 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myelodysplastic Syndrome, Thrombocytopenia
Safety Study of Eltrombopag Combined With Azacitidine to Treat Myelodysplastic Syndrome (MDS)
Patients with Myelodysplastic Syndromes (MDS) often suffer from low platelet levels which may lead to bleeding complications. Treatment with cytotoxic agents can decrease the platelet levels further.
- Trial name
- NMDSG10A (NCT01481220)
- Testing
- Eltrombopag
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Nordic MDS Group
Tendinopathy
Greater Trochanteric Pain Syndrome: Efficacy of Ultrasound Guided Platelet-rich Plasma vs Needle Tenotomy.
Great trochanteric pain syndrome (GTPS) is a difficult problem to manage and results in significant patient morbidity. This study is a single-center, randomized double-blind controlled trial.
- Trial name
- PRP-GTPS (NCT04231357)
- Testing
- platelet rich plasma
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Isabel Andia
Cancer
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
RATIONALE: Ketamine hydrochloride may lessen neuropathic pain in patients with cancer. It is not yet known whether ketamine hydrochloride given together with the best pain management is more effective than a placebo given…
- Trial name
- NCT01316744
- Testing
- ketamine hydrochloride, pharmacogenomic studies, questionnaire administration
- Where
- 3 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Glasgow
Acute Ischemic Stroke
Acute Ischemic Stroke Interventional Study
To assess safety of single IV (bolus + infusion) doses of ACT017 in patients with an acute ischemic stroke in addition to best emergency standard of care (including fibrinolysis by rtPA with or without added thrombectomy), with a…
- Trial name
- ACTIMIS (NCT03803007)
- Testing
- Intravenous ACT017 1000 mg
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Acticor Biotech
Gingival Recession Types One(RT1), Gingival Crevicular Fluid
Comparison of Connective Tissue and PRF in Gingival Recession
Aim: In this study, it was aimed to comparatively investigate the clinical and biochemical effects of subepithelial connective tissue graft and coronally advanced flap (SCTG + CAF) or titanium-prepared platelet rich fibrin and…
- Trial name
- NCT07877064
- Testing
- Titanium-prepared Platelet-Rich Fibrin, SCTG + CAF
- Volunteers
- 22 people
- Sponsor
- Ataturk University
Immune Thrombocytopenia, Thrombopoietin Receptor Agonist
Eltrombopag and Romiplostim Used Alternatively in Patients With Immune Thrombopenia (ITP): Efficacy and Safety.
TPO-r Switch is a retrospective study of the patients affected by Immune Thrombopenia (ITP) who received alternatively romiplostim and eltrombopag.
- Trial name
- NCT01618734
- Volunteers
- 50 people
- Sponsor
- Henri Mondor University Hospital
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