Clinical trials: Blood Platelets
AML, ALL
Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorders
Allogeneic stem cell transplantation may provide long-term remissions for some patients with hematological malignancies. However, allogeneic transplantation is associated with a significant risk of potentially life threatening…
- Conditions
- AML, ALL, CLL, Myelodysplastic Syndrome
- Trial name
- NCT00533923
- Testing
- Cyclophosphamide; Fludarabine; Cyclosporin; CAMPATH-1H (Alemtuzumab); GM-CSF
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Thrombocytopenia
Thrombopoietin Levels and Platelet Transfusion in Neonates
Infants who have low platelets and who require a platelet transfusion are included in this study. Platelet transfusions are routinely given to infants when their platelet count falls below a certain level.
- Trial name
- NCT00549484
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Episodic Migraine, Chronic Migraine
Aspirin Resistance in Women With Migraine
The purpose of this study is to compare the rates of aspirin resistance (high residual platelet reactivity) between women with episodic and chronic migraine and women without migraine.
- Trial name
- ARWM (NCT01257893)
- Testing
- Aspirin (acetylsalicylic acid)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Swedish Medical Center
HIV Seropositivity
Interaction Between HIV and Platelets
The investigators propose that the lack of immune response in InR is driven by HIV-containing platelets that might interact with macrophages and CD4+ T-cells although by different mechanisms.
- Trial name
- PLAQUEVIH (NCT04062825)
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Platelet Function Disorder, Platelet Disorder
Towards Improved Diagnostics for Suspected Platelet Function Disorders
This study aims to improve platelet function testing during bleeding investigations. To this end, the study will evaluate the diagnostic accuracy of novel platelet function tests in patients with confirmed or suspected platelet…
- Conditions
- Platelet Function Disorder, Platelet Disorder, Thrombocytopathy
- Trial name
- NCT05985668
- Where
- Sweden
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Healthy Volunteers
In Vivo Recovery and Survival Study of Platelets Collected on Trima Accel System and Stored in InterSol Solution
The purpose of this study is to evaluate the quality of platelets collected on the Trima Accel system after storage for 5 days in a Platelet Additive Solution (PAS), called InterSol.
- Trial name
- NCT03097289
- Testing
- Trima Accel system
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Terumo BCT
Healthy
Assessment of Whole Blood Cold Stored Platelets
The purpose of this study is to determine the life span and functional characteristics of platelets derived from whole blood that has been stored in a refrigerator for up to 21 days.
- Trial name
- Brrr (NCT02006368)
- Testing
- Blood Collection and autologous re-infusion
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Bloodworks
Primary Immune Thrombocytopenia (ITP)
A Phase Ib/II Clinical Trial of Multiple Doses of STSA-1301 Subcutaneous Injection in Healthy Subjects and Patients With Immune Thrombocytopenia (ITP)
A randomized, double-blind, placebo-controlled design was designed to evaluate the safety and tolerability, pharmacokinetic/pharmacodynamic profile, and immunogenicity of multiple administration of STSA-1301 subcutaneous…
- Trial name
- NCT06929299
- Testing
- STSA-1301 subcutaneous injection
- Where
- 7 sites in China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jiangsu BioJeTay Biotechnology Co., Ltd.
Neonatal Alloimmune Thrombocytopenia
Study on the Anti-HPA Antibodies Caused Neonatal Alloimmune Thrombocytopenia in Chinese Pregnant Women
This clinical study aims to investigate the anti-HPA antibodies caused neonatal alloimmune thrombocytopenia in Chinese pregnant women. The survey and data collect will help form an appropriate clinical screening procedure
- Trial name
- NCT02934906
- Testing
- Standard clinical treatment, including intravenous immunoglobulin and/or platelet transfusion
- Volunteers
- 55,497 people, healthy volunteers welcome
- Sponsor
- Xinqiao Hospital of Chongqing
PRF, Behavior Change Interventions
Influence of Hydration Status on the Yield of Injectable Platelet-Rich Fibrin
Due to the current lack of evidence regarding the influence of fluid intake on the amount of leukocyte- and platelet-rich fibrin fraction present in blood samples, this study aims to investigate the positive influence of this…
- Conditions
- PRF, Behavior Change Interventions, Implant Dentistry
- Trial name
- T-PRF (NCT07506252)
- Testing
- Hydration following a drinking protocol
- Where
- Austria
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Triple Negative Breast Cancer
Correlation Between TILs and Blood Cell Counts in Triple Negative Breast Cancer Patients
The PERCEPTION study aims to assess the correlation between blood cell counts (Leucocytes, Neutrophils, Lymphocytes, Platelets, NLR (Neutrophil-to-Lymphocyte Ratio) and PLR (Platelet-to-Lymphocyte Ratio)) and Tumor Infiltrating…
- Trial name
- PERCEPTION (NCT04068623)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Jean Perrin
Thrombocytopenia, Isolated, Thrombocytopenia 4
Unravelling the Role of Apoptosis in Platelets Biogenesis Through the Study of the Thrombocytopenia THC4
Inherited thrombocytopenias (ITs) are disorders characterized by a reduced platelet count, caused by variants in at least 40 genes. Mutations in CYCS cause a rare autosomal-dominant IT, named Thrombocytopenia 4 (THC4).
- Conditions
- Thrombocytopenia, Isolated, Thrombocytopenia 4, CYCS MUTATION- ASSOCIATED THROMBOCYTOPENIA THC4
- Trial name
- THC4 (NCT07026578)
- Testing
- Blood draw for the laboratory assessment
- Where
- Italy
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Blood Safety
Survival and Recovery of Radio-labeled Platelets Derived From Mirasol-treated Whole Blood
A total of twelve healthy volunteers will donate one unit of fresh whole blood. This unit will be treated with the Mirasol Pathogen Reduction Technology for Whole blood and then stored for 24h.
- Trial name
- Medic (NCT02330081)
- Testing
- Mirasol treatment of whole blood
- Where
- Norway
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Terumo BCTbio
Dental Implants
The Effect of Platelet Rich Fibrin Matrix With and Without Peripheral Blood Mesenchymal Stem Cells on Implant Stability
The Primary Objectives of the present study are : To Evaluate the effect of platelet rich fibrin matrix (PRFM) and peripheral blood mesenchymal stem cells (PBMSCs) on implant stability.
- Trial name
- NCT03044119
- Testing
- Dental Implant with PRFM, Dental Implant with PRFM and PBMSCs
- Where
- India
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- KLE Society's Institute of Dental Sciences
Impacted Wisdom Tooth
Comparison The Postoperative Effects of Local and Systemic Antibiotics Applied With Platelets Rich Fibrin
The aim of this study was investigate the comparison of postoperative effects of local antibiotics mixed with platelet-rich fibrin and postoperative systemic antibiotic applications prescribed for mandibular impacted third molar…
- Trial name
- NCT04989127
- Testing
- Diagnosis, traditional osteotomies, Platelet Rich Fibrin
- Where
- Cyprus
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ceren Melahat Donmezer
Healthy
In-Vivo Bleeding Volume Test for Platelet-Aspirin Interaction
Purpose of the present research project is to study a new in-vivo test for abnormal platelet function and to study the effect of certain drugs on clinical bleeding.
- Trial name
- Aspirin-BVT (NCT01047722)
- Testing
- Aspirin ingestion followed by doing a Bleeding Volume Test
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Klein, Jeffrey A., M.D.
Platelet-Rich Fibrin, Acceleration
The Effect of Multiple Injections of (PRF) on The Rate of Canine Retraction
this clinical trial aims to prove that multiple injections will produce a steady rate of acceleration of orthodontic tooth movement.
- Conditions
- Platelet-Rich Fibrin, Acceleration, Orthodontics
- Trial name
- NCT05766618
- Testing
- Injectable platelet rich fibrin (i-PRF): in acceleration of orthodontic tooth movement
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy Volunteers
Safety and Tolerability of ZE74-0282 in Healthy Volunteers
This first-in-human, randomized, double-blind, placebo-controlled Phase 1 study evaluates the safety, tolerability, and pharmacokinetics of single, split, and multiple oral doses of ZE74-0282 under fasted or fed conditions in…
- Trial name
- NCT07527221
- Where
- Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Eilean Therapeutics AU Pty Ltd
NAFLD- Non Alcoholic Fatty Liver Disease
Study of Neutrophils and Circulating Platelets in Correlation With the Activity of T Lymphocytes in Patients With NAFLD (Nonalcoholic Fatty Liver Disease)
The aim of the study is to define the relationship between neutrophils, platelets and the activity of T lymphocytes in patients with NAFLD (nonalcoholic fatty liver disease).
- Trial name
- NAFLD (NCT05358496)
- Testing
- Data collection
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of L'Aquila
Immune Thrombocytopenia, Thrombocytopathy
Assesment of the Functional Activity of Platelets for the Differential Diagnosis of Thrombocytopathies
The purpose of this study is to develop a highly sensitive method for assessing the functional activity of platelets for use in the differential diagnosis of thrombocytopenia and platelet defects.
- Conditions
- Immune Thrombocytopenia, Thrombocytopathy, Acute Leukemia, Hemorrhagic Disorders
- Trial name
- NCT05654766
- Testing
- Flow cytometry, Platelet aggregation and plasma coagulation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus