Clinical trials: Blood Pressure Control
Healthy Volunteers, Cardiovascular System
Effects of Transcutaneous Electrical Stimulation on the Autonomous Nerve System in Healthy Young People
Cardiovascular disease is one of the most important causes of death and disability in the world. An autonomic imbalance is associated to cardiovascular risks and disorders.
- Conditions
- Healthy Volunteers, Cardiovascular System, Autonomic Nervous System
- Trial name
- ESautonomous (NCT05289817)
- Testing
- Transcutaneous Vagus Nerve Stimulation (t-VNS), Transcutaneous Sympathetic Ganglion Electrical Stimulation (t-SES)
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
Type 2 Diabetes Mellitus
Acute Effect of Phototherapy With Light Emitting Diode (LED) on Muscle and Pulmonary Oxygen Consumption on Diabetes Mellitus
The purpose of this study is to determine the phototherapy may be adjuvant to exercise to improve muscular efficiency and increase aerobic capacity.
- Trial name
- NCT01889784
- Testing
- Phototherapy through light emitting diode (LED) - 150J, Phototherapy through light emitting diode (LED) - 300J
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aparecida Maria Catai
Ocular Physiology, Microcirculation
Role of Adenosine in the Control of Choroidal Blood Flow During Changes in Ocular Perfusion Pressure.
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. For a long time it had been assumed that the choroid is a strictly passive vascular bed, which shows no autoregulation.
- Trial name
- NCT00712764
- Testing
- Adenosine
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hypertension
Effectiveness of a Valsartan Based Versus an Amlodipine Based Treatment Strategy in naïve Patients With Stage 1 or Stage 2 Hypertension or in Patients Uncontrolled on Current Monotherapy
The population for this current study will include stage 1 and stage 2 hypertensive patients who are newly diagnosed or didn't have treatment during the last 3 months and patients who are currently treated but uncontrolled on…
- Trial name
- NCT00304226
- Testing
- valsartan, amlodipine
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 1,288 people, healthy volunteers welcome
- Sponsor
- Novartis
Hypertension
Equol Supplementation on Blood Pressure and Vascular Function
We propose to perform a 24-week randomized, double-blind a placebo-controlled trial among 207 non-equol producing postmenopausal women with prehypertension to examine the effectiveness of equol (10mg and 20mg/d) on 24h ambulatory…
- Trial name
- NCT02515682
- Testing
- High equol group, Low equol group
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Healthy
The Relative Effects of Olmesartan Medoxomil, Irbesartan and Valsartan on the Activity of the Blood Pressure Control System in Healthy Subjects
To assess the effects of 3 blood pressure drugs, called angiotensin receptor blockers, on the blood pressure control systems in healthy subjects.
- Trial name
- NCT00185055
- Testing
- Olmesartan medoxomil, Irbesartan, Valsartan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Daiichi Sankyo
Hypertension
LACTOPRES:Study on the Effect of Dairy Peptides on Blood Pressure in Untreated Hypertensive Subjects.
Hypertension is an increasingly important medical and public health issue. Literature suggests that there may be a role for dairy foods in the prevention and treatment of hypertension.
- Trial name
- NCT00167869
- Testing
- dairy peptides
- Where
- Netherlands
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Hypertension
The Effects of Antihypertensive Agents on Central Blood Pressure in Healthy Participants and Participants With Hypertension (MK-0000-166) (COMPLETED)
This study will test the relationship between CBP (central blood pressure) and PBP (peripheral blood pressure) effects after single and multiple doses of Isosorbide mononitrate extended release (ISMN ER) or Amlodipine besylate in…
- Trial name
- NCT01130168
- Testing
- Comparator: Amlodipine, Comparator: ISMN ER
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy Subjects
Study to Evaluate the Effect of Erenumab on Blood Pressure When Given Concomitantly With Subcutaneous Sumatriptan
The primary objective of this study was to assess the effects of subcutaneous sumatriptan alone and the effects of a single dose of erenumab (AMG 334) intravenous (IV) and sumatriptan concomitant therapy on resting blood pressure…
- Trial name
- NCT02741310
- Testing
- Sumatriptan, Erenumab
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Amgen
Hypertension
Reduction Of Dietary Salt Intake To Control Systolic Blood Pressure In Hypertensive Older Patients
REPRESS is an open label, pragmatic, multicenter, randomized controlled phase III trial with blinded endpoint with 1:1 (intervention to control arm) allocation ratio.
- Trial name
- REPRESS (NCT05976477)
- Testing
- educational intervention
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Healthy Volunteers, Low Back Pain
Effects of Blood Flow Restriction Exercises on Lumbar Muscle Endurance and Balance in Healthy Young Adults
This study aims to examine the effects of blood flow restriction (BFR) exercises on back muscle endurance and balance in healthy young adults.
- Conditions
- Healthy Volunteers, Low Back Pain, Postural Balance, Muscle Fatigue
- Trial name
- BFR-LUMBEX (NCT07182812)
- Testing
- Blood Flow Restriction Sit-to-Stand Exercise, Sit-to-Stand Exercise without Blood Flow Restriction
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mehmet Akif Guler
Uncontrolled Hypertension, Treatment Compliance
Integrative Nursing Based Multimodal Interventions for Uncontrolled Hypertensives
Purpose: The aim of this study is to evaluate the effect of multimodal interventions based on Integrative Nursing (IN) principles on blood pressure, stress, and hypertensive treatment compliance levels in individuals living in…
- Conditions
- Uncontrolled Hypertension, Treatment Compliance, Behavior, Health, Nurse's Role
- Trial name
- UHTINuM (NCT04809519)
- Testing
- Integrative Nursing based Multimodal Interventions for Uncontrolled Hypertensives, Ongoing treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Cerebral Autoregulation, Blood Pressure
Remote Ischaemic Conditioning in the Older Person and Effects on Dynamic Cerebral Autoregulation
Remote Ischaemic Conditioning (RIC) is the process of inducing short periods of ischaemia in a limb with the aim of improving vascular health systemically.
- Conditions
- Cerebral Autoregulation, Blood Pressure, Dynamic Cerebral Autoregulation
- Trial name
- RICE-DCA (NCT07179887)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Hypertension
Community Hypertension Assessment Trial (CHAT)
The Community Hypertension Assessment Trial (CHAT) is an investigation of the effect of community pharmacy based blood pressure (BP) monitoring sessions led by peer health educators, with feedback to family physicians, on the…
- Trial name
- NCT00217334
- Testing
- Volunteer-led pharmacy sessions with feedback to physicians
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Hypotension, Spinal Cord Injury
Prevention of Low Blood Pressure in Persons With Tetraplegia
The aim of this investigation is to determine the blood pressure response to NOS inhibition, with L-NAME, in persons with tetraplegia compared to non-SCI control subjects and to establish if blood pressure can be increased while…
- Trial name
- NCT00237770
- Testing
- N-Nitro L-arginine-methylester (L-NAME), Head-up Tilt maneuver
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Post-operative Cognitive Dysfunction
Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly
BACKGROUND: Post-operative cognitive dysfunction (POCD) is a potentially irreversible loss of brain functions observed in elderly patients after surgical operations under general anaesthesia.
- Trial name
- THE BRIDGE (NCT02428062)
- Testing
- Hemodynamic target, Phenylephrine, Intravenous fluids
- Where
- Italy
- Volunteers
- 1,812 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hypertension
Individually Tailored Web-Based Program to Improve Blood Pressure Control
High blood pressure affects 65 million adults in the United States, and more than one third of these individuals do not have adequate control of their blood pressure.
- Trial name
- NCT00377208
- Testing
- Web-Based Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Pain, Acute, Alloimmunisation in Pregnancy
Efficacy of Manuel Pressure and Local Cold Spray in Reducing Injection Pain in Pregnant Women
A randomized controlled study was planned to determine the effect of manual pressure and local cold spray application on the intensity of pain, fear, hemodynamic parameters, and satisfaction related to the pain reduction of human…
- Conditions
- Pain, Acute, Alloimmunisation in Pregnancy, Injection Site, Injection Fear
- Trial name
- NCT06231719
- Testing
- Cold Spray, Manuel Pressure, Standard Injection Procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Gulsum Coskun
Vagus Nerve Stimulations, Spirometry
Transcutaneous Auricular Vagus Nerve Stimulation and Spirometry: Sham-Controlled Randomized Trial
This study will examine the short-term effects of transcutaneous auricular vagus nerve stimulation (a non-invasive electrical stimulation delivered through the outer ear) on lung function measured by spirometry in healthy adults.
- Conditions
- Vagus Nerve Stimulations, Spirometry, Autonomic Nervous System (ANS) Functioning and Mood State, Blood Pressure Monitoring
- Trial name
- taVNS-SPIRO (NCT07482930)
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK
Blood Pressure
A Two-part Trial Assessing the Effects of 7α-methyl-19-nortestosterone (MENT) on Blood Pressure in Normal Men: an Open-label Pilot Study Followed by a Randomized, Double-blind, Placebo-controlled Study
This is a two-part trial assessing the effects of MENT on blood pressure. The first part of the trial is an open-label pilot study to verify the MENT gel formulation delivers appropriate drug levels.
- Trial name
- NCT00812630
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Population Council