Clinical trials: Body Weight Management
Obesity, Prostate Cancer
Weight Management Aimed to Reduce Risk and Improve Outcomes From Radical Prostatectomy
The purpose of this study is to test how a weight management program affects substances in the blood called biomarkers that can show the presence or severity of cancer, compared to a standardized diet and exercise educational…
- Trial name
- WARRIOR (NCT03261271)
- Testing
- Weight Loss Program, Standardized educational flyer, Weight Maintenance Program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Kansas Medical Center
Overweight and Obesity
Inhibitory Control and Pediatric Weight Management
The purpose of this pilot study is to explore the benefits of supplementing the Kurbo online program with a cognitive training game (PolyRules!) among youth ages 7-13 with overweight or obesity.
- Trial name
- NCT04747548
- Testing
- Kurbo Only, Kurbo + PolyRules!
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Obesity; Drug
Effect and Safety of Benaglutide or Metformin in Patients With Simple Obesity Who Have Inadequate Weight Control
This is a randomized, open, controlled and single-site clinical trail to investigate the effect and safety of Benaglutide or Metformin in patients with simple obesity who have inadequate weight control.
- Trial name
- NCT03593668
- Testing
- Metformin, Benaglutide
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Obesity, Impaired Health
Effectiveness of a Smartphone App for Adolescent Obesity Management
Though face-to-face treatment of childhood obesity can be effective, it is time consuming and costly. This study will test whether treatment can be delivered via an Android app and whether such treatment reduces obesity.
- Conditions
- Obesity, Impaired Health, Psychosocial Problem, Physical Activity
- Trial name
- NCT01804855
- Testing
- W82GO, smartphone application
- Where
- 2 sites in Ireland
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Children's University Hospital, Ireland
Prader Willi Syndrome, Syndromic Obesity
Prader-Willi Syndrome Macronutrient Study
The overall objective is to explore the mechanisms by which macronutrients regulate food intake and weight gain in Prader Willi Syndrome (PWS).
- Conditions
- Prader Willi Syndrome, Syndromic Obesity, Childhood Obesity
- Trial name
- NCT02011360
- Testing
- Low Carbohydrate diet, Low Fat diet
- Where
- 2 sites in United States, Canada
- Volunteers
- 10 people
- Sponsor
- Duke University
Obesity, Overweight
A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes
Study ASC30-302 (AURORA-2) is a Phase III, global, multicenter, randomized, double-blind, placebo-controlled study to investigate the long-term efficacy, safety, and tolerability of three maintenance doses of once-daily oral…
- Conditions
- Obesity, Overweight, Chronic Weight Management, Type 2 Diabetes Mellitus
- Trial name
- AURORA-2 (NCT07743450)
- Testing
- ASC30 tablets A1
- Where
- 135 sites in United States, Czechia and 4 more
- Volunteers
- 1,560 people
- Sponsor
- Ascletis Pharma (China) Co., Limited
Obesity
Trial of Provider-to-Patient Interactive Voice Response (IVR) Calls to Improve Weight Management in Community Health Centers (CHCs)
This study will test the effect of provider to patient interactive voice response (IVR) calls in local Community Health Centers within a weight management program.
- Trial name
- IVR (NCT01131143)
- Testing
- Provider Voice, Generic Voice
- Where
- United States
- Volunteers
- 1,228 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obesity
Efficacy and Safety of Oral Azelaprag Plus Once Weekly Tirzepatide Compared with Tirzepatide Alone in Participants with Obesity Aged 55 Years and Over
This study aims to find out how well a combination of oral azelaprag taken once a day (QD) or twice a day (BID), along with a weekly injection of tirzepatide, works for weight management in adults 55 years and older.
- Trial name
- STRIDES (NCT06515418)
- Testing
- Oral Azelaprag (BGE-105), Tirzepatide
- Where
- 14 sites in United States
- Volunteers
- 204 people
- Sponsor
- BioAge Labs, Inc.
Perioperative Respiratory Adverse Events, Airway Management
Airway Management and Weight in Children
The investigators in this study want to see how overweight/obese children who undergo elective surgery requiring airway management react to general anesthesia.
- Trial name
- NCT03996343
- Testing
- Endotracheal intubation, Laryngeal mask airway
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Weight Loss
VK2735 for Weight Management Phase 2 (Venture Oral Dosing)
This is a phase 2, 13-week randomized, double-blind, placebo-controlled, parallel arm dose-finding study that will evaluate the safety, tolerability, weight loss efficacy, pharmacodynamic effects, and pharmacokinetics of VK2735…
- Trial name
- NCT06828055
- Testing
- VK2735
- Where
- 15 sites in United States
- Volunteers
- 280 people
- Sponsor
- Viking Therapeutics, Inc.
Cardiovascular Diseases, Stroke Sequelae
Gait Training for Concurrent Optimization of Weight Mgt,bp Regulation and Functional Mobility
Stroke is a leading cause of long-term disability and death worldwide, with chronic survivors often experiencing gait disturbances (affecting up to 80%), reduced physical activity, and cardiometabolic comorbidities like obesity…
- Trial name
- NCT07420595
- Testing
- Weeks 1-6: EAGT (exoskeleton/end-effector devices; 30- 50% body-weight support, speed 1.5-2 km/h, ≥800-1200 steps/session). Weeks 7-12: CGT (overground walking, obstacles, stairs, dual-tasks)., Full 12 weeks CGT, progressing complexity and demands.
- Where
- Pakistan
- Volunteers
- 140 people
- Sponsor
- Iqra National University
Pediatric Obesity
Health4Kids Intervention Trial for Hispanic Families
The H4K Trial is a randomized controlled trial to improve children's body composition by testing a comprehensive, culturally and linguistically relevant, family-oriented intervention for overweight and obese Hispanic children…
- Trial name
- H4K (NCT02343367)
- Testing
- behavioral counseling, Education Materials, Face to face counseling session
- Where
- United States
- Volunteers
- 518 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Complication, Postoperative
Perioperative Fluid Management: Goal-directed Versus Restrictive Strategy
There is no ideal "cookbook recipe" for fluid prescription that would fit every surgical patient. In this study, the investigators working hypothesis is that the adoption of an integrative algorithm for perioperative fluid and…
- Trial name
- NCT02625701
- Testing
- Goal-directed therapy, Restrictive fluid therapy
- Where
- Switzerland
- Volunteers
- 400 people
- Sponsor
- University Hospital, Geneva
Metabolic Syndrome X
Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity and Insulin Secretion
The Metabolic Syndrome is a high prevalence disease worldwide. About a quarter of the adult population suffers the disease. Resveratrol is a substance found in many plants, including grapes, nuts and wine, but it's also found in…
- Trial name
- NCT02114892
- Testing
- Resveratrol
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- University of Guadalajara
Obesity, Childhood, Behavior, Eating
Pediatric Obesity Management Study
Childhood obesity is a critical public health issue. Obesity in childhood is associated with many complications, including high blood pressure, type II diabetes mellitus, abnormal blood lipid values, obstructive sleep apnea…
- Trial name
- NCT05622981
- Testing
- Age-specific educational materials and monitoring
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Corewell Health East
Gastric Cancer, Colorectal Cancer
Effect of Multi-modal Intervention Care on Cachexia in Patients With Advanced Cancer Compared to Conventional Management (MIRACLE)
Background Cancer Cachexia (CC) is a multi-factorial process characterized by progressive weight loss, muscle mass and fat tissue wasting, and adversely affecting their quality of life and survival in patients with advanced stage…
- Conditions
- Gastric Cancer, Colorectal Cancer, Pancreatic Cancer, Biliary Tract Cancer
- Trial name
- MIRACLE (NCT04907864)
- Testing
- Multi-modal intervention
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Kil Yeon Lee
Chronic Weight Management
A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC47 in Combination With Semaglutide
This will be a phase I, randomized, double-blind, placebo-controlled. This study will be conducted in three periods: the screening period, the treatment period, and the follow-up period.
- Trial name
- NCT06972992
- Testing
- ASC47 +Semaglutide
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ascletis Pharma (China) Co., Limited
Bipolar I Disorder, Schizophrenia
Study in Adolescents With Schizophrenia or Bipolar Disorder
Open-label safety study of oral olanzapine treatment in adolescents, aged 13 to 17 years, with bipolar I disorder (manic or mixed episodes) or schizophrenia.
- Trial name
- NCT00982020
- Testing
- Olanzapine, Standard behavioral weight intervention, Intense behavioral weight intervention
- Where
- 14 sites in United States, Poland and 2 more
- Volunteers
- 203 people
- Sponsor
- Eli Lilly and Company
Obesity Difficult Airway Airway Management
Videolaryngoscopes in the Morbidly Obese
This study will evaluate four videolaryngoscopes used for intubation of extremely obese (class 3 obesity) patients scheduled for bariatric surgery.
- Trial name
- NCT07787468
- Testing
- Airway management
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Uniwersytet Radomski im. Kazimierza Pułaskiego
Obesity
Effect of Momordica Charantia Administration on Anthropometric Indicators in Patients With Obesity
Momordica charantia has shown to exert anti-obesity effects through numerous mechanisms of action described in preclinical studies.
- Trial name
- NCT04916379
- Testing
- Momordica charantia
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- University of Guadalajara
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