Clinical trials: Bone Aging
Bone Health
An Intervention Study to Investigate the Effect of B-vitamin Supplementation for 2-years on Bone Health
An intervention study to investigate the effect of B-vitamin supplementation for 2-years on bone health. This is a dual centre (UCD and University of Ulster) 2-year randomised, placebo controlled, double blind intervention.
- Trial name
- Opti-Age (NCT03892395)
- Testing
- B-vitamin supplementation on bone health, Control group; Vitamin D, a daily capsule containing 10 µg/day vitamin D
- Where
- Ireland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Healthy Volunteers
Dose-Response of Gonadal Steroids and Bone Turnover in Older Men
The purpose of this study is to determine the levels of testosterone and/or estradiol at which changes in bone turnover, body composition, strength, sexual function etc. begin to occur in older men.
- Trial name
- NCT00114114
- Testing
- Testosterone, Goserelin acetate
- Where
- United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Maxillary Retrusion
Radiological Evaluation of Anterior Maxilla For Immediate Implant Placement
According to the literature age and gender may be associated with differences in skeletal size, anatomy and architecture in humans.
- Trial name
- NCT07133503
- Testing
- radiological evaluation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Healthy Volunteers
Effects of DHEA and Exercise in the Elderly
DHEA or dehydroepiandrosterone is a naturally occurring hormone secreted by tghe adrenal galnds. The secretion of HDEA declines with aging. DHEA is considered a food supplement and it is not regulated by the FDA.
- Trial name
- NCT00205686
- Testing
- DHEA, exercise
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pulmonary Disease, Chronic Obstructive, Osteoporosis
Chronic Obstructive Pulmonary Disease (COPD) and Osteoporosis
The main objective is to study important factors in the patho-physiology of osteoporosis in patients with COPD. Therefore, the investigators will study biological markers in plasma and urine and correlate them to markers of bone…
- Trial name
- NCT01067248
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Chronic Effect of Ultraviolet Radiation on Photoaged Skin, Dermatologic Disorders
Safety Study of Bone Marrow Derived Stem Cells on Patients With Cutaneous Photoaging
The purpose of this study is to determine whether a one-time injection of allogeneic mesenchymal bone marrow cells is safe and beneficial in the treatment of photodamage on the face.
- Trial name
- NCT01771679
- Testing
- Allogeneic Mesenchymal Bone Marrow Cells
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Stemedica Cell Technologies, Inc.
Normal Aging
Collection of Bone Marrow Aspirate From Normal Volunteers
Background: Bone marrow is the soft material found inside most large bones of the body. Bone marrow produces red blood cells, white blood cells, and platelets that are released into the blood stream.
- Trial name
- NCT03949647
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Aging Well
Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly
Due to age-related effects, the bone and cardiovascular health are damaged. Physical exercise and in particular the strength training has been proposed as a fundamental tool to these pathologies, especially in the elderly.
- Trial name
- NCT04281264
- Testing
- Passive Hypoxia, Normoxia Circuit Training with Elastic Bands, Hypoxia Circuit Training with Elastic Bands
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
Aging
Age-related Changes in Ovarian Follicular Wave Dynamics
The investigators hypothesize that age-related changes in the number and growth dynamics of ovarian follicles will be associated with changes in hormone levels and corresponding changes in musculoskeletal health.
- Trial name
- NCT01389141
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Osteoporosis
Study of Male Osteoporosis and Aging
The aim of this study is to identify potential risk factors for fragility fractures in men.
- Trial name
- NCT00463411
- Where
- Denmark
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Deficiency Growth Hormone
Assessment of the Acute Effect of IP
It is a nutraceutical system, consisting of oral tablet and an oral spray called Alpha GPC, which helps your body naturally restore the HGH levels.
- Trial name
- NCT03658187
- Testing
- IP
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Joint Discomfort, Wellbeing
Assessing the Potential for Improved Joint Health and Wellbeing by Providing a Whole Salmon Oil With Undenatured Type II Collagen Compared to Type II Collagen Alone
This study evaluates the combination of NT-II® salmon undenatured type II collagen with OmeGo® salmon oil in adults who regularly experience knee discomfort.
- Conditions
- Joint Discomfort, Wellbeing, Quality of Life
- Trial name
- NCT07875101
- Testing
- Undenatured collagen, Whole salmon oil
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hofseth Biocare ASA
Sarcopenia, Osteoporosis
Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
The purpose of this study is to determine if taking the pain reliever acetaminophen (ACET) interferes with some of the benefits of weight lifting on muscles and bone density in older men.
- Conditions
- Sarcopenia, Osteoporosis, Aging
- Trial name
- NCT01083901
- Testing
- Resistance training
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sarcopenia, Osteopenia
Nutrient Support to Body Composition and Healthy Ageing
The focus is healthy ageing, i.e. delaying the deterioration in health status in older adults. Loss of lean tissue (skeletal muscle) mass, a process termed sarcopenia, or bone tissue mass, a process called osteopenia, is a…
- Trial name
- BCHA (NCT02529124)
- Testing
- CONTROL, PROTEIN, PHYSICAL ACTIVITY
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Phil Jakeman
Vitamin D Deficiency
How Much Vitamin D is Required to be Protective Against Deficiency During the Winter Months?
Vitamin D is essential to bone health. In Canada, it is obtained by sunlight exposure of the skin (between April and October) or by a few foods such as fatty fish, eggs or fortified milk and margarine.
- Trial name
- NCT01437696
- Testing
- Vitamin D
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- McGill University
Aging
Effect of Two Years of Resistance Training on Health Status in Postmenopausal Women: Longitudinal Study Active Aging.
Aging is a natural process of the life cycle that can result in morphological, neuromuscular, metabolic, physiological, cognitive and behavioral changes that can compromise quality of life, autonomy, self-esteem, health and life…
- Trial name
- NCT06621368
- Testing
- Exercise, Control-no treatment
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Bone Loss, Age-related
Effects of Acute Estrogen Therapy on Bone Formation
This study is being done to study age-related bone changes in women. The investigators know that the major cause of osteoporosis is a shortage of the female hormone estrogen.
- Trial name
- NCT02349113
- Testing
- Estrogens (Climara)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Postmenopausal Women
Everolimus and/or Exercise to Prevent Bone Loss in Postmenopausal Women
It is estimated that women lose around 20-25% of bone mass during the 5-10 years period of postmenopausal transition, and menopause is considered a major risk factor for osteoporotic fragility fracture.
- Trial name
- RapaLoad (NCT06789900)
- Testing
- Everolimus (Afinitor®), Football Fitness Concept
- Where
- Denmark
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Cognitive Decline, Sarcopenia
Holistic Integration for Healthy Longevity and Aging in Place
Background: Taiwan is experiencing rapid population aging, with a growing prevalence of chronic diseases and functional impairments among older adults.
- Conditions
- Cognitive Decline, Sarcopenia, Depression Disorders, Nutrition Disorder
- Trial name
- HIHOPE (NCT06882434)
- Testing
- Local intervention program, Referral Process, Telehealth Education & Digital Integration
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Bone Health, Osteoporosis
Mediterranean Diet and Progressive Resistance Training Effects on BMD and Bone Turnover in the Elderly
This randomized controlled trial was designed to investigate the effects of progressive resistance training (PRT) combined with a Mediterranean diet on bone mineral density (BMD) and bone turnover markers (BTMs) in older adults.
- Trial name
- MED-RES-BONE (NCT07584785)
- Testing
- Mediterranean Diet combined with Resistance Training
- Where
- Italy
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Sfax