Clinical trials: Bone Alteration
Jaw Cysts
Radiographic Bone Volume Alteration After Jaw Cyst Enucleation With Different Bone Grafts
For decades, implantology has attracted extensive interest for restoration in patients with the defect of dentition. It has emerged as a very established prosthetic with a 5-year survival rate of 96% .
- Trial name
- NCT05478421
- Testing
- Collagen sponge, GBR, CS/GBR
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Ankylosing Spondylitis, Swallowing Disorder.Other Specified
Evaluation of Functions of Swallowing and Voice in Ankylosing Spondylitis Patients
In this study was to determine whether changes that occurred over time had an impact on the swallowing and voice functions depend of Ankylosing spondylitis patients.
- Conditions
- Ankylosing Spondylitis, Swallowing Disorder.Other Specified, Voice Alteration
- Trial name
- NCT04437394
- Testing
- flexible endoscopic evaluation of swallowing, The analysis of voice
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yavuz Atar
Pectus Excavatum
Multicenter Trial of Magnetic Mini-Mover for Pectus Excavatum
This study is a Phase 3, multicenter, non-randomized study to evaluate the safety and efficacy of the next-generation outpatient Magnetic Mini-Mover Procedure (3MP) in 15 patients aged 8-14 years for the correction of pectus…
- Trial name
- 3MP (NCT01327274)
- Testing
- Magnetic Mini-Mover Procedure (Magnimplant)
- Where
- 3 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Michael Harrison
Non-Small Cell Lung Cancer (NSCLC)
Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Relapsed or Refractory Advanced Non-Small Cell Lung Cancer With an FGFR Alteration
This is an open-label, single arm study to study the safety, efficacy and tolerability of Pemigatinib when used on participants with squamous or nonsquamous NSCLC with a documented FGFR1-3 mutations or fusions/rearrangement who…
- Trial name
- FIGHT-210 (NCT05253807)
- Testing
- Pemigatinib
- Where
- 36 sites in United States, France and 3 more
- Volunteers
- 8 people
- Sponsor
- Incyte Corporation
Dental Implant Placement, Socket Shield Technique Implant Placement
: SOCKET SHIELD TECHNIQUE VERSUS EMPTY SOCKET TECHNIQUE
To evaluate the clinical and radiographic outcomes of socket shield technique compared with conventional immediate implant placement.
- Trial name
- NCT02992366
- Testing
- implant placement
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy Volunteer, Bone Alteration
Ultralow Dose PET Imaging for 18F-NaF Uptake
The goal of this clinical trial is to evaluate an investigational ultralow dose positron emission tomography (PET imaging) technique for increased bone turnover that is found in diseases such as cancer, trauma, infection…
- Conditions
- Healthy Volunteer, Bone Alteration, Bone and Joint Cancer, Bone and Joint Infection
- Trial name
- NCT07284563
- Testing
- 18F-NaF
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akiva Mintz
Bone Alteration
Micromechanical Modeling Using Low Magnitude Mechanical Stimulation
The response to a daily 10 minute session of low-magnitude mechanical stimulation (LMMS) on bone in 100 postmenopausal women ages 45-65 years will be evaluated at baseline and 12 months using high-resolution magnetic resonance…
- Trial name
- LMMS (NCT01921517)
- Testing
- Low Magnitude Mechanical Stimulation
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Socket Preservation
Post Extraction Changes After Ridge Preservation Using Allogeneic Dentin Matrix Vs Demineralized Freeze Dried Allograft
the aim of this study is to establish if there are clinical, radio-graphical and histomorphometrical differences between using Allogenic Demineralized Dentin matrix versus Demineralized Freeze-Dried Bone Allograft (DFDBA) as a…
- Trial name
- NCT06318650
- Testing
- Demineralized Dentin Matrix, Demineralized freeze-dried bone allograft (DFDBA)
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pectus Excavatum
Magnetic Mini-Mover Procedure to Treat Pectus Excavatum
This is a medical research study. The study investigators have developed a method to gradually repair pectus excavatum (sunken chest) deformity by placing a magnet on the sternum (breastbone) and then applying an external…
- Trial name
- 3MP (NCT00466206)
- Testing
- Magnetic Mini-Mover Procedure (3MP), Magnatract (external magnet in a removable external brace), 3MP (Magnetic Mini-Mover Procedure)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Shwachman-Diamond Syndrome, SDS
Shwachman-Diamond Syndrome Global Patient Survey and Partnering Platform
The Shwachman-Diamond Syndrome Global Patient Survey and Collaboration Program (SDS-GPS) is an opportunity for patients and their families - from anywhere in the world - to share their experience living with SDS via a safe…
- Conditions
- Shwachman-Diamond Syndrome, SDS, IBMF, Congenital Neutropenia
- Trial name
- SDS-GPS (NCT06999954)
- Where
- United States
- Volunteers
- 8,000 people
- Sponsor
- Shwachman-Diamond Syndrome Alliance Inc
Myelodysplastic Syndrome
Study of REVLIMID (Lenalidomide) Versus Placebo in Patients With Low Risk Myelodysplastic Syndrome
Trial Design: This clinical trial is a phase III multicenter, randomized, double blind and controlled with placebo trial and with two arms designed to assess the efficiency and toxicity of the scheme Lenalidomide versus…
- Trial name
- SINTRA-REV (NCT01243476)
- Testing
- Lenalidomide
- Where
- 25 sites in France, Germany and 1 more
- Volunteers
- 61 people
- Sponsor
- Fundación General de la Universidad de Salamanca
Tooth Extraction, Dental Implantation
Immediate Implant Placement in Fresh Extraction Sockets and Delayed Implants in Healed Sockets.
The purpose of this prospective clinical study was to compare in delayed and immediately placed implants, the marginal vertical bone loss at 4 sides of the implant (buccal, palatal, mesial and distal), as well as the buccal and…
- Conditions
- Tooth Extraction, Dental Implantation, Bone Remodeling
- Trial name
- NCT04346706
- Testing
- Extraction and Implant insertion (test), Implant insertion (control)
- Where
- Lebanon
- Volunteers
- 24 people
- Sponsor
- Saint-Joseph University
Advanced or Recurrent Solid Tumors, FGFR Gene Alterations
NCCH2006/MK010 Trial (FORTUNE Trial)
This is a single-arm, open-label, multicenter, investigator-initiated Phase 2 trial to evaluate the efficacy and safety of E7090 in patients with advanced or recurrent solid tumors harboring FGFR genetic alterations (including…
- Trial name
- NCT04962867
- Testing
- E7090
- Where
- 7 sites in Japan
- Volunteers
- 75 people
- Sponsor
- National Cancer Center, Japan
Solid Tumors
A Safety and Tolerability Study of Pemigatinib in Japanese Subjects With Advanced Malignancies - (FIGHT-102)
The purpose of this study is to evaluate the safety and tolerability of pemigatinib in Japanese subjects with advanced malignancies.
- Trial name
- NCT03235570
- Testing
- Pemigatinib
- Where
- 12 sites in Japan
- Volunteers
- 44 people
- Sponsor
- Incyte Corporation
Chondrosarcoma, Osteosarcoma
Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration
This is a single-arm, phase II study that will enroll a total of 45 subjects. All subjects will have a confirmed diagnosis of metastatic or unresectable soft tissue sarcoma or bone sarcoma.
- Conditions
- Chondrosarcoma, Osteosarcoma, Soft Tissue Sarcoma
- Trial name
- NCT04040205
- Testing
- Abemaciclib
- Where
- 4 sites in United States
- Volunteers
- 44 people
- Sponsor
- Medical College of Wisconsin
Edentulous, Bone Resorption
Platform Switched Implant and Bone Level Alteration
This is a two-year prospective randomized clinical study to to evaluate whether the gingival thickness and insertion depth of dental implants have any influence on marginal bone levels changes around platform switched implants.
- Trial name
- NCT02867982
- Testing
- Subcrestal implant placement, Paracrestal implant placement, prophylactic antibiotics
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Beijing University Health Science Center
Bone Alteration, Dietary Modification
Efficacy of a Once Daily Calcium and Vitamin D Fortified Food Product to Improve Bone Microarchitecture
The primary objective of this randomized, double-blind, placebo controlled trial is to determine the efficacy of a once per day calcium (1000mg) and vitamin D (1000IU) fortified food product on bone turnover markers, including…
- Trial name
- NCT02375503
- Testing
- Calcium/Vitamin D
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Immediate Implant Placement, Bone Regeneration
Simvastatin Around Immediate Implant
The study evaluated the effect of local application of simvastatin around immediate implant on the amount of gap fill, ridge dimensional alterations and bone density in humans.
- Conditions
- Immediate Implant Placement, Bone Regeneration, Alveolar Bone Resorption
- Trial name
- NCT04803500
- Testing
- Simvastatin
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ain Shams University