Clinical trials: Bone Calcification, active
Periprosthetic Osteolysis
Assessment of Periprosthetic Bone Mineral Density in Patients Undergoing Total Knee Prosthesis of Different Design
compare changes in BMD via DXA at the level of the femoral and tibial periprosthetic bone between two groups of patients undergoing cemented TKA of different design (posterior stabilization vs posterior cruciate preservation)…
- Trial name
- DXA-TKA (NCT06309433)
- Testing
- dual energy x-ray absorptiometry
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Ortopedico Rizzoli
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Total Hip Arthroplasty
Bone Remodeling Around a Trabecular Titanium Cup in Total Hip Arthroplasty
The goal of this randomized controlled trial is to measure the periprosthetic bone mineral density changes around a 3D-printed highly-porous titanium acetabular cup used in primary total hip arthroplasty compared to a standard…
- Trial name
- NCT06287021
- Testing
- Jump System Traser® cup, Jump System HAX-Pore® cup
- Where
- 2 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Permedica spa
Osteopenia, Osteoporosis
Time-specific Exercise in Circadian Context
The project aims to explore the mechanisms, by which physical activity can support healthy ageing and decrease the negative impact of ageing on the circadian system, musculoskeletal system and immunity.
- Conditions
- Osteopenia, Osteoporosis, Aging
- Trial name
- CAEx (NCT06746649)
- Testing
- Combined training
- Where
- Slovakia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Comenius University
Coronary Artery Calcification, Arterial Stiffness
The InterVitaminK Trial - Effects of Vitamin K Supplementation on Cardiovascular, Metabolic, and Bone Health
The purpose of this study is to examine the effect of menaquinone-7 (MK-7) supplementation on cardiovascular, metabolic, and bone health.
- Trial name
- InterVitaminK (NCT05259046)
- Testing
- Menaquinone-7 (MK-7) tablet (333 µg)
- Where
- Denmark
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Osteoporosis, Chronic Kidney Disease Mineral and Bone Disorder
Osteoporosis & Renal Disease: Research in Primary Health Care Services
Osteoporosis, a silent and multifactorial systemic skeletal disorder, severely compromises bone strength and significantly increases the risk of fragility fractures.
- Trial name
- NCT07848490
- Testing
- Fracture risk assessment tool (FRAX), Dual-Energy X-ray Absorptiometry (DXA)
- Where
- Portugal
- Volunteers
- 622 people
- Sponsor
- Universidade do Porto
Post Menopausal, Osteoporosis
EFFECT OF CIRCUIT TRAINING ON BONE MINERAL DENSITY IN POST MENOPAUSAL PERIOD
This study will be conducted to determine the effect of circuit training on bone mineral density in post menopausal period.
- Trial name
- CWT and BMD (NCT06950463)
- Testing
- Group A (control group): It will be consisted of twenty two post menopausal women who will receive daily dosage of vitamin D3 supplement (600 IU/day) (Schleicher et al., 2016), for 6 week, 1-Dumbbells (set B08Z7SY6SP ,Gymbit , made in China) :They will be used for the treatment procedures of circuit training for all postmenopausal women in group B. Its surface is coated with vinyl fo
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Primary Osteoporosis
Community Smart Aging Model - Resistance Training
This clinical trial aims to evaluate the effectiveness of a smart community-based resistance training program in older adults aged 60 and older with primary osteoporosis.
- Trial name
- NCT07506538
- Testing
- Smart Community-Based Resistance Training, Routine Health Education
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Lingshu Sun
Nutrition, Health and Wellbeing
Early Time-Restricted Eating Combined With Exercise in Older Adults
This randomized controlled trial aims to investigate the effects of Early Time-Restricted Eating (eTRE) combined with a multicomponent exercise program on bone health, physical function, and fall risk in healthy older adults.
- Conditions
- Nutrition, Health and Wellbeing, Aging, Time Restricted Eating
- Trial name
- NCT07695961
- Testing
- Early Time-Restricted Eating (eTRE)+Exercise Intervention
- Where
- Tunisia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Manouba
Tumor Induced Osteomalcia, Osteomalacia
A Natural History Study of Bone and Mineral Disorders
This study has four objectives: 1) to provide investigators the opportunity to study bone specimens from patients with various skeletal diseases; 2) to treat patients with skeletal diseases at the NIH; 3) to expose NIH trainees…
- Conditions
- Tumor Induced Osteomalcia, Osteomalacia, Familial Tumoral Calcinosis
- Trial name
- NCT00024804
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Healthy
Bone Mineral Content in Healthy Children
The primary purpose of this study is to determine the effects of early diet on bone health.
- Trial name
- NCT01897168
- Testing
- No intervention
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Chronic Stroke, Osteoporosis
Incidence of Fragility Fractures and Osteoporosis Screening in Chronic Stroke Patients
Stroke is a known risk factor for the development of osteoporosis, leading to an increased risk of falls and fractures. Several international studies have associated stroke with hip fractures, showing an odds ratio ranging…
- Conditions
- Chronic Stroke, Osteoporosis, Fragility Fractures
- Trial name
- NCT06804252
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Palermo
Amenorrhea
Retrospective Observational Evaluation of the Bone Mineral Density Outcome in Young Women With Amenorrhea
The study aims to evaluate the outcomes of different estrogen therapy regimens in patients with amenorrhea who face prolonged periods of hypoestrogenism.
- Trial name
- NCT07015476
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Osteoporosis, Musculoskeletal Health
Functional Muscle-Bone Incongruity Index (FKUI): A Prospective Observational Study
The Functional Muscle-Bone Incongruity Index (FKUI) is a novel approach developed to evaluate the relationship between muscle function and bone health.
- Conditions
- Osteoporosis, Musculoskeletal Health, Sarcopenia, Osteopenia
- Trial name
- FKUI (NCT07677033)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Osteoporosis
Validation of a Deep Learning Tool for Opportunistic Osteoporosis Screening Using Routine Non-Contrast CT Scans
The goal of this clinical trial is to test if an artificial intelligence (AI) tool called DeepBMD can accurately identify people at high risk for osteoporosis using routine chest or abdomen CT scans.
- Trial name
- NCT07739628
- Testing
- DeepBMD model for osteoporosis risk screening
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Chronic Kidney Disease (Stage 3-4), Chronic Kidney Disease Mineral and Bone Disorder
Phosphate Assessment in Chronic Kidney Disease Patients Study
The proposed pilot feeding study aims to explore novel pathways in phosphate metabolism and identify new biomarkers, as well as to develop a compound index for assessing phosphate overload with high validity and reliability.
- Trial name
- PACK (NCT07368946)
- Testing
- Dietary Phosphorus Intake
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Osteoporosis in Post-menopausal Women
Bone Health in Postmenopausal Women: The Effect of Exercise With or Without Medication for Osteoporosis
Osteoporosis is a systemic bone disorder characterised by a reduced bone mass and structural deterioration, increasing the risk of fragility fractures, particularly in women post-menopause.
- Trial name
- BEAT-OP (NCT07267325)
- Testing
- EXERCISE TRAINING, Antiresorptive medication (routine clinical care)
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Breast Cancer
Efficacy of Denosumab on Normal BMD in Women Receiving Adjuvant Aromatase Inhibitors for Early Breast Cancer
This multicenter, randomized, comparative study will evaluate the efficacy of denosumab to prevent the adjuvant therapy of aromatase inhibitors-induced loss of bone mineral density (BMD) in breast cancer patients with normal BMD.
- Trial name
- NCT03324932
- Testing
- Denosumab Injection
- Where
- Japan
- Volunteers
- 160 people
- Sponsor
- Kyoto Prefectural University of Medicine
Bone Metabolism Biomarkers, Bone Mineral Density
Vitamin D and Physical Activity on Bone Health
This research will examine the effectiveness of vitamin D or placebo (the placebo is a tablet that looks like Vitamin D study drug, but has no Vitamin D study drug in it), with and without physical activity (walking and…
- Conditions
- Bone Metabolism Biomarkers, Bone Mineral Density, Physical Fitness
- Trial name
- NCT01419730
- Testing
- Vitamin D3, Physical Activity
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- University of Rochester