Clinical trials: Bone Defect
Intrabony Periodontal Defect
Comparison of the GTR Procedure Alone and in Combination With Immediate OTM
The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a GTR procedure, when it is combined with an immediate orthodontic tooth movement or used alone.
- Trial name
- NCT04896450
- Testing
- Guided tissue regeneration (GTR), Orthodontic tooth movement (OTM)
- Where
- Hungary
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Treatment of Periodontal Intra-bony Defects
The Present Study Was Performed to Evaluate the Efficacy of Lyophilized-PRF in Treatment of Periodontal Intra-bony Defects
The present study will be performed to evaluate the efficacy of lyophilized platelet-rich fibrin alone and combined with nanocrystalline hydroxyapatite in treatment of periodontal intra-bony defects through: 1.
- Trial name
- NCT06625528
- Testing
- open flap debridement
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Bone Loss, Bone Remodeling Disorder
Socket Preservation Using Dentin Graft Autogenous Dentin Graft With Collagen Sponge on Dental Implant Stability AUTOGENOUS TOOTH GRAFT WITH COLLAGEN SPONGE ON DENTAL IMPLANT STABILITY
The present study was performed to evaluate socket preservation using collagen sponge with autogenous dentin graft versus collagen sponge with de-mineralised freez-dried bone graft on dental implant stability
- Conditions
- Bone Loss, Bone Remodeling Disorder, Bone Resorption
- Trial name
- NCT06853392
- Testing
- Demineralized freeze dried allograft with collagen sponge, autogenous dentin graft with collagen sponge
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Parkinson Disease, Osteoporosis
Application of BHOHB SPINAL-METER and CervicalMeter for Posture Assessment
The postural observation of the patient has an important role for the evaluation and monitoring of orthopedic and neurological degenerative pathologies.
- Conditions
- Parkinson Disease, Osteoporosis, Scoliosis, Postural; Defect
- Trial name
- BHOHB (NCT06012032)
- Where
- Italy
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Alveolar Process Defect
Ridge Augmentation Comparing a Block Allograft to a Demineralized Bone Matrix Allograft.
This study with compare the ridge dimension changes for a block allograft vs. a demineralized bone matrix moldable allograft.
- Trial name
- NCT02127112
- Testing
- Block Allograft plus Matrix Allograft, Moldable Matrix Allograft
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Defect; Internal Prosthetic Device, Implants and Grafts, Orthopedic, Bone Graft
Clinical Application of Personal Designed 3D Printing Implants in Bone Defect Restoration
Objective: Clinical application of 3D printing implant in bone defect treatment. Study design: multicenter randomized controlled study .
- Trial name
- NCT03166917
- Testing
- 3D printing implant, autogenous bone grafting
- Where
- 3 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- fang guofang
Intrabony Periodontal Defect
Effect of Alendronate With β - TCP Bone Substitute in Surgical Therapy of Periodontal Intra-osseous Defects.
The aim of the present study was to evaluate the bone formation potential of 400µg alendronate delivered in β-TCP in the treatment of periodontal intra-osseous defects.
- Trial name
- NCT02795546
- Testing
- Alendronate sodium, beta-tricalcium phosphate bone substitute
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Horizontal Alveolar Bone Defect, Guided Bone Regeneration
Guided Bone Regeneration in Lower Posterior Edentulous Arch Using Resorbable or Non Resorbable Membrane.
the purpose of this study is to compare the efficiency of non-resorbable membrane versus resorbable membrane in guided bone regeneration in atrophic posterior mandible.
- Trial name
- NCT07254494
- Testing
- guided bone regeneration using Resorbable membrane pericardium, guided bone regeneration using non resorbable ptfe membrane
- Where
- Lebanon
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beirut Arab University
Periodontitis, Tooth Migration
Timing of Orthodontic Therapy and Regenerative Periodontal Surgery in Advanced Periodontitis Patients With Pathologic Tooth Migration
Pathologic tooth migration (PTM) is a common complication of advanced periodontitis and often motivation for patients to seek orthodontic therapy.
- Conditions
- Periodontitis, Tooth Migration, Intrabony Periodontal Defect
- Trial name
- NCT02761668
- Testing
- ParS+Ortho 4W, ParS+Ortho 6M
- Where
- 2 sites in Germany, Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Periodontal Diseases, Intrabony Periodontal Defect
Papilla Preservation Technique in Combination With Tooth Enamel Proteins and Animal Derived Bone Graft in Treating Isolated Bone Defects Between Teeth
The present three-arm study compared the clinical and tomographic efficacy of the Entire Papilla Preservation Surgical Technique (EPPT) alone and combined with enamel matrix derivative (EMD) plus bone mineral derivedxenograph…
- Trial name
- NCT07119307
- Testing
- Entire Papilla Preservation Technique, Entire Papilla Preservation Surgical Technique (EPPT) alone, Entire Papilla Preservation Surgical Technique (EPPT) alone and combined with enamel matrix derivative (EMD)
- Where
- India
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Rungta College of Dental Sciences and Research
Adolescent Idiopathic Scoliosis, Idiopathic Scoliosis
Adolescent Idiopathic Scoliosis and Proprioceptive Defect
This is the first clinical study to examine the spinal and peripheral proprioceptive deficits in longitudinal terms among subjects with adolescent idiopathic scoliosis.
- Conditions
- Adolescent Idiopathic Scoliosis, Idiopathic Scoliosis, Scoliosis
- Trial name
- NCT04682379
- Testing
- Proprioceptive assessment
- Where
- Hong Kong
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dental Diseases
A Clinical Trial to Evaluate the Safety and Effectiveness of MatrixOssTM Bone Graft
The objective of this clinical trial is to evaluate the efficacy and safety of MatrixOssTM Bone Graft in bone defect repair caused by tooth extraction.
- Trial name
- NCT05371535
- Testing
- MatrixOssTM Bone Graft plus Bio-Gide membrane
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Collagen Matrix
Intrabony Periodontal Defect
Evaluation of Autogenous Demineralized Dentin Graft Vs Autogenous Bone Graft in Management of Intrabony Defects
The main goal is to evaluate and compare the clinical and radiographic efficacy of autogenous demineralized dentin as bone graft substitute versus autogenous bone graft when performed with modified minimally invasive surgical…
- Trial name
- NCT06048042
- Testing
- Autogenous Demineralized Dentin Graft, Autogenous Bone Graft
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Bone Loss, Alveolar
Evaluation of Bone Gain Using Customized 3D Zirconia Barrier Versus Titanium Mesh
Evaluation of clinical and radiographical amount of bone gained using customized 3D printed zirconia barrier compared to titanium mesh in combined ridge defect at the esthetic zone.
- Trial name
- NCT06559605
- Testing
- zirconia barrier, titanium mesh
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Peri-implantitis
Implant Survival After Surgical Treatment of Peri-implantitis of Infra-bony Defects
To report the 10 years outcomes of a reconstructive surgical protocol for peri-implantitis defects with different morphologies, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC).
- Trial name
- Bony defects (NCT07809334)
- Testing
- Reconstructive therapy
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Craniosynostosis
Network Of Clinical Research Studies On Craniosynostosis, Skull Malformations With Premature Fusion Of Skull Bones
Craniosynostosis (CS) is a common malformation occurring in ~4 per 10,000 live births in which the sutures between skull bones close too early, causing long-term problems with brain and skull growth.
- Trial name
- NCT03025763
- Testing
- Craniosynostosis Network Environmental Survey, 2D/3D Photography, Buccal Swab Cell Sampling
- Where
- 20 sites in United States, France and 3 more
- Volunteers
- 2,145 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Myelomonocytic Leukemia
The Expression of PTEN Protein and mRNA in Malignant Cells of Chronic Myelomonocytic Leukemia
The purpose of this study is to evaluate the level of a specific protein (PTEN) in the cancer cells of chronic myelomonocytic leukemia (CMML) patients.
- Trial name
- NCT01010256
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Periodontitis
Clinical and Biochemical Assessment of Ozonated Olive Oil Mixed Bone Substitute in Treating Intra Bony Periodontal Defect
The goal of this study is to investigate the effect of ozonated olive oil in treating intra bony defect by means of clinical and radiographic parameters, and gingival cervicular fluid BMP2 level.
- Trial name
- NCT05655923
- Testing
- ozonized olive oil, xenograft bone substitute
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontal Bone Defects
Minimally Invasive Non-surgical Therapy With or Without Injectable Bone Putty
All periodontitis patients with infra bony pockets to be included in this study will diagnosed as having stage III periodontitis with probing pocket depth (PPD) ≥ 6 mm, and clinical attachment loss (CAL) ≥ 5mm will be treated by…
- Trial name
- NCT06553222
- Testing
- Putty bone - Tricalcium phosphate with Collagen gel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Cystic Fibrosis, Postural Defect
The Effect of Bone Mineral Density in Patients With Adult Cystic Fibrosis
The study was conducted in the age range of 18-45 December, who were diagnosed with Cystic fibrosis.
- Conditions
- Cystic Fibrosis, Postural Defect, Pulmonary Disease, Physical Inactivity
- Trial name
- NCT06088485
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University