Clinical trials: Bone Demineralization
Bone Demineralization Lesions in the Injured Marrow
Bone Demineralization Lesions in the Injured Marrow: Efficacy and Tolerability of Administration Early and Repeated the Zoledronic Acid. Comparative Study, Prospective, Double-blind Controlled (DBMZol)
Subjects with lesion bone marrow are at risk of fracture by fragility bone. The median time to onset of fracture was 8.5 years. Fracture increases costs of care, dependency.
- Trial name
- DBMZol (NCT01802658)
- Testing
- Zoledronic acid, NA Cl
- Where
- 9 sites in France
- Volunteers
- 12 people
- Sponsor
- Nantes University Hospital
Bone Demineralization
Alendronate for Prevention of AntiRetroviral Therapy-associated Bone Loss
Antiretroviral therapy (ART) initiation is associated with a significant loss of bone mineral density (BMD), characterised by increases in bone turnover, which is largely limited to the first 48 weeks of therapy.
- Trial name
- APART (NCT02322099)
- Testing
- Alendronate, calcium carbonate and colecalciferol, Tenofovir disoproxil
- Where
- 2 sites in Ireland
- Volunteers
- 53 people
- Sponsor
- University College Dublin
Decayed Teeth
Effect of Bone Marrow Mononuclear Cell Layer Seeded on Platelet-rich Fibrin on an Alveolar Socket After Extraction
Bone marrow aspiration from maxillary tuberosity will be centrifuged to separate the bone marrow mononuclear cell layer using the density gradient separation method, then it will be seeded in a platelet-rich fibrin membrane and…
- Trial name
- NCT05465421
- Testing
- bone marrow aspiration from maxillary tuberosity and BMMNCs separation to be seeded on PRF and used for socket preservation
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Menopause, Bone Demineralization
A Study to Learn More About the Menopausal Hormone Therapies in Korea
The purpose of this study is to learn about how the commonly used menopausal hormone therapies were prescribed and taken in practice.
- Trial name
- NCT06033521
- Testing
- Menopausal hormone therapy Intervention Type: Drug
- Where
- South Korea
- Volunteers
- 1,036,294 people
- Sponsor
- Pfizer
Muscle Atrophy, Weightlessness
The Effects of Whole Body Unloading on Physiological Function
This study is a collaboration between the Centre of Human \& Aerospace Physiological Sciences (CHAPS) and the Sleep and Brain Plasticity Centre (Department of Neuroimaging) at King's College London and the Sleep Disorders Centre…
- Conditions
- Muscle Atrophy, Weightlessness, Sleep Disturbance, Astronaut-Bone Demineralisation Syndrome
- Trial name
- NCT03195348
- Testing
- HBF Bed Rest
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- King's College London
Osteoporosis, Dental Caries
Salivary Cytokines, MMP-8 and Dental Caries in Osteoporosis Patients
This study examines saliva samples from patients with osteoporosis. The levels of cytokines and Matrix Metalloproteinase-8 (MMP-8) enzyme in saliva will be measured.
- Conditions
- Osteoporosis, Dental Caries, Biomarkers, Matrix Metalloproteinase 8
- Trial name
- NCT07709247
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Alveolar Bone Atrophy, Bone Resorption
Effect of Citric Acid Demineralization on Autogenous Bone Blocks Consolidation in Humans
This study evaluates the effect of citric acid demineralization in autogenous bone blocks consolidation. Half of participants will receive citric acid treatment at the bone block and recipient site.
- Trial name
- NCT03357068
- Testing
- Control, Acid
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo
Bone Demineralization, Hypoestrogenism
The Kampala Women's Bone Study
The primary objective of this study is to address critical safety questions with concurrent TDF-based PrEP and DMPA use. We hypothesize that young women using TDF-based PrEP and DMPA will have lower bone acquisition and altered…
- Conditions
- Bone Demineralization, Hypoestrogenism, Subclinical Kidney Injury, Bone Microarchitecture
- Trial name
- NCT03464266
- Testing
- FTC/TDF and DMPA, FTC/TDF, DMPA
- Where
- Uganda
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cartilage Injury
Clinical Study of Decalcification Bone Scaffold for Cartilage Lesions of the Knee
The trial evaluates the clinical efficacy and safety of decalcification bone scaffold for cartilage lesions of the knee. Half of participants will receive decalcification bone scaffold combined with microfracture, while the other…
- Trial name
- NCT03321812
- Testing
- decalcification bone scaffold, microfracture
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Tooth Loss, Tooth Diseases
The Cortical Shield for Facial Bone Reconstruction
To evaluate a novel technique of bone regeneration and simultaneous implant placement in severely damaged sockets.
- Conditions
- Tooth Loss, Tooth Diseases, Tooth Fracture, Tooth Injuries
- Trial name
- NCT04827693
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Verdugo, Fernando, DDS
Periodontitis, Dental Caries
Using Combination of Synthetic Bone Substitutes During Extractions
The study was designed to assess the effectiveness of conservation ridge preservation (horizontal and vertical dimension) after tooth extraction with and without combination of bone substitutes based on synthetic (calcium sulfate…
- Conditions
- Periodontitis, Dental Caries, Alveolar Bone Losses
- Trial name
- NCT01503593
- Testing
- Calcium Phosphate, Calcium Sulphate
- Volunteers
- 40 people
- Sponsor
- Rambam Health Care Campus
Dental Caries, Dental Fluoroses
Iowa Fluoride Study/Iowa Bone Development Study
A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries.
- Conditions
- Dental Caries, Dental Fluoroses, Bone Density
- Trial name
- (IFS/IBDS) (NCT03547128)
- Volunteers
- 1,882 people, healthy volunteers welcome
- Sponsor
- Steven M Levy
Caries Active, Tooth Decay
Effects of Platelet and Leukocyte-rich Fibrin on Alveolar Ridge Maintenance Through Three-dimensional Analysis
Understanding, through accurate and reliable volumetric analysis, how the biomaterial (LPRF) and the thickness of the vestibular bone plate influence changes in bone volume after extraction, is essential for making clinical…
- Conditions
- Caries Active, Tooth Decay, Tooth Loss / Rehabilitation
- Trial name
- NCT07278180
- Testing
- Alveolar socket preservation with graft and flap surgery
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Guarulhos
Burns, Bone Demineralization
Evaluation of Vitamin D Status in Children With Acute Burns
To see which vitamin D supplement (D2 vs D3) is most beneficial in burned children.
- Trial name
- VitaminD (NCT00536276)
- Testing
- Vitamin D2, Vitamin D3
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Shriners Hospitals for Children
Adverse Bone Health, HIV Infection
Calcium and High-dose Vitamin D Supplementation on Bone Mineral Density Among HIV-infected Children and Adolescents
Since there is no cure for HIV, therefore antiretroviral therapy must be taken life-long. Some of the HIV medications can negatively impact the health of the bone and is even more exacerbated in perinatally HIV-injected children…
- Trial name
- CAL-D (NCT02426840)
- Testing
- High dose vitamin D and calcium, Normal dose vitamin D and calcium
- Where
- 5 sites in Thailand
- Volunteers
- 200 people
- Sponsor
- Chiang Mai University
Dental Caries
Evaluation of Implants Placed Immediately or Delayed Into Extraction Sites
IRB4729 Study Hypothesis: Is there a significant difference in the hard and soft tissue response comparing immediate with delayed implant after tooth removal, with immediate provisionalization, in maxillary anterior sites.
- Trial name
- NCT01244997
- Testing
- Dental Implant
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Urolithiasis and Aging, Renal Calcul and Metabolic Diseases
Metabolic Assessment of Aging Men With Urinary Lithiasis
Urinary lithiasis is a common disease on young adults, but not so far on aging people. Nowadays, the investigators are seeing a gradative growth on men above sixty years old, mainly in industrialized countries.
- Conditions
- Urolithiasis and Aging, Renal Calcul and Metabolic Diseases, Urolithiasis and Osteoporosis
- Trial name
- NCT01246531
- Where
- Brazil
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Dental Caries
Evaluation of Implants Placed Immediately or Delayed Into Extraction Sites
The purpose of this study is to determine the difference in success when placing implants immediately into an extraction site compared to delaying the implant placement until the extraction site has healed.
- Trial name
- NCT00067392
- Testing
- Dental Implant
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Periodontal Diseases, Dental Caries
A Comparison of the Accurate Diagnosis of the Horizontal & Vertical Bitewing Images
The aims of this research are to determine if vertical bitewings will be more effective and more comprehensive for the diagnosis of caries and the level of alveolar bone loss than the horizontal bitewing technique for the…
- Trial name
- NCT04341636
- Testing
- Bitewing X ray
- Where
- Saudi Arabia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University