Clinical trials: Bone Expansion
Relapsed/Refractory Advanced Solid Tumors, Relapsed/Refractory Diffuse Large B-cell Lymphoma
A Study of PRT543 in Participants With Advanced Solid Tumors and Hematologic Malignancies
This is a Phase 1 cohort, dose-escalation, dose-expansion study of PRT543 in patients with advanced cancers who have exhausted available treatment options.
- Conditions
- Relapsed/Refractory Advanced Solid Tumors, Relapsed/Refractory Diffuse Large B-cell Lymphoma, Relapsed/Refractory Myelodysplasia, Relapsed/Refractory Myelofibrosis
- Trial name
- NCT03886831
- Testing
- PRT543
- Where
- 23 sites in United States
- Volunteers
- 232 people
- Sponsor
- Prelude Therapeutics Incorporated
Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome
Study of Orally Administered AG-881 in Patients With Advanced Hematologic Malignancies With an IDH1 and/or IDH2 Mutation
The purpose of this Phase I, multicenter study is to evaluate the safety, pharmacokinetics, pharmacodynamics and clinical activity of AG-881 in advanced hematologic malignancies that harbor an IDH1 and/or IDH2 mutation
- Conditions
- Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome, Hematologic Malignancies
- Trial name
- NCT02492737
- Testing
- AG881
- Where
- 6 sites in United States, France
- Volunteers
- 46 people
- Sponsor
- Agios Pharmaceuticals, Inc.
Horizontal Alveolar Bone Loss, Implant Therapy
Comparison of Two Expansion Techniques for Horizontal Bone Deficiency
This was a prospective, randomized clinical trial conducted at the Department of Oral and Maxillofacial Surgery, Ege University.
- Conditions
- Horizontal Alveolar Bone Loss, Implant Therapy, Primary Stability of the Implants, Complication
- Trial name
- NCT07848711
- Testing
- Bone expansion and implant placement with crest split, Bone expansion and implant placement with specifically design drills
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ege University
Orthodontic Appliance, Orthodontic Appliances
Short-term Stability of Tooth-borne vs Bone-borne Maxillary Expansion: A Parallel Cohort Study
This prospective parallel cohort study aimed to compare the short-term stability of maxillary expansion achieved with tooth-borne (Hyrax) and bone-borne expanders.
- Conditions
- Orthodontic Appliance, Orthodontic Appliances, Orthodontic Relapse
- Trial name
- NCT06916299
- Testing
- dental casts, tooth-borne expander insertion, miniscrew and bone-borne expander insertion
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- University of Roma La Sapienza
Myelodysplastic Syndrome
Birinapant With 5-azacitidine in MDS Subjects Who Are Naïve, Have Relapsed or Are Refractory to 5-azacitidine Therapy
This is a dose escalation followed by dose expansion study of TL32711 in combination with 5-Azacitidine in subjects with Myelodysplastic syndrome who are naïve, have relapsed or have failed prior 5-azacitidine therapy.
- Trial name
- NCT01828346
- Testing
- Birinapant, 5-Azacitidine
- Where
- 7 sites in United States
- Volunteers
- 21 people
- Sponsor
- TetraLogic Pharmaceuticals
Alveolar Cleft
Partial Maxillary Expansion With Post Grafting Expansion vs. Pre Full Maxillary Expansion in Secondary Alveolar Cleft
Intermediate grafting with both pre- and post- grafting maxillary expansion with time span after grafting 6-8 weeks for consolidation and final retention for 3 months after finalization of expansion will get the advantages of…
- Trial name
- NCT05941988
- Testing
- pre grafting partial maxillary expansion with post grafting expansion
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hearing Loss, Conductive, Hearing Loss, Mixed
Pediatric Expansion Study of the Sentio System
This study is performed to collect safety and performance data supporting the use of the Sentio system in children below 12 years of age. The system is currently available on the market for patients 12 years and above.
- Conditions
- Hearing Loss, Conductive, Hearing Loss, Mixed, Single Sided Deafness
- Trial name
- BC119 (NCT06976086)
- Testing
- Active transcutaneous bone conduction system
- Where
- 8 sites in Netherlands, Spain and 1 more
- Volunteers
- 50 people
- Sponsor
- Oticon Medical
Solid Tumor, Ovarian Cancer
A Phase I Study of XS-02 Capsules in Patients With Advanced Solid Tumors
A study to evaluate the safety, tolerability, pk, and efficacy of XS-02 capsules in patients with advanced solid tumors.
- Conditions
- Solid Tumor, Ovarian Cancer, Breast Cancer, Endometrial Cancer
- Trial name
- NCT06531486
- Testing
- XS-02 capsules
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.
Leukemia
Ex Vivo Expansion of Mafosfamide Purged CD34+ Cells in Patients With Acute Leukemia
RATIONALE: Giving colony-stimulating factors, such as G-CSF, and certain chemotherapy drugs, helps stem cells move from the bone marrow to the blood so they can be collected.
- Trial name
- NCT00245115
- Testing
- filgrastim, busulfan, cyclophosphamide
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Dental Implant, Osseodensification
Septal Bone Expansion Using Osseodensification Versus Piezoelectric Implant Site Preparation
: Implant placement in the inter radicular septum is usually considered the best option for an immediate molar implant, not only in terms of correct 3D positioning, but also regarding implant survival, Osseodensification was…
- Trial name
- NCT06957860
- Testing
- Piezotome, Densah burs
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Hams Hamed Abdelrahman
Low Bone Density
Evaluation of Implant Stability in Low Quality Bone Following the Use of Osseodensifiers Versus Ridge Expanders
the use of osseodensification technique compared to ridge expansion screws in low bone quality
- Trial name
- NCT05330546
- Testing
- Densah burs, Ridge expansion screws
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hematologic Malignancies, Solid Tumor
A Trial of PF-07901800 (TTI-621) for Patients With Hematologic Malignancies and Selected Solid Tumors
Multicenter, open-label, phase 1a/1b trial of PF-07901800 (TTI-621) in subjects with relapsed or refractory hematologic malignancies and selected solid tumors.
- Trial name
- NCT02663518
- Testing
- PF-0791800 (TTI-621), PF-07901800 (TTI-621) plus Rituximab, PF-07901800 (TTI-621) plus Nivolumab
- Where
- 51 sites in United States, Canada
- Volunteers
- 249 people
- Sponsor
- Pfizer
Alveolar Bone Resorption, Alveolar Bone Grafting
Split Crest Procedure: Is It Necessary to Fill the Gap?
This prospective controlled clinical study evaluates the effectiveness of adding bone graft or dentin graft material during the split crest (alveolar ridge splitting) procedure for horizontal ridge augmentation with simultaneous…
- Conditions
- Alveolar Bone Resorption, Alveolar Bone Grafting, Bone Expansion
- Trial name
- NCT07272694
- Testing
- Split Crest Technique
- Where
- Serbia
- Volunteers
- 24 people
- Sponsor
- Vladimir Biocanin
Primary Myelofibrosis, Thrombocytosis
A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MF
The purpose of this phase Ib/II clinical trial was to: a) evaluate the safety of the co-administration of LDE225 and INC424 in myelofibrosis patients and establish a maximum tolerated dose and/or Recommended Phase II dose of the…
- Conditions
- Primary Myelofibrosis, Thrombocytosis, Essential Thrombocythemia, Polycythemia Vera
- Trial name
- NCT01787552
- Testing
- LDE225, INC424
- Where
- 18 sites in Australia, Belgium and 9 more
- Volunteers
- 50 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Myelomonocytic Leukemia, Leukemia
Ruxolitinib for the Treatment of Chronic Myelomonocytic Leukemia (CMML): A Phase 2 Expansion
This study is to find out if treating Chronic Myelomonocytic Leukemia (CMML) with a study drug (ruxolitinib) can improve outcomes of patients with CMML.
- Trial name
- NCT03722407
- Testing
- Ruxolitinib
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Osteosarcoma
A Study of Azenosertib (ZN-c3) in Combination With Gemcitabine in Subjects With Osteosarcoma
This is a phase 1/2 study of azenosertib (ZN-c3) in combination with gemcitabine in adult and pediatric subjects with relapsed or refractory osteosarcoma.
- Trial name
- NCT04833582
- Testing
- Azenosertib, Gemcitabine
- Where
- 17 sites in United States, France
- Volunteers
- 31 people
- Sponsor
- K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
Leukemia, Myeloid, Chronic, Lymphomas
Post Transplant Donor Lymphocyte Infusion
The purpose of this study is to test the hypothesis that a pre-infusion preparative regimen of cyclophosphamide and fludarabine will improve the effectiveness of DLI in patients with blood cancers.
- Conditions
- Leukemia, Myeloid, Chronic, Lymphomas, Multiple Myeloma, Myelodysplastic Syndrome
- Trial name
- NCT00167180
- Testing
- Donor Lymphocyte Infusion, Induction Chemotherapy
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Maxillary Constriction in Growing Children, Transverse Maxillary Deficiency
Effects of BREA and MFT Expansion Appliances on Upper Airway Dimensions
This retrospective study evaluated whether orthodontic expansion using two types of appliances, a bimaxillary removable expansion appliance (BREA) and a maxillary fixed three screw palatal expander (MFT), influences upper airway…
- Conditions
- Maxillary Constriction in Growing Children, Transverse Maxillary Deficiency, Upper Airway Morphology in Children, Orthodontic Expansion Effects
- Trial name
- NCT07456917
- Testing
- Maxillary fixed three screw palatal expander (MFT), Bimaxillary removable expansion appliance (BREA)
- Where
- Poland
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Complete Edentulism
Effect of Mini Implants Supported Over Dentures Versus Conventional Implant After Bone Expansion
The better form of ridge will provide using wider implants that can have better abilities to with stand forces and to prevent alveolar bone loss as much as possible.
- Trial name
- NCT03326453
- Testing
- Mini dental implant
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Refractory Acute Myeloid Leukemia (AML), Relapsed Acute Myeloid Leukemia (AML)
CD64 CAR T Cell Therapy in Adults With Relapsed and/or Refractory AML
This is a Phase 1, open label, dose-escalation study to evaluate the safety, expansion, persistence, and preliminary clinical activity of lentivirally transduced autologous T cells expressing anti-CD64 chimeric antigen receptors…
- Conditions
- Refractory Acute Myeloid Leukemia (AML), Relapsed Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome, AML (Acute Myeloid Leukemia)
- Trial name
- NCT07347418
- Testing
- CD64 CAR T Cells
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver