Clinical trials: Bone Formation
Gaucher's Disease
Gene Therapy for Gaucher's and Fabry Disease Using Viruses and Blood-Forming Cells
Gaucher's disease is a lysosomal storage disease resulting from glycocerebroside GLUCOCEREBROSIDE (1) accumulation in macrophages due to a genetic deficiency of the enzyme glucocerebrosidase. It may occur in patients of all ages.
- Trial name
- NCT00001234
- Testing
- human glucocerebrosidase cDNA
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dental Implants
Histologic Evaluation of Bone Formation After Alveolar Augmentation by "Sandwich Osteotomy" Procedure for Dental Implants Insertion
The purpose of this study is to evaluate histologic bone remodeling after interpositional bone graft ("sandwich osteotomy" technique) using xenograft to fill the gap of the bone after moving and fixation it in the proper place.
- Trial name
- NCT00878332
- Where
- Israel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Bone Resorption, Bone Atrophy
The Effects of Low Energy Availability and High Impact Jumping on Markers of Bone (re)Modelling in Females
Osteoporosis is worldwide health epidemic categorized by poor bone health, primarily diagnosed by low bone mineral density, and costs healthcare systems billions every year.
- Conditions
- Bone Resorption, Bone Atrophy, Energy Supply; Deficiency, Female Athlete Triad
- Trial name
- NCT04790019
- Testing
- Low energy availability, High impact jumping
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Osteopenia
"VIBES"--Low Magnitude Mechanical Stimulation to Improve Bone Mineral Density
The purpose of this study is to determine if daily low magnitude, high frequency whole body vibration can improve bone density in seniors.
- Trial name
- NCT00396994
- Testing
- Low magnitude mechanical stimulation
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Inadequate Bone Height in Maxillary Posterior Area
A Comparison of Bone Formation With Three Different Bone Graft Materials Following Sinus Graft
The purpose of this study is to compare new bone formation following bone graft in sinus using three different commercially available bone graft materials.
- Trial name
- NCT01911819
- Testing
- Sinus augmentation, Equimatrix, OSSIF-i sem
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Osteoporosis
DeFRA Questionnaire as an Anamnestic Form
The DeFRA questionnaire is a new validated algorithm derived from FRAX. Here we use the DeFRA as a "primary anamnestic from" to identify subjects at risk of osteoporosis in a population never screened before and never treated for…
- Trial name
- NCT02003716
- Where
- Italy
- Volunteers
- 767 people, healthy volunteers welcome
- Sponsor
- Valmontone Hospital
Heterotopic Ossification
Naproxen for the Prevention of HO After Complex Elbow Trauma
Complex elbow fractures can lead to formation of new bone (called Heterotopic ossification). This new bone is unwanted and it can restrict motion.
- Trial name
- Naproxen (NCT00586365)
- Testing
- Naproxen
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Osteogenesis Imperfecta
Effects of Bisphosphonates on OI-Related Hearing Loss
Osteogenesis Imperfecta-related hearing loss usually occurs in individuals with mild (type I) OI and is much earlier in onset than age-related hearing loss, with the majority of individuals experiencing some minor hearing loss in…
- Trial name
- NCT04152551
- Testing
- Risedronate Oral Tablet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Horizontal Ridge Deficiency
The Horizontal Ridge Augmentation Using Equine Xenograft and a Collagenated Porcine Cortical Lamina
The primary aim of this study is to clinically, radiographically and histologically evaluate the lateral bone augmentation of the soft porcine cortical lamina (OsteoBiol®) using equine-derived bone particles (OsteoBiol®)
- Trial name
- NCT04376060
- Testing
- Gen-Os®; The soft lamina (OsteoBiol®)
- Where
- Lebanon
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Bone Augmentation
Effect of Healing Time on New Bone Formation Following Tooth Extraction and Ridge Preservation With Demineralized Freeze-Dried Bone Allograft
Bone grafting following tooth extraction is commonly performed to preserve bony ridge dimensions adequate to support subsequent implant placement.
- Trial name
- NCT02154386
- Testing
- Ridge preservation using DFDBA
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Postmenopausal Osteopenia
The Effect of Aerobic Exercise on Bone Turnover Markers in Postmenopausal Patients
The aim of the study was to evaluate the effect of light-moderate aerobic exercise on BMD in postmenopausal osteopenic women using bone formation-resorption markers.
- Trial name
- NCT06866561
- Testing
- aerobic exercise, cholecalciferol, calcium carbonate
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Dental Extraction, Wound Heal
Wound Healing Following Tooth Extraction and Ridge Preservation Using DFDBA Alone in Particulate Fiber Form and in Combination With Xenograft
The primary aim of the study is to determine the amount of newly formed vital bone, residual graft material, and "connective tissue/other" 18 to 20 weeks after ridge preservation is performed using DFDBA fibers alone, DFDBA…
- Trial name
- NCT05400213
- Testing
- Vallos (DCP), Vallomix (DCF), Vallos-F (DPX)
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Edentulous Alveolar Ridge
Transcrestal Maxillary Sinus Floor Elevation With Injectable Bone Substitute
To investigate clinical outcomes of transcrestal maxillary sinus floor elevation performed with an injectable xenograft in gel form, analyzing variables possibly influencing the results.
- Trial name
- INJTSFEXEN (NCT05305521)
- Testing
- transcrestal sinus floor elevation, Implant placement
- Where
- 2 sites in Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- International Piezosurgery Academy
Spinal Cord Injuries
Gut Peptides and Bone Remodeling in Individuals With Spinal Cord Injury
Both GLP-2 and GIP reduce bone resorption (measured as CTX) in healthy persons. In this study, we will investigate whether GLP-2 and GIP is reducing CTX in individuals with spinal cord injury.
- Trial name
- NCT05181150
- Testing
- Meal test, GIP, GLP-2
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Osteogenesis Imperfecta
Registry of Osteogenesis Imperfecta
ROI is a retrospective and prospective registry, finalized for care and research purposes. It is articulated in main sections - strongly related and mutually dependent on each other - corresponding to different data domains…
- Trial name
- ROI (NCT04115774)
- Testing
- bisphosphonates
- Where
- Italy
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Luca Sangiorgi
Osteogenesis
Clinical and Radiographic Assessment of PRF Versus Lutein Placement
Thirty patients seeking for prosthetic replacement of non-restorable single rooted maxillary teeth by dental implant placement will be selected from the Out-Patient Clinic of Oral and Maxillofacial Surgery Department, Faculty of…
- Trial name
- NCT06358352
- Testing
- Lutein / Zeaxanthin, Platelet rich fibrin
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Immediate Implant Placement
Socket Evaluation System to Predict Labial Bone Formation Around Immediate Implants. A Retrospective Cone Beam Computed Tomography Analysis.
Palate implant placement in extraction sockets, with a minimum of 2 mm between the implant and the inner side of the facial socket wall, has been advised as a step towards a 3D restorative-driven posture.
- Trial name
- NCT06246253
- Testing
- Virtual implant placement following safe angle concept, actual implant placement following safe angle concept
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Misr International University
Ossification Posterior Longitudinal Ligament, Cervical Spondylotic Myelopathy
Comparison of IONM Between Remimazolam and Propofol
Inhalation anesthetics significantly can delay latency and reduce amplitude of cortical MEPs and SSEPs signals compared to intravenous anesthetics by acting on not only GABA (γ-aminobutyric acid) receptors but also NMDA…
- Trial name
- NCT04968054
- Testing
- Arm I (Propofol), Arm II (Remimazolam)
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Bone Loss, Age-related
Effects of Acute Estrogen Therapy on Bone Formation
This study is being done to study age-related bone changes in women. The investigators know that the major cause of osteoporosis is a shortage of the female hormone estrogen.
- Trial name
- NCT02349113
- Testing
- Estrogens (Climara)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic