Clinical trials: Bone Neoplasms
Multiple Myeloma
Role of Osteocytes in Myeloma Bone Disease
Progress in the treatment of myeloma and myeloma bone disease has substantially increased overall survival, but relapse is inevitable and better treatment is needed.
- Trial name
- NCT02212262
- Where
- 2 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Attaya Suvannasankha
Multiple Osteochondroma, Enchondromatosis
Survey on Multiple Osteochondromas and Enchondromatoses During the Transition From Paediatric Care to Adult Care
This prospective observational study aims to understand the transition experiences and unmet needs of patients living with multiple osteochondromas or enchondromatoses during the paediatric to adult care, in order to produce a…
- Trial name
- PJMOE (NCT07839637)
- Where
- Italy
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Mastocytosis, Bones
Relationship Between Circulating Sclerostin and Bone Lesions in Patients With Mastocytosis
Mastocytosis is very rare and highly heterogeneous group of disorders, characterized by the accumulation of clonal mast cells which can infiltrate several organs and tissues.
- Trial name
- NCT06440148
- Testing
- SCLEROSTIN
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Myeloproliferative Neoplasm
Role of the Circulating Procoagulants Microparticles in the Hypercoagulability of MNP Ph1-
Patients with myeloproliferative neoplasms Philadelphia chromosome negative (MPNsPh1-) such as Essential thrombocytosis (ET), Polycythemia vera (PV) and Primary Myelofibrosis (PMF) have a higher risk of arterial or deep-vein…
- Trial name
- MICROP-SMP (NCT02862366)
- Testing
- Blood sampling
- Where
- 3 sites in France
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Alcohol-Related Carcinoma, Fanconi Anemia
Role of Acetaldehyde in the Development of Oral Cancer
This is a minimal risk intervention study where healthy volunteers and individuals with Fanconi anemia will consume a single dose of alcohol and provide primarily non-invasive biological samples at various time points.
- Conditions
- Alcohol-Related Carcinoma, Fanconi Anemia, Oral Cavity Carcinoma
- Trial name
- NCT05973656
- Testing
- Alcohol, Biospecimen Collection, Breath Test
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Ann Arbor Stage I Lymphoma, Ann Arbor Stage II Lymphoma
- Trial name
- NCT05334069
- Testing
- Questionnaire Administration, Biospecimen Collection
- Where
- 747 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology
Acute Myeloid Leukemia
Bone Marrow Angiogenesis in Acute Myeloid Leukemia - Evaluated by Dynamic Contrast Enhanced Magnetic Resonance (MR) Image
In malignant or neoplastic disease, angiogenesis is defined as the generation of new capillaries from preexisting blood vessels, e.g. by sprouting or by intusseption.
- Trial name
- NCT00172562
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Tyrosine Kinase Inhibitors, Chronic Myeloid Leukemia
Discontinuation of TyrosIne Kinase Inhibitors (TKI) in Chronic Myeloid Leukemia (CML) and Impact on the Immune System
Tyrosine kinase inhibitors (TKI) have revolutionized the management and prognosis of chronic myeloid leukemia (CML). Daily treatment with TKI, which is necessary due to lack of cure, is frequently associated with moderate…
- Trial name
- NCT05753384
- Testing
- treatment of TKI in CML
- Where
- 20 sites in France
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
PRP & Jaw Cysts
Role of Platelet Rich Plasma in Bone Regeneration After Enucleation of Odontogenic Jaw Cysts
in the present study, the effect of PRP on bone regeneration when applied to the site of removal of cyst of the jaws is evaluated. PRP was delivered to the site combined with gelfoam. Thrombin clot accelerator was not used.
- Trial name
- NCT06721806
- Testing
- PRP & bone regeneration
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia
Donor-Derived Humoral Immunity, Hematopoietic Stem Cell Transplantation, TAR
This research study is for subjects that are receiving a bone marrow transplant. As part of the transplant subjects will receive stem cells from a donor who has agreed to donate stem cells for them.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia, Chronic Myelogenous Leukemia, Myelodysplastic Syndrome
- Trial name
- TAR (NCT01611298)
- Testing
- Tetanus
- Where
- 2 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Robert Krance
Acute Leukemia
Quantitative MRI of Bone Marrow in Patients With Acute Lymphoblastic Leukemia
The study is aimed at assessing changes in the bone marrow of patients from 6 to 18 years old with a diagnosis of acute lymphoblastic leukemia during chemotherapy.
- Trial name
- NCT04767165
- Testing
- MRI
- Where
- Russia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Neoplasms, Hematologic Neoplasms
Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members
This study will collect biological samples for use in research experiments aimed at better understanding the clinical features of certain diseases.
- Conditions
- Neoplasms, Hematologic Neoplasms, Healthy Volunteers
- Trial name
- NCT00071045
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myeloproliferative Neoplasm
Cardiac Changes in Myeloproliferative Neoplasms
Myeloproliferative neoplasms are heterogeneous group of clonal hematopoietic stem cell neoplasms with excessive proliferation of one or more of the erythroid, megakaryocytic, or myeloid lineages and relatively normal maturation…
- Trial name
- NCT03177928
- Testing
- Transthorathic echocardiogram
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cardiovascular Diseases, Osteoporosis
Macrobiotic Diet and Flax Seed: Effects on Estrogens, Phytoestrogens, & Fibrinolytic Factors
This study will assess whether alternative, high phytoestrogen dietary interventions result in favorable effects on biological parameters that have been associated with hormone-dependent cancers, cardiovascular disease, and…
- Conditions
- Cardiovascular Diseases, Osteoporosis, Breast Cancer, Endometrial Cancer
- Trial name
- NCT00010829
- Testing
- American Heart Association Step 1 diet, American Heart Association Step 2 diet + 10 g/day flax seed, Macrobiotic dietary intervention
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Soft Tissue Sarcoma, Bone Sarcoma
Assessment of the Functional Outcome and Quality of Life in Sarcoma Patients
Primary bone and soft tissue sarcomas are an exceptionally rare form of cancer, collectively accounting for only 1% of all malignancies diagnosed.
- Trial name
- QOLSarcoma (NCT05051059)
- Testing
- Functional outcome, Health related quality of life (HRQoL) assessment
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Osteoporosis, Osteopenia
Dried Plums Prevent Inflammation And Improve Bone Health in Osteopenic Men
The goals of this study are 1) to investigate the extent to which dried plum improves bone health by measuring bone density (a measure of bone strength) of whole body, hip, and forearm, indicators of bone formation and bone…
- Trial name
- NCT03408119
- Testing
- Dried Plum, 800 IU vitamin D and 450mg elemental calcium
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Florida State University
Osteoporosis, Sarcopenia
Bone Microstructure by Using HR-pQCT in Long Courses After Gastrectomy
Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy.
- Conditions
- Osteoporosis, Sarcopenia, Gastric Cancer
- Trial name
- NCT03251430
- Testing
- gastrectomy
- Where
- Japan
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Kobayashi Shinichiro
Transplant-Related Cancer
Patient-donor Vaccination in the Context of Allogeneic Bone Marrow Transplant With Post-transplant Cyclophosphamide
This research is being done to understand the effects of certain types of bone marrow transplant (BMT) on the immune system. Your doctors are planning a BMT, using one of your family members as the bone marrow donor, for your…
- Trial name
- NCT01282216
- Testing
- Havrix, PCV13
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Acromegaly
A Prospective Study of Outcome After Therapy for Acromegaly
The purpose of this study is to evaluate hormone values and other markers of disease activity in a cohort of patients with acromegaly at the time of diagnosis and then prospectively after surgical or other treatment.
- Trial name
- NCT01809808
- Testing
- Surgery for acromegaly, Medications for acromegaly, Total body magnetic resonance imaging
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Columbia University
Basal Cell Carcinoma
A Clinical Trial of Dermacorder for Detecting Malignant Skin Lesions
The Dermacorder measures the electric field in the skin. Malignant skin lesions disrupt the skin's normal electric field and this abnormal electric field can be detected by the Dermacorder.
- Trial name
- Dermacorder (NCT01014819)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland