Clinical trials: Bone Regeneration
Alveolar Ridge Enlargement
Titanium Reinforced d-PTFE Membrane Versus Collagen Membrane For Guided Bone Regeneration
After tooth extraction, shrinkage of the bone is expected with 50% reduction of alveolar width. Patients at least 3months after tooth extraction and in need of single oral implant placement in the anterior maxilla with both…
- Trial name
- NCT05426616
- Testing
- collagen membrane (Creos Xenoprotect , Nobel Biocare AB, Göteborg, Sweden), titanium reinforced d-PTFE membrane (Creos Syntoprotect , Nobel Biocare AB, Göteborg, Sweden)
- Where
- 3 sites in Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Ghent
Cystectomy, Segmental Growing of Alveolar Tissue
Study of Collagen Membrane in Guided Bone Regeneration
The main purpose of this study is to investigate the efficacy of Hypro-Sorb® F, a bilayered bioabsorbable membrane in inducing bone regeneration in different dental procedures requiring GBR.
- Conditions
- Cystectomy, Segmental Growing of Alveolar Tissue, Sinus Lift, Root Amputation and Apicoectomy
- Trial name
- GBR (NCT00454038)
- Testing
- HYPRO SORB F
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Alveolar Bone Loss* / Therapy
Study on Silk Fibroin-Reinforced Collagen-Based Composite Membrane for Periodontal Bone Tissue Regeneration
Based on the mechanism of intramembranous ossification of the alveolar bone, it is necessary to design a biomimetic membrane material based on the principle of GBR (Guided Bone Regeneration) to simulate the biological…
- Trial name
- NCT07574853
- Testing
- Silk Fibroin-Reinforced Collagen-Based Composite Membrane
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Bone Loss, Alveolar
Tenting Screws in Combination With Platelet Concentrate for Vertical Alveolar Ridge Augmentation
Alveolar bone resorption often occurs after tooth extraction. At present, guided bone regeneration technique is widely used in clinic since it leads to less trauma and less complications.
- Trial name
- NCT04835532
- Testing
- guided bone gereration
- Where
- China
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Guided Bone Regeneration, Bone Augmentation
Lateral GBR Using Two Types of Membrane With a Combination of Allograft-xenograft
Bone width is critical for successful implant placement, as thin bone increases the risk of bone loss. Various augmentation techniques-especially guided bone regeneration (GBR)-are effective in restoring bone volume using grafts…
- Trial name
- NCT07525128
- Testing
- Lateral Guided bone regeneration
- Where
- Lebanon
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Guided Tissue Regeneration, Periodontal / Methods, Dental Enamel Proteins* / Therapeutic Use
Flapless Periodontal Regeneration Using Hyaluronic Acid Versus Enamel Matrix Derivative
The goal of this clinical trial is to radiographically assess the effectiveness of minimally invasive non-surgical technique (MINST) combined with local administration of sodium hypochlorite gel (Perisolv®) and 1.6% cross-linked…
- Conditions
- Guided Tissue Regeneration, Periodontal / Methods, Dental Enamel Proteins* / Therapeutic Use, Alveolar Bone Loss* / Therapy, Hyaluronic Acid* / Therapeutic Use
- Trial name
- NCT07339605
- Testing
- Flapless instrumentation of the defect following MINST in conjuction with NaOCl and hyaluronic acid application, Flapless instrumentation of the defect following MINST, root conditioning with EDTA and EMD application, Flapless instrumentation of the defect and product application simulation
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Valencia
Esthetic Zone, Single Tooth Lost
Cost Effectiveness of Various Implant Placement Protocols in the Esthetic Zone
Loss of teeth in the anterior upper jaw significantly affects both well-being and chewing function. Nowadays, dental implants are the treatment of choice for replacing missing teeth with fixed dental prostheses and are often…
- Conditions
- Esthetic Zone, Single Tooth Lost, Accuracy of Dental Implants, Dimensional Changes
- Trial name
- NCT05940662
- Testing
- Immediate Implant Placement, Early Implant Placement, Late Implant Placement
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- University of Bern
Intrabony Periodontal Defect
Comparison of the GTR Procedure Alone and in Combination With Immediate OTM
The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a GTR procedure, when it is combined with an immediate orthodontic tooth movement or used alone.
- Trial name
- NCT04896450
- Testing
- Guided tissue regeneration (GTR), Orthodontic tooth movement (OTM)
- Where
- Hungary
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Patients Undergoing Oral Implant Therapy
The Effect of Systemic Antibiotics on Post-surgical Complications and Patient-centered Outcomes in Patients Undergoing Implant Surgery With Guided Bone Regeneration and Simultaneous Sinus Floor Elevation
The primary aim of the trial is to evaluate the effect of systemic antibiotic administration compared to placebo in patients undergoing oral implant therapy with simultaneous lateral sinus floor elevation and guided bone…
- Trial name
- NCT04552080
- Testing
- Amoxicillin
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Tooth Extraction, Alveolar Bone Loss
Autogenous Dentin Graft for Alveolar Ridge Preservatio
When a tooth is extracted, the bone around the empty socket naturally shrinks over time, which can make it difficult to place a dental implant later without additional bone-building procedures.
- Trial name
- ARF-PRF (NCT07789262)
- Testing
- Autogenous Dentin Graft, Platelet-Rich Fibrin (PRF), Freeze-Dried Bone Allograft (FDBA)
- Where
- Turkey (Türkiye)
- Volunteers
- 9 people
- Sponsor
- Ankara Yildirim Beyazıt University
PRP & Jaw Cysts
Role of Platelet Rich Plasma in Bone Regeneration After Enucleation of Odontogenic Jaw Cysts
in the present study, the effect of PRP on bone regeneration when applied to the site of removal of cyst of the jaws is evaluated. PRP was delivered to the site combined with gelfoam. Thrombin clot accelerator was not used.
- Trial name
- NCT06721806
- Testing
- PRP & bone regeneration
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Assiut University
Bone Fracture
Enhancement of Bone Regeneration and Healing in the Extremities by the Use of Autologous BonoFill-II
The purpose of this clinical study is to evaluate the safety and the efficacy of BonoFill-II as an autologous bone-regenerating graft in the reconstruction of deficient bone in two clinical indications: 1.
- Trial name
- NCT03024008
- Testing
- BonoFill-II
- Where
- 6 sites in Israel
- Volunteers
- 40 people
- Sponsor
- BonusBio Group Ltd
Ankle and Hindfoot Arthrodesis
Long-term Safety and Effectiveness of AUGMENT® Injectable Bone Graft Compared to Autologous Bone Graft
The objective of this long-term study is to evaluate the long-term effectiveness and safety of AUGMENT® Injectable Bone Graft vs. autologous bone graft.
- Trial name
- NCT03998137
- Testing
- AUGMENT® Injectable Bone Graft, Standard of Care
- Volunteers
- 94 people
- Sponsor
- BioMimetic Therapeutics
Jaw Cysts
Volumetric Analysis of Bone Following Jaw Cysts Enucleation With and Without Alb-PRF
Cyst is the main cause for longstanding swelling in the mandible or the maxilla, its enlargement usually results in resorption and weakening of bone.
- Trial name
- NCT05658900
- Testing
- Enucleation with albumin PRF, Enucleation without albumin PRF
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Hams Hamed Abdelrahman
Microbiology, Alveolar Ridge Preservation
Microbiome Analysis of Dental Biofilm on High-Density Polytetrafluoroethylene Membranes Used in Socket Preservation
The goal of this clinical trial is to evaluate how different types of high-density polytetrafluoroethylene (d-PTFE) membranes impact dental biofilm accumulation and composition in patients undergoing socket preservation following…
- Conditions
- Microbiology, Alveolar Ridge Preservation, Infections, Bacterial
- Trial name
- MADBioS (NCT06694844)
- Testing
- Socket preservation with M1, Socket preservation with M2
- Where
- Croatia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Marija Čandrlić
Bone Loss
Lateral Ridge Augmentation Using Cross-linked or Non-cross-linked Collagen Membrane
The objective of the present trial is to test clinically, radiographically and histologically , in a lateral alveolar ridge augmentation model (without simultaneous implant placement) the efficiency in supporting bone formation…
- Trial name
- NCT04402671
- Testing
- non-cross-linked porcine skin collagen membrane, glutaraldehyde cross-linked bovine collagen membrane
- Where
- Lebanon
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss
Early Dental Implant Installation in Regeneration Sites: a Prof of Concept Prospective Case Study
This study will evaluate bone healing after tooth extraction and alveolar ridge preservation, a common procedure used to maintain the bone volume needed for future dental implant placement.
- Trial name
- NCT07766057
- Testing
- Alveolar Ridge preservation and early implant placement
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- Franco Cavalla
Open Fracture of Foot
In Vivo Clinical Trial of Porous Starch - Hydroxyapatite Composite Biomaterials for Bone Regeneration
Biodegradable scaffold is an accepted and commercialized medical alternative choice for bone regeneration. In this project we will used our new invention, porous starch- hydroxyapatite composite, for in vivo clinical trial.
- Trial name
- NCT02910232
- Testing
- bone void filler
- Where
- Thailand
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
Alveolar Process Defect
Ridge Augmentation Comparing a Block Allograft to a Demineralized Bone Matrix Allograft.
This study with compare the ridge dimension changes for a block allograft vs. a demineralized bone matrix moldable allograft.
- Trial name
- NCT02127112
- Testing
- Block Allograft plus Matrix Allograft, Moldable Matrix Allograft
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Alveolar Bone Grafting, Bone Regeneration Following Wisdom Teeth Extraction
Autogenous Tooth Bone Graft for Alveolar Socket Preservation
The purpose of this clinical experiment is to assess how well autogenous tooth bone grafting preserves the alveolar socket after surgical tooth extraction.
- Conditions
- Alveolar Bone Grafting, Bone Regeneration Following Wisdom Teeth Extraction, Tooth Extraction Site Healing
- Trial name
- ATBG (NCT07267637)
- Testing
- "Autogenous Tooth Bone Graft"
- Where
- Yemen
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Haifaa Mohammed Al-hussini