Clinical trials: Bone Regeneration
Alveolar Ridge Enlargement
Titanium Reinforced d-PTFE Membrane Versus Collagen Membrane For Guided Bone Regeneration
After tooth extraction, shrinkage of the bone is expected with 50% reduction of alveolar width. Patients at least 3months after tooth extraction and in need of single oral implant placement in the anterior maxilla with both…
- Trial name
- NCT05426616
- Testing
- collagen membrane (Creos Xenoprotect , Nobel Biocare AB, Göteborg, Sweden), titanium reinforced d-PTFE membrane (Creos Syntoprotect , Nobel Biocare AB, Göteborg, Sweden)
- Where
- 3 sites in Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Ghent
Periodontal Bone Loss, Periodontal Pocket
Locally Injected Vit D as a Non-surgical Modality for Periodontal Regeneration of Infrabony Defects
vitamin D has great role in bone regenration and soft tissue health. in the past periodontal regeneration was performed using bone graft and barrier membrane
- Trial name
- NCT03716765
- Testing
- locally injected vitamin D
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Guided Bone Regeneration
A Phase I Study of SB Cell for the Enhanced Osseointegration of Guided Bone Regeneration in Implant Surgery
This is a Phase 1 study to evaluate the safety profile of autologous-derived SB cells to enhance osseointegration of GBR in patients undergoing dental implant surgery.
- Trial name
- NCT04451486
- Testing
- SB cells
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Intrabony Periodontal Defect
Effect of Alendronate With β - TCP Bone Substitute in Surgical Therapy of Periodontal Intra-osseous Defects.
The aim of the present study was to evaluate the bone formation potential of 400µg alendronate delivered in β-TCP in the treatment of periodontal intra-osseous defects.
- Trial name
- NCT02795546
- Testing
- Alendronate sodium, beta-tricalcium phosphate bone substitute
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Bone Resorption Disorder
Guided Bone Regeneration in Atrophic Anterior Maxillary Ridges
This study is aiming to evaluate clinically, radiographically ,and histologically GBR using collagen membrane in combination with a mixture of ABBM and autogenous particulated bone compared to collagen membrane with ABBM in…
- Trial name
- NCT03731416
- Testing
- GBR by xenograft and autogenous bone
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Horizontal Ridge Deficiency
Assessment of GBR in Augmentation of Horizontally Atrophic Maxillary Ridge Using Collagen Membrane Versus Using Titanium Mesh
this study is aiming to Assess postoperative complications and bone quality and quantity in augmentation of horizontally atrophic maxillary ridge using a 1:1 mixture of autograft and xenograft particulate bone covered with…
- Trial name
- NCT03635658
- Testing
- titanium mesh, collagen membrane (Sausage technique)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Horizontal Alveolar Bone Defect, Guided Bone Regeneration
Guided Bone Regeneration in Lower Posterior Edentulous Arch Using Resorbable or Non Resorbable Membrane.
the purpose of this study is to compare the efficiency of non-resorbable membrane versus resorbable membrane in guided bone regeneration in atrophic posterior mandible.
- Trial name
- NCT07254494
- Testing
- guided bone regeneration using Resorbable membrane pericardium, guided bone regeneration using non resorbable ptfe membrane
- Where
- Lebanon
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beirut Arab University
Intrabony Periodontal Defect
Comparison of the GTR Procedure Alone and in Combination With Immediate OTM
The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a GTR procedure, when it is combined with an immediate orthodontic tooth movement or used alone.
- Trial name
- NCT04896450
- Testing
- Guided tissue regeneration (GTR), Orthodontic tooth movement (OTM)
- Where
- Hungary
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Horizontal Ridge Deficiency
Vascularized Inter-positional Periosteal Connective-tissue Flap Versus Collagen Membrane in Guided Bone Regeneration
this study compares 2 techniques in guided bone regeneration for horizontal ridge augmentation in aesthetic zone
- Trial name
- VIP-CT (NCT05813340)
- Testing
- Vascularized inter-positional periosteal connective tissue flap
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Patients with Posterior Maxillary Atrophy and Need for Sinus Lift Surgery to Allow Implant Placement
Efficacy of L-PRF Against Deproteinized Bovine Mineralized Bone (DBBM)
Objective: The main objective of this study is to evaluate whether the use of L-PRF combined with deproteinized bovine mineralized bone (DBBM; BioOss, Geistlich Pharma®) reduces healing time, through histomorphometric analysis…
- Trial name
- NCT06686836
- Testing
- Sinus lift augmentation with bone substitute (Bio-Oss), Open sinus lift surgery lift using Platelet- and leukocyte-rich fibrin (L-PRF) mixed with a bone substitute (Bio-Oss®(Geistlich AG, Wolhusen, Switzerland)) - L-PRF Block
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Bone Deformity
The Influence of 3D Surgical Template on the Contour of Bone Augmentation, in Patient With Labial Alveolar Ridge Defect and Simultaneous Implantation
Evaluate the impact of using 3D surgical template with guided bone regeneration technique on the contour of bone augmentation in patients with horizontal labial ridge defect and simultaneous implantation.
- Trial name
- NCT06312384
- Testing
- 3D Surgical Template on the Contour of Bone Augmentation, in Patient With Labial Alveolar Ridge Defect and Simultaneous Implantation, conventional guided bone regeneration,in Patient With Labial Alveolar Ridge Defect and Simultaneous Implantation
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Jaw Cysts, Curettage
Low-Intensity Pulsed Ultrasound as an Adjunctive Therapy for Bone Regeneration Following Jaw Cyst Enucleation
This study tested whether low-intensity pulsed ultrasound (LIPUS) could help patients recover better after surgery to remove jaw cysts. A total of 29 patients with 33 jaw cysts were included.
- Trial name
- LIPUS (NCT07210983)
- Testing
- Low-Intensity Pulsed Ultrasound
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Sadam Elayah
Periodontitis
Regeneration of Human Intrabony Defects With rhFGF-2/HA
BACKGROUND: Periodontal disease is an infection that results in progressive loss of dental support, which may lead to tooth loss..
- Trial name
- NCT02337166
- Testing
- a gel containing 4mg/ml rhFGF-2 in sodium hyaluronate, Periodontal flap surgery
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Asherman Syndrome
Pre-clinical Endometrial Tissular Renovation Study
The endometrium is a tissue with high capacity of renewal ("self-renewal"). This process is regulated by stem cells. Recent studies have shown that bone marrow-derived stem cells (BMDSCs) contribute to tissues and organs…
- Trial name
- PreENTIRE (NCT03665649)
- Testing
- CD133+ cells isolation
- Where
- Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Igenomix
Patients Undergoing Oral Implant Therapy
The Effect of Systemic Antibiotics on Post-surgical Complications and Patient-centered Outcomes in Patients Undergoing Implant Surgery With Guided Bone Regeneration and Simultaneous Sinus Floor Elevation
The primary aim of the trial is to evaluate the effect of systemic antibiotic administration compared to placebo in patients undergoing oral implant therapy with simultaneous lateral sinus floor elevation and guided bone…
- Trial name
- NCT04552080
- Testing
- Amoxicillin
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Healthy Volunteers Only
Efficacy of Buccal Pad of Fat, Advanced Platelet Rich Fibrin, Fibrin Glue and Oxidized Cellulose Plug in Management of Oro-Antral Communication, Comparative Clinical Study
Evaluation of the efficacy of different treatment protocols in the management of Oro-Antral Communications.
- Trial name
- OAC (NCT06220877)
- Testing
- Buccal Pad of Fat, A-PRF, fibrin glue
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- October 6 University
Chronic Periodontitis
Evaluation of SilOss® in Periodontal Surgery
Siloss® (Azurebio, Madrid, Spain) is a synthetic and inorganic bone graft material and is composed of a dicalcium phosphate anhydrous (monetite), hydroxyapatite (HA), and amorphous silica and trace amounts of zinc.
- Trial name
- NCT02639572
- Testing
- Siloss® bone graft, Hydroxyapatitie Bone graft
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Bone Graft; Complications, Infection or Inflammation, Ridge Deficency
To Compare Different Soft Tissue Grafts at the Time of Lateral Ridge Augmentation Procedure.
This study will compare two commonly used soft tissue grafting techniques (connective tissue graft, CTG vs Acellular Dermal Matrix, ADM) to augment the soft tissue at the time of lateral ridge augmentation procedure.
- Conditions
- Bone Graft; Complications, Infection or Inflammation, Ridge Deficency, Dental Implant
- Trial name
- NCT03774888
- Testing
- Connective tissue graft at time of bone graft, Acellular Demal Matrix at time of bone graft, No soft tissue grafting at time of bone graft
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Fibrin/Therapeutic Use, Blood Platelets
Effects of the Use of Platelet-rich Fibrin on Bone Regeneration After Impacted Third Molar Surgery
The purpose of this study is to evaluate the bone regeneration after impacted third molar surgery on split mouth design using platelet-rich fibrin.
- Conditions
- Fibrin/Therapeutic Use, Blood Platelets, Molar, Third, Bone Regeneration
- Trial name
- NCT02890680
- Testing
- Platelet-rich fibrin, Control group
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Tooth Extraction Site Healing, Alveolar Ridge Preservation
Biomaterials Exposed to Oral Environment: Which One is the Appropriate Option?
After tooth extraction, bone loss can compromise future dental implant treatment. Dentists often use biomaterials to preserve bone, but in many cases these materials are left exposed to the oral environment, where saliva and…
- Trial name
- NCT07589751
- Testing
- Alveolar Ridge Reconstruction
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul