Clinical trials: Bone Substitutes
Bone Substitutes, Calcium Phosphates
Biphasic Calcium Phosphate vs. Hydroxyapatite in Sinus Floor Elevation
Twenty patients scheduled for lateral-window sinus floor Elevation (SFE) are randomized into two groups: use of SYMBIOS® Biphasic Bone Graft Material (Group 1) or of Algipore® Bone Substitution Material (Group 2).
- Conditions
- Bone Substitutes, Calcium Phosphates, Hydroxyapatite, Rhodophyta
- Trial name
- NCT04331314
- Testing
- Use of Symbios Bone Graft Material, Algipore Bone Substitution Material
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Periodontitis
Evaluation of Advanced PRF Combined With Nano-crystalline Hydroxyapatite for Management of Grade II Furcation Defects
this study is to evaluate the use of advanced platelet rich fibrin (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (OPD) versus open flap debridement alone in the management of…
- Trial name
- NCT03804086
- Testing
- Advanced PRF (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement, Open flap debridement
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hadeer Ashraf Hassan Roushdy
Intrabony Periodontal Defect
Effect of Alendronate With β - TCP Bone Substitute in Surgical Therapy of Periodontal Intra-osseous Defects.
The aim of the present study was to evaluate the bone formation potential of 400µg alendronate delivered in β-TCP in the treatment of periodontal intra-osseous defects.
- Trial name
- NCT02795546
- Testing
- Alendronate sodium, beta-tricalcium phosphate bone substitute
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Sinus Floor Augmentation, Maxillary Sinus
Prospective Evaluation of Anorganic Bovine Bone Mineral Versus Calcium Phosphosilicate Alloplastic Bone Putty in Direct Sinus Augmentation: a Spilt-mouth Study
The purpose of this split-mouth clinical study is to evaluate the clinical, radiographic and histological outcomes of lateral window sinus augmentation with a bovine xenograft or a CPS putty bone substitute in posterior maxillary…
- Trial name
- NCT01942304
- Testing
- Calcium phosphosilicate alloplastic bone putty in direct sinus augmentation, Anorganic bovine bone mineral in direct sinus augmentation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Minnesota
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial
Spinal cord injury (SCI) results in lower limb muscle loss, bone loss, and high fat mass that impede the recovery of physical function, increase bone fracture risk, and worsen health and quality of life.
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Injuries, Spinal Cord, Spinal Cord Contusion
- Trial name
- TRT-SCI (NCT07742553)
- Testing
- testosterone cypionate, finasteride
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- VA Office of Research and Development
Bone Resorption, Tooth Loss
Hyaluronic Acid Effect on Xenogenic Bone Healing
The aim of this study is to test the hyaluronic acid hydrogel impact on the healing acceleration of xenogenic bone substitutes used in ridge preservation.
- Trial name
- NCT04377256
- Testing
- Ridge preservation: Tooth extration and immediat bone grafting in the socket
- Where
- 2 sites in Lebanon
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Alveolar Ridge Augmentation
Allograft Ridge Augmentation: 3D Analysis of CAD/CAM Custom Milled and Prefabricated Conventional Allogeneic Bone Blocks and Dental Implant Follow-up
To rehabilitate patients after the loss of their own teeth, dental implants are nowadays the therapy of choice if the indication is suitable.
- Trial name
- NCT06027710
- Testing
- Extensive alveolar ridge augmentation with allogeneic bone blocks; dental implant insertion in allogeneic bone graft
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Patients with Posterior Maxillary Atrophy and Need for Sinus Lift Surgery to Allow Implant Placement
Efficacy of L-PRF Against Deproteinized Bovine Mineralized Bone (DBBM)
Objective: The main objective of this study is to evaluate whether the use of L-PRF combined with deproteinized bovine mineralized bone (DBBM; BioOss, Geistlich Pharma®) reduces healing time, through histomorphometric analysis…
- Trial name
- NCT06686836
- Testing
- Sinus lift augmentation with bone substitute (Bio-Oss), Open sinus lift surgery lift using Platelet- and leukocyte-rich fibrin (L-PRF) mixed with a bone substitute (Bio-Oss®(Geistlich AG, Wolhusen, Switzerland)) - L-PRF Block
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Tooth Loss, Partial-edentulism
Retrospective Evaluation of a Novel Biomimetic Synthetic Bone Substitute (Creos® Syntogain)
Guided bone regeneration (GBR) is a commonly performed technique, using autogenous grafts, allografts, xenografts, or synthetic bone grafts (SBG).
- Conditions
- Tooth Loss, Partial-edentulism, Tooth Fracture, Edentulous Alveolar Ridge
- Trial name
- NCT06473545
- Where
- 2 sites in Spain
- Volunteers
- 173 people
- Sponsor
- International dentistry Research Group
Bone Substitutes, Bone Defect
Pre-market Study to Evaluate Safety and Performance of GreenBone Implant (Long Bone Study)
Multi-center, international, prospective, open-label, single-arm, first-in-human clinical investigation. The Patients enrolled in this clinical investigation will undergo a scheduled surgery for the treatment of long bone defects…
- Trial name
- NCT03884790
- Testing
- surgical repair of long bone defects
- Where
- 8 sites in Bosnia and Herzegovina, Israel and 4 more
- Volunteers
- 16 people
- Sponsor
- GreenBone Ortho S.p.A.
Alveolar Bone Resorption, Sequela
Bone Material Comparison in Maxillary Sinus Augmentation
Hard and soft tissue deficiencies of an alveolar ridge arise as sequelae of tooth extraction when socket preservation is not applied.
- Conditions
- Alveolar Bone Resorption, Sequela, Tooth Extrusion
- Trial name
- NCT04433117
- Testing
- Shefabone, Bio-Oss
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mohanad Al-Sabbagh
Osteoporotic Fractures
Effectiveness of Adipose Tissue Derived Mesenchymal Stem Cells as Osteogenic Component in Composite Grafts
Failure rates of up to 30% are reported after proximal humeral fractures despite angular-stable devices. This may devastate not only the functional outcome but also the independence of elderly patients.
- Trial name
- ROBUST (NCT01532076)
- Testing
- Cellularized composite graft augmentation, Acellular composite graft augmentation
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- University Hospital, Basel, Switzerland
Periodontitis, Dental Caries
Using Combination of Synthetic Bone Substitutes During Extractions
The study was designed to assess the effectiveness of conservation ridge preservation (horizontal and vertical dimension) after tooth extraction with and without combination of bone substitutes based on synthetic (calcium sulfate…
- Conditions
- Periodontitis, Dental Caries, Alveolar Bone Losses
- Trial name
- NCT01503593
- Testing
- Calcium Phosphate, Calcium Sulphate
- Volunteers
- 40 people
- Sponsor
- Rambam Health Care Campus
Periodontitis, Furcation Defects
Use of a Bone Substitute Material in the Surgical Therapy of Furcation Defects
The aim of this randomized clinical trial is to evaluate the potential benefit of the use of a bone substitute material in the treatment of furcation degree II-involved molars.
- Trial name
- NCT06270303
- Testing
- Access flap & surgical debridement, Application of bone substitute material (BioOss Collagen)
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Göteborg University
Degenerative Disc Disease, Spinal Stenosis
OssDsign® Spine Registry Study ("Propel")
The purpose of this multi-center, prospective, observational registry is to gather information on the clinical outcomes and real-world use of commercially available bone graft substitutes manufactured by OssDsign® AB, in patients…
- Trial name
- NCT05329129
- Testing
- OssDsign® Catalyst
- Where
- 16 sites in United States
- Volunteers
- 450 people
- Sponsor
- OssDsign
Periodontitis
Novel Bone Substitute (ALBO-OS) in Patients With Periodontal Disease or Who Need Alveolar Preservation
The recent Global Burden of Disease Study indicates that severe periodontitis is the 6th most prevalent disease worldwide, with an overall prevalence of 11.2% and around 743 million people affected, and the global burden of…
- Trial name
- NCT07500961
- Testing
- Albo Os
- Where
- Bosnia and Herzegovina
- Volunteers
- 20 people
- Sponsor
- Albos d.o.o. Beograd
Survival, Prosthesis, Bone Loss
Osteotome-mediated Sinus Floor Elevation With or Without Grafting Material
Implant placement in the posterior part of the maxilla is frequently compromised or impossible due to atrophy of the alveolar process and pneumatisation of the maxillary sinus.
- Conditions
- Survival, Prosthesis, Bone Loss, Patient Satisfaction
- Trial name
- NCT04618900
- Testing
- Sinus floor elevation with a grafting material
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Bone Regeneration, Bone Transplantation
Horizontal Ridge Augmentation With or Without Autogenous Block Grafts
To evaluate dimensional bone alterations following horizontal ridge augmentation using guided bone regeneration (GBR) with or without autogenous block graft (ABG) for the rehabilitation of atrophic jaws with dental implants.
- Conditions
- Bone Regeneration, Bone Transplantation, Bone Substitutes, Cone-beam Computed Tomography
- Trial name
- NCT03432702
- Testing
- Horizontal ridge augmentation
- Where
- Peru
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidad Científica del Sur
Disc Degeneration
Comparaison of Interbody Bone Fusion Between Two Osteoinductive Bioactive Bone Substitutes After Anterior Lumbar Interbody Arthrodesis in Degenerative Lumbar Disc Surgery in Adults
Disc degeneration is a progressive deterioration process of the intervertebral disc, which can manifest as significant low back pain and a loss of mobility that interferes with daily activities.
- Trial name
- FUSALIF (NCT07044206)
- Testing
- Use of bone substitute during intervertebral fusion surgery
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Disorder of Maxillary Sinus, Maxillary Sinus Floor Augmentation
Comparative Study of Algipore and Decalcified Freeze-dried Bone Allograft in Open Maxillary Sinus Augmentation
The aim of this study was the radiographic and clinical comparison of Algipore with decalcified freeze-dried bone allograft (DFDBA) in the open maxillary sinus lift technique using piezoelectric instruments.
- Trial name
- NCT01735721
- Testing
- Open Sinus Lift
- Where
- Iran
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences