Clinical trials: Bone Volume, active
Tooth Extraction Site Healing, Alveolar Ridge Preservation
Assessment of the Impact of Neobone® (Biphasic Calcium Phosphate) on Bone Volume in Alveolar Ridge Preservation After Tooth Extraction
The goal of this randomized clinical trial is to assess whether BCP (Biphasic Calcium Phosphate) improves alveolar ridge preservation (ARP) in patients who need tooth extraction.
- Trial name
- BCPARPBV (NCT07638358)
- Testing
- Neobone® (Biphasic Calcium Phosphate)
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Augmentation, Alveolar Ridge
Evaluation of the Bone Volume in Horizontal Atrophic Ridges Augmentation Using Tenting Grafting Technique Versus Khoury Technique in Mandibular Molar and Premolar Region: Randomized Clinical Trial
The aim of this study is to compare the effectiveness of the Tenting Grafting Technique and the Khoury Technique for horizontal augmentation of atrophic alveolar ridges in mandibular molar and premolar regions in dental implant…
- Trial name
- NCT06889558
- Testing
- tenting titanium technique, tenting titanium screw
- Volunteers
- 20 people
- Sponsor
- Cairo University
Thyroid Volume, Thyroid Ultrasound
Ultrasound Measurement of Thyroid Volume in Term Newborns
First, to date, no data are available on the thyroid volume of full-term newborns in Italy, making it essential to conduct studies to establish reference values for normality.
- Conditions
- Thyroid Volume, Thyroid Ultrasound, Congenital Hypothyroidism, Healthy Newborns
- Trial name
- NEOTIR (NCT07579988)
- Testing
- Thyroid ultrasound
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis
A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia (platelet count <50,000/μL).
- Conditions
- Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
- Trial name
- PACIFICA (NCT03165734)
- Testing
- Pacritinib, Physician's Choice medications
- Where
- 207 sites in United States, Australia and 22 more
- Volunteers
- 407 people
- Sponsor
- Swedish Orphan Biovitrum
Acute Respiratory Distress Syndrome ARDS
Driving Pressure-guided Tidal Volume Ventilation in the Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is associated with high mortality, some of which can be attributed to ventilator-induced lung injury (VILI) when artificial ventilation is not customized to the severity of lung injury.
- Trial name
- DRIVENT (NCT06322758)
- Testing
- Tidal volume customization in the acute respiratory distress syndrome
- Volunteers
- 750 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Insufficient Bone Volume Prior to Implant Surgery
The Tooth Collar Technique
The aim of this study is to evaluate wound healing after the application of the Tooth Collar Technique (TCT) for bone augmentation in the upper or lower jaw.
- Trial name
- TCTechnique (NCT07753525)
- Testing
- Tooth Collar Technique
- Where
- 4 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Osteoporosis
Effects of Teriparatide (PTH) on Bone in Men and Women With Osteoporosis
Teriparatide (PTH) is the only bone formation therapy that has been approved for the treatment of postmenopausal osteoporosis in Canada.
- Trial name
- NCT01155232
- Testing
- Teriparatide
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Metastases to Bone
Pilot Randomized Study for Treatment Volume De-Escalation for Spinal Metastases With Stereotactic Body Radiation Therapy
A single centre, non-profit, randomised, unblinded pilot study on volume definition for spinal stereotactic body radiation therapy treatment. Randomization will be 1:1 between two types of SBRT treatment for spinal metastases.
- Trial name
- REVOL-SPINE (NCT07538024)
- Testing
- Stereotactic Body Radiation Therapy (SBRT) in control arm, Stereotactic Body Radiation Therapy (SBRT) in experimental arm
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Myelofibrosis (MF)
Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis
Myelofibrosis (MF) is a rare blood cancer, notable for scarring of the bone marrow (the spongy tissue inside bones) and the spleen becoming larger.
- Trial name
- TRANSFORM-2 (NCT04468984)
- Testing
- Navitoclax, Ruxolitinib, Best Available Therapy (BAT)
- Where
- 229 sites in United States, Australia and 28 more
- Volunteers
- 330 people
- Sponsor
- AbbVie
Lumbar Disc Herniation, Lumbosacral Radiculopathy
Comparing Three Epidural Steroid Injection Approaches for Lumbar Radicular Pain
This study will compare three fluoroscopy-guided epidural steroid injection approaches for adults with unilateral lumbosacral radicular pain caused by lumbar disc herniation.
- Trial name
- NCT07813988
- Testing
- High-Volume Parasagittal Interlaminar Epidural Steroid Injection, Low-Volume Parasagittal Interlaminar Epidural Steroid Injection, Transforaminal epidural steroid injection
- Where
- Egypt
- Volunteers
- 99 people
- Sponsor
- Benha University
Osteoporosis
Teriparatide (PTH) and Bone Strength in Postmenopausal Women
This study will investigate the effects on bone quality of a medication (Teriparatide) used to treat people with severe osteoporosis.
- Trial name
- NCT01155245
- Testing
- Forteo
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Bone Metastasis, Oncology Pain
Spinal Palliation in Irradiation for Neoplastic Analgesia and Life Quality
The goal of this clinical trial is to assess the impact of reducing the volume of palliative metastatic bone irradiation on analgesic effectiveness at day 30 and to evaluate the efficiency of telemonitoring in identifying…
- Trial name
- SPINAL (NCT06884332)
- Testing
- Sparing irradiation, Conventional spinal irradiation
- Where
- 4 sites in France
- Volunteers
- 598 people
- Sponsor
- Institut de Cancérologie de Lorraine
Coenzyme Q10, Alveolar Cleft Grafting
Effect of Co-enzyme Q10 on the Bone Volume of Alveolar Cleft Reconstruction
Evaluate the effect of Co-enzyme Q10 on the bone volume in unilateral alveolar cleft repair
- Trial name
- NCT07045246
- Testing
- Coenzyme Q 10, iliac bone graft
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Myelofibrosis
A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis
This is a Phase 2, multicenter, two-arm, open-label study to evaluate the safety and efficacy of selinexor versus treatment per physician's choice (PC) in participants with myelofibrosis (MF) who had at least 6 months of…
- Trial name
- NCT04562870
- Testing
- Selinexor, Physician's Choice Treatment
- Where
- 21 sites in United States, China and 5 more
- Volunteers
- 112 people
- Sponsor
- Karyopharm Therapeutics Inc
Bone Neoplasms, Musculoskeletal Neoplasms
Predicting Allograft Volume in Orthopedic Oncology: Hemielipsoid Formula vs Intraoperative Fluid-Fill Measurement
Bone defects following primary musculoskeletal tumor resection are frequently reconstructed using structural allografts. Allograft availability is limited, and intraoperative waste due to oversized graft selection remains a…
- Conditions
- Bone Neoplasms, Musculoskeletal Neoplasms, Bone Transplantation
- Trial name
- PREDALL (NCT07653178)
- Testing
- Hemielipsoid Formula-Based Preoperative and Intraoperative Bone Defect Volume Estimation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Sakarya University
Myelofibrosis, Moderate Thrombocytopenia
A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia
The main purpose of this study is to evaluate the efficacy of selinexor in JAKi-naïve participants with myelofibrosis (MF) and with normal platelet counts or with mild to moderate thrombocytopenia based on spleen volume reduction…
- Conditions
- Myelofibrosis, Moderate Thrombocytopenia, Mild Thrombocytopenia
- Trial name
- SENTRY-2 (NCT05980806)
- Testing
- Selinexor 60 mg, Selinexor 40 mg, Ruxolitinib
- Where
- 70 sites in United States, Belgium and 17 more
- Volunteers
- 58 people
- Sponsor
- Karyopharm Therapeutics Inc
Maxillary Sinus Floor Augmentation, Dental Implant
Evaluation of Sinus Augmentation Bone Healing Using Autograft and Xenograft Compared to Xenograft Alone
To evaluate bone healing at 4 months after lateral sinus augmentation with a 4:1 ratio of autologous bone and xenograft or xenograft alone. A radiographic volumetric, histomorphometric, and histologic analysis.
- Conditions
- Maxillary Sinus Floor Augmentation, Dental Implant, Bone Substitute, Autogenous Bone Graft
- Trial name
- NCT06247098
- Testing
- Sinus Lift augmentation, Cone-beam computed tomography systems (CBCT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tufts University
FAMM Flap Functional & Radiographic Review
Facial Artery Musculomucosal Flap and Bone Volume Gain in Alveolar Cleft Repair"
Research question: Is the usage of the facial artery musculomucosal flap (FAMM) technique effective on the bone volume in the repair of alveolar cleft? Aim of the study: To evaluate the application of the facial artery…
- Trial name
- NCT07512531
- Testing
- Application of FAMM flap on bone graft in alveolar cleft
- Volunteers
- 5 people
- Sponsor
- Cairo University
Tooth Extraction, Tooth Extraction Site Healing
Assessment of the Impact of Neocement Inject P® (Beta-Tricalcium Phosphate) on Bone Volume in Alveolar Ridge Preservation After Tooth Extraction
The goal of this randomized clinical trial is to assess whether β-TCP (Beta-Tricalcium Phosphate) improves alveolar ridge preservation (ARP) in patients who need tooth extraction.
- Conditions
- Tooth Extraction, Tooth Extraction Site Healing, Alveolar Bone Grafting, Alveolar Bone Loss
- Trial name
- BTCPARPBV (NCT07638319)
- Testing
- Neocement Inject P® (Beta-Tricalcium Phosphate)
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Alveolar Cleft Grafting
Assessment of Bone Volume Using Patient Specific Autogenous Bone Plug Versus Particulate Autogenous Bone for Unilateral Alveolar Ridge Reconstruction
Most common complications that arise from alveolar cleft repair surgeries are; failure of graft integration, wound dehiscence, scar tissue formation, infections, bone exposure and oral-nasal fistula formation.
- Trial name
- NCT07137975
- Testing
- autogenous bone plug, regular autogenous bone grafting
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Cairo University