Clinical trials: Bone and Bones
Fractures, Hip, Local Anesthesia
Influence of Peri-operative Anesthetic and Analgesic Care on the Outcome of Patients Undergoing Hip Fracture Surgeries. A Prospective Study
The purpose of this voluntary research study is to clarify whether or not a single injection nerve block done before surgery and after surgery nerve block catheter can effectively enhance recovery in elderly hip fracture patients…
- Conditions
- Fractures, Hip, Local Anesthesia, Geriatric, Nerve Block
- Trial name
- NCT06925789
- Testing
- Ropivacaine
- Sponsor
- Milton S. Hershey Medical Center
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Magrolimab in Combination with Azacitidine After Allogeneic HCTin Treating Patients with High-Risk AML or MDS
This phase I trial studies how well the combination of magrolimab works with azacitidine after a donor stem cell transplant (allogeneic hematopoietic cell transplantation) in treating patients with high-risk acute myeloid…
- Trial name
- NCT05823480
- Testing
- Allogeneic Hematopoietic Stem Cell Transplantation, Azacitidine, Biospecimen Collection
- Sponsor
- City of Hope Medical Center
Disease Activity
14.0- 3.0- 3.0- η Protein With Rheumatoid Arthritis
Aim of work: to explore the potential association between serum 14.0-3.0-3.0- η protein level with disease activity and bone mineral density (BMD) in Egyptian patients with rheumatoid arthritis (RA).
- Trial name
- NCT05366608
- Testing
- Serum level of 14.0- 3.0- 3.0- η protein and IL_.6
- Where
- Egypt
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Hip Fracture, Postoperative Pain
Fascia Iliaca vs Femoral Nerve Block in Hip Fracture Patients
Hip fractures are common orthopedic injuries, especially in older adults, and surgical repair such as hip arthroplasty is often required.
- Conditions
- Hip Fracture, Postoperative Pain, Peripheral Nerve Block, Femoral Nerve
- Trial name
- CPTH (NCT07597317)
- Testing
- Fascia Iliaca Compartment Block (FICB)
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Central Park Teaching Hospital, Lahore
Osteoarthritis, Knee
Effects of Denosumab on Bone Microarchitecture After Total Knee Arthroplasty
This study evaluates single dose of Denosumab in decreasing systemic and periprosthetic bone resorption after Total Knee Arthroplasty compared to placebo in 60 patients (30 placebo and 30 Denosumab) within 2 months after surgery.
- Trial name
- NCT05559268
- Testing
- Denosumab 60 MG/ML Injectable Solution [Prolia]
- Volunteers
- 60 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Axial Spondyloarthritis, Psoriatic Arthritis
RAFTLIN-1 Levels in Axial Spondyloarthritis and Psoriatic Arthritis
Unlike other rheumatic diseases, acute phase reactants such as C-reactive protein and erythrocyte sedimentation rate are not diagnostic for patients with Spondyloarthropathies (SpA).
- Trial name
- NCT05771389
- Testing
- serum raftlin-1 protein levels
- Where
- Turkey (Türkiye)
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Aplastic Anemia
A Phase 2 Study to Evaluate the Efficacy and Safety of AMG531 in Aplastic Anemia
The present study will be conducted to evaluate the efficacy and safety of AMG531 and to determine the recommended initial dose of AMG531 on the basis of its efficacy and safety when it is administered subcutaneously (SC) to the…
- Trial name
- NCT02094417
- Testing
- AMG531
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Kyowa Kirin Korea Co., Ltd.
Chronic Myelogenous Leukemia
A Phase II Study to Evaluate the Efficacy and the Safety of Flumatinib in CML-AP or CML-BP Patients
Multi-center, single stage, phase II study to evaluate the efficacy and safety of Flumatinib in accelerated or blastic Phase chronic myelogenous leukemia patients.
- Trial name
- NCT02511340
- Testing
- Flumatinib mesylate tablet 600 mg qd
- Where
- China
- Volunteers
- 167 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Osteoporosis
Examination How the Administration Period of Teriparatide Affects Bone Metabolism and Bone Mineral Density Prior to Denosumab Therapy
The aim of this study is to examine the efficacy and adverse events in the following 3 groups in osteoporosis patients: 1. The administration period of teriparatide is less than 6 months and thereafter, denosumab for 24 months.
- Trial name
- NCT03702140
- Testing
- "Teriparatide", "Forteo® or Teribon"
- Where
- Japan
- Volunteers
- 90 people
- Sponsor
- Shinshu University
Humeral Fractures
Rotator Cuff Injury in Antegrade Locked Nailing for Humeral Fractures
The purpose of this study is to investigate the potential insults of rotator cuff muscle and the functional recovery of upper extremity function after antegrade nailing of humeral fractures.
- Trial name
- SRC (NCT00772850)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Diabetic Foot
a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis
Osteomyelitis is a frequent complication of diabetic foot ulcer. Several therapeutic strategies are used : medical treatment with antibiotics and foot offloading or surgical treatment consisting in the resection of infected bone…
- Trial name
- DIPIOS (NCT00578890)
- Testing
- Medical/surgical treatment versus medical treatment
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Covid19, Femur Fracture
Femoral frACturEs and COVID-19.
Retrospective cohort study comparing the early prognosis after surgically-treated proximal femur fragility fractures in patients affected and not affected by COVID-19.
- Conditions
- Covid19, Femur Fracture, Fragility Fracture
- Trial name
- FACE COVID-19 (NCT04657510)
- Testing
- COVID-19
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Multiple Myeloma
Effect of Combination of Bortezomib/Dexamethasone/Zoledronic Acid on Bone Disease in Patients With Multiple Myeloma Relapsed After 1-3 Prior Lines of Therapy
The aim of this study is to evaluate the effect of bortezomib in combination with dexamethasone and zoledronic acid on bone mineral density (BMD) and skeletal related events (SREs) in Patients with Multiple Myeloma who Have…
- Trial name
- NCT00972959
- Testing
- Bortezomib, Zoledronic Acid, Dexamethasone
- Where
- 3 sites in Greece
- Volunteers
- 17 people
- Sponsor
- University of Athens
Femoral Neck Fractures
Cemented Versus Uncemented Stems in Total Hip Arthroplasty in Patients With Femoral Neck Fractures
The purpose of this prospective randomized study is to compare the quality of treatment between cemented versus uncemented hydroxyapatite coated femoral stems in Total Hip Arthroplasty (THA) in patients who suffers from…
- Trial name
- NCT01578408
- Testing
- Total Hip Arthroplasty, Cemented Lubinus SPII stem (control arm), Uncemented HA Coated Corail stem
- Where
- Sweden
- Volunteers
- 109 people
- Sponsor
- Sahlgrenska University Hospital
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Megakaryoblastic Leukemia (M7)
Omacetaxine Mepesuccinate, Cytarabine, and Decitabine in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
This phase II trial studies the side effects and how well omacetaxine mepesuccinate, cytarabine, and decitabine work in treating older patients with newly diagnosed acute myeloid leukemia.
- Conditions
- Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a)
- Trial name
- NCT02029417
- Testing
- cytarabine, omacetaxine mepesuccinate, decitabine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Roswell Park Cancer Institute
Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury
Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)
The purpose of this study is to determine whether growth hormone replacement therapy (GHRT) is effective versus placebo in the improvement of Quality of Life in patients with adult growth hormone deficiency (AGHD) and mild…
- Trial name
- GRIT (NCT04867317)
- Testing
- Somatropin
- Where
- 16 sites in United States
- Volunteers
- 172 people
- Sponsor
- VA Office of Research and Development
Osteoporosis, Risk of Falls
EFFECTIVENESS AND CLINICAL OPTIMIZATION OF A STANDARDIZED PHYSIOTHERAPY EXERCISE PROGRAM TARGETING BALANCE-POSTURE INTERACTION AND FALL RISK IN OSTEOPOROSIS: A RANDOMIZED CONTROLLED TRIAL
Osteoporosis is a systemic disorder of the skeletal system characterized by decreased Bone Mass and deterioration of the Microarchitecture, making it significantly easier to fracture the bones.
- Conditions
- Osteoporosis, Risk of Falls, Rehabilitation
- Trial name
- EFFECTIVENESS (NCT07763717)
- Testing
- Structured Physiotherapy Exercise Program
- Where
- Kosovo
- Volunteers
- 88 people
- Sponsor
- Alma Mater Europaea - Slovenia
Hip Fractures
Enhancing Recovery in Hip Fracture Surgeries
The purpose of this study is to look at how two different types of anesthesia, spinal and general, affect participants with broken hips who are getting a special kind of pain block before surgery.
- Trial name
- NCT06249789
- Testing
- Spinal Anesthesia, General Anesthesia
- Volunteers
- 102 people
- Sponsor
- Hartford Hospital
Pain, Postoperative
The Effect of Femoral Nerve Block on Opioid Requirements After Surgery for a Femur Fracture in Children
This study evaluates the effect of a femoral nerve block on opioid requirements following femoral fracture fixation with flexible nails in the paediatric population. This is a double blind, prospective randomized clinical trial.
- Trial name
- NCT00175591
- Testing
- Administration of a femoral nerve block (bupivacaine HCL)
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of British Columbia
Ankle Fracture
Insole Sensor to Determine Optimal Limb Loading in the Rehabilitation of Ankle Fractures
The purpose of this study is to use a novel load monitoring technology to correlate limb loading to ankle fracture outcomes. This study will collect continuous limb loading data and will provide the first objective insight into…
- Trial name
- NCT02334618
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Utah
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