Clinical trials: Botulinum Toxin
Focal Hand Dystonia
Impact Of Physiotherapy And Botox In Improving Functional Outcomes Among Post Stroke Focal Dystonia Patients
This study was conducted to assess the combine role of Physiotherapy by providing task specific trainings and Botulinum Toxin Type A in improving the functional outcomes of upper limb in post stroke patients with focal hand…
- Trial name
- NCT03664375
- Testing
- Botulinum toxin type A, Task Specific Training
- Volunteers
- 39 people
- Sponsor
- Isra University
Deglutition Disorders
Study of a Series of Patients Treated for Retrograde Cricopharyngeal Muscle Dysfunction Syndrome
R-CPD syndrome (Retrograde Cricopharyngeal Dysfunction syndrome) is an inability to burp. It is a syndrome whose diagnosis is clinical, and for which there is effective treatment.
- Trial name
- R-CPD-Syndrome (NCT06174831)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Focal Dystonia
A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of Blepharospasm
Background: Blepharospasm is caused by excessive contraction of the muscles that close the eye. It can be treated with injections of botulinum neurotoxin (BoNT), which works by weakening those muscles.
- Trial name
- NCT00942851
- Testing
- Acetyl-Hexapeptide Topical Treatment
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hyperactive Masseter Muscle
Evaluation the Efficacy of Zinc on Botulinum Toxin A Injection
This clinical trial seeks to investigate a promising new approach to enhance the effectiveness and duration of Botulinum Toxin A (BTX-A) for the treatment of hyperactive masseter muscles.
- Trial name
- BTX-A (NCT07270042)
- Testing
- BOTOX 100U in normal saline with zinc
- Where
- Syria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Latakia University
Spastic Hemiparesis
The Effect of a Self-rehabilitation Program in Addition to Usual Treatment for Spasticity on Impairment and Activity Limitation in Patients With Spastic Hemiparesis Following Stroke
The addition of a self-rehabilitation program to repeated Botulinum Toxin Injections (BTI) and usual physiotherapy should increase the proportion of patients who attain their Primary Treatment Goal (impairments and function) more…
- Trial name
- ADJU-TOX (NCT02944929)
- Testing
- Self-rehabilitation program
- Where
- France
- Volunteers
- 220 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vomiting, Feeding Disorders
Use of Intrapyloric Botulinum Injections in Children
This study aims to evaluate the effect of intrapyloric botulinum toxin in children with feeding disorders.
- Conditions
- Vomiting, Feeding Disorders, Gastroparesis
- Trial name
- NCT04250844
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Cerebral Palsy, Spasticity
Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy
The purpose of this study is to determine whether injections of Botulinum toxin type A into muscles of one or both arms alone or in combination with injections into one or both legs are effective and safe in treating…
- Trial name
- XARA (NCT02002884)
- Testing
- IncobotulinumtoxinA (8 Units per kg body weight), IncobotulinumtoxinA (6 Units per kg body weight), IncobotulinumtoxinA (2 Units per kg body weight)
- Where
- 32 sites in United States, Argentina and 4 more
- Volunteers
- 351 people
- Sponsor
- Merz Pharmaceuticals GmbH
Patellofemoral Pain Syndrome
Botox for Non-surgical Lateral Release in Patellofemoral Pain
The purpose of this study is to determine whether the use of botulinum toxin A injected into the lateral thigh muscle improves knee function and reduces knee pain secondary to patellofemoral syndrome.
- Trial name
- NCT00496964
- Testing
- Botulinum toxin A + exercise
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Virginia Commonwealth University
Surgical Wound Healing, Botulinum Toxin, Type A
Botulinum Toxin Type A for Wound Healing After Laparoscopic Colectomy
This study aims to evaluate the efficacy and safety of botulinum toxin type A (BTX-A) injection as an adjunct to surgical wound healing in patients undergoing laparoscopic colectomy.
- Trial name
- NCT07795463
- Testing
- Botulinum toxin type A (Botox®, Allergan)
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Pham Ngoc Thach University of Medicine
Cold Hypersensitivity, Vascular System Injuries
Treatment of Frostbite Sequelae With Botulinum Toxin A
Background Digital vasospasm as part of frostbite sequelae is comparable to the vasospastic disorders found in Raynaud's phenomenon which has been successfully treated with Botulinum toxin type A injections in the palm of the…
- Conditions
- Cold Hypersensitivity, Vascular System Injuries, Vibration; Disorder, Sensory Disorders
- Trial name
- NCT06460194
- Testing
- Botuinum toxin
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Scar, Hypertrophic Scar
The Efficacy and Molecular Mechanism of Botulinum Toxin in the Reduction of Breast Reduction Mammoplasty Scar Formation
1. Test the ability of botulinum toxin type A, when injected into the surgical incision at the time of surgery, to decrease postoperative scar scores compared to control (normal saline) in a double-blinded randomized control…
- Conditions
- Scar, Hypertrophic Scar, Mammary Disorder
- Trial name
- NCT03887377
- Testing
- Botulinum Toxins, Normal saline
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Vulvodynia
Placebo-controlled RCT of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia
Women with provoked vestibulodynia (PVD) suffer from severe dyspareunia and often present a hyperactivity of the pelvic floor muscles (PFM) which maintain the dyspareunia.
- Trial name
- NCT02773641
- Testing
- Botulinum Toxin Type A, Sterile Saline Solution
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Stroke, Muscle Spasticity
Early Use of Botulinum Toxin in Spasticity Post Stroke.
Patients who survive a stroke are often left with an arm that cannot be used. One reason for this is that the muscles affected by the stroke become overactive. This is known as spasticity.
- Conditions
- Stroke, Muscle Spasticity, Contracture
- Trial name
- EUBoSS (NCT01882556)
- Testing
- onabotulinumtoxinA
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Hyperhidrosis
A Study Using Botulinum Toxin Type A in Patients With Axillary Hyperhidrosis
This is a three-year study in subjects with axillary hyperhidrosis involving injection of Botulinum Toxin Type A into the axilla to reduce sweating.
- Trial name
- NCT00168402
- Testing
- Botulinum Toxin Type A
- Volunteers
- 193 people
- Sponsor
- Allergan
Low Back Pain
Pilot Study to Assess the Efficacy of Botulinum Toxin A Treatments on Pain and Disability in Sub-Acute Low Back Pain
This study will test the hypothesis that Botulinum toxin A (BOTOX®) treatment reduces pain and disability in subjects suffering from sub-acute low back pain due to an identifiable muscle strain or back trauma occurring 6 to 16…
- Trial name
- NCT00384371
- Testing
- Botulinum Toxin A
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- United States Department of Defense
Notalgia Paresthetica
Treatment of Notalgia Paresthetica With Xeomin
Patients will be randomized (1:1) to receive either injections of Xeomin in 0.9% NaCl or NaCl alone. Xeomin will be reconstituted with 2 mL of NaCl 0.9 which will give a final concentration of 5 U of botulinum toxin A per 0.1 mL.
- Trial name
- NCT01098019
- Testing
- Xeomin
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Innovaderm Research Inc.
Systemic Sclerosis (SSc), Raynaud Disease Secondary to Scleroderma
Efficacy of A Non-Invasive Botulinum Toxin Microneedle Pad for the Treatment of Secondary Raynaud's Phenomenon
Raynaud's Phenomenon (RP), a vasospastic disorder causing digital ischemia and potential tissue necrosis, is effectively treated with Botulinum Toxin Type A (BTX-A) in refractory cases.
- Trial name
- Botox SSc-RP (NCT07759557)
- Testing
- Botulinum toxin A via microneedle, Control (Normal saline)
- Volunteers
- 72 people
- Sponsor
- Khon Kaen University
Stroke
Evaluation of BOTOX® With Rehabilitation Therapy for the Treatment of Wrist and Hand Spasticity in Post-Stroke Patients
The present study is designed to determine the safety and effectiveness of injections of BOTOX® in spastic muscles of the arm and hand compared with injections of saline (which would do nothing) when combined with rehabilitation…
- Trial name
- Botox/Rehab (NCT00565201)
- Testing
- Botox and rehab
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Emory University
Vestibulodynia
Long-Term Assessment of Quality of Life and Effectiveness of Onabotulinumtoxina Injections in Provoked Vestibulodynia
The study aims to assess and compare the pain in women suffering from provoked vestibulodynia, before treatment with botulinum injections, 3 months after treatment and 18 months after treatment.
- Trial name
- QUALVESTO (NCT02858375)
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Hamstring Contractures
Cyclops Syndrome After Anterior Cruciate Ligament Reconstruction
Monocentric, prospective, randomised, double-blind study of two parallel groups of 66 patients with post-reconstruction ACL hamstring contracture treated with an ultrasound-guided injection at two points on the body of the…
- Trial name
- SCALA (NCT05008731)
- Testing
- Botulinum toxin
- Where
- France
- Volunteers
- 13 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche