Clinical trials: Botulinum Toxin
Obstetrical Brachial Plexus Palsy
Study of the Biological Function of Muscle Satellite Cells From Patients With Obstetric Brachial Plexus Palsy
The purpose of this prospective work is to study the consequences of obstetrical brachial plexus paralysis on the rotator muscles of the shoulder.
- Trial name
- SCOPE (NCT05403034)
- Testing
- Muscle biopsy
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Montpellier
Chronic Migraine
Chronic Migraine Treatment With Botulinum Toxin-A: an Investigation of Functional Magnetic Resonance Imaging Changes.
Pilot study evaluating effect of Botox injection treatment for 12 individuals suffering from chronic migraine on function MRI imaging, before and after treatment.
- Trial name
- NCT02436499
- Testing
- Botulinum Toxin-A
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Manitoba
Neurogenic Bladder Dysfunction Nos, Spinal Cord Injury
Botox-A Injection to Improve Bladder Function in Early Spinal Cord Injury (#H-20344)
The purpose of this study is to see what the effect of Botox has on bladder function for those who have recently suffered spinal cord injury.
- Trial name
- NCT00711087
- Testing
- BOTOX-A, Saline injection
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Baylor College of Medicine
Sialorrhea, Cerebral Palsy
Application of Botulinum Toxin Type A in Salivary Glands in the Treatment of Drooling in Patients With Cerebral Palsy
The purpose of this study is to evaluate the safety and efficacy of botulinum toxin-A in salivary glands as a treatment for decrease drooling in patients with cerebral palsy and evaluate the long-term effects and tolerance .
- Trial name
- NCT01489904
- Testing
- BOTULINUM NEUROTOXIN TYPE-A
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Vall d'Hebron
Bruxism, Bruxism, Sleep
Repeated Botulinum Toxin Type A Injections on Intramuscular Fat Accumulation in Individuals With Sleep Bruxism.
This study investigates whether repeated botulinum toxin type A (BoNT-A) injections used to manage sleep bruxism lead to structural changes-specifically intramuscular fat accumulation-in the masseter muscle.
- Conditions
- Bruxism, Bruxism, Sleep, Bruxism, Sleep-Related
- Trial name
- NCT07266064
- Testing
- Botilinum Toxin injection
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Melek Volkan Yazici
Lower Back Pain
Investigation of Efficacy of Botulinum Toxin A (Dysport) in Chronic Low Back Pain
The scientific aim of this study is to investigate the efficacy of abobotulinumtoxinA (Dysport - Ipsen Pharmaceuticals) in chronic low back pain.
- Trial name
- NCT02221648
- Testing
- AbobotulinumtoxinA Treatment
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Yale University
Dystonia
Strategy to Adapt Botulinum Toxin Doses in Dystonia
The study is designed to observ and collect the doses of botulinum toxin injected in dystonia in different centres to compare the initial dose and the dose recommended.
- Trial name
- NCT06386848
- Testing
- Botulinum toxin
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Myofacial Pain, Trigger Points, Myofascial
Comparison Between Botox and Magnesium Sulfate Effect in Treatment of Myofascial Pain Trigger Points Within the Masseter Muscle
The goal of this randomized clinical trial is to compare the effectiveness of Botulinum toxin type A, magnesium sulfate and saline injections in treatment of the masseter muscle trigger points, in patients between 16 - 50 years…
- Trial name
- MPS MTrPs BTA (NCT06676475)
- Testing
- MgSO4, BOTOX-A
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Misr University for Science and Technology
Upper Facial Lines
A Study to Evaluate Participant Satisfaction and Natural Outcomes Following Administration of BOTOX Cosmetic Injections in Adult Participants for Treatment of Upper Facial Lines
Facial lines that develop from repeated facial expression, such as glabellar lines (GL), lateral canthal lines (LCL), and forehead lines (FHL), are typically treated by selectively weakening specific muscles with small quantities…
- Trial name
- UFL BOND 974 (NCT06218251)
- Testing
- BOTOX
- Where
- 10 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- AbbVie
Obstructed Defecation Syndrome (ODS)
Effects of Botox in Obstructed Defecation Syndrome
The purpose of this study is to determine if Botulinum Toxin-A (Botox) injection will improve symptoms of constipation in obstructed defecation syndrome (ODS).
- Trial name
- NCT02160288
- Testing
- Botulinum Toxin-A, Normal Saline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital
Cerebral Palsy, Botulinum Toxin
Pros and Cons of Botulinum Injection Treatment in Cerebral Palsy
The aim of this study is to quantitatively record the opinions regarding the pros and cons of this treatment of the caregivers of children with cerebral palsy who had botulinum toxin applied in investigators' clinic.
- Trial name
- NCT04256187
- Testing
- Qualitative interview
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Marmara University
Overactive Bladder, Neurogenic Bladder
A Randomized, Placebo-controlled Trial of Nitrous Oxide During In-office Bladder Botox Injections
The goal of this clinical trial is to assess if a mix of nitrous oxide and oxygen can improve pain control during bladder Botox injections.
- Conditions
- Overactive Bladder, Neurogenic Bladder, Urge Incontinence, Pain
- Trial name
- NCT07387315
- Testing
- Pro-Nox Nitrous Oxide/Oxygen Delivery System, Standard Care for Bladder Botox Injection
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- TriHealth Inc.
Excessive Gingival Display
The Effect of Botulinum Toxin A In Patients With Excessive Gingival Display With And Without Zinc Supplementation
It has been noted since the start of using botulinum toxin for both medical and cosmetic indications that some patients simply don't achieve the responses to the drug that others do, leading to increased dose requirements and…
- Trial name
- NCT03717987
- Testing
- Botulinum toxin type A, Zinc supplementation
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Psoriasis Vulgaris
An Exploratory Trial Investigating the Neurogenic Component in Psoriasis Vulgaris by Use of Botulinum Toxin A
The purpose of this study is to evaluate the anti-psoriatic effect of injected Botulinum toxin type A compared to that of injected vehicle.
- Trial name
- NCT02577185
- Testing
- Botulinum Toxin Type A, Sodium chloride 9 mg/ml
- Where
- 2 sites in Denmark
- Volunteers
- 10 people
- Sponsor
- LEO Pharma
Urinary Bladder, Overactive, Urinary Bladder, Neurogenic
Observational Study of Botulinum Toxin Type A in Patients With Urinary Incontinence Associated With Overactive Bladder
This study will describe the prescription conditions of botulinum toxin Type A (Botox®) injection for the treatment of urinary incontinence due to neurogenic detrusor overactivity (NDO) or idiopathic overactive bladder (IOAB) as…
- Trial name
- BOREAL (NCT02673047)
- Testing
- botulinum toxin Type A
- Where
- 50 sites in France
- Volunteers
- 474 people
- Sponsor
- Allergan
Tennis Elbow
Comparison Between Steroid and Different Sites of Botulinum Toxin Injection in the Treatment of Lateral Epicondylalgia
The aim of the study is to compare two different injection sites of low dose botulinum toxin type A with steroid in treating lateral epicondylalgia.
- Trial name
- NCT02767635
- Testing
- Botox-Epic, Botox-Tend, triamcinolone acetonide (Steroid)
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Cheng-Kung University Hospital
Masseter Muscle Prominence
A Study to Assess the Effectiveness of BOTOX (Botulinum Toxin Type A) Injections for the Change of Masseter Muscle Prominence in Adult Participants
The masseter muscle is one of the muscles in the lower face used for chewing. Prominence of the masseter muscle can appear as a widened and square lower face shape, which is an aesthetic concern for individuals who prefer a…
- Trial name
- MMP EU P3 (NCT06068855)
- Testing
- BOTOX
- Where
- 27 sites in Belgium, Bulgaria and 5 more
- Volunteers
- 249 people
- Sponsor
- AbbVie
Sleep Bruxism, Adult
Bruxism Xeomin® Intervention Trial
The purpose of this study is to test whether severe masticatory muscle spasms during sleep (e.g. teeth clenching and grinding, known as "bruxism" in technical jargon) demonstrably decrease after application of botulinum toxin…
- Trial name
- BRUX-XIT (NCT04792398)
- Testing
- Incobotulinumtoxin A (BTX A) Xeomin®
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- Dominik Ettlin
Urge Incontinence, Overactive Bladder
The Effect of Local Anesthetic Solution in the Bladder Prior to Botox Injections in the Bladder
The purpose of this study is to investigate the effect of Lidocaine solution versus placebo (isotonic Sodium Chloride NaCl) disposed inside the urinary bladder as intravesical anesthesia prior to onabotulinum toxin A injections…
- Conditions
- Urge Incontinence, Overactive Bladder, Anesthesia, Local, Pain, Procedural
- Trial name
- NCT05415865
- Testing
- Alkalinized Lidocaine
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Herlev and Gentofte Hospital
Cerebral Palsy
Evaluation of the Efficacy of the Injection of Botulinum Toxin A vs Scopolamine Patches in the Treatment of Drooling in Children With Cerebral Palsy
Cerebral palsy is the first cause of motor disability in developed countries. It is associated with altered motor function but also with mental, sensorial and behavior deficiencies.
- Trial name
- TOXSIALO (NCT03616067)
- Testing
- Botox® injection, Scopoderm® patches arm
- Where
- 11 sites in France
- Volunteers
- 23 people
- Sponsor
- Hospices Civils de Lyon