Clinical trials: Bowel Functions
Irritable Bowel Syndrome
Use of Functional Magnetic Resonance Imaging (fMRI) to Study Brain Activation in Children With Irritable Bowel Syndrome
The purpose of the study is to map regions of brain activation following rectal stimulation in children with irritable bowel syndrome (IBS) and healthy controls.
- Trial name
- fMRI (NCT00677976)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Metabolic Diseases, Immune System Disorder
Study on the Effects of Wheat and Corn Germ Blend Oil on Antioxidation and Immune Regulation of Dyslipidemia Population
The goal of this clinical trial is to explore the role of wheat and corn germ blended oils in regulating oxidative stress and immunomodulation in dyslipidaemic populations, to explore their effects on intestinal flora…
- Conditions
- Metabolic Diseases, Immune System Disorder, Dyslipidemias, Fatty Acid Metabolism Disorder
- Trial name
- NCT06060509
- Testing
- Phytosterol-rich Wheat and Corn Germ Blended Oil, Peanut oil
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
IBS - Irritable Bowel Syndrome, Diarrhea
A Multi-Strain Probiotic Reduces the Frequency of Diarrhea in IBS-D Patients
The goal of this interventional clinical study is to study whether the consumption of QiMeiYan Probiotics in 25-35 young people with Mild irritable bowel syndrome (IBS Score 75 - 175) will reduce the frequency of Diarrhea.
- Trial name
- NCT05900752
- Testing
- QiMeiYan Probiotics
- Where
- 2 sites in China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shenzhen Precision Health Food Technology Co. Ltd.,
Crohn's Disease, CAM
Efficacy of Acupuncture and Moxibustion Treatment in Patients With Quiescent Crohn's Disease:Evaluation With fMRI
The purpose of this study is to determine whether acupuncture or moxibustion therapies are effective in the treatment of Crohn's disease.
- Trial name
- NCT01696838
- Testing
- electroacupuncture, moxibustion
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Sleep, Cardiovascular Diseases
Effects of Milk-based Drinks on Gut Microbiome, Sleep and Cardiometabolic Markers
The purpose of this study is to evaluate the effects of kefir on gastrointestinal health, sleep quality, and biochemical parameters in adults who have sleep problems.
- Conditions
- Sleep, Cardiovascular Diseases, Gut Microbiome, Cognitive Function and Mood
- Trial name
- NCT07071181
- Testing
- Original flavour kefir, Milk
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Functional Dyspepsia
Mechanisms of Electroacupuncture for Functional Dyspepsia Based on "Enterotypes" and Metabolomics
The goal of this clinical trial is to explore the clinical efficacy and possible mechanisms of electroacupuncture treatment for functional dyspepsia (FD).
- Trial name
- NCT05920395
- Testing
- Electro-acupuncture
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Wuhan Central Hospital
Irritable Bowel Syndrome (IBS), Sucrase Isomaltase Deficiency
Genetic Carbohydrate Maldigestion as a Model to Study Food Hypersensitivity
Irritable bowel syndrome (IBS) affects one in seven people with gastrointestinal (GI) symptoms. IBS strongly impacts quality of life, is a leading cause of work absenteeism, and consumes 0.5% of the healthcare annual budget.
- Trial name
- GenMalCarb (NCT05795049)
- Testing
- Stool and saliva sample collection, Questionnaire completion
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Brain Insulin Sensitivity, Brain Vascular Function
High-Dairy Food Patterns and Gut-Brain Axis
Disturbances in brain insulin sensitivity are associated not only with obesity and type 2 diabetes, but also with brain aging and cognitive decline.
- Conditions
- Brain Insulin Sensitivity, Brain Vascular Function, Cerebral Blood Flow, Cognitive Performance
- Trial name
- NCT07355309
- Testing
- High-dairy food pattern, Low-dairy food pattern
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Apnea, Sleep
Effects of CPAP on Cognitive Function, Neurocognitive Architecture and Function in Patients With OSA: The SMOSAT Trial
Multiple clinical studies have indicated that obstructive sleep apnea (OSA), the most common chronic sleep disorder, may affect neurocognitive function, and that treatment for continuous positive airway pressure (CPAP) has some…
- Trial name
- NCT02886156
- Testing
- CPAP, BSC
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Inflammatory Bowel Diseases
Effect of Yogurt Added With Bifidobacteria and Soluble Fiber on Bowel Function.
The aim of this study was to evaluate the effect of the consumption of yogurt added with bifidobacteria and soluble fiber on gastrointestinal function of healthy adults.
- Trial name
- NCT01173588
- Testing
- yogurt added with bifidobacteria and soluble fiber (YBF)
- Where
- Mexico
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Instituto Lala
Irritable Bowel Syndrome
Altered Faecal Protease Activity in Irritable Bowel Syndrome Patients in China
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder haracterised by abdominal pain or discomfort associated with altered bowel habits,while the mechanism is still not understood.Recent advances have…
- Trial name
- NCT01060527
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Gastrointestinal, Hypoperfusion
Effects of Citrulline on Gut Functioning During Excercise
During exercise, splanchnic perfusion is compromised, resulting in organ damage in healthy individuals. Improving the availability of NO might result increase splanchnic perfusion and prevent organ damage during exercise.
- Conditions
- Gastrointestinal, Hypoperfusion, Gut Damage
- Trial name
- NCT01239303
- Testing
- Citrulline, alanine
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Biomarkers of B-vitamin Status and Gut Microbiome Composition
Effect of a Food Intervention With a Prebiotic Alone or Combined With B-vitamins on Gut Microbiota Diversity, Inflammation and Mental Health Outcomes in Older Adults (GutFood)
Ageing is associated with changes in gut microbiota composition, increased inflammation, and a greater risk of poor mental health outcomes.
- Trial name
- NCT07592975
- Testing
- Inulin and B-vitamins, Inulin
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Metabolically Healthy Obesity
Gut, Immune, and Vascular Health in Metabolically Healthy Obesity
The investigators seek to better understand how a single high-fat meal impacts gut, immune, and vascular outcomes in individuals with "metabolically healthy obesity" (obesity and largely normal cardiometabolic profile) and…
- Trial name
- NCT07559227
- Testing
- Inulin Supplementation, High-fat meal
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ball State University
Irritable Bowel Syndrome (IBS)
Irritable Bowel Syndrome and Control Volunteers: Diet Challenge
The study will investigate the relationship between fecal bile acids, short-chain fatty acids (SCFAs), and the gut microbiota in irritable bowel syndrome (IBS).
- Trial name
- NCT06668922
- Testing
- Inulin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Irritable Bowel Syndrome
Efficacy and Safety Evaluation of Fecal Microbiota Transplantation in Irritable Bowel Syndrome
Participants will be given FMT through oral capsules or nasojejunal tube once a month. After three-time treatment, participants were followed up for three months.
- Trial name
- NCT05740319
- Testing
- FMT
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Gastrointestinal Function, Intestinal Bacteria Flora
Effects of Probiotics on Improving the Gastrointestinal Function and Intestinal Bacterial Flora
The purpose of this study is to evaluate the effect of "combined probiotics" to improve the gastrointestinal function and intestinal bacteria flora
- Trial name
- NCT01428999
- Testing
- probiotics
- Where
- Taiwan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Irritable Bowel Syndrome
Mediterranean Diet and the Gut Microbiome
This study will evaluate the impact of a Mediterranean-style diet on microbiome diversity compared to a typical American diet. The study will observe the microbiome composition comparisons in healthy volunteers as well as in…
- Trial name
- NCT03269032
- Testing
- American Diet, Mediterranean-style Diet
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Irritable Bowel Syndrome
Effect of Pre-dosing With Methylcellulose or Psyllium on Colonic Fermentation of Inulin
The aim for this pilot study is to test the hypothesis that pre-dosing with gel-forming dietary fibres (methylcellulose or psyllium) will alter the colonic fermentation of a model fermentable dietary fibre (Inulin) when delivered…
- Trial name
- COCOA3 (NCT06494137)
- Testing
- inulin
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome, Abdominal Pain
Impact of a Yoga Intervention on Pain and Multiomics in Participants With IBS
The purpose of this research study is to see if a six-week yoga program delivered online/virtually via Zoom, reduces abdominal pain in people with irritable bowel syndrome (IBS).
- Trial name
- NCT04315714
- Testing
- Yoga Program
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore