Clinical trials: Bowel Resection
Rectal Cancer, Ileostomy; Functional Disturbance
Trial Evaluating the Tailored Versus the Systematic Use of Defunctioning Stoma After Total Mesorectal Excision for Rectal Cancer (GRECCAR17)
GRECCAR 17 will be the first prospective and randomized trial to assess a tailored policy in the use of defunctioning stoma after TME according to the personalized risk of anastomotic leakage.
- Trial name
- GRECCAR17 (NCT05233787)
- Testing
- Tailored use of defunctioning stoma after TME, Systematic use of defunctioning stoma
- Where
- 28 sites in France
- Volunteers
- 212 people
- Sponsor
- University Hospital, Bordeaux
Colorectal Cancer
Combination Chemotherapy in Treating Patients With Resected Colon Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug is a way to kill more tumor cells.
- Trial name
- NCT00378716
- Testing
- 5-fluorouracil, leucovorin calcium, tegafur
- Volunteers
- 1,608 people
- Sponsor
- NSABP Foundation Inc
Colo-rectal Surgery, Anastomotic Leak Large Intestine
Comparison of Rates of Anastomotic Leak in Patients Undergoing Colo-rectal Surgery When Bowel Perfusion and Resection Margin is Deterimined by Intra-operative Infra-red Thermography or by Conventional Method
Pilot RCT with 20 patients in both test and control group. In the control group resection \& anastomosis was done using the conventional method.
- Conditions
- Colo-rectal Surgery, Anastomotic Leak Large Intestine, Anastomotic Leak Rectum
- Trial name
- NCT06180564
- Testing
- Intra-operative Infra-red thermography
- Where
- India
- Volunteers
- 43 people
- Sponsor
- Sir Ganga Ram Hospital
Colon Cancer, Gastrointestinal Cancer
Seal-G / Seal-G MIST Study
A prospective, multi-center, open label, study to evaluate safety and performance of Seal-G and Seal-G MIST in reinforcing colonic anastomosis, in subjects undergoing Colon Resection surgery
- Trial name
- NCT04532515
- Testing
- Seal-G Surgical Sealant, Seal-G MIST System
- Where
- 2 sites in Israel
- Volunteers
- 160 people
- Sponsor
- Advanced Medical Solutions Ltd.
Rectal Cancer, Low Anterior Resection Syndrome
Autologous Fecal Microbiota Transplantation for Anal Function Recovery After Ileostomy Reversal in Rectal Cancer
This prospective, single-center, single-arm, open-label clinical study aims to evaluate whether autologous fecal microbiota transplantation can improve bowel and anal function after ileostomy reversal in patients with rectal…
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, Fecal Incontinence, Diversion Colitis
- Trial name
- NCT07711509
- Testing
- Autologous Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Peking University People's Hospital
Metastatic Colorectal Cancer
"Cancersensor" Metastasis Resection
Observational, non randomized study aimed at measuring the effect of surgical resection of metastasis in the urinary concentrations of physiological modified nucleosides in 45 patients with metastatic colorectal cancer.
- Trial name
- NCT01693848
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Colorectal Cancer, Liver Metastasis Colon Cancer
Fluorescence-guided Resection Of Colorectal Liver Metastases Using SGM-101 and Indocyanine GREEN
This will be the first trial testing the feasibility of working simultaneously with the two fluorescent dyes ICG and SGM-101 in 10 patients with colorectal metastases.
- Conditions
- Colorectal Cancer, Liver Metastasis Colon Cancer, Image
- Trial name
- FOCUS GREEN (NCT05965817)
- Testing
- SGM-101 op top of ICG
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Leiden University Medical Center
Crohn's Disease (CD)
An Observational, Multicenter Study to Evaluate the Effectiveness of Guselkumab for the Treatment of Participants With Crohn's Disease After Surgical Resection
The goal of this single arm ,non-interventional, prospective, descriptive study is to evaluate the efficacy of guselkumab treatment in preventing endoscopic recurrence of Crohn's Disease in adult participants who have a…
- Trial name
- POST-CD (NCT07528040)
- Testing
- Guselkumab
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Shanghai 10th People's Hospital
Rectal Cancer Stage II, Rectal Cancer Stage III
Optimal Surgery and MRI Based Radiochemotherapy in Rectal Carcinoma
The objective of the study is to provide proof that a MRI based preoperative radiochemotherapy in patients with locally advanced rectal carcinoma allows limiting RCT to high risk patients without increase of locoregional…
- Trial name
- OCUM (NCT01325649)
- Testing
- total mesorectal excision / long course radiochemotherapy, long course 5-FU bases radiochemotherapy
- Where
- Germany
- Volunteers
- 1,051 people
- Sponsor
- Johannes Gutenberg University Mainz
Submucosal Tumor of Gastrointestinal Tract
Hydrogel Injection to Assist Endoscopic Submucosal Dissection
The aim of the investigators' study is to evaluate the mucosa-elevating capacity and clinical safety of Sodium Alginate (SA) mixed with Calcium Lactate in assisting Endoscopic Submucosal Dissection/Endoscopic Mucosal Resection.
- Trial name
- NCT03321396
- Testing
- sodium alginate mixed with calcium lactate
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- National Cheng-Kung University Hospital
Rectal Cancer
The Evaluation of the Safety and the Efficacy of Transanal Total Mesorectal Excision
The purpose of this study is evaluation of the safety and the efficacy of transanal total mesorectal excision.
- Trial name
- NCT01938027
- Testing
- Transanal total mesorectal excision
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- National Cancer Center, Korea
Postoperative Pain, Acute, Postoperative Pain, Chronic
Postoperative Pain in Patients Undergoing Scheduled Laparoscopic Intestinal Resection Surgery
This observational prospective study aims to evaluate the postoperative analgesic effect of a regional anesthesia thechnique (TAP block) in patients undergoing scheduled laparoscopic intestinal resection for intestinal cancer.
- Trial name
- TAP (NCT05222789)
- Testing
- TAP
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Rectocele
STARR Trans-anal Resection Versus Vaginal Rectocele Repair Using Elevate: Effects on Defecatory Function
The primary objective of this study is to compare the function results between two methods for surgically repairing rectoceles: vaginal versus endo-anal surgery.
- Trial name
- RectoVerso (NCT01257659)
- Testing
- STARR rectocele repair, Elevate mesh rectocele repair
- Where
- 6 sites in France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Wounds and Injuries, Surgery--Complications
Preoperative Oral Antibiotics With vs Without Mechanical Bowel Preparation to Reduce Surgical Site Infections Following Colonic Resection: an International Randomized Controlled Trial.
The ORALEV Study found that preoperative oral antibiotics can reduce the incidence of surgical site infections after colonic resection, compared with no preparation.
- Trial name
- ORALEV2 (NCT04161599)
- Testing
- Cefuroxime (750mg) I.V, Colonic Surgery, Cefuroxime 750mg oral
- Where
- 10 sites in China, Greece and 4 more
- Volunteers
- 968 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Rectal Cancer, Low Anterior Resection Syndrome
The Effects of Kegel Exercise Combined With Biofeedback Therapy on Bowel Function Recovery, Emotional Distress, and Quality of Life in Patients Following Low Anterior Resection for Rectal Cancer
This randomized controlled trial aims to evaluate the effects of combining Kegel exercise with a single biofeedback session on bowel function, emotional distress, and quality of life in patients who have undergone low anterior…
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, LARS - Low Anterior Resection Syndrome
- Trial name
- BFT in LARS (NCT07253298)
- Testing
- Kegel Exercise with Biofeedback, Kegel Exercise Only
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- National Taiwan University Hospital
Rectal Cancer
Organ Preservation Following Enverolimab-based Total Neoadjuvant Therapy for Locally Advanced Very Low Rectal Cancer
Patients diagnosed with locally advanced very low rectal cancer were chosen to participate in a comprehensive neoadjuvant therapy (TNT) protocol.
- Trial name
- TRACE-LE (NCT05969847)
- Testing
- split-course hypofraction radiotherapy, CAPOX, Envafolimab
- Where
- China
- Volunteers
- 72 people
- Sponsor
- 池畔
Rectal Cancer
NEO: Neoadjuvant Chemotherapy, Excision and Observation for Early Rectal Cancer
The purpose of this study is to find out the effects of chemotherapy followed by less invasive surgery on patients and their early rectal cancer.
- Trial name
- NCT03259035
- Testing
- Folfox Protocol, Capox
- Where
- 11 sites in United States, Canada
- Volunteers
- 58 people
- Sponsor
- Canadian Cancer Trials Group
Sterility, Postpartum
Effect of Simethicone on Reducing Bowel Interference During Tubal Resection
Tubal ligation is an everyday procedure for permanent female sterilization. It is usually performed after a vaginal delivery. Minilaparotomy is generally performed by doing small incision at infraumbilical area.
- Trial name
- NCT03429621
- Testing
- Simethicone 80 MG
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
Colonic Polyps
The Efficacy and Safety of a Hybrid Hemostatic Device (ClearCoajet)
The ClearCoajet is a new hemostasis device with a hybrid function (Coagulation + Injection) and is developed to provide effective coagulation, injection, and marking around lesions without changing devices during the endoscopic…
- Trial name
- NCT05737017
- Testing
- ClearCoajet
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Seoul St. Mary's Hospital
Secondary Malignant Neoplasm of Liver, Colorectal Neoplasms
Oslo Randomized Laparoscopic Versus Open Liver Resection for Colorectal Metastases Study
The purpose of the study is to compare outcomes of laparoscopic versus open liver resection for colorectal metastases in a prospective and randomized study.
- Trial name
- Oslo-CoMet (NCT01516710)
- Testing
- Open liver resection, Laparoscopic liver resection
- Where
- Norway
- Volunteers
- 280 people
- Sponsor
- Oslo University Hospital
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