Clinical trials: Bowel Resection
Malignant Neoplasm of Large Intestine, Colon Cancer Liver Metastasis
Colectomy in Patients With Asymptomatic and Unresectable Stage IV Colon Cancer
The present study is a multicentric randomized phase III trial designed to assess whether overall survival and quality of life are improved in patients with asymptomatic colon cancer and unresectable SLM treated with resection of…
- Trial name
- CLIMAT (NCT02363049)
- Testing
- Colectomy, Chemotherapy
- Where
- France
- Volunteers
- 278 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metastatic Colorectal Cancer
Study Comparing Pathological Responses Observed on Colorectal Cancer Metastases Resected After Preoperative Bevacizumab With FOLFOX or FOLFIRI.
The study is designed to analyze the pathological tumor response on resected colorectal cancer metastases after preoperative treatment with bevacizumab combined with FOLFOX or FOLFIRI regimen in a prospective cohort and to…
- Trial name
- BEV-ONCO2012 (NCT01858649)
- Testing
- Metastases resection, Bevacizumab, 5 FU
- Where
- 11 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Rectal Cancer, Quality of Life
Quality of Life After Transanal Total Mesorectal Excision Compared to Traditional Total Mesorectal Excision
The improvement in prognosis of rectal cancer through modern therapy modalities rises questions regarding quality of life (QoL) and functional outcomes.
- Conditions
- Rectal Cancer, Quality of Life, Functional Outcome, Surgery
- Trial name
- NCT06505863
- Testing
- Transanal total mesorectal excision, Abdominal total mesorectal excision
- Where
- Switzerland
- Volunteers
- 249 people
- Sponsor
- Cantonal Hospital of St. Gallen
Early Colorectal Cancer, Non-curative Endoscopic Resection
Clinical Outcomes After Non-curative Endoscopic Resection in Early Colorectal Cancer: A Multicenter Study
This multicenter study aims to evaluate clinical outcomes and optimize management strategies in patients with early colorectal cancer who undergo non-curative endoscopic resection.
- Trial name
- NCT07542171
- Testing
- Additional Surgery, Surveillance
- Where
- 3 sites in China
- Volunteers
- 400 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Wounds and Injuries, Surgery--Complications
Preoperative Oral Antibiotics With vs Without Mechanical Bowel Preparation to Reduce Surgical Site Infections Following Colonic Resection: an International Randomized Controlled Trial.
The ORALEV Study found that preoperative oral antibiotics can reduce the incidence of surgical site infections after colonic resection, compared with no preparation.
- Trial name
- ORALEV2 (NCT04161599)
- Testing
- Cefuroxime (750mg) I.V, Colonic Surgery, Cefuroxime 750mg oral
- Where
- 10 sites in China, Greece and 4 more
- Volunteers
- 968 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Colorectal Cancer
Follow-Up Study of Patients Who Have Undergone Surgery for Stage I, Stage II, or Stage III Colorectal Cancer
RATIONALE: Following patients who have undergone surgery for colorectal cancer may help doctors learn more about the disease and plan better follow-up care.
- Trial name
- NCT00560365
- Testing
- laboratory biomarker analysis, computed tomography, magnetic resonance imaging
- Where
- 31 sites in United Kingdom
- Volunteers
- 4,760 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Colorectal Cancer
Combination Chemotherapy With or Without Cetuximab in Treating Patients With Stage III Colon Cancer That Was Completely Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, or fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00265811
- Testing
- Folfox, Cetuximab
- Where
- 8 sites in France
- Volunteers
- 2,559 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Polyp of Colon, Endoscopic Mucosal Resection
Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.
The goal of this randomized clinical trial is to learn if a combination of hot and cold EMR technique is associated with a lower risk of polyp recurrence without increasing the risk of complication when removing large polyps.
- Trial name
- NCT06937671
- Testing
- Cold EMR, Hybrid EMR
- Where
- 2 sites in United States
- Volunteers
- 194 people
- Sponsor
- The Cleveland Clinic
Low Anterior Resection Syndrome
Transanal Irrigation for Low Anterior Resection Syndrome.
The aim of this study is to investigate whether the high-volume transanal irrigation (TAI) performed by the Peristeen Plus® system is superior to the low-volume TAI performed by standard 250ml water enema for the treatment of Low…
- Trial name
- HiLoV_TAI (NCT05245331)
- Testing
- Peristeen® Transanal irrigation system with the conic catheter, Standard reusable enema
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Universitari de Bellvitge
Inflammatory Bowel Diseases, Colon Cancer
Pre-Habilitation Exercise Intervention
The purpose of this study is to see whether exercise can improve the health and well-being of patients scheduled to undergo surgery for a bowel related condition.
- Conditions
- Inflammatory Bowel Diseases, Colon Cancer, Rectal Cancer, Diverticular Disease
- Trial name
- NCT02849717
- Testing
- Exercise for Cancer Patients
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Rochester
Low Anterior Resection Syndrome
Transanal Irrigation to Prevent Major Low Anterior Resection Syndrome
Bowel dysfunction after rectal cancer resection comprises a vast array of bowel symptoms and associated quality-of-life impairment, collectively termed as low anterior resection syndrome (LARS).
- Trial name
- TAILARS (NCT04758195)
- Testing
- Transanal irrigation, Best supportive therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Ileus
Study of Inhaling Carbon Monoxide to Treat Patients With Intestinal Paralysis After Colon Surgery.
Post operative ileus (POI), a temporary paralysis of the intestines, is a serious health care problem. It normally occurs in all patients after surgery to the abdomen but in some cases can result in serious complications.
- Trial name
- NCT01050712
- Testing
- Inhaled Carbon Monoxide, Synthetic Air
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Queen's University
Colorectal Liver Metastases, Colon Cancer
Multiple Minor Hepatectomies Versus Major or Extended Hepatectomies for Colorectal Liver Metastases.
The performance of multiple minor hepatectomies (MMH) instead of major hepatectomies (MH) in patients with colorectal liver metastases (CLM) is object of debate.
- Trial name
- NCT02331641
- Testing
- Hepatectomy
- Volunteers
- 554 people
- Sponsor
- University of Milan
Anastomosis, Perfusion
PPG vs. ICG in Gastrointestinal Resections
This randomized controlled trial compares a novel optical technique against the standard of care for assessing tissue perfusion in gastrointestinal surgery.
- Conditions
- Anastomosis, Perfusion, Postoperative Complications, Gastrointestinal Neoplasms
- Trial name
- NCT06222645
- Testing
- ICG fluorescence imaging technology, Imaging Photoplethysmography System
- Where
- 3 sites in China, Russia
- Volunteers
- 200 people
- Sponsor
- Saint Petersburg State University, Russia
Endometriosis, Bowel Endometriosis
Mesenteric Sparing Surgery in Laparoscopic Colorectal Resection for Endometriosis
Colorectal resection is a standard surgical treatment of bowel deep infiltrating endometriosis (DIE). Nevertheless, concerns about different bowel functional outcomes related to radical surgery versus conservative surgery as…
- Conditions
- Endometriosis, Bowel Endometriosis, Constipation
- Trial name
- IRE-1 (NCT03565848)
- Testing
- Mesenteric vascular and nerve sparing surgery in laparoscopic segmental colorectal resection
- Volunteers
- 50 people
- Sponsor
- Università degli Studi dell'Insubria
Metastatic Colorectal Cancer
Sotevtamab (AB-16B5) Combined With FOLFOX as Neoadjuvant Treatment Prior to Resection of Colorectal Cancer Liver Metastasis
This Phase II study will recruit 17 colorectal cancer patients with liver-dominant metastases. All recruited patients will receive Sotevtamab at a dose of 800 mg once weekly for 6 cycles combined with FOLFOX once every 2 weeks…
- Trial name
- EGIA-003 (NCT06225843)
- Testing
- Sotevtamab, FOLFOX
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Alethia Biotherapeutics
Colonic Polyps
Comparison of Small Colorectal Polyp Removal Using Cold EMR With Hot EMR
This study evaluates the efficacy of small colorectal polyp removal using cold endoscopic mucosal resection with hot endoscopic mucosal resection.
- Trial name
- NCT03000868
- Testing
- Cold endoscopic mucosal resection, Hot endoscopic mucosal resection
- Where
- South Korea
- Sponsor
- Chonnam National University Hospital
Rectal Neoplasm Malignant
Total Mesorectal Excision(TME) With Lateral Lymph Node Dissection Versus TME After Neoadjuvant Chemo-radiotherapy
Treatment for Low rectal cancer, especially in patients with regional lymph node metastasis are quite different between Japanese guideline (JSCCR) and western countries' guideline (NCCN, ESMO).
- Trial name
- TELEPHOME (NCT03587480)
- Testing
- TME+LLND, TME+nCRT
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Metabolomics
A Metabolomics-based Study to Explore the Mechanism of Remission of Metabolic Syndrome Radical Resection of Colorectal Cancer
1. Analysis of preoperative and postoperative metabolite changes: Through metabolomics technology, the changes of preoperative and postoperative metabolites in patients with colorectal cancer complicated with metabolic syndrome…
- Trial name
- NCT06710314
- Testing
- Colorectal cancer patients with hypertension, Colorectal cancer patients with diabetes, Colorectal cancer patients with fatty liver
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Dong Peng
Colorectal Cancer
Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418)
This is an open-label, randomized, controlled, multicenter, phase III study with two parallel arms. Patients with metastatic colorectal cancer after definite interventional therapy of all lesions are randomized in a 2:1 fashion…
- Trial name
- NCT05008809
- Testing
- mFOLFOX6, mFOLFOXIRI, FOLFIRI
- Where
- 79 sites in Germany
- Volunteers
- 507 people
- Sponsor
- Dominik Paul Modest