Clinical trials: Brain Activity
Epilepsy
Electrohaemodynamic Activity in Epileptic Children : Combined Video-EEG and Near-infrared Spectroscopy (NIRS) Analysis
Evaluate the contribution of multimodal high-resolution EEG-NIRS electrical and local haemodynamic analysis to spatial localization of epileptogenic foci
- Trial name
- NIRS Epilepsie (NCT02814331)
- Testing
- multimodal high-resolution EEG-NIRS
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Perinatal Hypoxia, Dopamine
Measuring Brain Activity of School Age Children
This observational study will investigate whether differences in birth events and oxygen levels during the newborn period affects the brain activity of children during the middle childhood years.
- Conditions
- Perinatal Hypoxia, Dopamine, Neurobehavioral Manifestations
- Trial name
- NCT03407729
- Testing
- Magnetic Resonance Imaging, Cognitive Performance Testing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Non-valvular Atrial Fibrillation
LAMax Vs. Watchman LAAC Device for Subjects With Non-valvular AF to Reduce the Risk of Stroke
This is a prospective, multicenter, randomized, active controlled, clinical trial to evaluate the safety and effectiveness of the LAMax Left Atrial Appendage (LAA) Closure System.
- Trial name
- NCT04429646
- Testing
- Percutaneous left atrial appendage closure-LAMax, Percutaneous left atrial appendage closure-Watchman
- Where
- 12 sites in China
- Volunteers
- 236 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Low Back Pain, Recurrent
Exercise Therapy for Recurrent Low Back Pain: Unraveling the Puzzle of Peripheral Muscle and Central Brain Changes (B670201420984)
Exercise therapy has been shown to be effective in decreasing pain and improving function for patients with recurrent low back pain (LBP).
- Trial name
- ExTraS (NCT05706103)
- Testing
- Specific skilled motor training, General extension training
- Where
- Belgium
- Volunteers
- 62 people
- Sponsor
- University Ghent
Parkinson Disease, Idiopathic Parkinson Disease
An Active-Controlled Extension Study to NCT01155466 [P04938] and NCT01227265 [P07037] (P06153)
The primary purpose of this extension study is to assess the long-term safety and tolerability of preladenant in participants from parent studies NCT01155466 [P04938] and NCT01227265 [P07037] with moderate to severe Parkinson's…
- Trial name
- NCT01215227
- Testing
- Preladenant, Rasagiline
- Volunteers
- 839 people
- Sponsor
- Merck Sharp & Dohme LLC
Alzheimer's Disease, Seizures
Seizure Activity in Alzheimer's Disease
The main purpose of this research project is to study how seizure-like activity affects the blood flow in the brain of patients with Alzheimer's disease (AD).
- Trial name
- NCT01554683
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Beth Israel Deaconess Medical Center
Brain Injury Traumatic Mild
Web-Based Self-Monitoring Activity-Restriction and Relaxation Training Program for Kids With Mild Traumatic Brain Injury
SMART is an interactive web-based program that will allow youth with mild traumatic brain injuries (mTBI) to monitor their symptoms and receive education on problem-solving and coping strategies.
- Trial name
- SMART (NCT03498495)
- Testing
- Self-Monitoring Activity-restriction and Relaxation Training (SMART)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Stroke
Impact of Active Breathing Exercises on Respiratory Rhythm Disorders in Stroke Patients
The goal of this clinical trial is to explore The Effect of Active Breathing Exercises in Stroke Patients With Respiratory Rhythm Disorder.
- Trial name
- NCT06328803
- Testing
- Rehabilitation training, Active Breathing Exercises
- Volunteers
- 80 people
- Sponsor
- Copka Sonpashan
Idiopathic Parkinson Disease
Quantification of Dopamine Active Transporter (DAT) in Humans: Validation of a New Radiophamaceutical, the [18F] LBT-999
Idiopathic Parkinson's disease (IPD) is a degenerative disease affecting the dopaminergic system. Clinical symptoms of IPD commonly begin after the loss of at least 40 to 50% of striatal dopaminergic terminals (specially…
- Trial name
- LBT 999 (NCT02393027)
- Testing
- [18F] LBT-999 PET
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Parkinson Disease
Gamification and Physical Activity in PD
Despite overwhelming evidence that exercise can improve motor and non-motor symptoms of Parkinson's Disease (PD), less than 25% of Veterans with PD meet recommended activity goals.
- Trial name
- NCT07286994
- Testing
- Gamification, Feedback control
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- VA Office of Research and Development
Post Concussion Syndrome
Effects of Osteopathic Treatment on Vestibular Disturbed Active Post Concussed Individual
The proposed study is a randomized clinical trial with the purpose of determining the efficacy of osteopathic treatment on vestibular symptoms of the post concussed vestibular disturbed athlete as determined by the Dizziness…
- Trial name
- PCS (NCT01962883)
- Testing
- Osteopathic treatment
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Collège d'Études Ostéopathiques
Cerebral Palsy
Chronic Constipation With Cerebral Palsy
This study was performed to evaluate posture, sleep, physical activity and quality of life in individuals with chronic constipation Cerebral Palsy.
- Trial name
- NCT04588766
- Testing
- constipation group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Bartın Unıversity
Insulin Sensitivity
The Importance of Insulin Action in the Brain for the Immune System During Physical Activity
The goal of this clinical trial is to clarify the interaction of central insulin action and physical activity with the immune system. Therefore, participants will undergo bicycle spiroergometer tests.
- Trial name
- NCT06552130
- Testing
- Spiroergometer test with intranasal insulin spray
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Alzheimer Disease, Telerehabilitation
Comparison of the Effect of Online Physical Exercise and Computerized Cognitive Stimulation in Patients With Alzheimer's Disease
Our aim has been determined to investigate the effect of physical exercise alone and in combination with cognitive exercise, on cognitive, physical function and quality of life in individuals with Alzheimer's Disease during the…
- Conditions
- Alzheimer Disease, Telerehabilitation, Online Physical Exercise, Computerized Cognitive Stimulation
- Trial name
- NCT04842734
- Testing
- Physical exercise, Physical exercise and computerized cognitive training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yeditepe University
Brain Concussion, Head Injury
ReCoUPS: Post-Concussion Patient Reports
Physical and cognitive rest are recommended as treatment for concussion, but debate persists about the utility of this recommendation for patients recovering from concussion.
- Trial name
- NCT04499937
- Testing
- Streak incentive, Loss-based incentive, Flat-fee control status quo condition
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Philadelphia
Dementia With Lewy Bodies
Exploration of GCase Activity to Identify a Subpopulation Eligible for a Therapeutic Trial in Dementia With Lewy Bodies
This research focuses on the activity of an enzymatic protein: glucocerebrosidase, in dementia with lewy bodies (DLB). Indeed, the mutation of the GBA gene responsible for a decrease in the activity of glucocerebrosidase is the…
- Trial name
- EGELY (NCT05304195)
- Testing
- Glucocerebrosidase, GBA gene, Macrophage biomarkers
- Where
- France
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Relapsing-Remitting Multiple Sclerosis
A fMRI(Functional Magnetic Resonance Imaging) Research Study to Learn More About Multiple Sclerosis and Individuals Potentially Experiencing Memory Difficulties
The purpose of this study is to determine if medication designed to improve memory will help patients with Multiple Sclerosis (MS) who are experiencing memory problems using fMRI to track brain activity.
- Trial name
- NCT00315367
- Testing
- Donepezil HCI (drug)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Neurognostics
Mental Health Wellness 1
Acute Effects of Physical Activity On Memory, Cognitive Performance and Brain Activity
The overall aim of the study is to investigate the effects of an acute bout of physical activity on cognitive performance and long-term memory in elementary school children.
- Trial name
- NCT03391505
- Testing
- Small-sided soccer game, Walking soccer game, Rest group watching soccer
- Where
- Denmark
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Stroke
Enabling Bedside Brain Measurement of Motor Outcomes Post Stroke
The goal of this basic neuroscience study is to learn whether visual feedback of brain activity can help improve arm and hand recovery in people who recently had a stroke.
- Trial name
- fNIRS-NFB (NCT07876700)
- Testing
- fNIRS-neurofeedback, Control
- Volunteers
- 60 people
- Sponsor
- Sue Peters
Cognitive Impairment, Dementia
Older Adults With Cognitive Impairment Doing Sit to Stands, Walking in Transitional Care Programs: A Feasibility Study
The goal of this intervention study is to test the effects of a nurse-led mobility intervention (known as the OASIS Walking Intervention (Older Adults performing Sit to Stands and Walking Intervention)) in older adults with…
- Conditions
- Cognitive Impairment, Dementia, Delirium, Functional Decline
- Trial name
- OASIS (NCT06150339)
- Testing
- OASIS Walking Intervention
- Where
- 2 sites in Canada
- Volunteers
- 6 people
- Sponsor
- University Health Network, Toronto
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