Clinical trials: Brain Aging
Transcranial Direct Current Stimulation (tDCS), Ageing
Investigating the Effectiveness of a 2-week Novel Non-invasive Brain Stimulation Technique on Cognitive Outcomes in Healthy Adults
The goal of this randomised controlled trial is to investigate the effects of a 2-week high-frequency transcranial pulsed current stimulation (tPCS) on cognitive outcomes in older and healthy adults.
- Conditions
- Transcranial Direct Current Stimulation (tDCS), Ageing, Executive Functioning, Transcranial Electric Stimulation
- Trial name
- NCT06991764
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Lewy Body Disease, Dementia
MIBG in Aging and Neurologic Disorders
The purpose of the study is to investigate the use of a special radioactive drug called 123I-MIBG and myocardial MIBG scintigraphy.
- Conditions
- Lewy Body Disease, Dementia, Parkinsonism, Mild Cognitive Impairment
- Trial name
- NCT05514106
- Testing
- meta-iodobenzylguanidine (MIBG) (123I), 123I-MIBG scintigraphy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Mild Cognitive Impairment, Healthy Aging
Novel, Individualized Brain Stimulation, Network-based Approaches to Improve Cognition
Impaired working memory (WM) plays a crucial role in normal aging, in mild cognitive impairment (MCI) and cognitive decline associated with dementia, such as Alzheimer's disease (AD).
- Trial name
- NiBS-iCog (NCT04986787)
- Testing
- tACS, TMS, TIS
- Where
- Czechia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Mild Cognitive Impairment, Cognitive Decline
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function in two groups of individuals: those with mild cognitive impairment…
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
- Trial name
- NCT03954899
- Testing
- melatonin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Natalie Denburg
Aging Disorder, Parkinson Disease
Contribution of Virtual Reality and Modelling in Falling Risk Assessment in Elderly and Parkinson's Disease Patients
The process of ageing affects at the same time the sensory, cognitive and driving functions. Furthermore, ageing is often accompanied by pathologies increasing the effects of the senescence.
- Trial name
- PrévSim (NCT03848897)
- Testing
- Metrology of motor behavior
- Where
- France
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Alzheimer's Disease, Mild Cognitive Impairment
Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease
This is a prospective cohort study for cognitively normal (young and old), mild cognitive impairment, and Alzheimer's disease people
- Trial name
- KBASE (NCT02137460)
- Where
- South Korea
- Volunteers
- 721 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cardiovascular Diseases, Non-communicable Disease
Effects of Primary Prevention in Elderly People-The Healthy Aging Initiative
The number of elderly will increase rapidly in Europe in the next 30 years, which affects the country's economic and social development, welfare, health care, and also the individuals.
- Trial name
- HAI (NCT03312439)
- Testing
- Given advice
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Region Västerbotten
Sleep Disturbance, Cognitive Change
Integrating Systematic Data of Geriatric Medicine to Explore the Solution for Health Aging
This project aims to build up the comprehensive database of geriatric medicine for local Taiwanese.
- Conditions
- Sleep Disturbance, Cognitive Change, Aging
- Trial name
- NCT04207502
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Older Adults (50-90 Years)
Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults
The beneficial effect of nocturnal as well as daytime sleep on memory consolidation is well-documented in young, healthy subjects.
- Trial name
- NCT01840839
- Testing
- brain stimulation
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Brain Aging
Blueberry Intervention Study for Brain Aging
The purpose of this study is to determine if increased blueberry intake helps increase brain antioxidant (glutathione) and cerebral blood flow in older adults.
- Trial name
- NCT05024916
- Testing
- Intervention, Control
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Aging, Parkinson's Disease (PD)
Impact of Force Control of Hip Abductor Muscles in Healthy Adults and Individuals With Parkinson's Disease
Both aging and Parkinson's disease (PD) negatively affect postural control and increase the risk of falls, with frontal plane balance being particularly challenging for these populations.
- Trial name
- NCT07568951
- Testing
- Age, Parkinson's disease (PD)
- Where
- 2 sites in Taiwan
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cannabis Use
Cannabis and Aging
With increased availability and use of cannabis by older adults aged ≥ 50 years, a rigorous evaluation of the benefits and risks of cannabis use in these individuals is necessary.
- Trial name
- NCT05084105
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Thorsten Rudroff
Cognitive Aging, Adverse Childhood Experiences
Physical Exercise for Augmenting Cognitive Health (PEACH)
PEACH is a pilot project which is being conducted to determine the feasibility and acceptability of a 12-week home-based exercise intervention among Black and African American adults.
- Trial name
- PEACH (NCT04922710)
- Testing
- Home-based aerobic exercise
- Where
- 2 sites in United States, Jamaica
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Caesarean Delivery
Regenerative Effects of Birth Material Derived Extracellular Vesicles
Stem cells offer great hope for a wide range of disorders, including age-related brain disease such as dementia. Mesenchymal stem cells (MSCs) are special types of adult stem cells found in various tissues like the umbilical…
- Trial name
- ReGAIN (NCT06866184)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Pharmacokinetics of New Curcumin Formulations, Safety of New Curcumin Formulations
Improved Oral Bioavailability of Curcumin Incorporated Into Micelles
Curcumin, a lipophilic polyphenol derived from the plant curcuma longa possesses numerous health-promoting activities. The oral bioavailability of curcumin is low due to its poor aqueous solubility, limited gastrointestinal…
- Trial name
- NCT01982734
- Testing
- curcumin
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Aging, Music
Brain Imaging and Behavioural Changes Following Cued-movement Training of Finger Sequences in Healthy Older Adults
The goal of this study is to examine changes in the brain, behavior, and personal experience when music is used to guide learning of finger movement sequences (compared to visual stimuli alone) in healthy older adults.
- Conditions
- Aging, Music, Motor Activity, Magnetic Resonance Imaging
- Trial name
- NMSOA (NCT06174740)
- Testing
- Music-cued audiovisual motor training, Visually-cued motor training
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiteit Leiden
Aging
Brain Correlates of Visual Processing of Emotional Scenes in ACTion and EMOtional Judgments During Normal VIeillissement
It is accepted that emotional events engage more attention and are detected and identified faster than neutral events. The same is true of negative events with regard to positive events.
- Trial name
- ACTEMOVI (NCT03969043)
- Testing
- MRI
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Lewy Body Disease, Healthy Aging
Language and Lewy Body Diseases: Sentence Comprehension Problems and Modifying Noninvasive Brain Stimulation Treatment
Lewy body diseases (LBDs) represents a group of neurodegenerative disorders characterized by the abnormal accumulation of aggregates of α-synuclein protein leading to the formation of Lewy bodies (LB) and Lewy neurites resulting…
- Trial name
- LANG-LBD (NCT05847985)
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Cardiovascular, Diabetic
Exercise and Cardiovascular Control During Upright Tilt in Older Adults With Type 2 Diabetes
Older persons with diabetes have a harder time maintaining blood pressure when standing up. When blood pressure drops when standing up, fainting may occur.
- Trial name
- NCT00387452
- Testing
- Aerobic Exercise and Strength Exercise, Strength training
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy Older Adults Ages 60-89
Longitudinal Innate Immunity and Aging Study
This study plans to examine biological bases of cognitive aging. The goals of the study are to better understand how immune system markers, measured in the blood and in the spinal fluid, are related to clinical features of aging…
- Trial name
- LIIA (NCT03944603)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver