Clinical trials: Brain Concussion, open to volunteers
Olfactory Disorder, Smell Disorder
Olfactory Training in Various Populations
To date, there is no validated pharmacotherapy for olfactory disorders. Interestingly, olfactory training - the intentional exposure to odorants for the purposes of retraining the sense of smell - has shown success with as many…
- Conditions
- Olfactory Disorder, Smell Disorder, Traumatic Brain Injury, Concussion, Brain
- Trial name
- NCT06115291
- Testing
- Smell Test
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Kansas Medical Center
Mild Traumatic Brain Injury, Concussion
Advancement of Vestibular Intervention Via Portable Electrical Stimulator (VIPES)
The goal is to assess the potential benefit of stochastic galvanic vestibular stimulation (sGVS) in improving patient performance with respect to balance, gait, and/or overall vestibular function for individuals with known…
- Trial name
- NCT07466589
- Testing
- Stochastic Galvanic Vestibular Stimulation (sGVS)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Vivonics, Inc.
Dizziness, Concussion (Diagnosis)
Dizziness Due to Visual Stimuli in Patients With Concussion and Other Causes of Dizziness: Examination of Balance Behaviour
This research project aims to measure how balance is affected by special visual stimulation. Dizziness caused by complex moving visual patterns, known as optokinetic stimulation, is usually called visually induced dizziness…
- Conditions
- Dizziness, Concussion (Diagnosis), Traumatic Brain Injury, Balance Assessment
- Trial name
- NCT06893029
- Testing
- Postural Response upon physical optokinetic stimulation, Postural Response upon virtual optokinetic stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Dominik Straumann
Concussion, Depression
Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion
Concussion and depression have long been recognized to be intertwined pathologies.1-3 Although female athletes are more likely to suffer from mental health symptoms than males athletes following a concussion,2 research in this…
- Trial name
- NCT07507214
- Testing
- ONE-D TMS protocol and d-cycloserine (125 mg)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Florida
Post-Traumatic Headache
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 2
Anesthetic greater occipital nerve (GON) blockade is a simple, inexpensive, and safe procedure that has demonstrable headache pain suppressing effects.
- Trial name
- NCT07796074
- Testing
- Bupivacaine bilateral greater occipital nerve block
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Yale University
Mild Traumatic Brain Injury (mTBI), Sports-related Concussion
Mobile Dual-Task Brain and Balance Intervention for Concussion Recovery
This research study examines recovery after a sports-related concussion or mild head injury. Many athletes experience lingering problems with thinking, balance, and mood months after a concussion.
- Conditions
- Mild Traumatic Brain Injury (mTBI), Sports-related Concussion, Heart Rate Variability (HRV), Walking
- Trial name
- NCT07599475
- Testing
- Home-Based Mobile Dual-Task Intervention (BraW-Day™)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hyunhwa Lee
Concussion Post Syndrome, Concussion
Effect of Vestibular Rehabilitation on Gait, Balance, and Coordination in Post Concussion Combat Athletes
This randomized controlled trial aims to evaluate the effectiveness of vestibular rehabilitation in improving gait and balance among post-concussion combat athletes aged 18-25 years.
- Trial name
- NCT07717528
- Testing
- Vestibular Rehabilitation Program, Conventional Post-Concussion Rehabilitation
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Brain Concussion, Post-Concussion Syndrome
Exercise in Postconcussion Symptoms and Posttraumatic Headache
The goal of this clinical trial is to compare two models of delivery of guided exercise in patients with exercise intolerance after mild head injury.
- Conditions
- Brain Concussion, Post-Concussion Syndrome, Post-Traumatic Headache, Craniocerebral Trauma
- Trial name
- NCT06015451
- Testing
- Sub-symptom threshold exercise
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- St. Olavs Hospital
Traumatic Brain Injury (TBI); Concussion, Initial Encounter
Wearable Device-Based Analysis of the Relationship Between Sleep Patterns and Clinical Prognosis in Patients With Traumatic Brain Injury
In patients with traumatic brain injury, post-traumatic sleep patterns have the potential to impact clinical prognosis. While some progress has been made in the study of sleep and prognosis in patients with traumatic brain…
- Trial name
- NCT06790979
- Where
- China
- Volunteers
- 50 people
- Sponsor
- General Hospital of Ningxia Medical University
Mild Traumatic Brain Injury, Intracranial Lesions
TES HT100 Clinical Validation for Brain Injury Screening in Patients With Mild Head Trauma or Neurological Symptoms
The goal of this clinical study is to evaluate how accurately and safely the TES HT100 device can identify intracranial abnormalities in adult emergency department patients with mild head trauma or neurological symptoms that are…
- Conditions
- Mild Traumatic Brain Injury, Intracranial Lesions, Neurological Symptoms Not Related to Head Trauma
- Trial name
- TESCO (NCT07490418)
- Testing
- Temnographic Brain Screening Examination
- Where
- 3 sites in Italy, Poland
- Volunteers
- 850 people
- Sponsor
- B&B srl
Traumatic Brain Injury (TBI) Patients, Neuroinflammation
Vitamin D3 for Moderate to Mild Traumatic Brain Injury: A Randomized Trial on Inflammation and Recovery (VIMOT)
This study is a Phase II, randomized, quadruple-blinded, placebo-controlled clinical trial designed to test whether vitamin D₃ supplementation can improve recovery after mild-to-moderate traumatic brain injury (TBI) in adults.
- Trial name
- VIMOT (NCT07269457)
- Testing
- Vitamin D3 (Cholecalciferol)
- Where
- Nigeria
- Volunteers
- 240 people
- Sponsor
- Lagos State University
Mild Traumatic Brain Injury, Concussion
Psychologically Informed Cervicovestibular Rehabilitation (PIC Rehab) for Mild Traumatic Brain Injury: A Feasibility Trial
Mild traumatic brain injuries ("mTBIs") affect over 480,000 Canadians each year. While many individuals recover in the initial 4 weeks following mTBI, in up to 30% of individuals symptoms and functional impairments often persist…
- Trial name
- PIC Rehab (NCT07402733)
- Testing
- Psychologically Informed CVPT (PIC) Rehab, Cervicovestibular Rehabilitation (CVPT)
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Sport Injury Prevention Research Centre
Epilepsy, Functional Neurological Disorder
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers.
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia
- Trial name
- EXPLAIN (NCT07883720)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Insomnia Disorder, Mild Traumatic Brain Injury
Sleep MAPP in the Polytrauma/TBI System of Care
This pilot implementation trial will evaluate the Sleep Disorder Management Assistance for Providers and Patients (Sleep MAPP) Care Pathway in one Veterans Health Administration Polytrauma/TBI System of Care clinic.
- Trial name
- Sleep MAPP (NCT07886398)
- Testing
- Sleep MAPP Care Pathway
- Where
- 2 sites in United States
- Volunteers
- 900 people
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury, Post Concussion Syndrome
Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline
The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain.
- Trial name
- NCT07044596
- Testing
- Functional near-infrared spectroscopy (fNIRS), V1 stimulation electrodes, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
TBI Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder
Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy
The purpose of this study is to evaluate how hyperbaric oxygen therapy (HBOT) may affect cognitive functioning, post-traumatic stress disorder (PTSD), depression, anxiety, and overall quality of life in veterans. 1.
- Conditions
- TBI Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder, Post Concussive Syndrome
- Trial name
- NCT07214415
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Summit Hyperbarics and Wellness
Mild Traumatic Brain Injury, Suicidal Ideation
Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury
The investigators hope to develop a treatment for suicidal ideation (SI), impulsivity and functional impairments (such as difficulties in social and work settings) that occur after a mild traumatic brain injury (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Suicidal Ideation, Impulsivity
- Trial name
- NCT05647044
- Testing
- intermittent theta burst stimulation
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder
HBOT Effects on First Responders' Cognition and Well-Being
The goal of this study is to examine changes in cognitive functioning and post-concussive symptoms following hyperbaric oxygen therapy (HBOT) in current and former first responders with a history of traumatic brain injury.
- Conditions
- Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder, Anxiety, Depression
- Trial name
- NCT07852728
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Summit Hyperbarics and Wellness
Concussion, Brain
Interest of an Attentional Evaluation by a Computerized Battery in the Management of Concussion in Young Rugby Players
The goal of this study is to test the ability of a computerized neuropsychological battery to identify attentional disorders resulting from a concussion occurring during the practice of rugby.
- Trial name
- NeuropsyCor (NCT05719844)
- Testing
- Neuropsychological tests
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Mild Traumatic Brain Injury, Concussion, Mild
Facilitating Access to Specialty Treatment
The goal of this hybrid implementation-effectiveness study is to evaluate the effectiveness (hastened recovery times) and feasibility (fidelity in connecting to concussion specialty care) of a novel mobile health intervention…
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
- Trial name
- NCT05741411
- Testing
- RPM-assisted specialist access
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Children's Hospital of Philadelphia