Clinical trials: Brain Disorder
Alzheimer's Disease, Dementia
A Study of Acupuncture for Patients With Behavioural and Psychological Symptoms of Dementia
The purpose of the study is to evaluate the safety and tolerability of acupuncture for patients with BPSD \& healthy volunteers.
- Trial name
- NCT01055561
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Meniere Disease
Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS)
This prospective study aims to better characterize inner ear's perilymphatic structures with Magnetic Resonance Imaging using contrast media and delayed injection in healthy subjects MR Perfusion Imaging will be assess in both…
- Trial name
- HYDROPS (NCT02529475)
- Testing
- Gadoteric acid
- Where
- 3 sites in France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Parkinson Disease
A Study Evaluating Potential Screening Tools for Detecting Parkinson Disease
This study is designed as a prospective cohort study to test the strategy of combining two biomarkers of parkinsonism, olfaction and brain imaging with a radioactively labeled drug, [123I]β-CIT , in a population of first-degree…
- Trial name
- NCT00387075
- Testing
- [123I]β-CIT and SPECT imaging, [123I]β-CIT
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Pompe Disease
CPAP for Infantile Pompe Disease
Patients with infantile onset Pompe disease will be trained with continuous positive airway pressure to see if hypernasality can be improved.
- Trial name
- NCT02405624
- Testing
- continuous positive airway pressure
- Where
- Taiwan
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Friedreich Ataxia
Evaluation of the Effects of Calcitriol's in the Neurological Symptoms of Friedreich's Ataxia Patients
Friedreich's Ataxia (FA) is an autosomal recessive disease the mutation of which leads to a deficiency of a protein called frataxin, which is responsible for the symptoms of the disease.
- Trial name
- CalcitriolFA (NCT04801303)
- Testing
- Calcitriol, Blood analysis for frataxin's level measurement, Blood analysis for hypercalcemia's control
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Berta Alemany
Parkinson Disease
Respiratory Functions in Parkinson's Disease
The aim is to examine respiratory functions, inspiratory muscle strength, respiratory function, physical fitness and aerobic capacity in Parkinson's disease patients.
- Trial name
- NCT07010783
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ankara University
Cerebral Palsy, Spastic
Effect of Task-Specific Training in an Augmented Reality Context on Upper Limb Function and Activities in Children With Spastic Cerebral Palsy
Children with Cerebral Palsy (CP), a condition that affects movement and coordination, face difficulties in daily activities such as dressing, reaching for objects in high places, and getting up from seats.
- Trial name
- INTERACT (NCT06571929)
- Testing
- INTERACT
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Sao Carlos
Stroke, Urinary Incontinence
Effect of Pelvic Floor Muscle Training in Stroke
Aim: To evaluate the long term effect of pelvic floor muscle training in women with urinary incontinence after ischemic stroke measured by quality of life paramters.
- Trial name
- NCT00258037
- Testing
- Pelvic Floor Muscle training
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Safety Issues, Effect of Drugs
The Treatment of Premature Infants With Brain Injury by Autologous Umbilical Cord Blood Stem Cells
To study the safety and effect of autologous umbilical cord blood stem cells for treatment brain injury
- Trial name
- NCT03696745
- Testing
- autologous umbilical cord blood stem cells, 0.9% Sodium-chloride
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangdong Women and Children Hospital
Parkinson Disease, Neurodegenerative Diseases
Mobile Parkinson Observatory for Worldwide, Evidence-based Research (mPower)
The purpose of this study is to understand variation in the symptoms of Parkinson disease. This study uses an iPhone app to record these symptoms through questionnaires and sensors.
- Conditions
- Parkinson Disease, Neurodegenerative Diseases, Movement Disorders, Central Nervous System Diseases
- Trial name
- mPower (NCT02696603)
- Testing
- Participant self-assessment surveys, Phonation, Gait and balance
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sage Bionetworks
Urge Urinary Incontinence
Brain Imaging Plus Urodynamics to Investigate the Brain's Control of the Bladder
The goal of this project is to evaluate the applicability of non-invasive optical imaging for the measurement of brain function during investigation of the lower urinary tract.
- Trial name
- NIRS/fBFB (NCT01619995)
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cardiovascular Disease, Stroke
Heart Outcomes Prevention Evaluation-3
Heart disease and stroke are major causes of death and disability worldwide and are largely preventable. Cholesterol and blood pressure are major cardiovascular risk factors.
- Trial name
- HOPE-3 (NCT00468923)
- Testing
- Candesartan/HCT, Rosuvastatin
- Where
- Canada
- Volunteers
- 12,705 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Parkinson's Disease, Restless Leg Syndrome
A Single Dose, 2-Period, 2-Treatment, 2-Way Crossover Bioequivalency Study of Ropinirole 0.25 mg Tablets Und Fasted Conditions
The objective of this study was to assess the single dose bioequivalence of Roxane's Ropinirole Tablets, 0.25 mg to ReQuip Tablets, 0.25 mg (GlaxoSmithKline) under fasting conditions using a single-dose, randomized, 2-treatment…
- Trial name
- NCT00673088
- Testing
- Ropinirole Hydrochloride
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Brain Trauma
Magnetic Resonance (MR) Spectroscopy and Diffusion Tensor Imaging in Determining Brain Injury and Subsequent Clinical Outcome in Patients of Moderate Brain Trauma
The purpose of this study is to use magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) to assess for traumatic brain injury and determine if there is any correlation of these findings to clinical outcome.
- Trial name
- NCT00760903
- Testing
- Conventional MRI of the brain, MR spectroscopy (MRS), MR Diffusion Tensor Imaging (DTI)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Ischemic Stroke, Transient Ischemic Attack (TIA)
NUTRITION: Natural Tocotrienol Against Ischemic Stroke Event
A natural form of vitamin E called tocotrienol (TCT), found in many common foods such as barley, decreases stroke size in animal models.
- Trial name
- NUTRITION (NCT01578629)
- Testing
- Vitamin E tocotrienol (TCT) capsules ; Low dose Aspirin
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Andrew Slivka
Parkinson Disease
Neuro-immune Interactome in Parkinson's Disease
This study will be observational and have a prospective case-control longitudinal design. Eligible subjects with idiopathic REM behavior disorder (RBD), Parkinson's disease with RBD, and healthy controls will be recruited.
- Trial name
- NCT07026929
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Yale University
Alzheimer's Disease, Healthy Volunteer
Single-Ascending-Dose Study of BIIB076 in Healthy Volunteers and Participants With Alzheimer's Disease
The primary objective of the study is to evaluate the safety and tolerability of single-ascending intravenous (IV) infusions of BIIB076 in healthy volunteers and participants with Alzheimer's disease (AD).
- Trial name
- NCT03056729
- Testing
- BIIB076
- Where
- 8 sites in United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Biogen
Diffuse and Focal Liver Diseases, Cerebral Function
MRE-IA in Liver Disease and Neurovascular Imaging
The objective of this research project is to develop Magnetic Resonance Elastography by Intrinsic Activation (MRE-IA) imaging methods at two imaging centers (CRCHUS and CRCHUM) for use in ongoing studies in liver disease and…
- Trial name
- MRE-IA (NCT03601845)
- Testing
- Stimuli, No stimuli
- Where
- 2 sites in Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Acromegaly
Oral Glucose Tolerance Testing (OGTT) on Patients Taking Somatostatin Analogs
The purpose of this study is to test the effect of long-acting somatostatin analog medications, taken by patients with acromegaly or carcinoid syndrome, on growth hormone in comparison to healthy controls who are not receiving…
- Trial name
- NCT01371045
- Testing
- Oral Glucose Tolerance Test (OGTT)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Alzheimer's Disease
A Study to Evaluate the Use of an Indwelling Catheter to Obtain Cerebrospinal Fluid (CSF) by Low-rate Continuous Sampling (MK-0000-211)
This is a study to evaluate the feasibility and tolerability of low-rate continuous Cerebrospinal Fluid (CSF) sampling and to estimate the number of participants who exhibit severe baseline instability of CSF amyloid beta isoform…
- Trial name
- NCT01325662
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
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