Clinical trials: Brain Disorder
Parkinson Disease
First-in-Human Single and Multiple Dose of HL-400
This is a randomized, double-blind, placebo-controlled, dose-escalation study in healthy subjects to evaluate the safety, tolerability, pharmacokinetics of HL-400 (a NLRP3 inhibitor) following oral single and multiple ascending…
- Trial name
- NCT06997484
- Testing
- HL-400
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Highlightll Pharmaceutical (USA) LLC
Traumatic Brain Injury, Co-Occurring Behavioral Health Issues
Identifying the Needs of Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans and Their Families: TBI and Co-Occurring Behavioral Health Issues
The purpose of this study is to explore and potentially increase the capacity of the non-VA community mental health system within the state of Colorado to provide a comprehensive and coordinated service delivery system for…
- Trial name
- NCT01502852
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Giant Cell Arteritis (GCA)
Mapping B-cell Biology Across the Cardiovascular Territories of Giant Cell Arteritis: Towards a New Therapeutic Approach (RituxiMAP GCA)
B cells are a component of the immune system which appear be important in causing all forms of cardiovascular disease. Until now, it has not been possible to directly study these cells in living patients (essential to assess…
- Trial name
- RituxiMAP GCA (NCT07269938)
- Testing
- Zirconium Zr 89 labelled rituximab
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Stroke, Cerebro-vascular Accident
Studying Fatigue and Movement After Stroke
The goal of this observational study is to learn how neuromuscular fatigue develops after stroke and how changes in brain activity, muscle activity, and their interaction contribute to reduced motor performance in stroke…
- Conditions
- Stroke, Cerebro-vascular Accident, Ischemia Stroke, Hemorrhage Stroke
- Trial name
- NCT07594938
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Ischemic Stroke
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LWP779 in Healthy Participants
This study is a randomized, double-blind, placebo-controlled clinical trial featuring both single ascending dose (SAD), food effect and multiple ascending dose (MAD) phases intended to evaluate the safety, tolerability, PK, PD…
- Trial name
- NCT07371455
- Testing
- LWP779
- Where
- Australia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Longwood Pharmaceuticals (Hangzhou) Co., Ltd.
Parkinson Disease
The Differential Diagnosis and Prognosis of Idiopathic and Atypical Parkinson Disease by Using Diffusion MRI
The hypothesis is that the differential extent of microstructural damages in the affected brain regions can be specific to the disease of interest and could reflect the clinical severity.
- Trial name
- NCT04472325
- Where
- Taiwan
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Anxiety
Investigating How the Brain Processes Different Experiences
The goal of this clinical trial is to test the efficacy of an app-based program in reducing anxiety and exploring associated changes in brain activity.
- Trial name
- NCT06051084
- Testing
- App-Delivered Mindfulness Training (MT), App-Delivered Coloring
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Brown University
Menopause, Perimenopause
Effects of a Synbiotic Intervention on Perimenopausal/Menopausal Symptoms
FemmeBiome Meno is a synbiotic supplement, meaning it contains both probiotics (beneficial bacteria) and prebiotics (a special kind of fiber that feeds these bacteria).
- Conditions
- Menopause, Perimenopause, Perimenopausal Women
- Trial name
- NCT07759908
- Testing
- Femmebiome Meno
- Where
- Ireland
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University College Cork
Mild Neurocognitive Disorder, Healthy Aging
tFUS for Memory in mNCD and Healthy Adults
Dementia is an ongoing and growing public health crisis in the US and worldwide. The purpose of this study is to examine a form of noninvasive brain stimulation called transcranial focused ultrasound (tFUS) to the hippocampus…
- Trial name
- NCT06718140
- Testing
- Transcranial Focused Ultrasound
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Late Onset Alzheimer Disease
Response to Donepezil, Drug Plasma Concentration and the CYP2D6 and APOE Genetic Polymorphisms
Pharmacological treatment of AD is currently based on cholinesterase inhibitors (ChEI) and memantine, which have been shown to lead to modest, although effective, clinical benefits.
- Trial name
- NCT03349320
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Epilepsy, Temporal Lobe, Temporal Lobe
Light Scattering Spectroscopy to Determine Brain Tumors
This study will use light scattering spectroscopy (LSS) to analyze brain tissue removed from patients during brain surgery to determine if this new technology can be used to differentiate between normal and cancerous cells.
- Trial name
- NCT00067418
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke, Ischemic, Healthy
Stochastic Resonance Stimulation in Brain Plasticity and Post Stroke Motor Recovery
This study evaluates the effectiveness of stochastic resonance electric stimulation on neuromuscular control and proprioception in healthy and individuals with stroke.
- Trial name
- NCT03839810
- Testing
- stochastic resonance electrical stimulation
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Electric Stimulation Therapy, Obesity
Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment
This study will determine whether electrical stimulation of an area of the brain called the dorsolateral prefrontal cortex, which is important in determining the feeling of fullness after eating, affects how much food a person…
- Conditions
- Electric Stimulation Therapy, Obesity, Weight Loss, Eating
- Trial name
- NCT00739362
- Testing
- Transcranial Direct Current Stimulation (TDCS)
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Brain Ischemia
Cerebral Perfusion Associated With Postural Changes: an ASL MR Perfusion Study
Postural changes are commonly used as therapeutic maneuver to enhance or reduce cerebral perfusion. For instance, in acute stroke, the patient can be positioned in head down tilt position so as to increase perfusion of cerebral…
- Trial name
- PerfIRMAVC (NCT02912546)
- Testing
- MRI
- Where
- Martinique
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University Hospital Center of Martinique
Frontotemporal Lobar Degeneration, Alzheimer Disease
PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620
The investigators will compare [18F]-PI-2620 tau PET scans from patients with frontotemporal lobar degeneration (FTLD), patients with non-amnestic presentations of Alzheimer's disease (naAD), and demographically matched…
- Conditions
- Frontotemporal Lobar Degeneration, Alzheimer Disease, Cognitively Normal
- Trial name
- NCT05456503
- Testing
- [18F]-PI-2620
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Stroke, Spasticity
Effects of Low-level Laser Therapy on Spasticity and Gait Parameters in Chronic Stroke Patients With Spastic Plantar Flexors
Stroke is one of the leading causes of long-term disability worldwide. Many patients who survive a stroke experience muscle stiffness (called spasticity), especially in the ankle and foot muscles, which makes walking difficult…
- Conditions
- Stroke, Spasticity, Plantar Flexors
- Trial name
- LLLT-STROKE (NCT07273591)
- Testing
- Low Level Laser Therapy, conventional physical therapy
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Montiha Azeem
Multiple Sclerosis, Stroke
A Comprehensive Assessment of Trunk, Scapula and Upper Limb in Neurological Patients. Reliability, Validity and Interrelatedness
The study aimed to provide insights in the coordination between trunk, shoulder and upper limb while reaching. Two main phases are present in this study: In phase A: the psychometric properties of two tests: Clinical Scapular…
- Trial name
- NCT04908891
- Testing
- Clinical Scapular protocol (ClinScaP), the prevalence of trunk, scapula and upper limb impairments., the interaction between trunk, scapula and upper limb impairments.
- Where
- 4 sites in Belgium
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Dementia
Dementia Communication Training Program for Novice Home Care Workers
This study aims to evaluate the effects of a dementia communication training program using a real-time interactive virtual trainer among novice home care workers.
- Trial name
- NCT07244497
- Testing
- virtual trainer-based dementia communication training, scenario-based discussions dementia communication training
- Where
- Taiwan
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Tzu Chi University
Alzheimer Disease (AD), Cognitive Dysfunction, Cognitive Disorder
Aβ PET and Tau PET Imaging in the Diagnosis and Progression Assessment of Alzheimer's Disease
This prospective study recruited 20 healthy volunteers and 50 patients diagnosed with Alzheimer's disease (AD) and mild cognitive impairment (MCI) according to clinical guidelines.
- Conditions
- Alzheimer Disease (AD), Cognitive Dysfunction, Cognitive Disorder, PET Imaging
- Trial name
- NCT07114224
- Testing
- AV45/AV-1、AV1451 PET
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Parkinson Disease (PD)
Enhancing Nursing Students' Empathy and Learning in Parkinson's Disease Through High-Fidelity Simulation and Blended Learning
The goal of this randomized controlled trial is to evaluate the effectiveness of a multimodal Parkinson's disease-focused intervention on empathy levels and perceived theoretical-practical learning in third-year undergraduate…
- Trial name
- NCT07503418
- Testing
- Blended-learning capsules, High-Fidelity Physical Simulation, Simulated Home Environment
- Where
- Spain
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Cadiz
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.