Clinical trials: Brain Disorder
Brain Injuries, Traumatic, Neuropsychology
The Role of Hyperbaric Oxygen and Neuropsychological Therapy in Cognitive Function Following Traumatic Brain Injury
Traumatic brain injury (TBI) caused by accidents is a very important public health problem in Taiwan. There are many people with brain damage and cognitive dysfunction caused by traumatic brain injury every year.
- Trial name
- NCT03900182
- Testing
- Hyperbaric Oxygen Therapy
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hung-Chen Wang
Brain Injuries
D-aspartate and Therapeutic Exercise
An important mechanism responsible for clinical recovery after neurological damage of different types is synaptic plasticity. Nervous tissue can enhance or de-energize inter-neuronal transmission at synaptic level in a lasting…
- Trial name
- DAsp&TerapEx (NCT03228524)
- Testing
- D-Aspartate, Therapeutic exercise
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Alzheimer's Disease
Apoe Impact Study on Brain Structure and Function, in a Population 45 to 75 Years Old
The purpose of this study is to investigate the influence of the APOE genotype on brain morphology, function and metabolism, related to other factors such as cognitive reserve, cognition and episodic memory, in subjects at…
- Trial name
- NCT02198586
- Where
- Spain
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Type 1 Diabetes, Healthy
Cerebral Responses to Insulin Induced Hypoglycemia
This research study is designed to investigate the effect of hypoglycemia (low blood sugar) on blood flow to and biochemistry in the brain.
- Conditions
- Type 1 Diabetes, Healthy, Hypoglycemia Unawareness
- Trial name
- 1018 (NCT02747680)
- Testing
- hypoglycemia (low blood sugar) in MRI
- Where
- United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Traumatic Brain Injury, Brain Concussion
Comparison of the DANA to the ANAM in the Evaluation of Cognitive Changes After Concussion
The Defense Automated Neurobehavioral Assessment (DANA) was recently developed as a durable, portable, and "field-hardened" NeuroCognitive Assessment Tool.
- Trial name
- NCT01728142
- Testing
- DANA Brief, ANAM
- Where
- Afghanistan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Spinal Cord Injury
Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in Spinal Cord Injury
As the spinal cord injured population ages, these individuals are being exposed to an increased prevalence of age-associated diseases, which coupled with the secondary complications of the injury may contribute to the reduced…
- Trial name
- NCT01984476
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Huntington's Disease
HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease
HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable…
- Trial name
- HDClarity (NCT02855476)
- Where
- 40 sites in United States, Canada and 8 more
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University College, London
Alzheimer Disease
A Clinical Trial to Access Pharmacokinetic Profiles and Safety of IVL3003.
A Clinical Trial to Assess Pharmacokinetic Profiles and Safety of IVL3003
- Trial name
- NCT05345509
- Testing
- Aricept Tablet, IVL3003
- Where
- Australia
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Inventage Lab., Inc.
Healthy, Stroke, Acute
Study of Cerebral Activation by fNIRS During Vibration-induced Illusion of Movement in Healthy and Stroke Participants.
The purpose of this study is to investigate the cerebral activation of healthy and stroke participants in 4 or 2 different conditions (repeated 2 times) of vibration-induced illusion of movement respectively, resulting in 8 or 4…
- Trial name
- VIBRANIRS (NCT06218563)
- Testing
- vibration-induced illusion of movement
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Mild Cognitive Impairment (MCI), Dementia Alzheimer Type
Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort
The goal of this observational study is to learn how daily emotional stress affects cognitive function and inflammation in community-dwelling older adults aged 60 and older in Seoul, Republic of Korea.
- Conditions
- Mild Cognitive Impairment (MCI), Dementia Alzheimer Type, Chronic Pain, Depression - Major Depressive Disorder
- Trial name
- KoCoA cohort (NCT07485387)
- Where
- South Korea
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Korea University
Dementia Alzheimer Type
Pain Perception in Alzheimer's Disease
The purpose of this study is to determine response to pain in Alzheimer's disease.We plan to study the effect of diffuse noxious inhibitory controls(counterirritation phenomenon)and the autonomic nervous system reaction(reflected…
- Trial name
- NCT00192816
- Testing
- reaction to pain
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Myopia, Amblyopia
Myopia Control With Three Lever Irradiance of PBM Therapy in Children and Adults
Photobiomodulation therapy, that is, Low-level red-light technology provides a new and innovative myopia control approach. This strategy enables relatively high energies of light to be delivered at much shorter durations of…
- Conditions
- Myopia, Amblyopia, Refractive Error - Myopia Axial, Ametropia
- Trial name
- MCPT (NCT05957458)
- Testing
- Airdoc device of red light for Myopia
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beijing Airdoc Technology Co., Ltd.
Parkinson Disease(PD)
Gait Initiation Difficulty and Anticipatory Postural Adjustment (APA) Impairment in People With PD - Evaluation and Training
Gait initiation (GI) difficulty is common in people with Parkinson's disease (PD). Studies showed that the GI difficulty was related to impaired anticipatory postural adjustments (APA).
- Trial name
- NCT02656355
- Testing
- Weight shift training and APA feedback, Weight shift training without APA feedback
- Where
- Taiwan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Ornithine Transcarbamylase Deficiency
Safety, Tolerability and Pharmacokinetics of ARCT-810 in Healthy Adult Subjects
Determine the safety, tolerability and pharmacokinetics of single doses of ARCT-810 in healthy adult subjects.
- Trial name
- NCT04416126
- Testing
- ARCT-810
- Where
- New Zealand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Arcturus Therapeutics, Inc.
Epilepsy
Role of Hormones in Susceptibility to Seizures in Women With Epilepsy
This study will measure and compare hormone levels in women with catamenial epilepsy (epilepsy in which seizures are more frequent during menstrual periods), women with seizures not related to their menstrual cycle, and normal…
- Trial name
- NCT00044252
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Lumbar Disc Herniation
Brain Connectomic Mechanisms of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRI
Low back and leg pain caused by lumbar disc herniation (LDH) is common. Lever positioning manipulation (LPM) is a spinal manual therapy used to relieve this pain, but how it affects the brain is unclear.
- Trial name
- NCT07728149
- Testing
- Active Lever Positioning Manipulation
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Premature Birth
2-Brain Regulation to Achieve Improved Neuroprotection During Early Development
Each year 15 million infants are born preterm (PT). Even without severe comorbidities, they are exposed to sensory stress during the Neonatal Intensive Care Unit (NICU) stay and are at greater risk of neurodevelopmental problems…
- Trial name
- 2-BRAINED (NCT06659809)
- Testing
- Tele-care video-feedback intervention (TVFI)
- Where
- 2 sites in Italy
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Stroke, Cerebrovascular Disorders
Novel Brain Stimulation Therapies in Stroke Guided Expressions of Plasticity
The investigators ultimate goal is to personalize brain stimulation for stroke so outcomes of the upper limb can be maximized for each individual patient.
- Conditions
- Stroke, Cerebrovascular Disorders, Nervous System Diseases, Brain Diseases
- Trial name
- NCT03020433
- Testing
- rTMS Contralesional M1, rTMS Contralesional PMC, rTMS Ipsilesional PMC
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Infant, Premature, Brain Injuries
Structural Brain Abnormalities in Children Born Prematurely: New Detection Methods and Clinical-Pathological Correlates
The purpose of the study is to detect structural brain changes using MRI and to correlate these findings with neurodevelopmental assessments in two-year old children previously enrolled in the NIH sponsored trial of inhaled…
- Trial name
- NCT00153855
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Study Focus: 30-day Rehospitalizations Among At-risk Older Adults Randomized to a Social Work-driven Care Transitions Intervention, Heart Disease
Social Work Intervention Focused on Transitions
In response to Program Announcement (PA)-09-164, "NIH Exploratory/Developmental Research Grant Program (R21) a randomized pilot study testing the efficacy of SWIFT: Social Work Intervention Focused on Transitions among at-risk…
- Conditions
- Study Focus: 30-day Rehospitalizations Among At-risk Older Adults Randomized to a Social Work-driven Care Transitions Intervention, Heart Disease, Diabetes, Hypertension
- Trial name
- SWIFT (NCT02232126)
- Testing
- SWIFT home intervention
- Where
- 2 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- University of Southern California
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