Clinical trials: Brain Fog
Brain Activity
Effects of USP Methylene Blue on Cognitive and fMRI Brain Activity
The purpose of the study is to evaluate whether low-dose USP methylene blue (MB) will: i) improve short-term memory retention in a delayed match-to-sample task, ii) reduce reaction time in a psychomotor vigilance test, and iii)…
- Trial name
- NCT01836094
- Testing
- Methylene Blue (USP grade, 280mg oral)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Focus of Study, Stress
The Effectiveness of Guided Imagery for a Nonprofit's Employees
Primary Aim A. To determine if listening to prerecorded guided imagery 3 times per week for 4 weeks will reduce state anxiety, perceived stress, burnout, compassion fatigue, and vicarious trauma in Fronltine Service staff.
- Trial name
- NCT02191345
- Testing
- Guided Imagery
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- FrontLine Service
Quality of Life (QOL), Communication Barriers
The Mental Cost and Burden of Listening
This randomised controlled trial aims to test the effect of hearing adjustment using hearing aids, on the ease and effectiveness of communication such as listening effort, fatigue, and sentence recognition in noise, in addition…
- Conditions
- Quality of Life (QOL), Communication Barriers, Cognitive Performance, Fatigue, Mental
- Trial name
- NCT06951815
- Testing
- Hearing aids programmed to each participant's hearing loss.
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Sleep Quality, Mood
A Clinical Trial to Evaluate the Effects of the Edge+Ease PM+AM System on Mood, Mental Clarity, Sleep Quality, and Digestive Wellbeing
This is a decentralized, single-arm, open-label clinical trial evaluating the effects of the Edge+Ease PM+AM dietary supplement system on sleep quality, mood, mental clarity, focus, and digestive comfort in 35 generally healthy…
- Conditions
- Sleep Quality, Mood, Mental Clarity, Brain Fog
- Trial name
- NCT07721506
- Testing
- Edge+ease PM
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Edge+Ease
Mental Fatigue
Music Intervention on Golfers Under Mental Fatigue
This study aims to evaluate the effects of music intervention on golf-specific skill performance under mental fatigue. It is a randomised, controlled, double-blind design.
- Trial name
- NCT06952283
- Testing
- Inducing mental fatigue, Music intervention
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pan Xiaoyang
Psychological Distress, Secondary Trauma
Feasibility of SOLAR Group Program Among MHPSS Workers After the Earthquake
The goal of this intervention program is to provide the feasibility of a culturally adapted version of the SOLAR program among mental health and psychosocial support (MHPSS) workers who provide psychological or psychosocial…
- Conditions
- Psychological Distress, Secondary Trauma, Depression, Anxiety
- Trial name
- NCT06231927
- Testing
- The Skills for Life Adjustment and Resilience (SOLAR) program
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Koç University
Posttraumatic Stress Disorder, Major Depressive Disorder
An Augmented Training Program for Preventing Post-Traumatic Stress Injuries Among Diverse Public Safety Personnel
Public safety personnel (PSP; e.g., border services personnel, correctional workers, firefighters, paramedics, police, public safety communicators) are frequently exposed to potentially psychologically traumatic events.
- Conditions
- Posttraumatic Stress Disorder, Major Depressive Disorder, Panic Disorder, Generalized Anxiety Disorder
- Trial name
- NCT05530642
- Testing
- Emotional Resilience Skills Training (ERST)
- Where
- Canada
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University of Regina
Anxiety, Depression
Online Multi-component Psychological Intervention for Healthcare Workers During COVID-19 Pandemic
The objective of this study is to carry out a randomized clinical trial with healthcare workers in Mexico through a web platform.
- Conditions
- Anxiety, Depression, Sleep Disturbance, Quality of Life
- Trial name
- NCT04890665
- Testing
- Online psychological intervention for healthcare workers
- Where
- 3 sites in Mexico
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidad Internacional de Valencia
Fatigue; Muscle, Heart, Fatigue, Mental
Effects of Oral Nicotine and Caffeine Pouches on Anaerobic Performance, Autonomic Function, Cognition, and Behavior
The goal of this randomized placebo controlled crossover trial is to determine effects of oral nicotine and caffeine pouches on anaerobic performance, autonomic function, cognition, and behavior in adult non-obese adult male…
- Trial name
- NCT06529055
- Testing
- Oral Pouch - Nicotine, Oral Pouch - Caffeine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern Mississippi
Parkinson Disease, Idiopathic, Freezing of Gait
AID-FOG: Artificial Intelligence-Driven Freezing of Gait Detection in the Home
Freezing of gait (FOG) is a debilitating symptom of Parkinson's disease increases the risk of falling. Despite being a common symptom, it is still difficult to evaluate freezing of gait quickly and accurately.
- Conditions
- Parkinson Disease, Idiopathic, Freezing of Gait, Validation, Wearable Sensors
- Trial name
- AID-FOG (NCT07580612)
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Mental Fatigue
Mental Fatigue Effects on Posture and Spinal Reflexes
This randomized crossover study investigates the effects of mental fatigue on postural control and spinal reflex excitability in healthy physically active adults aged 18-35 years.
- Trial name
- NCT07650903
- Testing
- Mental Fatigue Induction, Control Condition
- Where
- Belgium
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University
Esport Players, Gaming Performance
Mental Fatigue on Reaction Time and Game Performance in Esport Players
Electronic sports (e-sports) gained popularity in the early 2000s within the computer gaming community and reached an audience of approximately 395 million people worldwide by 2018 (Bányai et al., 2019; Nagorsky and Wiemeyer…
- Conditions
- Esport Players, Gaming Performance, Mental Fatigue
- Trial name
- NCT06729060
- Testing
- Combination of Motor Imagery and Physical Performance, Physical Performance
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Bandırma Onyedi Eylül University
Cognitive Fatigue, Mental Fatigue
Effects of Natural Sounds on Attention Restoration Outdoors
This study aims to examine whether listening to natural sounds in a noisy outdoor environment compared to no natural sounds influences behavioural, cognitive, affective, and physiological markers.
- Conditions
- Cognitive Fatigue, Mental Fatigue, Behavioral Performance, Heart Rate Variability
- Trial name
- NEO (NCT05679882)
- Testing
- Masking Sounds, No Masking Sounds
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Mental Fatigue
Impact of Astaxanthin on Cognition in Recreationally Active Females
The purpose of this study is to examine the protentional that the antioxidant Astaxanthin has on mitigating cognitive decline following mental fatigue.
- Trial name
- NCT06460181
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of North Alabama
Red Tide, Neurologic Disorder
Investigating Health Impacts of Exposure to Harmful Algal Blooms
The goals of this project are to study the biological effects of environmental toxins (ET), in particular aquatic toxins such as brevetoxins (PbTx) and microcystin or their metabolites.
- Conditions
- Red Tide, Neurologic Disorder, Florida
- Trial name
- NCT06883227
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Roskamp Institute Inc.
Exogenous Ketosis, Endurance Cycling Performance
The Effects of Exogenous Ketosis on Ultra-endurance Recovery and Performance
The study aims to investigate the effects of post-exercise and pre-sleep ketosis via oral ketone ester supplementation on physical and mental recovery during a multi-day cycling stage race.
- Conditions
- Exogenous Ketosis, Endurance Cycling Performance, Fatigue; Muscle, Heart, Fatigue, Mental
- Trial name
- NCT06965491
- Testing
- Ketone ester supplement
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Healthy Adults
The Effect of Different Physical Activity Strategy on Cognitive Efficiency and Mental Fatigue Resistance
The main aim of this biomedical study is to determine the effect of moderate-intensity aerobic exercise, before and after an 8-hour workday and a combined work model, on the performance and efficiency of cognitive functions…
- Trial name
- NCT07130825
- Testing
- 8 hours simulated mental workday, Moderate intensity aerobic activity, Combined work model
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Menopause
A Cognitive Intervention to Manage 'Brain Fog' in Menopause Transition: Feasibility Study
Cognitive complaints at menopause transition (MT), often described as 'brain fog'; can include difficulty recalling words and numbers, misplacing items, trouble concentrating and forgetfulness.
- Trial name
- NCT06940466
- Testing
- Online cognitive intervention
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University College, London
Neck Pain, Mental Fatigue
Body Awareness and Mental Fatigue in Neck Pain
The primary aim of the study was to examine the difference between mental fatigue, in-body, out-of-body and mindfulness parameters in people with chronic neck pain compared to a healthy control group, and to analyze the…
- Conditions
- Neck Pain, Mental Fatigue, Mindfulness, Awareness
- Trial name
- NCT06434688
- Testing
- Mental Fatigue:, Body Awareness:, Neck Disability Level
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Mental Fatigue, Muscle Strength Dynamometer
Acute Mental Fatigue and Muscle Strength
This study will investigate the acute effects of mental fatigue on lower-extremity muscle strength and limb symmetry in healthy young adults.
- Trial name
- NCT07846618
- Testing
- Computer-Based Mental Fatigue Protocol
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition