Clinical trials: Brain Function, active
Stroke
Efficacy of Music-Based Telerehabilitation After Stroke
The goal of this clinical trial is to learn if a music-based telerehabilitation intervention implemented at home works to treat different kinds of neurological deficits caused by stroke.
- Trial name
- NCT06804304
- Testing
- Music-based telerehabilitation
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Teppo Sarkamo
Traumatic Brain Injury, Stroke
Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without…
- Conditions
- Traumatic Brain Injury, Stroke, Brain Disease, Movement Disorders (Incl Parkinsonism)
- Trial name
- NCT07056348
- Testing
- Deep Brain Stimulation (DBS) of the Motor Thalamus
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jorge Gonzalez-Martinez
COPD - Chronic Obstructive Pulmonary Disease, Healty Controls
Hemodynamic Responses and Brain Activity During Dual Tasks in COPD Patients Versus Healthy Individuals
Abstract Cognitive dysfunction is joint in patients with chronic obstructive pulmonary disease (COPD). In particular, there are effects in tasks that require attention, executive functions, and working memory related to the…
- Trial name
- NCT06974448
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Athetoid CP, Cerebral Palsy (CP)
Comparison of Sensory Integration Therapy and Conventional Physical Therapy on Gross Motor Function in Children With Athetoid Cerebral Palsy: A Randomized Controlled Trial
This is an RCT aiming to explore the comparison of Sensory Integration Therapy and Conventional Physical Therapy on Gross Motor Function in Children with Athetoid Cerebral Palsy
- Trial name
- NCT07611565
- Testing
- Sensory Integration Therapy and Conventional Physical Therapy, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Ibadat International University, Islamabad
Parkinson Disease, REM Sleep Behavior Disorder
Implementing a National Biobank of PD With WGS and Functional Assessment of Polygenic Inheritance by iPSC Technology
The genetic complexity and heterogeneity of the sporadic forms of Parkinson's disease (PD) are posing a formidable challenge to disentangle their direct molecular causes.
- Trial name
- NCT05721911
- Testing
- whole genome sequencing
- Where
- Italy
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Depressive Symptoms, Mild Traumatic Brain Injury
rTMS for Military TBI-related Depression
The purpose of this study is to investigate the efficacy, safety, and tolerability of two dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) protocols to alleviate symptoms of depression in…
- Conditions
- Depressive Symptoms, Mild Traumatic Brain Injury, Concussion
- Trial name
- ADEPT (NCT05426967)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- 3 sites in United States
- Volunteers
- 198 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
TBI Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder
Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy
The purpose of this study is to evaluate how hyperbaric oxygen therapy (HBOT) may affect cognitive functioning, post-traumatic stress disorder (PTSD), depression, anxiety, and overall quality of life in veterans. 1.
- Conditions
- TBI Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder, Post Concussive Syndrome
- Trial name
- NCT07214415
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Summit Hyperbarics and Wellness
High Risk of Stroke
Oriental Intervention for Enhanced Neurocognitive Health (Orient) Diet in Populations With High Risk of Stroke (ENDS)
This randomized controlled trial will enroll 160 individuals aged over 40 without dementia who are at high risk of stroke, collecting multi-modal MRI imaging, serum, and fecal samples to investigate the impact of the ORIENT diet…
- Trial name
- NCT06098235
- Testing
- Usual Diet advice, ORIENT diet intervention
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke
Diaphragm Function and Urinary Incontinence in Stroke
Stroke affects respiratory functions by causing structural and strength impairments in both inspiratory and expiratory respiratory muscles.
- Trial name
- NCT07048210
- Volunteers
- 50 people
- Sponsor
- Istinye University
Quality of Life (QOL), Anxiety
Testing the Efficacy of the "Syd" App on Improving Quality of Life and Mental Health Among University Students in the Kingdom of Saudi Arabia
The goal of this clinical trial is to learn if using the "See Yourself Differently" (syd) app can help improve quality of life and mental health for university students in Saudi Arabia.
- Conditions
- Quality of Life (QOL), Anxiety, Stress, Affect (Mental Function)
- Trial name
- NCT06979778
- Testing
- See Yourself Differently (syd) mobile app
- Where
- Saudi Arabia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- iamYiam Limited
Parkinson's Disease (PD), Deep Brain Stimulation
The Relation Between the Prognosis of Subthalamic Nucleus Deep Brain Stimulation Surgery by Microlesion Effect and Electrode Position
BACKGROUND: Parkinson's disease (PD) is a common movement disorder whose main symptoms include resting tremor, rigidity and bradykinesia.
- Trial name
- Microlesion Ef (NCT06685510)
- Testing
- the score of UPDRS item
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Mild Cognitive Impairment, Dementia
Remote Game-based Exercise Program for Cognitive and Motor Function Improvement
As our population ages, more older adults face motor-cognitive declines, increasing their risk of falls and fear of falling. Exercise is an effective way to maintain cognitive function, as supported by recent studies.
- Conditions
- Mild Cognitive Impairment, Dementia, Cognitive Impairment, Memory Loss
- Trial name
- NCT05235113
- Testing
- Tele-Exergame Platform, No Tele-Exergame Platform
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- University of California, Los Angeles
Healthy, Brain Insulin Sensitivity
Long-Term Effects of Walnut Consumption on Brain Function
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Conditions
- Healthy, Brain Insulin Sensitivity, Cerebral Blood Flow, Brain Vascular Function
- Trial name
- WalBrain (NCT07422220)
- Testing
- Walnuts
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Stroke Ischemic, Stroke Acute
Posterior Circulation ASTRAL Prognostic Score
The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke…
- Conditions
- Stroke Ischemic, Stroke Acute, Posterior Circulation Brain Infarction, Risk Score
- Trial name
- NCT05906420
- Testing
- ASTRAL prognostic score
- Where
- 2 sites in Greece, Switzerland
- Volunteers
- 2,000 people
- Sponsor
- University of Thessaly
Autism Spectrum Disorder
pBFS Guided rTMS Over Cognitive Control Network for ASD
The aim of this trial is to assess the efficacy and safety of precision neuromodulation for alleviating core symptoms in patients with autism spectrum disorder (ASD) who also have intellectual or developmental delay.
- Trial name
- NCT06255535
- Testing
- active iTBS treatment
- Where
- 6 sites in China
- Volunteers
- 215 people
- Sponsor
- Changping Laboratory
Premature Baby, Pulmonary Hypertension of Newborn
Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography
This study aims to improve how neonatologists check the heart function of newborn babies, especially those who are sick. While standard heart ultrasound scans are useful, a more advanced and sensitive technique called 2D speckle…
- Conditions
- Premature Baby, Pulmonary Hypertension of Newborn, Hypoxic Ischaemic Encephalopathy (HIE), Congenital Diaphragmatic Hernia
- Trial name
- NCT07364682
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Healthy
Chatbot Intervention Effects on Resting-State Brain Function in Anhedonia
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on resting-state brain function in college students with elevated anhedonia and depressive…
- Trial name
- NCT07665216
- Testing
- MI Chatbot Interaction, Active Control Chatbot Interaction
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Aphasia
LEXURE for Post-Stroke Aphasia
This study evaluates the efficacy of digital language rehabilitation using LEXURE for the treatment of post-stroke aphasia. Half of participants will receive structured language training using the LEXURE application, while the…
- Trial name
- NCT07570264
- Testing
- LEXURE, Workbook
- Where
- 12 sites in South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Nunaps Inc
Stroke
Effects Of Functional Action Observation With Auditory Cueing In Stroke Patients
This study aims to determine the effects of functional action observation therapy with and without rhythmic auditory cueing on balance and gait in patients with stroke.
- Trial name
- NCT07428824
- Testing
- Functional Action Observation Therapy, Functional Action Observation Therapy with rhythmic auditory stimulation group
- Where
- 2 sites in Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
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