Quality of Life (QOL)NCT06979778
Testing the Efficacy of the "Syd" App on Improving Quality of Life and Mental Health Among University Students in the Kingdom of Saudi Arabia
A study testing See Yourself Differently (syd) mobile app in people with Quality of Life (QOL) and Anxiety, run by iamYiam Limited at 1 site in Saudi Arabia.
Trial summary
The goal of this clinical trial is to learn if using the "See Yourself Differently" (syd) app can help improve quality of life and mental health for university students in Saudi Arabia. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Quality of Life (QOL), Anxiety, Stress
- What is being tested?
- See Yourself Differently (syd) mobile app
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 600 participants
- Where
- 1 siteSaudi Arabia
- Study dates
- May 2025to Aug 2025
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age ≥ 18 years.
- Enrolled as a full-time medical student at the Alfaisal university.
- Owning a smartphone (iOS or Android) compatible with the "syd" app.
- Willing to provide informed consent and comply with study procedures
Who cannot join
- Known severe psychiatric or cognitive conditions that impede app usage
- Inability to provide informed consent
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Lorena Puica contact
Saudi Arabia1 site
Alfaisal University
Riyadh, 11533
Ahmed Abu-Zaid, MD, +966568104818, amabuzaid@alfaisal.edu
Ahmed Abu-Zaid, MD
About this study
Official title: A Randomized Controlled Trial to Assess the Efficacy of the "Syd" App on Improving Quality of Life and Mental Health Among University Students in the Kingdom of Saudi Arabia
The goal of this clinical trial is to learn if using the "See Yourself Differently" (syd) app can help improve quality of life and mental health for university students in Saudi Arabia. The study also aims to see if the app can help lower anxiety and stress, and increase positive feelings while decreasing negative feelings.
The main questions it aims to answer are:
Read more
- Does the "syd" app improve the quality of life for university students?
- Does the "syd" app help lower anxiety and stress in university students
- Does the "syd" app help increase positive feelings and decrease negative feelings in university students?
Researchers will compare students who use the "syd" app to see if it works.
Participants will:
- Use the "syd" app for 3 months.
- Complete surveys about their quality of life, anxiety, stress, and feelings.
Read the detailed description
This clinical trial outlines a prospective, parallel-group, single-blind randomised controlled trial to be conducted at Alfaisal University in the Kingdom of Saudi Arabia. The study will enrol 600 university students and staff members and will run for a 3-month intervention period.
The intervention focuses on the 'syd' mobile application, an AI-powered "Life Quality Mentor" designed to enhance users' quality of life. The app aims to support positive habit development by providing personalised feedback and continuous support. Key features include personalised guidance across various domains such as nutrition, sleep performance, stress management (including guided meditations and journaling), and financial well-being. The 'syd' app utilizes an advanced Artificial Intelligence (AI) platform, offering an AI conversational agent for motivational coaching, habit tracking tools, and integration with wearable technology.
Participants will be randomly allocated to either an experimental group, which will use the 'syd' app, or a control group. Those in the experimental group will be instructed to use the 'syd' app for the 3-month duration of the study.
Data will be collected at multiple time points: at baseline (prior to intervention), monthly during the 3-month intervention period, and at a final follow-up post-intervention. The primary data collection methods will involve validated research instruments (WHOQOL-BREF, PANAS-X, GAD-7, PSS) administered via Typeform surveys. Additionally, in-app data will be collected to monitor app usage, specifically the frequency and duration of engagement. Socio-demographic information will also be gathered.
Survey data will be stored securely within Typeform, and in-app data will be stored within the 'syd' application's database, hosted securely on Amazon Web Services (AWS). All data storage will comply with Alfaisal University's data security policies. To protect participant privacy, data will be anonymised or de-identified where possible, and access will be restricted to authorised research team members. Data will be encrypted during storage and transmission.
For data analysis, linear mixed-effects modelling will be employed, incorporating random intercepts for participants and fixed effects for time, group, and the time x group interaction. The analysis will adhere to intention-to-treat principles. Should missing data occur, multiple imputation will be considered if feasible. Data from Typeform surveys will be exported and cleaned, in-app data will be extracted and processed, and data from these different sources will be merged for comprehensive analysis
- Conditions
- Quality of Life (QOL), Anxiety, Stress, Affect (Mental Function)
- Being tested
- See Yourself Differently (syd) mobile app
- Keywords
- syd, QoL, See Yourself Differently, Quality of Life, mHealth, App, RCT
- Medical subject headings
- Anxiety Disorders, Alzheimer Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
See Yourself Differently (syd) mobile appDevice
Also called syd, See Yourself Differently
The 'syd' mobile app is designed as an AI-powered "Life Quality Mentor" with the primary aim of enhancing users' quality of life. The app focuses on positive habit development, personalised feedback, and continuous support. It offers personalised guidance across various domains, including Physical health, Emotional health, Brain power, Self-awareness, Purpose, Career, Financial health, Social life and Environment. It utilizes an advanced AI platform and offers features like personalised recommendations, supportive interaction with an AI mentor, habit tracking tools, and integration with wearable technology.
| Study group | Role | What they receive |
|---|---|---|
| syd app | Experimental | The 'syd' application is designed as an AI-powered "Life Quality Mentor" with the primary aim of enhancing users' quality of life. The app focuses on positive habit development, personalised feedback, and continuous support. It offers personalised guidance across various domains, including Physical health, Emotional health, Brain power, Self-awareness, Purpose, Career, Financial health, Social life and Environment. It utilizes an advanced AI platform and offers features like personalised recommendations, supportive interaction with an AI mentor, habit tracking tools, and integration with wearable technology.
The intervention arm will have full access to the 'syd' app and be able to interact with it for the 3 months duration of the trial Receives: Device: See Yourself Differently (syd) mobile app |
| Wait list control | No intervention | The wait list control arm will not receive access to the 'syd' app for the 3 months' duration of the trial, but will be given full lifetime access thereafter. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Quality of Life Domain Scores
Quality of Life (QoL) as measured through the WHOQOL-BREF instrument. The WHOQOL-BREF is a 26-item questionnaire which uses a scoring system that assesses quality of life across four domains: physical health, psychological health, social relationships, and environmental health. Each item is scored on a 5-point scale (1-5) and transformed to a 0-100 scale. Domain scores are calculated by summing relevant item scores and transforming them to a 0-100 scale. Higher scores indicate better quality of life in a specific domain.
Measured: From enrolment to the end of treatment at 3 months
Secondary outcomes (3)
Change in Anxiety Score
Change in Anxiety scores as measured through the General Anxiety Disorder-7 (GAD-7) questionnaire. The GAD-7 scoring system uses a simple system to assess anxiety levels. Each of the seven questions on the GAD-7 questionnaire is scored from 0 to 3, with 0 representing "not at all" and 3 representing "nearly every day." The total score is calculated by adding up the scores for all seven questions, resulting in a total score ranging from 0 to 21. Score interpretation: 0-4: Minimal to no anxiety; 5-9: Mild anxiety; 10-14: Moderate anxiety; 15 or higher: Severe anxiety.
Measured: From enrolment to the end of treatment at 3 months
Change in Perceived Stress Score
Change in Perceived Stress Score as measured through the Perceived Stress Scale (PSS) questionnaire. The PSS scores are determined by summing individual item responses and interpreting the total score. Higher scores indicate a higher level of perceived stress. The total score can range from 0 to 56, with higher scores reflecting higher levels of stress.
Measured: From enrolment to the end of treatment at 3 months
Change in Positive and Negative Affect Scores
Change in Positive and Negative Affect Scores as measured through the Positive and Negative Affect Schedule - Expanded Version (PANAS-X) questionnaire. The PANAS-X is composed of 60 items (emotions) on a 5-point scale (1 to 5) where participants can indicating how much they feel each emotion. A total positive and negative affect score is calculated by summing the responses for the respective sets of items. Higher scores on the positive affect scale indicate greater positive affect, while lower scores on the negative affect scale indicate less negative affect.
Measured: From enrolment to the end of treatment at 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 May 2025
- Study startMay 2025 (estimated)
- Primary completionAug 2025 (estimated)
- Study completionAug 2025 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Quality of Life (QOL)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 600 participants (estimated)
Sponsor and investigators
- Lead sponsor
- iamYiam Limited
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Alfaisal University
- Responsible party
- Sponsor
- Investigators
- Ahmed Abu-Zaid, MD, Principal investigator, Alfaisal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06979778
- Sponsor's protocol ID
- 20250512
- Status last verified
- May 2025
- First submitted
- 12 May 2025
- Last updated
- 23 May 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 23 May 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Randomized Controlled Trial to Assess the Efficacy of the "Syd" App on Improving Quality of Life and Mental Health Among University Students in the Kingdom of Saudi Arabia
- ClinicalTrials.gov ID
- NCT06979778
- Acronym / sponsor ID
- 20250512
- Conditions
- Quality of Life (QOL), Anxiety, Stress, Affect (Mental Function)
- Keywords
- syd, QoL, See Yourself Differently, Quality of Life, mHealth, App, RCT
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 600 participants (estimated)
- Lead sponsor
- iamYiam LimitedIndustry (pharma, biotech, devices)
- Collaborators
- Alfaisal University
- Study start
- May 2025 (estimated)
- Primary completion
- Aug 2025 (estimated)
- Study completion
- Aug 2025 (estimated)
- First posted
- 20 May 2025 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn if using the "See Yourself Differently" (syd) app can help improve quality of life and mental health for university students in Saudi Arabia. The study also aims to see if the app can help lower anxiety and stress, and increase positive feelings while decreasing negative feelings.
The main questions it aims to answer are:
- Does the "syd" app improve the quality of life for university students?
- Does the "syd" app help lower anxiety and stress in university students
- Does the "syd" app help increase positive feelings and decrease negative feelings in university students?
Researchers will compare students who use the "syd" app to see if it works.
Participants will:
- Use the "syd" app for 3 months.
- Complete surveys about their quality of life, anxiety, stress, and feelings.
Detailed description
This clinical trial outlines a prospective, parallel-group, single-blind randomised controlled trial to be conducted at Alfaisal University in the Kingdom of Saudi Arabia. The study will enrol 600 university students and staff members and will run for a 3-month intervention period.
The intervention focuses on the 'syd' mobile application, an AI-powered "Life Quality Mentor" designed to enhance users' quality of life. The app aims to support positive habit development by providing personalised feedback and continuous support. Key features include personalised guidance across various domains such as nutrition, sleep performance, stress management (including guided meditations and journaling), and financial well-being. The 'syd' app utilizes an advanced Artificial Intelligence (AI) platform, offering an AI conversational agent for motivational coaching, habit tracking tools, and integration with wearable technology.
Participants will be randomly allocated to either an experimental group, which will use the 'syd' app, or a control group. Those in the experimental group will be instructed to use the 'syd' app for the 3-month duration of the study.
Data will be collected at multiple time points: at baseline (prior to intervention), monthly during the 3-month intervention period, and at a final follow-up post-intervention. The primary data collection methods will involve validated research instruments (WHOQOL-BREF, PANAS-X, GAD-7, PSS) administered via Typeform surveys. Additionally, in-app data will be collected to monitor app usage, specifically the frequency and duration of engagement. Socio-demographic information will also be gathered.
Survey data will be stored securely within Typeform, and in-app data will be stored within the 'syd' application's database, hosted securely on Amazon Web Services (AWS). All data storage will comply with Alfaisal University's data security policies. To protect participant privacy, data will be anonymised or de-identified where possible, and access will be restricted to authorised research team members. Data will be encrypted during storage and transmission.
For data analysis, linear mixed-effects modelling will be employed, incorporating random intercepts for participants and fixed effects for time, group, and the time x group interaction. The analysis will adhere to intention-to-treat principles. Should missing data occur, multiple imputation will be considered if feasible. Data from Typeform surveys will be exported and cleaned, in-app data will be extracted and processed, and data from these different sources will be merged for comprehensive analysis
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| syd app | Experimental | Device: See Yourself Differently (syd) mobile appThe 'syd' application is designed as an AI-powered "Life Quality Mentor" with the primary aim of enhancing users' quality of life. The app focuses on positive habit development, personalised feedback, and continuous support. It offers personalised guidance across various domains, including Physical health, Emotional health, Brain power, Self-awareness, Purpose, Career, Financial health, Social life and Environment. It utilizes an advanced AI platform and offers features like personalised recommendations, supportive interaction with an AI mentor, habit tracking tools, and integration with wearable technology. The intervention arm will have full access to the 'syd' app and be able to interact with it for the 3 months duration of the trial |
| Wait list control | No intervention | –The wait list control arm will not receive access to the 'syd' app for the 3 months' duration of the trial, but will be given full lifetime access thereafter. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age ≥ 18 years.
- Enrolled as a full-time medical student at the Alfaisal university.
- Owning a smartphone (iOS or Android) compatible with the "syd" app.
- Willing to provide informed consent and comply with study procedures
Key exclusion criteria (2 listed)
- Known severe psychiatric or cognitive conditions that impede app usage
- Inability to provide informed consent
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| See Yourself Differently (syd) mobile appAlso: syd, See Yourself DifferentlyThe 'syd' mobile app is designed as an AI-powered "Life Quality Mentor" with the primary aim of enhancing users' quality of life. The app focuses on positive habit development, personalised feedback, and continuous support. It offers personalised guidance across various domains, including Physical health, Emotional health, Brain power, Self-awareness, Purpose, Career, Financial health, Social life and Environment. It utilizes an advanced AI platform and offers features like personalised recommendations, supportive interaction with an AI mentor, habit tracking tools, and integration with wearable technology. | Device | syd app |
Primary outcome
Change in Quality of Life Domain Scores
Time frame: From enrolment to the end of treatment at 3 months
Quality of Life (QoL) as measured through the WHOQOL-BREF instrument. The WHOQOL-BREF is a 26-item questionnaire which uses a scoring system that assesses quality of life across four domains: physical health, psychological health, social relationships, and environmental health. Each item is scored on a 5-point scale (1-5) and transformed to a 0-100 scale. Domain scores are calculated by summing relevant item scores and transforming them to a 0-100 scale. Higher scores indicate better quality of life in a specific domain.
3 secondary outcomes
Change in Anxiety Score
Time frame: From enrolment to the end of treatment at 3 months
Change in Perceived Stress Score
Time frame: From enrolment to the end of treatment at 3 months
Change in Positive and Negative Affect Scores
Time frame: From enrolment to the end of treatment at 3 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 May 2025.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Lorena Puica contact
Ahmed Abu-Zaid, MD principal investigator
Alfaisal University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing See Yourself Differently (syd) mobile app in people with Quality of Life (QOL) and Anxiety, run by iamYiam Limited at 1 site in Saudi Arabia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 23 May 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Saudi Arabia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Pedro M Henriques, PhD (+351928091841, pedro.henriques@syd.life), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Quality of Life Domain Scores (time frame: From enrolment to the end of treatment at 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 May 2025.