Clinical trials: Brain Herniation
Cervical Disc Disease, Cervical Stenosis
Is There a Risk of Perioperative Stroke Due to the Retraction Used During Anterior Cervical Discectomy?
In anterior cervical disc surgery, head and neck extansion position and, surgical retraction used while reaching the anterior surface of the cervical vertebra can be affect the carotid blood flow and constituting a risk for…
- Conditions
- Cervical Disc Disease, Cervical Stenosis, Cervical Disc Herniation
- Trial name
- NCT05717010
- Testing
- Near infrared spectroscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Samsun University
Epidural Hematoma, Brain Herniation
Prospective Randomized Evaluation of Decompressive Ipsilateral Craniectomy for Traumatic Acute Epidural Hematoma
Although craniotomy provides a more complete evacuation of the acute epidural hematoma, there are insufficient data to support specific surgical treatment method.
- Conditions
- Epidural Hematoma, Brain Herniation, Decompressive Craniectomy, Craniotomy
- Trial name
- PREDICT-AEDH (NCT04261673)
- Testing
- Decompressive Craniectomy, Craniotomy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- RenJi Hospital
Pituitary Tumor, Meningioma
Long-Term Longitudinal QoL in Patients Undergoing EEA
This is a prospective longitudinal study to access postoperative 2-year quality of life in patients who undergo endonasal endoscopic approach surgeries of the skull base.
- Conditions
- Pituitary Tumor, Meningioma, Rathke Cleft Cysts, Chordoma
- Trial name
- NCT04087902
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Ohio State University
Lumbar Disc Herniation
Brain Effect Mechanism of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRI
The clinical symptoms of Lumbar Disc Herniation (LDH) can be effectively ameliorated through Spinal Manipulative Therapy (SMT), which is closely linked to the brain's pain-regulating mechanisms.
- Trial name
- NCT06277739
- Testing
- Spinal Manipulative Therapy
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zhou Xingchen
Lumbar Disc Herniation, Multimodal Brain Function
Brain Effect Mechanism of Lever Positioning Manipulation on LDH Analgesia Based on Multimodal MRI
In order to further investigate the key brain targets and central response mechanism characteristics of analgesia, the dominant disease of LDH was taken as the object of this study, which was divided into operation group, comfort…
- Conditions
- Lumbar Disc Herniation, Multimodal Brain Function, Analgesia Mechanism, Lever Positioning Manipulation
- Trial name
- NCT05613179
- Testing
- Group1 (lever positioning manipulation)
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Subarachnoid Hemorrhage
Impact of Herniation on WFNS Grading in Spontaneous Subarachnoid Hemorrhage - a SWISS SOS Observational Trial
All patients (≥18 years) with a spontaneous SAH proven by computed tomography (CT), magnetic resonance imaging (MRI) or lumbar puncture will be considered for this trial.
- Trial name
- hWFNS (NCT02304328)
- Testing
- Clinical assessment
- Where
- 8 sites in Switzerland
- Volunteers
- 250 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Skull Fractures, Stroke
Simulation Training in Emergency Department Imaging 2
Background and study aims: Computerised Tomography (CT) head scans are frequently requested by Emergency Department (ED) clinicians as one of the investigations for their patients.
- Conditions
- Skull Fractures, Stroke, Intracranial Bleed, Brain Tumor
- Trial name
- STEDI2 (NCT05427838)
- Testing
- Online training
- Where
- 6 sites in United Kingdom
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Cognitive Impairment, Brain Herniation
Cranioplasty Cognitive Outcome Study
This will be a multicenter prospective randomized study of adult patients with an acquired skull defect as a result of craniectomy and considered suitable for cranioplasty, i.e.
- Trial name
- NCT03791996
- Testing
- "Early" cranioplasty
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Kwong Wah Hospital
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Lumbar Disc Disease, Lumbar Spinal Stenosis
The Effects of Anesthesia on Cerebral Perfusion in Patients With High Blood Pressure
High blood pressure is a serious and common health problem. This disease affects 1 billion people all over the world and responsible for 7,1 million deaths.
- Conditions
- Lumbar Disc Disease, Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Fracture
- Trial name
- NCT04587401
- Testing
- normotensive patients, patients with hypertension diagnosis, patients who do not know they are hypertensive but actual blood pressure is high
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Akdeniz University
Cerebral Herniation
Hemicraniectomy in Patients With Malign Middle Cerebral Artery Infarction
This trial is a prospective, randomized, controlled, clinical trial based on a stroke center. We randomly assigned 151 patients 41 years of age or older (median, 65 years; range, 41 to 83) with malignant middle cerebral artery…
- Trial name
- NCT04555460
- Testing
- Hemicraniectomy, Conservative medical therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 151 people
- Sponsor
- Ege University
Lumbar Disc Herniation, Respiratory Mechanics
Pulmonary Mechanics and Cerebral Oxygenation During Prone Lumbar Disc Surgery
This prospective observational study aims to evaluate the relationship between changes in respiratory mechanics and cerebral oxygenation in adult patients undergoing elective lumbar disc surgery in the prone position under…
- Conditions
- Lumbar Disc Herniation, Respiratory Mechanics, Cerebral Oxygenation
- Trial name
- NCT07862257
- Testing
- Prone Positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Acute Cerebrovascular Accident, Cerebral Edema
Study of Stroke Related Edema Treatments
Stroke remains the fourth leading cause of death in the United States (second worldwide) and a leading cause of long-term disability, resulting in total direct and indirect costs of approximately $73.7 billion annually.
- Trial name
- NCT01954290
- Testing
- Conivaptan, Hypertonic saline, Mannitol
- Sponsor
- University of Florida
Tracheo Esophageal Fistula, Congenital Diaphragmatic Hernia
Cerebral Blood Flow in Neonates During Thoracoscopic Surgeries
the aim of this study is to compare the effect of different modes of mechanical ventilation by using volume-controlled ventilation and pressure-controlled ventilation on cerebral blood flow monitored by cerebral oximetry during…
- Trial name
- NCT04507295
- Testing
- cerebral oximetry ( INVOS 5100 )
- Volunteers
- 30 people
- Sponsor
- Cairo University
Inguinal Hernia, Arterial Disease
Inguinal Hernia and Arterial Disease
Inguinal hernias are associated with problems related to the venous system by the linking to extracellular matrix alterations (ECM).
- Trial name
- HEARD (NCT04428138)
- Testing
- In-office vascular visit, Echo duplex scan of arterial system
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Catanzaro
Esophageal Atresia With Tracheo-esophageal Fistula, Congenital Diaphragmatic Hernia
Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases
This is a pilot randomised controlled trial comparing open versus thoracoscopic surgery for repair of oesophageal atresia with tracheo-oesophageal fistula or congenital diaphragmatic hernia in neonates.
- Trial name
- CO2 (NCT01467245)
- Testing
- Hypercapnia during thoracoscopy, Open surgery
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Premature Baby, Pulmonary Hypertension of Newborn
Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography
This study aims to improve how neonatologists check the heart function of newborn babies, especially those who are sick. While standard heart ultrasound scans are useful, a more advanced and sensitive technique called 2D speckle…
- Conditions
- Premature Baby, Pulmonary Hypertension of Newborn, Hypoxic Ischaemic Encephalopathy (HIE), Congenital Diaphragmatic Hernia
- Trial name
- NCT07364682
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Middle Cerebral Artery Infarction
Stereotactic Infarct Tissue Aspiration for Malignant Infarction of Middle Cerebral Artery
Malignant middle cerebral artery infarction(MMCI) has a high rate of disability and mortality. At present, there is no effective treatment except for craniotomy decompression, but the controversy of the craniotomy decompression…
- Trial name
- SMART (NCT02609256)
- Testing
- Stereotactic infarct tissue aspiration, Medical therapy
- Where
- China
- Volunteers
- 12 people
- Sponsor
- General Hospital of Shenyang Military Region
Lumbar Disc Herniation
Brain Connectomic Mechanisms of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRI
Low back and leg pain caused by lumbar disc herniation (LDH) is common. Lever positioning manipulation (LPM) is a spinal manual therapy used to relieve this pain, but how it affects the brain is unclear.
- Trial name
- NCT07728149
- Testing
- Active Lever Positioning Manipulation
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University