Clinical trials: Brain Injuries
Mild Traumatic Brain Injury
HEAD Injury Serum Markers and Multi-modalities for Assessing Response to Trauma
The goal of HeadSMART II (HEAD injury Serum markers and Multi-modalities for Assessing Response to Trauma II) is to develop an In-Vitro Diagnostic, the BRAINBox TBI test, to aid in the diagnosis and prognosis of patients with…
- Trial name
- HeadSMART II (NCT04423198)
- Testing
- Cognitive Assessment, Patient Reported Neurological Outcome Assessments, Blood Draw
- Where
- 11 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- BRAINBox Solutions Inc
Acquired Brain Injury, Mental Health
Occupational Therapy for Mental Health and Engagement in Neurorehabilitation
Changes in mental health are common after acquired brain injury (ABI), defined as any traumatic or non-traumatic injury to the brain after birth, affecting approximately 1 in 3 adults with ABI.
- Conditions
- Acquired Brain Injury, Mental Health, Depressive Symptoms, Anxiety Symptoms
- Trial name
- OT for ME (NCT07375485)
- Testing
- Multifaceted implementation program
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Epilepsy, HHV6B Infection
Relationship of HHV-6B Virus to Seizures and Brain Injury
This study will look for evidence that a virus called HHV-6B may be related to seizures and to a form of brain injury called mesial temporal sclerosis that is associated with seizures.
- Trial name
- NCT00597285
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Traumatic Brain Injury
Automated Extracranial Internal Carotid Artery Ultrasound Sensor for Traumatic Brain Injury
Traumatic brain injury (TBI) affects 1.7 million people in the United States each year, resulting in 2.5 million emergency department visits, 280,000 hospitalizations, >50,000 deaths, and more than $60 billion in economic cost.
- Trial name
- NCT03482206
- Testing
- Automated extracranial internal carotid artery ultrasound sensor
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Cerebral Palsy
The Engineer-Built System, Video-Game Based Kinect Sensor in Upper Extremities Problems in Cerebral Palsy Children
There are 3 phases of this project. First phase is to study the satisfaction in healthy children aged 10-15 years old when they are playing our computer games. The sample size of this phase was 10.
- Trial name
- NCT05311358
- Testing
- The engineer-built system, video-game based Kinect sensor
- Where
- Thailand
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Cerebral Palsy
Relationships Between OLST, GMFM and Pedobarographic Values in CP
The primary aim of this study was to investigate the relationship between the One Leg-Standing Test (OLST) and the Gross Motor Function Measurement (GMFM) and stance phase stability during gait in Unilateral Cerebral Palsy (UCP).
- Trial name
- NCT04273204
- Testing
- one leg standing test, gross motor function measurement, pedobarographic measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Istanbul Kültür University
Concussion, Brain
The TRAIN Study: A Concussion Prevention Strategy in Middle Schools
Purpose: The purpose of this study is to evaluate the effectiveness of a theory-driven intervention (TRAIN concussion education) to improve parental concussion-related attitudes, beliefs, intentions, confidence in knowledge, and…
- Trial name
- NCT04841473
- Testing
- TRAIN Concussion Education, Standard Concussion Education
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Robot-aided Arm Therapy, Brain Injury, Motor Relearning Programme, Activities of Daily Living
Robot-Aided Neurorehabilitation of the Upper Extremities
Task-oriented repetitive movement can improve movement performance in patients with neurological or orthopedic lesions. The application of robotics can serve to assist, enhance, evaluate, and document neurological and orthopedic…
- Trial name
- NCT02434237
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cervical Spinal Cord Injury, Tetraplegia/Tetraparesis
Spinal Cord Associative Plasticity Study
Spinal cord associative plasticity (SCAP) is a combined cortical and spinal electrical stimulation technique developed to induce recovery of arm and hand function in spinal cord injury.
- Conditions
- Cervical Spinal Cord Injury, Tetraplegia/Tetraparesis, Cervical Myelopathy
- Trial name
- SCAP (NCT05163639)
- Testing
- Non-invasive pairing of cortical and spinal stimulation, Intraoperative pairing of cortical and spinal stimulation, Non-invasive repeated pairing of cortical and spinal stimulation (SCAP)
- Where
- 3 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Columbia University
Brain Injuries, Traumatic, Biomarkers
Detecting Traumatic Intracranial Hemorrhage With Microwaves and Biomarkers
This study will evaluate if traumatic intracranial hemorrhage can be safely ruled out by using a microwave scanner (MD100) in conjunction with a combination of different brain biomarkers analyzed in serum.
- Conditions
- Brain Injuries, Traumatic, Biomarkers, Microwave Imaging
- Trial name
- MBI01 (NCT04666766)
- Testing
- Microwave scanning of the head
- Where
- Sweden
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Region Skane
Alzheimer Disease, Biomarker in Early Diagnosis
miR-342-5p/AnkG Pathway in Early AD Synaptic Dysfunction
Alzheimer's disease is the most common memory loss disease among the elderly. This disease affects the patient's memory, language, attention, and behavioral abilities.
- Trial name
- NCT07353502
- Testing
- Collect peripheral blood, and if the patient consents, also collect cerebrospinal fluid.
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Concussion
Driving Performance of Teenage Patients With mTBI: a Longitudinal Assessment
This study will synthesize a behavioral profile of impaired driving performance for teenage patients with mild traumatic brain injury (mTBI), or concussion, from one week post-concussion to six weeks post-concussion.
- Trial name
- NCT02278029
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cortical/Cerebral Visual Impairment, Cerebral Palsy
Examining the Effect of Eye Gaze Technology on Children With Cortical Visual Impairment
The goal of this study is to learn about eye gaze technology's use as an assessment and intervention of visual skills and the impact on occupational performance in children with cortical/cerebral visual impairment.
- Trial name
- NCT06067607
- Testing
- eye gaze technology
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rockhurst University
Cerebral Palsy, Muscle Spasticity
Effect of Botox and Vibration on Bone in Children With Cerebral Palsy
Cerebral palsy (CP) is a neuromuscular disorder that affects approximately 800,000 individuals in the U.S. An estimated 70-80% of these individuals have spasticity which affects ambulation and requires management.
- Trial name
- NCT01803464
- Testing
- Low-magnitude vibration, Botox
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Osteoarthritis, RA
Surgical Tourniquets and Cerebral Emboli
BACKGROUND In 2012 76,497 primary total knee (TKR) replacements were performed in England, Wales and Northern Ireland . Traditionally TKR surgery is undertaken with the aid of a surgical tourniquet.
- Conditions
- Osteoarthritis, RA, Trauma
- Trial name
- NCT02240732
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Perinatal Brain Injury, Healthy Participants
Sparking Potential, Revealing Infant Neurocognitive Traits
This research focuses on the long-term cognitive development of children, including healthy infants and those who had a perinatal brain injury. As part of this research study, children complete virtual game and assessments.
- Trial name
- SPRINT (NCT07390136)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cerebral Palsy
Strength and Dexterity of Less Affected Hand of Hemiparetic Cerebral Palsy Children
The contralateral hand deficits are often masked by the complex clinical presentation of the more affected hand in children with spastic hemiparesis.
- Trial name
- NCT05546164
- Testing
- Assessment of hand grip strength, Assessment of pinch strength, Assessment of upper limb dexterity
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Subdural Hematoma
Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a common disease after minor head trauma, especially in elderly patients. This medical condition is characterized by blood collection in the subdural space, which can result in severe…
- Trial name
- TRACE (NCT03280212)
- Testing
- Tranexamic Acid 500 MG
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cerebral Palsy (CP)
Effect Of Virtual Reality On Strength and Coordination in Cerebral Palsy
ABSTRACT: Purpose: To investigate the effect of interactive training on muscle strength and coordination in children with hemiparesis.
- Trial name
- NCT06520644
- Testing
- Wii-based interactive training program, Traditional physical therapy program
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shimaa Mohamed Reffat
Concussion, Mild, Convergence Insufficiency
Spectacles Lens in Concussed Kids
We will be looking at 3 treatment arms in the form of different type of glasses to see if one is superior to helping kids have sustained a concussion and are symptomatic.
- Conditions
- Concussion, Mild, Convergence Insufficiency, Accommodation; Insufficiency
- Trial name
- SLICK (NCT03123822)
- Testing
- Glasses
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
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