Clinical trials: Brain Injuries
Postdural Puncture Headache, Post-Lumbar Puncture Headache
Incidence of Headache Following an Unintentional Dural Puncture
The purpose of this study is to evaluate the use of intrathecal morphine administration following an unintentional dural puncture, to decrease the incidence of post dural puncture headaches (PDPH) in obstetric patients.
- Conditions
- Postdural Puncture Headache, Post-Lumbar Puncture Headache, Cerebrospinal Fluid Leaks
- Trial name
- NCT01977898
- Testing
- Morphine, Saline
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Traumatic Brain Injury, Brain Concussion
Comparison of the DANA to the ANAM in the Evaluation of Cognitive Changes After Concussion
The Defense Automated Neurobehavioral Assessment (DANA) was recently developed as a durable, portable, and "field-hardened" NeuroCognitive Assessment Tool.
- Trial name
- NCT01728142
- Testing
- DANA Brief, ANAM
- Where
- Afghanistan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Cerebral Palsy
Universal Exercise Unit Versus Functional Electrical Stimulation On Genu Recurvatum In Diplegic Cerebral Palsy
Summary: Inclusion Criteria: Children aged four to eight years. Grade of spasticity ranging from 1 to 1+ on the Modified Ashworth scale. Classified as Level I or II on the Gross Motor Functional Classification System (GMFCS).
- Trial name
- NCT06332729
- Testing
- universal exercis unit, functional electrical stimulation
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mahmoud Reda Elsharkawy
Carpal Tunnel Syndrome
Brain Plasticity in Carpal Tunnel Syndrome and Its Response to Acupuncture
This study will characterize brain plasticity in Carpal Tunnel Syndrome and will determine how this central fMRI biomarker is modulated by acupuncture.
- Trial name
- NCT01345994
- Testing
- electro-acupuncture
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Martinos Center for Biomedical Imaging
MTBI - Mild Traumatic Brain Injury, Concussion, Mild
Controlled DTI Evaluations in High School Football and Female Soccer to Evaluate Efficacy of Jugular Compression Collar
The purpose of the study is to monitor longitudinal changes in brain structure between the preseason and postseason, in a population of football and soccer playing athletes wearing the Device and compared to a similar population…
- Trial name
- NCT04068883
- Testing
- Q collar
- Where
- 2 sites in United States
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cerebral Palsy, Care Giving Burden
Caregiver Burden in Cerebral Palsy Undergoing Hip and Knee Surgery
The aim of this observational study was to obtain information about the change in the burden of care of parents of children with cerebral palsy after hip and knee surgeries.
- Trial name
- Caregiver CP (NCT06224322)
- Testing
- Assesment Scale
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Major Depressive Disorder
Characterizing Psychological Consequences of Childhood Trauma
This study will characterize the mental health consequences of early-life trauma.
- Trial name
- NCT00209105
- Testing
- DEX-CRF stimulation test, Psychosocial stress induction, Brain imaging of sad mood , self-reference, reward
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Emory University
Physical Fatigue, Return to Sport
The Effect of Physical Fatigue on Different Balance Tests and Brain Activity in a Healthy Population
The main objective of this project is: 1. To assess the influence of physical fatigue on brain functioning during a balance and reaction time task in a healthy population.
- Conditions
- Physical Fatigue, Return to Sport, Injury Prevention, EEG
- Trial name
- NCT04030390
- Testing
- Physical Fatigue, Control
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Cerebral Palsy, Infant Development
Neuroimaging of Babies During Natural Sleep to Assess Typical Development and Cerebral Palsy
Background: Early diagnosis of cerebral palsy (CP) is crucial, enabling intervention when neuroplasticity is at its highest. Magnetic resonance imaging (MRI) plays a vital role in CP diagnosis.
- Conditions
- Cerebral Palsy, Infant Development, Development, Infant
- Trial name
- NIBS-CP (NCT06396520)
- Testing
- No intervention, observational
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Danish Research Centre for Magnetic Resonance
Neuromuscular Disorders, Neurodevelopmental Disorders
Safety, Usability, and Effectiveness of a Gait Exoskeleton for Children and Adolescents With Neurodevelopmental Disorders.
Neurodevelopmental disorders often result in abnormal development of the Central Nervous System (CNS), frequently causing motor dysfunctions such as the inability to stand and walk.
- Trial name
- NCT07159360
- Testing
- CLINICAL EXPLORER
- Where
- 2 sites in Mexico, Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- MarsiBionics
Traumatic Brain Injury
Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military
The study includes people who have recently had a traumatic brain injury (TBI) and healthy controls who have not had a TBI and is designed to measure brain blood flow serially after a TBI.
- Trial name
- NCT04058132
- Testing
- Sildenafil Citrate 50Mg Tab, functional Near-infrared Spectroscopy (fNIRS), Carbon Dioxide (CO2) 5%
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Cerebral Palsy, Early Developmental Impairment
Use of Tools for Early Detection of Cerebral Palsy
High risk of infant is defined as an infant who has a history of negative environmental and biological factors and these factors can cause neuromotor development problems.
- Conditions
- Cerebral Palsy, Early Developmental Impairment, Infant Development
- Trial name
- tooluse (NCT06531330)
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Spastic Cerebral Palsy, Acquired Brain Injury
Evaluation of Macroscopic Muscle Growth in Infants and Young Children With Spastic Cerebral Palsy
A mixed longitudinal design study will be carried out to explore the onset and time course of morphological muscle changes on a macroscopic level in children with spastic cerebral palsy (SCP).
- Trial name
- 3D-MMAP (NCT05197764)
- Where
- Belgium
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Traumatic Brain Injury, Hearing Loss
Improving Speech in Noise Using Noninvasive Stimulation
Traumatic brain injury, a common injury in military service personnel, often leads to poor processing of speech in noisy environments.
- Trial name
- NCT07176936
- Testing
- Cymba Conchae stimulation, Earlobe stimulation
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Florida
Mild Traumatic Brain Injury
Disparity Driven Vergence in Mild Traumatic Brain Injury (mTBI)
This study aims to determine the validity and safety of disparity driven vergence using a portable goggle system (I-PAS) using a pseudorandom ternary sequence of frequencies for testing.
- Trial name
- NCT03529799
- Testing
- I-PAS Goggles
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Miami
Traumatic Brain Injury
Long-term Clinical Correlates of Traumatic Brain Injury
Background: Traumatic brain injury may have a range of effects, from severe and permanent disability to more subtle functional and cognitive deficits that often go undetected during initial treatment.
- Trial name
- NCT01132898
- Where
- United States
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Body Temperature Changes
Development of a Head Cooling Device
This study is testing a head-cooling device on volunteers to assess temperature reduction.
- Trial name
- NCT02226614
- Testing
- University of Edinburgh head cooling device
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Cerebral Palsy
The Influence of Muscle Contraction on the Cardiac Autonomic System
Population: 16 children with cerebral palsy, GMFCS 1-3.16 children typically developed, matched for age. All children aged 6-12 yrs who understand simple commands. Tools: 1.
- Trial name
- NCT02621138
- Where
- Israel
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Alyn Pediatric & Adolescent Rehabilitation Hospital
Sport-related Concussion
Sub-acute Exercise Following Sport-Related Concussion
Determine the safety and efficacy of sub-maximal aerobic exercise during the subacute phase of recovery following sport-related concussion.
- Trial name
- NCT03575455
- Testing
- Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Florida State University
Brain Injuries, Traumatic
Traumatic Brain Injury Positive Strategies
This study evaluates the effectiveness of The Traumatic Brain Injury Positive Strategies (TIPS) program, a comprehensive educational and training resource to help families improve their knowledge and skills in supporting a child…
- Trial name
- TIPS (NCT03867968)
- Testing
- TIPS Intervention, Control
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Oregon
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