Clinical trials: Brain Injuries
Ankle Disease, Foot Deformities
Effect of Systematic Dexamethasone on the Duration of Popliteal Nerve Block for Anesthesia After Pediatric Ankle Surgery
Effect of systematic dexamethasone on the duration of popliteal nerve block after pediatric ankle/foot surgery
- Conditions
- Ankle Disease, Foot Deformities, Foot Diseases, Cerebral Palsy
- Trial name
- NCT05887765
- Testing
- Sodium Chloride 0.9% Inj, 0,1mg/kg Dexamethasone, 0,2mg/kg Dexamethasone
- Where
- 2 sites in Poland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Head Injury, Traumatic Brain Injury (TBI)
The Head Injury-associated Photosensitivity and Pupillary Function (HIPP) Study
After a head injury, many people find that exposure to light causes them increased discomfort. By measuring how the pupil in the eye constricts to flashes of red and blue light, this study will investigate whether this phenomenon…
- Conditions
- Head Injury, Traumatic Brain Injury (TBI), Photosensitivity, Photophobia
- Trial name
- HIPP (NCT01942564)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Traumatic Brain Injury, Healthy
Measuring Blood Flow in the Brain
This study will test a method of measuring brain blood flow called near infrared spectroscopy (NIRS). It will determine whether NIRS gives the same results as the more commonly used technique, functional magnetic resonance…
- Trial name
- NCT00466934
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Brain Injuries, Stroke
Novel Head Protection Prototype Device for Decompression Craniectomy
A proof-of-concept (POC) proposal to study the feasibility of customized head protection prototype device (HPPD) using 3D printed externally-applied moulded skin prosthesis integrated to the craniectomy bony skull defect.
- Trial name
- HPPD (NCT04021095)
- Testing
- Head protection prototype device
- Where
- Singapore
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Stroke, Acute, Parkinson Disease
Assessment of the Rehabilitative Effects of Curved-walking Training in Stroke, Parkinson and Orthopaedic Populations
The recovery of walking ability is crucial to promote independence in daily living and is one of the major goal of neuromotor rehabilitation.
- Conditions
- Stroke, Acute, Parkinson Disease, Femur Fracture
- Trial name
- NCT03545477
- Testing
- Novel locomotion treatment: curved-walking training, Standard locomotion treatment: straight-walking training, Standard physical therapy
- Where
- Italy
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Autism, Cerebral Palsy
Near-infrared Spectroscopy and Electroencephalography to Assess Cortical Activation During Motor Tasks in Infants and Toddlers With and Without Cerebral Palsy
Background: New ways to study the brain as people move include near-infrared spectroscopy (NIRS) and electroencephalography (EEG).
- Trial name
- NCT03434080
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Skull Fractures, Stroke
Simulation Training in Emergency Department Imaging 2
Background and study aims: Computerised Tomography (CT) head scans are frequently requested by Emergency Department (ED) clinicians as one of the investigations for their patients.
- Conditions
- Skull Fractures, Stroke, Intracranial Bleed, Brain Tumor
- Trial name
- STEDI2 (NCT05427838)
- Testing
- Online training
- Where
- 6 sites in United Kingdom
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Cerebral Palsy, Bilateral Cerebral Palsy
Stepping to Understand Lower Limb Impairments in Bilateral Cerebral Palsy
The purpose of this study is to investigate lower limb impairments in children with bilateral cerebral palsy during stepping tasks.
- Conditions
- Cerebral Palsy, Bilateral Cerebral Palsy, Diplegic Cerebral Palsy
- Trial name
- NCT04957277
- Testing
- load modulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cerebral Palsy, Prematurity
Study of Generalized Movements for Early Prediction of Cerebral Palsy
The purpose of this study is to assess the predictive value of generalized movements in preterm and term infants who are at risk for development of cerebral palsy.
- Trial name
- NCT00749008
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Charles R. Neal,
Stroke, Able Bodied
Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways
The goal of this study is to assess cervical (neck) reflexes by intra-operatively stimulating the neck nerve roots to evoke motor responses through their connections to spinal motoneurons.
- Trial name
- NCT07401186
- Testing
- Bipolar Neural Stimulation Electrode
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Peter C. Gerszten, MD
Major Depressive Disorder
Depression, Epinephrine, and Platelet Function
Men and women who have suffered sexual and/or physical abuse before the age of 12 are at increased risk for anxiety and mood disorders, other serious psychiatric disorders, and likely medical illnesses.
- Trial name
- NCT00166114
- Testing
- Escitalopram, Desipramine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Acquired Brain Injury, Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic)
Regulating Emotions and Behaviors After Brain Injury
After acquired brain injury (ABI), persons can experience emotional and behavioral difficulties, that can be painful both for the person and his/her family.
- Conditions
- Acquired Brain Injury, Stroke/ Cerebrovascular Accident (Ischemic or Hemorrhagic), Brain Tumor (After Recovery), Encephalitis
- Trial name
- GREMO-LCA (NCT05393492)
- Testing
- Dialectical Behavior Therapy and Radically Open dialectical behavior therapy
- Where
- France
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Stroke, Trauma
Focused Ultrasound Stimulation of the Cerebellum to Induce Changes in Cognition and Brain Activity
The goal of this preclinical study is to assess the effects of focused ultrasound stimulation to the cerebellum on brain dynamics and cognition in healthy volunteers aged 18 to 40.
- Conditions
- Stroke, Trauma, Cognition, Agency
- Trial name
- FUSCBM (NCT07389447)
- Testing
- Focused ultrasound, EEG
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy, Concussion (Diagnosis)
Reliability of the SOT Over Clinical Administration Time Intervals of Concussion Assessment
The goal of this study has two parts. First, it examines whether performing multiple Sensory Organization Tests (SOT) on the SMART Balance Master, using two different testing orders, leads to different levels of practice…
- Conditions
- Healthy, Concussion (Diagnosis), Balance Assessment
- Trial name
- NCT07024368
- Testing
- Reliability of the Sensory Organization Test on the SMART Balance Master across multiple administrations
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Hyung Rock Lee
Cerebral Palsy
Task-oriented Game Therapy Using Enhances Functions in Children With Cerebral Palsy.
Cerebral Palsy is an umbrella definition that refers to a disorder that occurs after a problem affecting a person's brain functions and has symptoms such as sensory, motor and mental deficits.
- Trial name
- NCT06071182
- Testing
- Task-oriented Fruit ninja game
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Erzurum Technical University
Cognitive Deficits, Proprioceptive Disorders
Effects of Multiple Concussions in Retired NHL Players
To investigate long term affects of multiple concussions on the cognition, balance, proprioception, and biomarkers in retired National Hockey League players
- Trial name
- NHL (NCT02746523)
- Testing
- Sensory Organization Test, Biomarkers, Conners' Adult ADHD Rating Scale (CAARS)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- New York Institute of Technology
Cerebral Palsy
Motor Imagery Training in Children With Unilateral Cerebral Palsy
Motor imagery (MI) is a promising method to improve more cognitive aspects of motor behaviour, and may, thus, be effective for facilitating motor planning in children with Cerebral Palsy (CP).
- Trial name
- NCT03954808
- Testing
- Motor Imagery Training, Traditional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Traumatic Brain Injury
Sertraline vs. Placebo for Symptoms Following Traumatic Brain Injury
The purpose of this study is to investigate the efficacy of an SSRI, sertraline for the use of post-concussive symptoms following a traumatic brain injury.
- Trial name
- NCT00208585
- Testing
- sertraline
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Stroke, Dystonia
MyoSense- Automated Muscle Hypertonicity Classification System
It is often difficult to quantify and distinguish aspects of abnormal muscle tone due to neurological injury. This makes it difficult to evaluate therapies that aim to reduce the effects of abnormal muscle tone.
- Conditions
- Stroke, Dystonia, Cerebral Palsy
- Trial name
- NCT02076581
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Demyelinating Disorders, MCI
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
The overall objective is to obtain an assessment of the pharmacokinetics of [18F]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple…
- Conditions
- Demyelinating Disorders, MCI, Alzheimer's Disease (AD), MS (Multiple Sclerosis)
- Trial name
- NCT06999434
- Testing
- [ 18F]3F4AP, [18F]MK6240, [11C]PIB
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Yale University
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