Clinical trials: Brain MRI
Alzheimer Disease, Mild Cognitive Impairment
BioFINDER-Brown: Examination of Alzheimer's Disease Biomarkers
This research study aims to examine biomarkers of Alzheimer's disease as early as possible which could potentially be a screening tool for the general population.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- NCT05457998
- Testing
- Flutemetamol F18 Injection, [18F]-RO6958948 Injection, [18F]-MK-6240 Injection
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Functional Movement Disorders
Brain Activity in People With Functional Movement Disorders
This study will use functional MRI (fMRI, a technique that shows what areas of the brain are active when performing different mental tasks), to examine how the brain in people with functional movement disorders (FMD) may differ…
- Trial name
- NCT00448084
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Metabolic Syndrome X
Mechanisms of Cerebrovascular Control
The objective of this study is to identify insulin-specific cerebral blood flow (CBF) control mechanisms, and establish cerebrovascular responsive baseline in younger (18-45 yrs) metabolic syndrome adults (MetSyn) who are at…
- Trial name
- NCT02936687
- Testing
- NOS Inhibition, ET-1 Inhibition, 3 Tesla MRI
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Healthy
Comparison of Magnetic Resonance Techniques for the Measurement of Cerebral Blood Perfusion
In this project, we aim at implementing a te-ASL sequence and to compare it to two reference ASL sequences with a fixed PLD on healthy individuals.
- Trial name
- NCT04486248
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Mild Cognitive Impairment, Healthy Aging
Novel, Individualized Brain Stimulation, Network-based Approaches to Improve Cognition
Impaired working memory (WM) plays a crucial role in normal aging, in mild cognitive impairment (MCI) and cognitive decline associated with dementia, such as Alzheimer's disease (AD).
- Trial name
- NiBS-iCog (NCT04986787)
- Testing
- tACS, TMS, TIS
- Where
- Czechia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Traumatic Brain Injury, Subarachnoid Hemorrhage
Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury
The purpose of this study is to examine the safety and feasibility of using hyperpolarized metabolic MRI to study early brain metabolism changes in subjects presenting with head injury and suspected non-penetrating traumatic…
- Trial name
- NCT06103201
- Testing
- Hyperpolarized 13C-Pyruvate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Healthy
Magnetic Resonance Imaging of the Effect of Music Listening on Brain Activity Under Anesthesia
This study is to better understand the systems-level neuronal mechanisms by which general anesthetics produce loss of consciousness.The researchers believe that anesthetics suppress consciousness by disrupting the functioning of…
- Trial name
- NCT04464265
- Testing
- Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Parkinson's Disease, Healthy Controls Group - Age and Sex-matched
Innovative Biomarkers in de Novo Parkinson's Disease
This study aims at identifying potential new and innovative biomarkers in de novo Parkinson's disease patients. New finding will help phenotyping patients since the diagnosis of the disease and potentially also in the preclinical…
- Trial name
- INNOBIOPARK (NCT03940677)
- Testing
- Brain MRI, TMS-EEG, Behavioral and cognitive battery
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Alzheimer Disease
Evaluating Simvastatin's Potential Role in Therapy
The purpose of this study is to see how simvastatin, a cholesterol-lowering drug, affects processes related to the development of Alzheimer's disease, including: 1) levels of a substance called beta-amyloid-42 found in the spinal…
- Trial name
- ESPRIT (NCT00486044)
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Concussion, Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2
This is an open-label, non-randomized, prospective, multi-site, parallel group (segment), hypothesis-generating study designed to collect data that will aid in future scientific and engineering exploration of correlations between…
- Trial name
- mTBI-phase2 (NCT02556177)
- Testing
- MRI
- Where
- 7 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Schizophrenia, Schizoaffective Disorder
Quantifying Abnormalities in Cortical Activation Associated With Auditory Hallucinations Using Functional Magnetic Resonance Imaging
The goal of the project is to characterize abnormalities in brain structure and function related to schizophrenia. The investigators will use advanced magnetic resonance imaging (MRI) techniques to measure the degree and…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Hallucinations
- Trial name
- NCT00288340
- Testing
- functional magnetic resonance imaging
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Functional Motor Disorders
Study of Biomorkers and Rehabilitation Strategies in Functional Motor Disorders (FMD)
Functional motor disorders (FMD) are prevalent and highly disabling conditions characterized by abnormal movements (functional weakness, tremor, dystonia) significantly altered by distractive manoeuvres and incongruent with…
- Trial name
- NCT06328790
- Testing
- Multidisciplinary Rehabilitation Training, Cross-sectional study on patients with FMD and patients with structural/organic diseases, Cross-sectional study on patients with FMD and healthy controls (HC)
- Where
- 3 sites in Italy
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Michele Tinazzi, MD, PhD
Parkinson Disease, Progressive Supranuclear Palsy
Early Biomarkers of Neurodegeneration in Parkinsonian Syndromes
Parkinson's disease (PD) is the most common degenerative Parkinson's syndrome and is linked, among other things, to the excessive accumulation of an abnormally aggregating protein, alpha-synuclein.
- Trial name
- SODIPARK (NCT06155942)
- Testing
- 7 Tesla MRI
- Where
- 6 sites in France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Epilepsy, Temporal Lobe
Enhanced MRI Imaging in Healthy Participants and Participants With Epilepsy
Temporal lobe epilepsy (TLE) is a common type of epilepsy and one of the most likely to not be controlled by medication. For patients who do not respond to medication, surgery can result in a cure of seizures.
- Trial name
- NCT06483061
- Testing
- Ferumoxytol
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Obesity
Obesity and Brain: Genes and Environment
The aim of this study is to investigate the effects of genetic and environmental risk factors on central nervous system (CNS) reward and satiety circuits in the etiology of obesity.
- Trial name
- NCT02025595
- Where
- Netherlands
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Huntington Disease
Accelerated Diffusion MRI for Diagnosis of Hungtington Disease
The hypotheses of the project are 1. Diffusion MRI using compressed sensing could have reduced motion sensitivity and improved susceptibility related artifact because of accelerated acquisition. 2.
- Trial name
- NCT01884181
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wang . Jiun-Jie
Parkinson Disease, REM Sleep Behavior Disorder
Ultra High Field Magnetic Resonance Imaging as a Biomarker for Premotor Parkinson's Disease
This is a prospective observational study investigating the utility of 7 Tesla MRI to quantify nigrosome1 signal in a cohort of individuals with recent onset Parkinson's disease and in at-risk cohorts at a premotor state of…
- Trial name
- NCT03288909
- Testing
- MRI
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Nicotine Dependence
The Impact of Real-time Functional Magnetic Resonance Imaging (fMRI) Feedback on Response to Nicotine Cues
The purpose of this study is to develop a technique to provide feedback of brain activity and to use this technique to reduce levels of craving in nicotine dependent smokers.
- Trial name
- RTSmoking (NCT01411007)
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
COPD, Cognitive Impairment
Cerebral and Cardiac Blood Flow During Exercise in Patients With COPD
Heart disease and conditions related to the blood vessels are responsible for a large proportion (over a quarter) of the deaths in people with chronic obstructive pulmonary disease (COPD).
- Trial name
- REFLEX-COPD (NCT04138563)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Blindness
Sensory Substitution and Brain Plasticity Following Vision Loss
The goal of this clinical investigation is to learn how the brain responds when visual information is converted into patterns of sound or touch in blind and sighted participants.
- Trial name
- SenSubMRI (NCT07450677)
- Testing
- Electrotactile display (BrainPort), Vision-to-sound converter (AI Sight)
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stanford University