Clinical trials: Brain Mapping
Glioblastoma, IDH-wildtype, Glioblastoma
The RECMAP-study: Resection With or Without Intraoperative Mapping for Recurrent Glioblastoma
Resection of glioblastoma in or near functional brain tissue is challenging because of the proximity of important structures to the tumor site.
- Conditions
- Glioblastoma, IDH-wildtype, Glioblastoma, Glioblastoma Multiforme of Brain, Astrocytoma, Malignant
- Trial name
- RECMAP (NCT06273176)
- Testing
- Awake mapping under local anesthesia, Asleep mapping under general anesthesia, Resection under general anesthesia without mapping
- Where
- 8 sites in United States, Belgium and 3 more
- Volunteers
- 225 people
- Sponsor
- Erasmus Medical Center
Migraine
Prediction of WMH in Migraine Using a BOLD-CVR Map
Brain white matter hyperintensities (WMHs) are prevalent in migraineurs, of which the mechanism is still unclear. The investigators aimed to test the spatial association between areas with reduced cerebrovascular reactivity (CVR)…
- Trial name
- NCT03494673
- Testing
- BOLD MRI
- Where
- South Korea
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Parkinson Disease, Essential Tremor
Brain Network Activation in Patients With Movement Disorders
The diagnosis and management of movement disorders, such as Parkinson's disease (PD), parkinson-plus syndromes (PPS), dystonia, essential tremor (ET), normal pressure hydrocephalus (NPH) and others is challenging given the lack…
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia, Normal Pressure Hydrocephalus
- Trial name
- BNA-MDi (NCT03269201)
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Sheba Medical Center
Brain Mapping, Language Disorder
Brain Areas Involved in Sound and Spoken Word Memory
Background: Studies have shown that animals such as monkeys and dogs have excellent sight and touch memory but perform poorly on sound memory tasks.
- Conditions
- Brain Mapping, Language Disorder, Adult, Healthy
- Trial name
- NCT01375595
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Traumatic Brain Injury, Cerebrocardiac Syndrome
Neural Mechanism of Cerebrocardiac Syndrome Following Traumatic Brain Injury
Cerebrocardiac syndrome (CCS), including myocardial injury, arrhythmia or heart failure is one of serious complications of traumatic brain injury (TBI), mostly occurs within seven days after TBI, which directly aggravates the…
- Trial name
- NCT06958406
- Where
- 2 sites in China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai 6th People's Hospital
Low Grade Glioma of Brain
Measure of the Potential Evoked by Electric Stimulation
This study is about an experimental biomedical monocentric search concerning twelves patients presenting a infiltrative glioma of low rank OMS type II and realizing a surgery awakened on the site of the CHU of Montpellier.
- Trial name
- PE&CE (NCT02509442)
- Testing
- Diffusion of direct electric stimulation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Montpellier
Healthy
Magnetic Resonance Imaging in Children and Adults Using Arterial Spin Tagging Techniques
This study will use magnetic resonance imaging (MRI) to examine how blood flow to the brain differs at different ages with the brain is at rest, and during performance of tasks that involve language, memory, motor control, and…
- Trial name
- NCT00034073
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy
Mapping the Impact of Gut Microbiota on Brain and Behavior Through the Lens of GABA
Gut microbiota produce different metabolites within the human body, which include neurotransmitters. Animal studies have demonstrated a critical role for the gut microbiota in various aspects of brain and behavioural function…
- Trial name
- GutBrainGABA (NCT05698862)
- Testing
- Probiotic
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Reading
Brain Neoplasms
Presurgical Language Mapping With fMRI: Comparison of BOLD and fASL Techniques
One of the aim of the neurosurgical treatment of brain tumor is to offer the maximal resection with the minimal neurological risk.
- Trial name
- MALTA (NCT01793714)
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Rennes University Hospital
Epilepsy, Brain Injury
Optimization of Human Cortical Stimulation
We will observe epileptic patients who already have electrodes implanted on the brain and are receiving high-level brain stimulation for clinical purposes while testing their motor and language function.
- Trial name
- BCI (NCT01198964)
- Testing
- Low-level cortical stimulation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Washington
Central Cord Syndrome
The Natural History of Traumatic Spinal Cord Injury Using fMRI, MRS and DTI
Traumatic spinal cord injury is a common injury to the spine and can lead to a clinical syndrome called central cord syndrome (CCS).
- Trial name
- NCT00790361
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Epilepsy
Intracranial Stimulation Mapping In Epilepsy
This is a single group prospective study to determine the feasibility for generating brain maps that localize cerebral functions and inter-regional information flow in partial epilepsy in adult patients.
- Trial name
- NCT05290610
- Testing
- Functional mapping
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Healthy Volunteer, Traumatic Brain Injury
Estimating Brain Biomechanics Using MRI
Objective: In this study we will develop and apply imaging techniques to perform the first three-dimensional (3-D) measurements of brain biomechanics during mild head movement in healthy human subjects.
- Conditions
- Healthy Volunteer, Traumatic Brain Injury, Brain Mapping, Craniocerebral Trauma
- Trial name
- NCT01633268
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Alzheimer's Disease
Longitudinal Quantitative Susceptibility Mapping (QSM) in Alzheimer 's Disease
In this explorative longitudinal study 50 patients with Alzheimer's disease (AD) and 50 age-matched control subjects will be recruited for their 2 years follow-ups and undergo extensive cognitive testing and quantitative 3 Tesla…
- Trial name
- NCT02752750
- Testing
- MRI
- Volunteers
- 50 people
- Sponsor
- Medical University of Graz
Voice Disorders
Brain Mapping of Voice Control
Some voice disorders are caused by uncontrolled muscle actions that affect the larynx or voice box. The purpose of this study is to understand 1) how the brain controls voice production; 2) how changes in sensation within the…
- Trial name
- NCT00066911
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Brain Disease, Brain Mapping
PET Imaging in Chronic Traumatic Encephalopathy
Background: Chronic traumatic encephalopathy (CTE) is a brain disease caused in part by head injury. The brain changes from CTE can only be seen at autopsy.
- Trial name
- NCT02211820
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Fragile X Associated Tremor-ataxia Syndrome, FXTAS
Brain Network Activation and Gait and Posture in FXTAS
In this study the investigators aim to identify and characterize a potential neurophysiological biomarker by mapping functional networks of brain activity (Brain Network Activation, BNA) based on analysis of evoked response…
- Trial name
- FXTAS-BNA (NCT02936531)
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Healthy Nutrition
DHA & Lutein and fMRI Brain Mapping in Healthy Children
Studies suggest that lutein and n-3 fatty acids may influence the development of a child's brain and may be related to how well children learn.
- Trial name
- NCT01789866
- Where
- Canada
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Glioma, Brain Tumor Adult
Movie-Watching Functional MRI for Mapping Brain Function in Neurosurgical Patients
This research will compare a new type of functional MRI (fMRI) called naturalistic viewing (also called movie watching) to standard clinical fMRI techniques.
- Trial name
- NCT07650994
- Testing
- Functional magnetic resonance imaging (fMRI), Neuropsychological Assessments
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Brigham and Women's Hospital
Brain Tumor
A Comprehensive Clinical fMRI Software Solution to Enable Mapping of Critical Functional Networks and Cerebrovascular Reactivity in the Brain
Our preliminary work demonstrates that an integrated fMRI software solution, incorporating tb-fMRI, rs-fMRI, and CVR mapping, is clinically feasible and helps clinicians plan brain tumor resection.
- Trial name
- NCT05342454
- Where
- United States
- Volunteers
- 1,720 people
- Sponsor
- M.D. Anderson Cancer Center