Clinical trials: Brain Plasticity
Healthy, Cognition
Reliability of Standardized IQ Testing Under Modafinil, Racetam-Class Compounds, Sleep Restriction and Daily Activity
This study examined whether standardized IQ test scores in healthy adults aged 18-35 are stable measures of cognitive ability and evaluated whether standardized cognitive-test performance and response-initiation measures vary…
- Conditions
- Healthy, Cognition, Sleep Deprivation
- Trial name
- NCT07852130
- Testing
- Modafinil, Oxiracetam, Pramiracetam
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Abdulraheem Mohamed Gouda
Amblyopia
Establishing New Treatment Approaches for Amblyopia: Perceptual Learning and Video Games
Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast.
- Trial name
- NCT05522972
- Testing
- Video Game Vision Training, Perceptual Learning, Occlusion Therapy
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Cryptogenic Epilepsy
Diffusion Tensor Imaging in Epilepsy With Continuous Spikes and Waves During Sleep
Continuous Spikes and Waves during Sleep (CSWS) is a rare paediatric epileptic encephalopathy. Even if the correlation between the severity of the epilepsy and the cognitive consequences is well established, the mechanisms…
- Trial name
- POCS-DTI (NCT03035513)
- Testing
- Continuous spikes and waves during slow sleep (CSWS)
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Overweight and Obesity, Cognitive Change
The Effect of Ketone Ester Supplementation and Ketogenic Diet on Brain Plasticity in Overweight/Obese Adults
This project comprises an initial crossover placebo-controlled neurophysiological study to ascertain the effect of acute ketone ester ingestion on motor cortex plasticity, followed by a second 2-week intervention study aimed to…
- Conditions
- Overweight and Obesity, Cognitive Change, Psychophysiologic Reaction
- Trial name
- NCT06368297
- Testing
- Ketone Monoester Supplementation, Ketogenic diet
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Macau
Dysphagia, Videofluoroscopy
Dysphagia After Different Swallowing Therapies
Dysphagia after stroke is associated to increased pulmonary complications and mortality. The swallowing therapies could decrease the pulmonary complications and improve the quality of life after stroke.
- Conditions
- Dysphagia, Videofluoroscopy, Stroke
- Trial name
- NCT03048916
- Testing
- general swallowing therapy, NMES therapy
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Amblyopia, Amblyopia, Anisometropic
Stochastic Resonance Applied to Amblyopia Training and the Plasticity of Brain
The prevalence of Taiwan's population with amblyopia is 2-5%. Amblyopia affects the daily life and learning ability. The human visual system can be developed normally with exposure of clear images on the retina, which often drive…
- Trial name
- NCT04213066
- Testing
- Portable tablet
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Cerebral Palsy, Typically Developing Children
Repetitive Transcranial Magnetic Stimulation on Motor Function and Meta-Plasticity in Cerebral Palsy: TMS-EEG Study
This project examines the use of repetitive transcranial magnetic stimulation (rTMS) as a therapeutic approach to improve motor function in children with cerebral palsy (CP).
- Trial name
- NCT07567053
- Testing
- MRI, HD-EEG Recording, rTMS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cook Children's Health Care System
Adult Brain Tumor
Induction of Cortical Plasticity
The study aims to induce plastic reorganization by a therapeutic protocol to increase the rate of gross total resection (GTR) and to optimize the oncological result.
- Trial name
- NCT04553341
- Testing
- Navigated repetitive transcranial magnetic stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Stroke With Hemiparesis
Strategies for Recovery of Dexterity Post Stroke
Motor learning can be affected by the sensory difficulties that may be experienced as a result of a stroke. This study will help us better understand what kinds of sensory information can help with the re-learning of grasping…
- Trial name
- NCT01977027
- Testing
- Alternate Hand Training or Affected Hand Training
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Stroke, Hemiplegia
Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) Over the Brain on the Neurotransmitter Binding
The purpose of this study is to determine whether repetitive transcranial magnetic stimulation (rTMS) over the brain can modulate the binding of neurotransmitter (GABA in this study) to its receptor using the special PET study.
- Trial name
- NCT01819675
- Testing
- Low frequency rTMS, High frequency rTMS
- Where
- South Korea
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Stroke, Cerebrovascular Accident
Non-invasive Brain Stimulation and Occupational Therapy To Enhance Stroke Recovery
The purpose of this study is to determine whether a non-painful, non-invasive, brain-stimulation technique called transcranial direct current stimulation (tDCS) combined with traditional physical-occupational therapy (OT) will…
- Conditions
- Stroke, Cerebrovascular Accident, CVA, Acute Stroke
- Trial name
- TDCS+OT (NCT00792428)
- Testing
- Real Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Cerebrovascular Accident
Structural and Functional Brain Changes in Response to Post-Stroke Rehabilitation
The purpose of this research study is to improve methods for evaluation of brain changes during motor learning for patients with stroke, who have difficulty performing daily tasks with their arm and hand.
- Trial name
- NCT02351947
- Testing
- upper limb rehabilitation for chronic stroke
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Louis Stokes VA Medical Center
Cerebral Vascular Accident
Evaluation of the Benefit of the Training of the Manual Dexterity Post Stroke.
Stroke is the second leading cause of death and disability in France: more than half of stroke survivors have a disabling motor deficit, affecting mainly the upper limb.
- Trial name
- DEXTRAIN (NCT03934073)
- Testing
- DEXTRAIN, CONVENTIONNELLE, CONTROLE
- Where
- France
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Stroke, Chronic, Aging
AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions
The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors.
- Conditions
- Stroke, Chronic, Aging, Cognitive Decline, Motor Dysfunction
- Trial name
- AMPLIFI (NCT06950060)
- Testing
- High intensity cycling, Low-intensity cycling, Health education session
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy Young Adults
Boosting and Mapping Non-invasive Brain Stimulation Techniques
In this study we applied TMS to the hand area of M1 whilst acquiring fMRI of the brain. This study tested whether a higher-frequency form of brain stimulation, called high-gamma (100Hz) intermittent theta burst stimulation…
- Trial name
- BoMAP NIBS (NCT07431697)
- Testing
- Intermittent theta burst stimulation (iTBS) as a protocol of repetitive transcranial magnetic stimulation (rTMS)
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
ADHD, Attention Deficit Hyperactivity Disorder
Brain Plasticity Underlying Acquisition of New Organizational Skills in Children-R61 Phase
Organizational, time management and planning (OTMP) skills deficits are seriously impairing features of developmental disorders, such as Attention Deficit Hyperactive Disorder (ADHD) and autism, which compromise school…
- Conditions
- ADHD, Attention Deficit Hyperactivity Disorder, Neurodevelopmental Disorders
- Trial name
- NCT03148782
- Testing
- OST Intervention for participants with Organizational skill difficulties
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Hallucinations, Verbal Auditory
Symptom Based Treatment Affects Brain Plasticity - the Role of Verbal Auditory Hallucinations
The aim of the study is the examination of brain plasticity on verbal auditory hallucinations (AVH) after neuromodulation with fMRI (functional magnetic resonance imaging) neurofeedback.
- Trial name
- APIC-II (NCT02722915)
- Testing
- fMRI, Neurofeedback, PANAS
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Brain Function, Cerebral Palsy
7T Anatomo-functional Characterization of Structures in the Action Observation Network
The goal of this study is to explore the anatomical-functional characteristics of the AON circuit (with particular interest for subcortical areas and the cerebellum), and the cortico-subcortical connectivity of the nodes of the…
- Trial name
- 7T-ATHENA (NCT06826287)
- Testing
- 7T MR exam, clinical assessment
- Where
- 2 sites in Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Ischemic Stroke,
Intermittent Theta Burst Stimulation After Acute Stroke
This pilot sham-controlled study aims to determine the safety and efficacy of repetitive transcranial magnetic stimulation given as a facilitatory intermittent theta burst stimulation (iTBS1200, 1200 stimuli/session) paradigm to…
- Trial name
- NCT01323881
- Testing
- Intermittent theta burst stimulation
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Profound Hearing Impairment
Positron Emission Tomography Imaging of Brain Reorganisation of the Central Auditory Cortex in Asymetrical Profound Deaf Patient With a Cochlear Implantation.
Our main objective is to study how the extent of reorganization of the central auditory system is related to the binaural integration in cochlear implanted subjects with asymmetric hearing loss.
- Trial name
- UniTEP (NCT03117413)
- Testing
- Positron emission tomography scan
- Where
- 2 sites in France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse