Clinical trials: Brain Plasticity
Stroke
Effect of Neural Constraints on Movement in Stroke
This study investigates the effects of Tizanidine on the voluntary movement controls of the arms of participants who have had a stroke and have not had a stroke by measuring medication-induced changes in upper extremity…
- Trial name
- ENCMS (NCT06666673)
- Testing
- Tizanidine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Northwestern University
ADHD, Attention Deficit Hyperactivity Disorder
Brain Plasticity Underlying Acquisition of New Organizational Skills in Children
Organizational, time management and planning (OTMP) skills deficits are impairing features of developmental disorders, such as Attention Deficit Hyperactive Disorder (ADHD), which compromise school performance and family…
- Conditions
- ADHD, Attention Deficit Hyperactivity Disorder, Neurodevelopmental Disorders
- Trial name
- NCT04108273
- Testing
- Organizational Skills Training
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- NYU Langone Health
Multiple Sclerosis (MS)
Serious Game Rehabilitation and Brain Plasticity in MS
This prospective, interventional, longitudinal, multicentre study aims to evaluate the impact of the "Serious game", an innovative cognitive remediation tool on brain reorganization in Multiple sclerosis patients, using…
- Trial name
- REVEILLE (NCT07474129)
- Testing
- Serious Game
- Volunteers
- 40 people
- Sponsor
- Lille Catholic University
Cerebral Stroke, Traumatic Brain Injury
Telerehabilitation Early After CNS Injury
The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke, traumatic brain injury (TBI) and/or spinal cord injury (SCI).
- Conditions
- Cerebral Stroke, Traumatic Brain Injury, Spinal Cord Injuries
- Trial name
- NCT06069999
- Testing
- HandyMotion Treatment Program
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- TRCare, Inc.
Brain Injury
Training in Goal-directed Attention Regulation for Individuals With Brain Injury
Brain injuries affect the lives of numerous Veterans. This study examines how the brain is affected by injury and how rehabilitation training for attention dysfunction may change brain functioning.
- Trial name
- NCT01035606
- Testing
- training in goal-directed attention regulation, brain health education, computer-assisted training in goal-directed attention regulation
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- VA Office of Research and Development
Amblyopia
Vision Therapy Outcomes in Amblyopia: Linking Brain Plasticity With Visual Perceptual Skills
The primary objective of this study is to evaluate the effects of a personalized vision therapy programme tailored to baseline visual-cognitive abilities in treatment-resistant amblyopia.
- Trial name
- NCT07437807
- Testing
- Motor Free Perception Vision Test
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Okan University
Chronic Stroke, Subacute Stroke
IMPULSE - StIMulation of Brain Plasticity to Improve Upper Limb Recovery After StrokE
Stroke is a leading cause of adult long-term disability worldwide. Recovery of arm and hand function after stroke is limited to about 50% of patients and full recovery is achieved in only 12% of stroke survivors by 6 months after…
- Trial name
- IMPULSE (NCT04124367)
- Testing
- Cerebrolysin, non-invasive brain stimulation
- Where
- Austria
- Volunteers
- 4 people
- Sponsor
- Ever Neuro Pharma GmbH
Ischemic Stroke,
Intermittent Theta Burst Stimulation After Acute Stroke
This pilot sham-controlled study aims to determine the safety and efficacy of repetitive transcranial magnetic stimulation given as a facilitatory intermittent theta burst stimulation (iTBS1200, 1200 stimuli/session) paradigm to…
- Trial name
- NCT01323881
- Testing
- Intermittent theta burst stimulation
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Multiple Sclerosis
Neuroproprioceptive "Facilitation, Inhibition" and Brain Plasticity
This study investigates whether neuroproprioceptive "facilitation, inhibition" physical therapy induces plastic and adaptive processes of the CNS (white matter integrity changes), if they relate to clinical improvement, and…
- Trial name
- NEFAI (NCT04355663)
- Testing
- Motor program activating therapy, Vojta's reflex locomotion, Functional electric stimulation
- Volunteers
- 92 people
- Sponsor
- Charles University, Czech Republic
Parkinson
EMG Modules as a Novel Biomarker of Basal Ganglia Plasticity in Parkinson's Disease
Study Purpose: Parkinson's disease leads to severally impaired motor control. The purpose of this study is to better understand and analyze the characteristics of arm muscle activity while doing some reaching tasks and of leg…
- Trial name
- NCT02896816
- Testing
- Surface EMG, MRI and PET Scan, Surface EMG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Motor Neuropathy
Stroke Recovery Research Based on EEG-fMRI
This study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from EEG-fMRI data.
- Trial name
- EEG-fMRI (NCT05427422)
- Testing
- MRI recording, EEG recording
- Where
- China
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Stroke
Paired Associative Stimulation in Stroke
Stroke is the third most common cause of death in the United States after heart disease and cancer, and the leading cause of long-term disability.
- Trial name
- NCT02586597
- Testing
- Transcranial magnetic stimulation & median nerve stimulation
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Stroke, Ischemic
Motor Recovery Through Plasticity-Inducing Cortical Stimulation
Using the CorTec Brain Interchange (BIC) System, we will examine the effect of a plasticity-inducing therapy regime on the rehabilitation of upper limb impairment post-stroke.
- Trial name
- MRPICS (NCT06506279)
- Testing
- CorTec Brain Interchange (BIC) System
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Washington
Other Conditions of Brain
Roflumilast and TMS Motor Plasticity
Repetitive transcranial magnetic stimulation (rTMS) uses a magnetic field to non-invasively induce electrical function within the brain.
- Trial name
- NCT06457191
- Testing
- Roflumilast, Intermittent theta-burst stimulation transcranial magnetic stimulation, Continuous theta-burst stimulation transcranial magnetic stimulation
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Stroke
Exploring Cerebellar Inhibition of the Motor Cortex in Stroke Patients
The past 10 years of research in post stroke patients have shown certain types of rehabilitation can help neuronal plasticity of the brain.
- Trial name
- NCT02401698
- Testing
- Functional clinical and TMS diagnostic
- Where
- Brazil
- Volunteers
- 8 people
- Sponsor
- University of Sao Paulo General Hospital
Cerebrovascular Disorders, Healthy
Non-Invasive Electrical Stimulation of the Human Brain
This study is designed to allow researchers to use transelectrical stimulation to explore the function of the human nervous system and improve diagnosis of neurological disorders.
- Conditions
- Cerebrovascular Disorders, Healthy, Nervous System Diseases, Spinal Cord Injuries
- Trial name
- NCT00001216
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Autism Spectrum Disorder, Intellectual Disability
TMS for the Investigation of Brain Plasticity in Autism Spectrum Disorders
The main purpose is to study brain plasticity (the changes that occur in the brain through experience) in individuals with autism spectrum disorder (ASD).
- Trial name
- NCT02836405
- Testing
- Transcranial Magnetic Stimulation
- Where
- 2 sites in United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Neuronal Plasticity
Simultaneous PET/MR Imaging of Human Brain Plasticity
Background: Neuronal plasticity is the brain's ability to continuously adapt to experiences and learning of new skills. Although this affects multiple characteristics of the brain such as structure, function and metabolism…
- Trial name
- NCT03485066
- Testing
- Tetris
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rupert Lanzenberger
Anhedonia, Major Depressive Disorder (MDD)
Efficacy of kTMP, a Novel Non-invasive Brain Stimulation Method, for the Treatment of Anhedonia
The goal of this proposal is to provide a first assessment of the efficacy of our innovative non-invasive brain stimulation system, kTMP, in the treatment of anhedonia in MDD.
- Trial name
- kTMP Anhedonia (NCT07032428)
- Testing
- A new non-invasive brain stimulation tool
- Volunteers
- 104 people
- Sponsor
- Magnetic Tides
Mild Cognitive Impairment (MCI)
Non-invasive Deep Brain Stimulation to Enhance Motor Skill Acquisition in Individuals With Mild Cognitive Impairment
The goal of this study is to investigate the impact of non-invasive deep brain stimulation on motor skill acquisition in individuals with Mild Cognitive Impairment.
- Trial name
- NCT07092839
- Testing
- transcranial electric stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 15 people
- Sponsor
- Friedhelm Hummel