Clinical trials: Brain Plasticity
Inhibition (Psychology), Updating
Attentional Control Training in Older Adults: Efficacy, Transfer and Brain Substrates
Formal education and cognitively stimulating hobbies and profession have a protective effect against age-related cognitive decline and Alzheimer's disease.
- Conditions
- Inhibition (Psychology), Updating, General Knowledge, No Training
- Trial name
- NCT03532113
- Testing
- Updating, Inhibition, General knowledge
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Stroke
Telerehabilitation Early After Stroke
The purpose of this research study is to assess the feasibility of initiating telerehab in early stages after stroke during patient admission to an inpatient rehabilitation facility.
- Trial name
- NCT04657770
- Testing
- Telerehabilitation
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of California, Los Angeles
Phantom Limb Pain
Predicting Pain Response to Transcranial Direct Current Stimulation for Phantom Limb Pain in Limb Amputees
This study explores the effects transcranial Direct Current Stimulation (tDCS, Soterix ©) on Phantom Limb Pain for patients experiencing chronic phantom limb pain in open-label study design.
- Trial name
- NCT02627495
- Testing
- transcranial Direct Current Stimulation (tDCS): (Soterix ©)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Spaulding Rehabilitation Hospital
Depression, Schizophrenia
Symptom Based Treatment Affects Brain Plasticity - Cognitive Training in Patients With Affective Symptoms
The aim of the study is the examination of brain plasticity on on affective symptoms after neuromodulation with fMRI (functional magnetic resonance imaging) neurofeedback.
- Trial name
- APIC-II (NCT03183947)
- Testing
- fMRI, Neurofeedback, PANAS
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Stroke, Hemiplegia
Efficacy and Safety Study of rTMS for Upper Extremity Motor Function Recovery in Ischemic Stroke Patients
The purpose of this study is to Evaluate Efficacy and Safety of rTMS 『TMS』 for Upper Extremity Motor Function Recovery in Patients with Ischemic Stroke
- Trial name
- TAMAS (NCT02082015)
- Testing
- Low frequency rTMS
- Where
- 3 sites in South Korea
- Volunteers
- 77 people
- Sponsor
- Seoul National University Bundang Hospital
Stroke, Cerebral Palsy
Modulation of Brain Plasticity After Perinatal Stroke
Newborn stroke is the leading cause of a common type of cerebral palsy (CP) that affects thousands of Canadian children and families.
- Trial name
- PLASTIC CHAMPS (NCT01189058)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Constraint-induced movement therapy (CIMT)
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of Calgary
Spinal Cord Diseases
Reorganization of Brain Functions in Patients With Cervical Myelopathy Using fMRI and MRS
Decompressive surgery to relieve symptoms of spinal cord compression due to dysfunction, such as arthritis, has proved variable in success.
- Trial name
- NCT00447343
- Testing
- Decompressive cervical spine surgery, fMRI and MRS scan
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Brain Injuries, Visually Impaired Persons
Functional Vision in TBI
The objective of this study is to test functional vision outcome measures that reflect the loss in everyday life tasks that require vision and that are sensitive to changes after a course of vision rehabilitation in…
- Trial name
- NCT01214070
- Testing
- Vision Restoration Therapy, NVT Eye Scanning Therapy, Eccentric Viewing Training
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis
Adaptive Plasticity Following Rehabilitation in Multiple Sclerosis
Motor learning can induce significant changes in the human brain through neural plasticity processes, which play a crucial role in the brain functional reorganization in response to external stimuli and/or to pathological…
- Trial name
- NCT03608527
- Testing
- Voluntary-based upper limb motor rehabilitation, Passive upper limb mobilization
- Volunteers
- 30 people
- Sponsor
- Fondazione Italiana Sclerosi Multipla
Healthy, Neurologic Manifestations
Study of Brain Changes Shaped by Experience
This study will use magnetic resonance imaging (MRI) scans to explore how the brain changes (reorganizes itself) in response to learning and to brain lesions in healthy people and people with various physical disabilities.
- Trial name
- NCT00006424
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alzheimer Disease and Related Dementias, Cognition
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function…
- Conditions
- Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
- Trial name
- TDCS4MCR (NCT06821568)
- Testing
- Personalized Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States, Israel
- Volunteers
- 128 people
- Sponsor
- Hebrew SeniorLife
Ischemic Cerebrovascular Accident
Long-Term Effects of Task-Oriented Lower Extremity Strengthening Training
Task-oriented exercises combined with strengthening have been shown effective in improving walking functions in patients with chronic stroke.
- Trial name
- NCT01934374
- Testing
- Task-Oriented Lower Extremity Strengthening Training
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Stroke, Hemiparesis
Efficacy of Tele-CPASS Compared to In-person CPASS Therapy for Upper Extremity Motor Recovery
This study evaluates whether a home-based telerehabilitation program (tele-CPASS) is as effective as an in-person rehabilitation program (CPASS) for improving arm and hand function after stroke.
- Conditions
- Stroke, Hemiparesis, Upper Extremity Impairments, Stroke Rehabilitation
- Trial name
- NCT07661849
- Testing
- Tele-CPASS, In-person CPASS therapy
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of Texas, El Paso
Metaplasticity
Improving Hand Movement Training Through Electrical Stimulation of the Brain
This study will determine if applying electrical stimulation of the brain can influence training to perform finger movements. The study may provide information that can be used to design rehabilitation therapies for people who…
- Trial name
- NCT00331318
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy Volunteers
Main Study: Influence on Plasticity of Brain Temperature Sub-Study: Phase Triggered Paired Associative Stimulation (PAS)
Sub-Study: Phase Triggered Paired Associative Stimulation (PAS) (completed - analysis only) Background: -Previous research has shown that the brain s activity changes with changes in brain waves.
- Trial name
- NCT02363296
- Testing
- TMS
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Mental Health (NIMH)
Parkinson Disease
Cerebral Contributions to Symptom Progression in PD
Motor symptom progression in early-stage Parkinson's disease varies substantially between individual patients. This progression correlates poorly with striatal dopamine depletion, which is largely complete four years…
- Trial name
- NCT05169827
- Where
- Netherlands
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cerebral Palsy
Quadriceps Muscle Plasticity in Children With Cerebral Palsy
Our primary aim is to determine whether and how muscle architecture of the quadriceps muscles in cerebral palsy (CP) adapts to two separate training programs: traditional strength training (ST) vs.
- Trial name
- NCT00629070
- Testing
- Traditional strength training, Velocity-enhanced training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical University of South Carolina
Alzheimer Disease, Mild to Moderate
TMS Stimulation and Cognitive Training in Alzheimer Patients
The aim of this study is to examine if combined treatment with TMS and cognitive training (CoTra) for several weeks can produce a sustained improvement in cognitive and behavioral symptomatology of mild to moderate Alzheimer's…
- Trial name
- NCT01168245
- Testing
- NICE-System
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Neuronix Ltd
Older Adults, Aging Brain
Plasticity-based Adaptive Cognitive Remediation for Alzheimer Disease
The primary objective of this study is to evaluate the effects of the experimental treatment (cognitive training) further outlined in this protocol on the cognitive abilities (e.g., processing speed, attention, working memory…
- Trial name
- PACR-AD (NCT02331784)
- Testing
- Computerized Plasticity-based Software, Commercially available Video Game
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Cerebral Palsy
Intense Physiotherapies to Improve Function in Young Children With Cerebral Palsy
Cerebral palsy (CP) is a non-progressive disorder caused by an insult or injury to the brain when the brain is most rapidly developing and which results in some motor dysfunction.
- Trial name
- NCT02167022
- Testing
- Physical and occupational therapy
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Arizona