Clinical trials: Brain Stroke
Traumatic Brain Injury, Stroke
Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without…
- Conditions
- Traumatic Brain Injury, Stroke, Brain Disease, Movement Disorders (Incl Parkinsonism)
- Trial name
- NCT07056348
- Testing
- Deep Brain Stimulation (DBS) of the Motor Thalamus
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jorge Gonzalez-Martinez
Stroke, Caregiving Burden
CaknaStrok Education Package for Stroke Caregivers
This study evaluated the feasibility and potential effectiveness of the CaknaStrok Education Package (CEP), a culturally tailored education package developed to support informal caregivers of stroke survivors.
- Conditions
- Stroke, Caregiving Burden, Caregiver, Caregiver Burden for Those Who Care for Adults With Impaired Functional Status
- Trial name
- CaknaStrok (NCT07807332)
- Testing
- CaknaStrok Education Package (CEP)
- Where
- Malaysia
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Clinical Research Centre, Malaysia
Stroke, Swallowing Disorders
Description and Modeling of Swallowing Disorders After a Stroke
The oropharyngeal junction participates in 3 interpenetrating functions: Swallowing, Breathing and Speech. In the context of ischemic or hemorrhagic stroke, these are altered, isolated or associated manner, causing major…
- Trial name
- AVC-MODE (NCT02974530)
- Testing
- Neurological evaluation, Laryngological evaluation, MRI evaluation
- Where
- 4 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Ischemic Stroke, Transient Ischemic Attack
Ticagrelor Based De-Escalation of Dual Antiplatelet Therapy in Ischemic Stroke
This is a randomized, controlled, outcome assessor blind, parallel group design pilot study on 100 patient with diagnosis of ischemic stroke admitted in Bou-Ali Sina Hospital, Sari,Iran.The aim of study is to compare the efficacy…
- Trial name
- DEDAPT-TICA (NCT06653348)
- Testing
- Ticagrelor 60 + Aspirin, Ticagrelor 90 + aspirin
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mazandaran University of Medical Sciences
Cerebrovascular Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis)
A SAD/MAD Study of Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Volunteers
Study BT200-01 is a first in human (FIH) study in male and female normal human volunteers (NHVs) that uses an Integrated Protocol Design.
- Conditions
- Cerebrovascular Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis), Intracranial Arteriosclerosis
- Trial name
- NCT04103034
- Testing
- BT200, Desmopressin
- Where
- Austria
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Band Therapeutics
Stroke, Hemiparesis
Telerehabilitation Through Serious Games in Virtual Reality in a Stroke Population (AutoRReVi)
After a stroke, individuals present with motor and/or cognitive impairments. These impairments limit activity, restrict participation and affect quality of life.
- Conditions
- Stroke, Hemiparesis, Cognitive Impairment, Healthy Subjects
- Trial name
- AutoRReVi (NCT04694833)
- Testing
- Motor and cognitive virtual reality-based assessments, Motor and cognitive virtual reality-based serious games
- Where
- Belgium
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Stroke
Reproducibility of fNIRS Parameters During Walking
Brain activation can be studied using the Functional Near InfraRed Spectroscopy (fNIRS). It was shown that CPF activation during walking and during dual task could be different in stroke patients and in healthy subjects.
- Trial name
- REPROXY (NCT04882930)
- Testing
- Functional Near-Infrared Spectroscopy (fNIRS)
- Where
- 3 sites in France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Cerebral Amyloid Angiopathy, Intracranial Hemorrhages
Multimodal Biomarkers for Diagnosis and Prognosis in CAA
By combination of plasma (Aβ40, Aβ42, total tau, and phosphorylated tau, etc.), genetic (ApoE ε2 or ε4 allele), MRI (cerebral perfusion, microbleeds, cortical superficial siderosis, enlarged perivascular space, etc.) and PET…
- Conditions
- Cerebral Amyloid Angiopathy, Intracranial Hemorrhages, Alzheimer Disease
- Trial name
- CAA (NCT03969732)
- Testing
- 1. amyloid PET；2. T807 PET
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Stroke
Non-use After Stroke: Influence of Applied Force and Precision When Reaching With the Paretic Upper Limb
After a stroke, 80% of patients have an upper limb deficit, limiting activity. Some develop a non-use: they can, but do not, use their paretic limb.
- Trial name
- OPTISTROKE (NCT04747587)
- Testing
- Reaching Session
- Where
- 2 sites in France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Stroke, Aphasia
Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia
Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke.
- Trial name
- MOTOLANG-AVC (NCT05776368)
- Testing
- Syntactic comprehension battery (BCS), Montreal Cognitive Assessment (MOCA), Purdue Pegboard Test
- Where
- 3 sites in France
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Ischemic Heart Disease, Transient Ischemic Attack
TomVasc - Vascular Effects of Tomato Extract
Does tomato extract improve blood vessel function in healthy people and people with cardiovascular disease? Atherosclerosis ('furring' of the arteries) affects the functioning of blood vessels, narrowing and eventually blocking…
- Conditions
- Ischemic Heart Disease, Transient Ischemic Attack, Stroke, Peripheral Vascular Disease
- Trial name
- TomVasc (NCT01100385)
- Testing
- Ateronon
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Quality of Life, Stroke, Acute
Cerebrovascular Disease: Quality of Life (CODE: QoL)
The goal of this observational study is to learn about quality of life, stress and caregiver burden in patients with stroke and their caregivers.
- Conditions
- Quality of Life, Stroke, Acute, Sexual Behavior, Stress
- Trial name
- CODE:QoL (NCT06443268)
- Testing
- questionnaire, hair samples, blood samples, clinical exam
- Where
- Switzerland
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Stroke Sequelae, Cognitive Impairment
Remote Bimanual Virtual Rehabilitation Post CVD
The aim of the study is to develop the BrightBrainer G (grasp), a game-based upper-extremity motor and cognitive rehabilitation system using custom virtual reality simulations.
- Conditions
- Stroke Sequelae, Cognitive Impairment, Depression
- Trial name
- NCT04713384
- Testing
- Integrative tele-rehalitation of chronic stroke survivors using custom therapeutic games
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Grigore Burdea
Stroke
The Changes of Masticatory / Swallowing Functions and Oropharyngeal Muscle Mass on Sonography After Comprehensive Swallowing Training and Tongue - Pressure Resistance Training in Stroke Patients With Dysphagia
The aims of this study are: 1. Comparing the ultrasound imaging performance of swallowing and chewing function, tongue pressure and oropharyngeal muscle thickness in stroke patients with different levels of swallowing function 2.
- Trial name
- NCT06269718
- Testing
- swallowing therapy, IOPI therapy
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Healthy Volunteers
An Investigational Study to Assess the Effect of BMS-986177 on Aspirin in Healthy Participants
The purpose of this study is to investigate the effect of taking multiple doses of BMS-986177 when aspirin is taken once-daily. Eligible participants will receive twice-daily doses of BMS-986177 or placebo, with a once-daily dose…
- Trial name
- NCT03341390
- Testing
- Aspirin, BMS-986177
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Mobile Applications, Secondary Prevention
The Use of Samsung Health and ECG M-Trace Base II Applications in the Secondary Prevention After Stroke
The aim of the present study was to quantitatively assess the risk factors that may affect the re-occurrence of a CVD event and the use of a commercially available mobile application Samsung Health for the assessment of…
- Conditions
- Mobile Applications, Secondary Prevention, Stroke
- Trial name
- NCT04821518
- Where
- Poland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Aphasia
LEXURE for Post-Stroke Aphasia
This study evaluates the efficacy of digital language rehabilitation using LEXURE for the treatment of post-stroke aphasia. Half of participants will receive structured language training using the LEXURE application, while the…
- Trial name
- NCT07570264
- Testing
- LEXURE, Workbook
- Where
- 12 sites in South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Nunaps Inc
Stroke, Stroke, Ischemic
Efficacy of REMO Training for Hand Motor Recovery After Stroke
Upper limb motor impairment is one of the most common sequelae after stroke. Indeed, the recovery of upper limb sensory-motor functions remains one of the most important goals in stroke rehabilitation.
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic, Stroke Sequelae
- Trial name
- REMO (NCT05815368)
- Testing
- REMO, Task-Oriented Training
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Stroke, Rehabilitation
Virtual Reality Mirror Therapy With Focused Object-Directed Attention System
In this study, the investigators hypothesized that Virtual Reality Mirror Therapy with Focused Object-Directed Attention (VRMTFOA) would yield superior therapeutic effects compared to conventional Virtual Reality Mirror Therapy…
- Conditions
- Stroke, Rehabilitation, Virtual Reality, Mirror Movement Therapy
- Trial name
- NCT07525713
- Testing
- task-oriented training
- Where
- Taiwan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Stroke
Active Smart Wearable Orthosis for Enhanched Rehabilitation THErapy
The purpose of this study is to investigate the usability of a new upper limb robot assisted therapy device in stroke patients.
- Trial name
- ARTHE (NCT03153254)
- Testing
- Test upper limb robot assisted therapy device, Training with new upper limb robot assisted therapy device
- Where
- 4 sites in Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas More Kempen
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