Clinical trials: Brain Stroke
Atrial Fibrillation
Apixaban Drug Utilization Study In Stroke Prevention In Atrial Fibrillation (Spaf)
Apixaban is a direct anticoagulant, which inhibits the factor Xa. Its clinical efficiency in prevention of stroke and systemic embolism in adult patients with NVAF (non/valvular atrial fibrillation) was demonstrated as well as…
- Trial name
- SPAF (NCT03441633)
- Testing
- apixaban, dabigatran, VKA
- Where
- Spain
- Volunteers
- 51,690 people
- Sponsor
- Pfizer
Stroke
The Outcomes of Seamless ADL Training Between Occupational Therapist and Nurse in Stroke Patients
This study aimed to develop and implement an interdisciplinary team model with integration of all the relevant expertise and to establish powerful collaboration and communication among the team.
- Trial name
- NCT02361307
- Testing
- Seamless ADL training, Conventional ADL training
- Where
- Thailand
- Volunteers
- 36 people
- Sponsor
- Mahidol University
Stroke
Patient Targeted Upper Extremity Rehabilitation After Stroke
Each year in the US, approximately 795,000 people have a stroke, and the overwhelming majority of those who survive are unable to resume meaningful daily activities because of impaired movement in one arm/hand.
- Trial name
- TARG (NCT01819506)
- Testing
- Task Practice Physical Rehabilitation Therapy
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- VA Office of Research and Development
Stroke, Hemiplegia
Usability Testing of Affordable Haptic Robots for Stroke Therapy
Stroke survivors with hemiplegia will be evaluated by rehabilitation professionals and asked to perform a battery of assessments to test the viability and usability of a force-feedback robot that adapts to each individual…
- Trial name
- Theradrive (NCT02772809)
- Testing
- Haptic Robot Therapy with Games
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pennsylvania
Aphasia, Apraxia of Speech
Treatments of Acquired Apraxia of Speech
This study was designed to examine the effects of speech therapy on ability to produce speech sounds in persons with acquired apraxia of speech.
- Conditions
- Aphasia, Apraxia of Speech, Stroke
- Trial name
- Apraxia (NCT01483807)
- Testing
- Sound Production Treatment - Blocked, Sound Production Treatment - Random
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Stroke, Hemiparesis
Long Term Split Belt Treadmill Training for Stroke Recovery
The purpose of this study is to determine whether split belt or conventional treadmill training can be used to treat walking pattern deficits from stroke and to determine whether this improves gait asymmetry and metabolic…
- Trial name
- NCT01646216
- Testing
- Split belt treadmill
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Atherosclerosis
Aliskiren Effect on Aortic Plaque Progression
This study is being done to assess the effectiveness of short term (~9 months) Aliskiren/Placebo therapy to slow down the progression of atherosclerotic disease in thoracic and abdominal aorta.
- Trial name
- ALPINE (NCT01417104)
- Testing
- Aliskiren
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Ohio State University
Stroke
WAveCrest Vs. Watchman TranssEptal LAA Closure to REduce AF-Mediated STroke 2
The WAVECREST 2 trial is a prospective, multicenter, randomized, active controlled, clinical trial to evaluate the safety and effectiveness of the Coherex WaveCrest Left Atrial Appendage (LAA) Occlusion System.
- Trial name
- WAVECREST2 (NCT03302494)
- Testing
- Coherex WaveCrest® Left Atrial Appendage Occlusion System, Watchman® LAA Closure Device
- Where
- 25 sites in United States, Australia
- Volunteers
- 248 people
- Sponsor
- Coherex Medical
Stroke
American Heart Association- Stroke/Hypoxia Study
Of the 795,000 people who experience a stroke every year in the US, only a small percentage will achieve full recovery. While current therapies promote strength and endurance, none directly address the unique potential of the…
- Trial name
- NCT04019522
- Testing
- Acute Intermittent Hypoxia (AIH)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Shirley Ryan AbilityLab
Acute Stroke, Stroke, Ischemic
Measuring Ambulation, Motor, and Behavioral Outcomes With Post-Stroke Fluoxetine in Tanzania
This is a phase II, randomized study of 120 adults age 18 or above who will prescribed 20mg daily Fluoxetine for 90 days following acute, ischemic stroke.
- Trial name
- MAMBO (NCT03728153)
- Testing
- Fluoxetine 20 MG Oral Tablet
- Where
- Tanzania
- Volunteers
- 34 people
- Sponsor
- Massachusetts General Hospital
Stroke, Hemiparesis
Upper Extremity Rehabilitation With the BURT Robotic Arm
The overall objective of the proposed study is to carry out usability and design-evaluation assessments of the BURT robotic device for delivering long-term intervention in stroke survivors.
- Trial name
- NCT03965403
- Testing
- Arm motor function retraining with BURT
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Spaulding Rehabilitation Hospital
Hypertension
Reach Out: Emergency Department-Initiated Hypertension Behavioral Intervention Connecting Multiple Health Systems
This study evaluates a health theory based mobile health behavioral intervention to reduce blood pressure (BP) among hypertensive patients evaluated in a community Emergency Department (ED) setting.
- Trial name
- ReachOut ED (NCT03422718)
- Testing
- Healthy Behavior Texts, No healthy behavior texts, BP Monitoring Daily Via Text Messaging
- Where
- United States
- Volunteers
- 488 people
- Sponsor
- University of Michigan
Muscle Spasticity
Intrathecal (IT) Baclofen Drug Distribution
The goal of this pilot study to determine whether there is a significant therapeutic advantage to place the ITB catheter within the cervical, thoracic or lumbar region of the spine.
- Trial name
- ITB (NCT02903823)
- Testing
- Baclofen bolus injection
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Vanderbilt University
Arterial Ischemic Stroke
A Proof of Concept Study to Evaluate the Safety of Afamelanotide in Patients With Acute Arterial Ischaemic Stroke (AIS)
The primary study objective is to assess the safety of afamelanotide while the secondary objective is to assess whether the therapy affects the size of the penumbra, by increasing blood flow, restoring oxygen supply to the brain…
- Trial name
- NCT04962503
- Testing
- Afamelanotide
- Where
- Australia
- Volunteers
- 6 people
- Sponsor
- Clinuvel Pharmaceuticals Limited
Bleeding Disorder, Stroke, Ischemic
XIENCE 28 Global Study
XIENCE 28 Global Study is a prospective, single arm, multi-center, open label, non-randomized trial to further evaluate the safety of 1-month (as short as 28 days) dual antiplatelet therapy (DAPT) in subjects at high risk of…
- Conditions
- Bleeding Disorder, Stroke, Ischemic, Stroke Hemorrhagic, Hematological Disease
- Trial name
- NCT03355742
- Testing
- XIENCE, DAPT
- Where
- 52 sites in Austria, Belgium and 11 more
- Volunteers
- 963 people
- Sponsor
- Abbott Medical Devices
Pediatrics, Muscle Spasticity
BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity
This study will evaluate the long-term safety of BOTOX® (botulinum toxin Type A) for the treatment of pediatric upper limb spasticity.
- Conditions
- Pediatrics, Muscle Spasticity, Cerebral Palsy, Stroke
- Trial name
- NCT01603615
- Testing
- Botulinum Toxin Type A
- Where
- 48 sites in United States, Canada and 7 more
- Volunteers
- 220 people
- Sponsor
- Allergan
Stroke
Fatiguing Arm Exercise Following Stroke
This study investigates the effects of sub-maximal exercise to task-failure (e.g., fatigue) with the less involved, or so-called non-paretic hand, in people who have experienced a stroke.
- Trial name
- NCT03194464
- Testing
- submaximal exercise (grip)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Office of Research and Development
Stroke
Mirror-Box Training in Adults With Chronic Hemiparesis Secondary to Stroke
The purpose of this project is to assess the effects of four weeks of mirror-box training on weakness of one arm secondary to stroke. Primary measures are function and strength.
- Trial name
- NCT00643864
- Testing
- mirror training
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wake Forest University Health Sciences
Ischemic Stroke
Mayo Acute Stroke Trial for Enhancing Recovery
This study involves treating patients that have suffered an acute ischemic stroke with the medication donepezil (Aricept ®). The hypothesis is that taking donepezil (FDA-approved for the treatment of Alzheimer's Disease) for the…
- Trial name
- MASTER (NCT00805792)
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Mayo Clinic
Stroke, Acute Stroke
Soft Exosuits for Functional Gait Recovery in Acute Stroke Rehabilitation
The purpose of this study is to develop and evaluate the use of soft exosuits in patients post stroke.
- Trial name
- NCT06231511
- Testing
- Hip flexion soft exosuit, ReWalk ReStore soft exosuit, Conventional physical therapy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Shirley Ryan AbilityLab