Clinical trials: Brain Stroke
Stroke
Development of Walk Assist Device to Improve Community Ambulation
Hypothesis/Specific Aims: The purpose of this study is to determine the effect of training with the Stride Management Assist (SMA) device vs.
- Trial name
- NCT01994395
- Testing
- The Stride Management Assist (SMA) System, Impairment based therapy
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Myocardial Infarctions
Aspirin Resistance and Stroke Risk: Platelet Function Analysis in Patients With Ischemic Events
The purpose of this study is to determine if PFA results correlate with ischemic event outcomes as well as bleeding complications.
- Trial name
- NCT01586975
- Testing
- Clopidogrel, Aspirin 81 mg, Aspirin >300 mg
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Northwestern University
Stroke, Aphasia
Evaluating Anodal tDCS Preceding Aphasia Therapy
The purpose of this study is to determine if non-invasive brain stimulation (transcranial direct current stimulation) delivered prior to language therapy will improve word-finding in individuals with aphasia who are 6 months or…
- Trial name
- NCT02249819
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Northwell Health
Post-stroke Depression
SCED - Wisdom Enhancement for Post-Stroke Depression
One-third of stroke survivors experience post-stroke depression, but there are currently no official guidelines for supporting them.
- Trial name
- WE-PSD (NCT06451965)
- Testing
- Timeline Intervention
- Where
- United Kingdom
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Brain Infarct
Normal Saline Infusion for Stroke After Intravenous Thrombolysis
This study aims to explore the safety and efficacy of 0.9% normal saline （NS） infusion on stroke after intravenous thrombolysis (IVT), we decided to conduct this multi-centre randomized controlled trial for the first time.
- Trial name
- NS-STAR (NCT05993078)
- Testing
- 0.9% NaCl 2000ml, 0.9% NaCl 200-400ml
- Where
- 3 sites in China
- Volunteers
- 241 people
- Sponsor
- Tianjin Medical University General Hospital
Brain Edema, Stroke, Acute
Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction
The primary objective of Part 1 of the study is to determine if BIIB093 improves functional outcome at Day 90 as measured by the modified Rankin Scale (mRS) when compared with placebo in participants with Large Hemispheric…
- Trial name
- CHARM (NCT02864953)
- Testing
- BIIB093
- Where
- 250 sites in United States, Australia and 22 more
- Volunteers
- 535 people
- Sponsor
- Remedy Pharmaceuticals, Inc.
Ischemic Stroke
Albumin in Acute Ischemic Stroke Trial
The goal of the trial is to determine whether human albumin, administered within 5 hours of symptom onset, improves the 3-month outcome of subjects with acute ischemic stroke.
- Trial name
- ALIAS (NCT00235495)
- Testing
- Albumin, Saline
- Where
- 89 sites in United States, Canada and 2 more
- Volunteers
- 841 people
- Sponsor
- University of Miami
Atrial Fibrillation, Stroke
IMplementation of an RCT to imProve Treatment With Oral AntiCoagulanTs in Patients With Atrial Fibrillation
The purpose of this study is to use a decentralized claims database to determine whether education on stroke prevention in atrial fibrillation (AF) among AF patients and their providers can result in increased use of oral…
- Trial name
- IMPACT-AFib (NCT03259373)
- Testing
- Early Patient-Level and Provider-Level Educational Intervention, Delayed Provider-Level Educational Intervention
- Where
- 4 sites in United States
- Volunteers
- 64,666 people
- Sponsor
- Harvard Pilgrim Health Care
Ischemic Stroke
Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy Pilot Trial
Prospective, single center, non-randomized, pilot study to assess the feasibility of IA TNK following standard of care mechanical thrombectomy (MT) in patients with AIS.
- Trial name
- ALLY (NCT05172934)
- Testing
- intra-arterial tenecteplase
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- ProMedica Health System
Stroke
Biofeedback to Increase Propulsion During Walking After Stroke
Approximately 15,000 Veterans are hospitalized for stroke each year with new cases costing an estimated $111 million for acute inpatient, $75 million for post-acute inpatient, and $88 million for follow-up care over 6 months…
- Trial name
- NCT02667392
- Testing
- Gait Training with Biofeedback, Gait Training with Verbal Feedback
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- VA Office of Research and Development
Ischemic Stroke
Occult Paroxysmal Atrial Fibrillation in Non-Cryptogenic Ischemic Stroke
The purpose of this study is to determine the incidence of paroxysmal atrial fibrillation (AF) in ischemic stroke patients who have a presumed known stroke etiology other than atrial fibrillation.
- Trial name
- NCT02232022
- Testing
- Reveal LINQ Insertable Cardiac Monitor
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Northwell Health
Atrial Fibrillation, Deep Vein Thrombosis
Weekly Monitoring Strategy of Capillary INR Versus Monthly Monitoring Strategy of Venous INR in Elderly Patients in a Nursing Home.
This primary care study aims to compare the "time in therapeutic range" (TTR) of two strategies for monitoring the international normalized ratio (INR) over 6 months in nursing homes.
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Stroke
- Trial name
- INR-CAP (NCT05561244)
- Testing
- Weekly monitoring using the capillary International Normalised Ratio strategy
- Where
- 33 sites in France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Chronic Post-stroke Headache
TMS and Exercise for Post-stroke Pain
There are over 7 million people living with stroke in the United States. Per year, approximately 17,000 Veterans are admitted to the VA for acute stroke. Chronic pain after stroke can occur between 10-50% of stroke survivors.
- Trial name
- NCT04672044
- Testing
- Active rTMS and exercise
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Stroke, Hemiparesis
Functional Electrical Stimulation Mediated Neuroplasticity: Lower Extremity CCNMES in Stroke
This is a small pilot randomized controlled trial which will enroll both subacute (<6 mos) and chronic (>6 mos) stroke survivors with ankle dorsiflexion weakness.
- Conditions
- Stroke, Hemiparesis, Footdrop
- Trial name
- NCT02199795
- Testing
- Contralaterally Controlled Neuromuscular Electrical Stimulation, Cyclic Neuromuscular Electrical Stimulation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- MetroHealth Medical Center
Stroke, Ischemic, Acute Coronary Syndrome
PRediction of Acute Coronary Syndrome in Acute Ischemic StrokE
The primary goal of the PRAISE study is to develop a diagnostic algorithm that allows the prediction of acute coronary syndrome in stroke patients with elevated levels of cardiac troponin.
- Trial name
- PRAISE (NCT03609385)
- Testing
- Coronary angiography
- Where
- 28 sites in Germany
- Volunteers
- 254 people
- Sponsor
- Charite University, Berlin, Germany
Stroke
Improving Ambulation Post Stroke With Robotic Training
The purpose of this research study is to look at a new rehabilitation technique for individuals who have suffered a stroke and have difficulties walking.
- Trial name
- NCT00975156
- Testing
- Physical Therapy, Lokomat
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The University of Texas Health Science Center, Houston
Stroke, Cerebrovascular Accident (CVA)
The Role of Trans-spinal Direct Current Stimulation (tsDCS) in Treating Patients With Hand Spasticity After Stroke
The purpose of this study is to evaluate if 5 consecutive sessions of PathMaker anodal DoubleStim treatment, which combines non-invasive stimulation of the spinal cord (tsDCS- trans-spinal direct current stimulation) and of the…
- Conditions
- Stroke, Cerebrovascular Accident (CVA), Hemiparesis, Spasticity as Sequela of Stroke
- Trial name
- NCT03080454
- Testing
- anodal Doublestim
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Northwell Health
MELAS Syndrome
Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes
The purpose of this study is to compare the efficacy of two (2) different doses of idebenone with that of a placebo over a one month period on cerebral lactate concentration as measured by magnetic resonance spectroscopy.
- Trial name
- MELAS (NCT00887562)
- Testing
- Idebenone
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Michio Hirano
Stroke, Stroke, Ischemic
Passive Tactile Stimulation for Stroke Rehabilitation
Stroke can lead to weakness and spasticity in the arm or hand. The purpose of this study is to optimize the design of gentle vibratory stimulation delivered to the hands of individuals with chronic stroke, and explore the effect…
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke
- Trial name
- PTS (NCT03814889)
- Testing
- Vibration pattern, No vibration
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Stanford University
Ischemic Stroke
Randomized Controlled Trial of Argatroban With Tissue Plasminogen Activator (tPA) for Acute Stroke
Randomized controlled clinical trial to estimate overall treatment benefit (improvement in disability) among stroke patients treated with rt-PA who are randomized to also receive either low-dose Argatroban, high-dose Argatroban…
- Trial name
- ARTSS-2 (NCT01464788)
- Testing
- Low Dose Argatroban, High Dose Argatroban, rt-PA (alteplase)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Andrew D. Barreto, MD