Clinical trials: Brain and Mobility Changes
Mobility Limitation, Balance Impairment
TIME™ at Home Feasibility Study: Evaluation of a Virtually Delivered, Community-based, Task-oriented Exercise Program
Balance and mobility limitations can lead to increased difficulty with everyday function and increased dependence on caregivers.
- Trial name
- NCT05369741
- Testing
- TIME™ at Home
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Toronto
Multiple Sclerosis, Relapsing-Remitting
Exploration of Brain Changes Due to a Targeted Ballet Program in Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) affecting roughly 900,000 people in the United States that frequently results in impaired mobility.
- Trial name
- NCT04073940
- Testing
- Targeted Ballet Program
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Illinois at Urbana-Champaign
Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene
Evaluation of Impaired Mobility in Chronic Illness Constitution of a Cohort
Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern.
- Conditions
- Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene, Parkinson Disease, Chronic Obstructive Pulmonary Disease, Unspecified
- Trial name
- EVALMOB (NCT04375280)
- Testing
- Development of a screening algorithm designed to determine a "dysmobility" profile in patients with chronic illness.
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cerebral Palsy, Spastic Diplegia
Effect of Physical Activity Intervention Children With Spastic Diplegia After Resistance Training
The purpose of this study is to investigate the effects of a 6-month physical activity intervention program on mobility and participation after the termination of a 6-week functional strengthening program for school-age children…
- Trial name
- NCT01367340
- Testing
- Loaded sit-to-stand resistance exercise, Physical activity intervention
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- National Taiwan University Hospital
Parkinson Disease
Novel Tools for the Delivery and Assessment of Exercise Programs Adapted to Individuals With Parkinson's Disease
The study will aim to determine whether a technology-based personalized home exercise program delivered asynchronously and supervised remotely by a kinesiologist is more effective in improving gait than a similar home-based…
- Trial name
- NCT04078217
- Testing
- Jintronix, Booklet
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Université du Québec a Montréal
Cerebral Palsy
Exoskeleton-assisted Physiotherapy for Children With Mobility Impairments
Non-ambulatory children with cerebral palsy (CP) and similar childhood-onset neuromotor conditions face many challenges to fulsome participation in everyday life.
- Trial name
- NCT05463211
- Testing
- Trexo Plus Pediatric Exoskeleton
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Idiopathic Normal Pressure Hydrocephalus (INPH)
Change in Cognition and Frailty After Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus (iNPH)
The goal of this observational study is to describe changes in cognitive profile and frailty from pre shunt to one year after the shunt surgery and to identify clinical predictors of an improvement in terms of cognition and…
- Trial name
- NCT07642726
- Testing
- Ventriculoperitoneal shunt
- Where
- Norway
- Volunteers
- 276 people
- Sponsor
- Oslo University Hospital
Parkinson Disease, Bone Loss
Bone Mineral Density Changes Among Clinical Subtypes of Parkinson's Disease
The bone loss in Parkinson's disease (PD) emerges as a non-motor symptom with motor and non-motor outcomes, such as fracture and musculoskeletal pain.
- Trial name
- NCT03806517
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ordu University
Clinical Pain, Brain and Mobility Changes
Pain, Brain and Mobility Study
The aim of this project will be to document the central and peripheral mechanisms, which may predict clinical pain characteristics and associated physical performance in older adults.
- Trial name
- PBAM (NCT02240303)
- Testing
- Quantitative Sensory Testing (QST), Physical Performance, Magnetic Resonance Imaging (MRI)
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson's Disease (PD)
Observational Study Evaluating Robotic Spinal Mobilization in 16 Parkinson's Disease Participants. The Study Recorded Changes in Mobility, Sit-to-stand Performance, and Pain Scores After a 2-week Intervention With the BackHug Device.
The goal of this completed observational pilot study was to evaluate the immediate and short-term clinical effects of robotic spinal mobilization on motor and non-motor symptoms in community-dwelling adults with Parkinson's…
- Trial name
- NCT07384364
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Pacla Medical Limited
Spastic Cerebral Palsy, Acquired Brain Injury
Evaluation of Macroscopic Muscle Growth in Infants and Young Children With Spastic Cerebral Palsy
A mixed longitudinal design study will be carried out to explore the onset and time course of morphological muscle changes on a macroscopic level in children with spastic cerebral palsy (SCP).
- Trial name
- 3D-MMAP (NCT05197764)
- Where
- Belgium
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Effect of Age-related Changes in the Brain on Walking Ability
"Mind in Motion": Multimodal Imaging of Brain Activity to Investigate Walking and Mobility Decline in Older Adults
The objective of this study is to determine the central neural control of mobility in older adults by acquiring data with multiple modalities of neuroimaging (EEG, fNIRS, MRI) and associating these data with a comprehensive set…
- Trial name
- NCT03737760
- Where
- United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson Disease, Walking, Difficulty
BeatPark: Self-rehabilitation in Walking With Parkinson's Disease
Physical activity has beneficial effects on the quality of walking for persons with Parkinson's disease (PD). However, regular physical activity is still limited in most patients' daily lives.
- Trial name
- BeatPark (NCT04543058)
- Testing
- BeatPark Application, BeatPark Application without synchronized music, BeatPark Application without music
- Where
- France
- Volunteers
- 396 people
- Sponsor
- Clinique Beau Soleil
Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene
Towards the Use of Instrumented Tests for Screening the Risk of Falling in Patients With Chronic Illness.
In patients with chronic illness, screening for falls and their health consequences are major public health issues. Muscle weakness, gait and balance disorders are among the most common risk factors for falling.
- Conditions
- Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene, Parkinson Disease, Chronic Obstructive Pulmonary Disease, Unspecified
- Trial name
- DETECACTI (NCT04368858)
- Testing
- Exploratory physiopathology study, including non-invasive functional explorations carried out in patients with chronic pathology.
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
Migraine, Temporomandibular Joint Disorders
Changes and Associations Between Cervical Range of Motion, Pain, TMJ Range of Motion and Quality of Life in Migraineurs Applying Physical Therapy
The purpose of this study is to assess the effects of physiotherapy program and review the associations between neck movements, pain, temporomandibular joint (TMJ) movements and quality of life in individuals with migraine.
- Conditions
- Migraine, Temporomandibular Joint Disorders, Myofascial Trigger Point Pain
- Trial name
- NCT04729699
- Testing
- Aerobic exercise and exercise for TMJ, Aerobic exercise at home
- Where
- Lithuania
- Volunteers
- 19 people
- Sponsor
- Lithuanian University of Health Sciences
Cerebral Palsy, Spastic
Altered Back Geometry and Mobility Function After Backward Walking Training in Children With Cerebral Palsy
PURPOSE: To assess the effect of backward walking training on back geometry and mobility function in children with hemiparetic cerebral palsy through a comparative analysis with forward walking training.
- Trial name
- NCT04981964
- Testing
- Exercise training
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Cairo University
Parkinson Disease
Modulation of GABA-A Receptors in Parkinson Disease-Transdermal Flumazenil Arm
The arm of this study evaluates possible GABA-A receptor target engagement effects of the FDA-approved medication, transdermal flumazenil (added 4/2020, replaced clarithromycin), in the setting of Parkinson's disease.
- Trial name
- GABA-A (NCT03440112)
- Testing
- Clarithromycin (Not used as of 4/2020), Transdermal flumazenil (Added 4/2020)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Nicolaas Bohnen, MD, PhD
Alzheimer Disease, Early Onset
Adapted Home-based Exercise Program "T&E" (Test-and-Exercise) in Persons With Alzheimer's Disease (HOPE Trial)
The aim of this exploratory pilot study is to assess the feasibility and effectiveness of the adapted T\&E home-based exercise program on the basic functional mobility and executive functions in persons with mild or probable…
- Trial name
- HOPE (NCT04916964)
- Testing
- Test and exercise home-based program
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- HES-SO Valais-Wallis
Obesity, Stroke
EMPOWER: Effects of Weight Loss and Exercise Post-stroke
The prevalence of obesity among U.S. adults is ~40% and is projected to climb. It is well documented that obesity is associated with increased levels of disability as well as risk for numerous adverse health-related outcomes…
- Trial name
- EMP (NCT05901675)
- Testing
- Lifestyle Management Program, Post-stroke Optimization of Walking using Explosive Resistance
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Medical University of South Carolina
Stroke
Xeomin® and Gait Related Mobility After Stroke
The aim of the present pilot study is to evaluate the association between change in gait related mobility in ambulatory male and female adult hemiparetic patients before and 4-6-weeks after Xeomin® injection into the upper limb…
- Trial name
- NCT04908423
- Testing
- Xeomin®
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences