Clinical trials: Brainstem Stroke
Locked-in Syndrome, Neuromuscular Diseases
Investigation on the Cortical Communication System
The goal of this clinical trial is to demonstrate communication through a brain implant in people in locked-in state, i.e. people with severe paralysis and communication problems.
- Conditions
- Locked-in Syndrome, Neuromuscular Diseases, Brainstem Stroke, Traumatic Brain Injury
- Trial name
- CortiCom (NCT06207591)
- Testing
- ECoG (electrocorticography) sensing
- Where
- Netherlands
- Volunteers
- 2 people
- Sponsor
- UMC Utrecht
Dysphagia
tDCS for Dysphagia Associated to Brainstem Stroke
The aim of the study is to investigate the effect of anodal transcranial direct current stimulation applied over the pharyngeal motor area in 60 dysphagic patients with acute isolated brainstem stroke.
- Trial name
- NCT04308733
- Testing
- Anodal tDCS
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Presidio Ospedaliero Garibaldi-Centro
Brain Stem Hemorrhage, Robotic Surgical Procedures
A Multicenter, RAndomIzed, coNtrolled, umBrella Trial fOr Minimally Invasive Neurosurgery With AI-assisted Robotic guidanCe for Hemorrhagic Stroke
The purpose of this clinical trial is to observe the improvements in clinical symptoms and imaging outcomes for brainstem hemorrhage using robot-assisted stereotactic puncture, evaluate the clinical efficacy and safety of this…
- Trial name
- RAINBOW-BSH (NCT06459427)
- Testing
- Robot-assisted minimally invasive puncture and aspiration surgery, Standard medical management
- Where
- 15 sites in China
- Volunteers
- 142 people
- Sponsor
- Yanbing Yu
Amyotrophic Lateral Sclerosis, Brain Stem Stroke
Real World Testing of a Brain-Computer Interface
The goal of this project is to test a new AAC-BCI device comparing gel and dry electrode headgear used for communication while providing clinical care.
- Conditions
- Amyotrophic Lateral Sclerosis, Brain Stem Stroke, Cerebral Palsy, Traumatic Brain Injury
- Trial name
- NCT04026581
- Testing
- Speech generating device (SGD) evaluation including BCI access, Training and treatment
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Pittsburgh
Tetraplegia, Locked-in Syndrome
Investigation on the Cortical Communication (CortiCom) System
The CortiCom system consists of 510(k)-cleared components: platinum PMT subdural cortical electrode grids, a Blackrock Microsystems patient pedestal, and an external NeuroPort Neural Signal Processor.
- Conditions
- Tetraplegia, Locked-in Syndrome, Brainstem Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- CortiCom (NCT03567213)
- Testing
- Surgical implantation of CortiCom system
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Johns Hopkins University
Stroke
Coughing in Infratentorial Brain Lesion Patients
To record diaphragm excursion in infratentorial brain lesions patients with dysphagia during coughing and compare them to those with supratentorial brain lesion patients with dysphasia and those with no dysphagia at a university…
- Trial name
- NCT02081040
- Testing
- Not applicable (observational study with no active intervention)
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- The Catholic University of Korea
Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS)
Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)
The goal of this clinical trial is to evaluate the safety and preliminary efficacy of an implantable device that records and stimulates different areas of the brain to allow adults affected by disabling paralysis (see Eligibility…
- Conditions
- Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS), Muscular Disorders, Atrophic, Brain Stem Stroke
- Trial name
- INTENT (NCT07521930)
- Testing
- INTENT Neural Interface System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Basal Ganglia Hemorrhage, Intraventricular Hemorrhage
RAINBOW-ICH Trial of AI Guided Minimally Invasive Neurosurgery for ICH
Intracerebral hemorrhage (ICH) is one of the most devastating forms of stroke, with high rates of death and disability worldwide. Despite advances in medical and surgical care, effective therapeutic options remain limited.
- Conditions
- Basal Ganglia Hemorrhage, Intraventricular Hemorrhage, Brainstem Stroke, Intracranial Hemorrhage, Spontaneous
- Trial name
- RAINBOW-ICH (NCT07205263)
- Testing
- AI-assisted robotic-guided endoscopic hematoma evacuation, Conventional craniotomy, AI-assisted robotic-guided puncture and hematoma evacuation
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cavernous Malformations, Intracerebral Hemorrhage
Hemorrhagic Brainstem Cavernous Malformations Treatment With Sirolimus: aSingle Centre, Randomized, Placebo-controlled Pilot Trial
The aim of this pilot phase trial is to assess the safety and tolerability, and estimate the efficacy of sirolimus in reducing the incidence of ICH during high-risk periods for rebleeding, compared to placebo.
- Conditions
- Cavernous Malformations, Intracerebral Hemorrhage, Brainstem Stroke
- Trial name
- CALM (NCT06091332)
- Testing
- Sirolimus, Starch flake
- Where
- 2 sites in China
- Volunteers
- 75 people
- Sponsor
- Huashan Hospital
Neurologic Disorder, Paralysis
SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
The Synchron Motor Neuroprosthesis (MNP) is intended to be used in subjects with severe motor impairment, unresponsive to medical or rehabilitative therapy and a persistent functioning motor cortex.
- Conditions
- Neurologic Disorder, Paralysis, Paralysis; Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- NCT05041114
- Testing
- Motor Neuroprosthesis
- Where
- 3 sites in Australia
- Sponsor
- Synchron Medical, Inc.
Tetraplegia, Spinal Cord Injury
Microelectrode Brain-Machine Interface for Individuals With Tetraplegia
The purpose of this research study is to demonstrate the safety and efficacy of using two NeuroPort Arrays (electrodes) for long-term recording of brain activity.
- Trial name
- NCT01364480
- Testing
- Implantation of NeuroPort Arrays in the motor cortex
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Michael Boninger
Leukodystrophy, White Matter Disease
LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
Leukodystrophies, and other heritable disorders of the white matter of the brain, were previously resistant to genetic characterization, largely due to the extreme genetic heterogeneity of molecular causes.
- Conditions
- Leukodystrophy, White Matter Disease, 4H Syndrome, Adrenoleukodystrophy
- Trial name
- NCT02699190
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Children's Hospital of Philadelphia
Deglutition Disorders, Lateral Medullary Syndrome
Cortical Function Changes During Swallowing in Patients With Dysphagia in Lateral Medullary Syndrome
The goal of this observational study is to detect the alteration of cortical activation and functional connectivity during swallowing in patients with Lateral Medullary Syndrome (LMS) dysphagia by functional near infrared…
- Trial name
- NCT06208020
- Testing
- Functional near-infrared spectroscopy (fNIRS) detection
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Paralysis; Quadriplegic, Quadraplegia
MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System
This research study is being done to develop a novel brain-computer interface (BCI) technology that can enable severely paralyzed individuals to interact with the world through direct brain-control of a computer.
- Conditions
- Paralysis; Quadriplegic, Quadraplegia, Tetraplegia, Tetraplegic Motor Dysfunction Following Brainstem or Spinal Cord Injury
- Trial name
- NCT05936619
- Testing
- Mind Extender (MindEx)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Nader Pouratian
Lateral Medullary Syndrome, Deglutition Disorders
The Motor Imagery Based on Action Observation Treatment on Dysphagia in Wallenberg Syndrome
The goal of this clinical trial is to learn about on dysphagia in wallenberg syndrome. The main questions it aims to answer are: the efficacy of motor imagery based on action observation treatment in the rehabilitation of…
- Trial name
- NCT06224686
- Testing
- conventional dysphagia treatment, motor imagery based on action observation treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Le Wang
Stroke
Effects of Upper Extremity Rehabilitation Robot and Transcranial Direct Current Stimulation Among Patients With Stroke
Effects of upper extremity rehabilitation robot and transcranial direct current stimulation on upper extremity function among subjects with tremor after stroke
- Trial name
- NCT04055597
- Testing
- Robot and tDCS on-line
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- National Rehabilitation Center, Seoul, Korea
Tetraplegia/Tetraparesis, Quadriplegia
GB-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices
The GB-PRIME Study is an early feasibility study designed to assess the clinical safety and functionality of the Neuralink N1 Implant and R1 Robot.
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Quadriplegia/Tetraplegia, Cervical Spinal Cord Injury
- Trial name
- GB-PRIME (NCT07127172)
- Testing
- N1 Implant, R1 Robot
- Where
- 2 sites in United Kingdom
- Volunteers
- 7 people
- Sponsor
- Neuralink Corp
Sturge - Weber Syndrome (SWS)
Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS)
Sturge-Weber Syndrome (SWS) is a neurological disorder characterized at birth by seizures and a large port-wine stain birthmark on the forehead and upper eyelid of one side of the face.
- Trial name
- NCT00610402
- Testing
- blood sample tear drop sample
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of California, Irvine
Tetraplegia, Spinal Cord Injury
Cortical Recording and Stimulating Array Brain-Machine Interface
The purpose of this research study is to demonstrate the safety and efficacy of using two CRS Arrays (microelectrodes) for long-term recording of brain motor cortex activity and microstimulation of brain sensory cortex.
- Conditions
- Tetraplegia, Spinal Cord Injury, Brainstem Stroke, Brachial Plexus Injury
- Trial name
- CRS-BMI (NCT01894802)
- Testing
- Implantation of CRS Arrays
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Michael Boninger
Brainstem Stroke, ALS
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)
People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), or other disorders can become unable to move or speak despite being awake and alert.
- Conditions
- Brainstem Stroke, ALS, Tetraplegia, Spinal Cord Injuries
- Trial name
- BG-Tablet-01 (NCT06511934)
- Testing
- BrainGate Neural Interface System
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.